Amino acid dipepetide frequency for Streptomyces paucisporeus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	25.31AlaAla: 25.31 ± 0.173	1.104AlaCys: 1.104 ± 0.02	9.177AlaAsp: 9.177 ± 0.077	8.187AlaGlu: 8.187 ± 0.091	3.617AlaPhe: 3.617 ± 0.042	14.721AlaGly: 14.721 ± 0.093	2.952AlaHis: 2.952 ± 0.034	3.43AlaIle: 3.43 ± 0.048	2.607AlaLys: 2.607 ± 0.044	14.853AlaLeu: 14.853 ± 0.116	2.53AlaMet: 2.53 ± 0.035	2.094AlaAsn: 2.094 ± 0.036	7.747AlaPro: 7.747 ± 0.082	4.005AlaGln: 4.005 ± 0.045	10.203AlaArg: 10.203 ± 0.082	5.967AlaSer: 5.967 ± 0.052	7.744AlaThr: 7.744 ± 0.072	13.02AlaVal: 13.02 ± 0.09	1.921AlaTrp: 1.921 ± 0.031	2.931AlaTyr: 2.931 ± 0.039	0.0AlaXaa: 0.0 ± 0.0
Cys	1.067CysAla: 1.067 ± 0.02	0.098CysCys: 0.098 ± 0.007	0.514CysAsp: 0.514 ± 0.015	0.336CysGlu: 0.336 ± 0.012	0.203CysPhe: 0.203 ± 0.01	0.959CysGly: 0.959 ± 0.027	0.206CysHis: 0.206 ± 0.01	0.153CysIle: 0.153 ± 0.007	0.113CysLys: 0.113 ± 0.007	0.739CysLeu: 0.739 ± 0.02	0.122CysMet: 0.122 ± 0.008	0.174CysAsn: 0.174 ± 0.011	0.457CysPro: 0.457 ± 0.014	0.186CysGln: 0.186 ± 0.009	0.587CysArg: 0.587 ± 0.017	0.451CysSer: 0.451 ± 0.014	0.542CysThr: 0.542 ± 0.016	0.63CysVal: 0.63 ± 0.018	0.133CysTrp: 0.133 ± 0.008	0.17CysTyr: 0.17 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	8.073AspAla: 8.073 ± 0.081	0.451AspCys: 0.451 ± 0.015	3.558AspAsp: 3.558 ± 0.039	3.25AspGlu: 3.25 ± 0.04	1.73AspPhe: 1.73 ± 0.029	6.384AspGly: 6.384 ± 0.065	1.436AspHis: 1.436 ± 0.026	1.873AspIle: 1.873 ± 0.03	1.003AspLys: 1.003 ± 0.023	6.513AspLeu: 6.513 ± 0.065	0.764AspMet: 0.764 ± 0.017	1.018AspAsn: 1.018 ± 0.022	4.802AspPro: 4.802 ± 0.051	1.658AspGln: 1.658 ± 0.032	4.913AspArg: 4.913 ± 0.055	2.674AspSer: 2.674 ± 0.035	3.391AspThr: 3.391 ± 0.043	4.655AspVal: 4.655 ± 0.043	0.97AspTrp: 0.97 ± 0.018	1.208AspTyr: 1.208 ± 0.024	0.0AspXaa: 0.0 ± 0.0
Glu	6.559GluAla: 6.559 ± 0.075	0.342GluCys: 0.342 ± 0.015	2.493GluAsp: 2.493 ± 0.033	2.72GluGlu: 2.72 ± 0.045	1.24GluPhe: 1.24 ± 0.026	3.619GluGly: 3.619 ± 0.043	1.36GluHis: 1.36 ± 0.028	1.891GluIle: 1.891 ± 0.033	0.982GluLys: 0.982 ± 0.023	5.879GluLeu: 5.879 ± 0.064	0.797GluMet: 0.797 ± 0.019	0.831GluAsn: 0.831 ± 0.018	3.201GluPro: 3.201 ± 0.043	2.11GluGln: 2.11 ± 0.033	4.684GluArg: 4.684 ± 0.059	2.291GluSer: 2.291 ± 0.032	2.438GluThr: 2.438 ± 0.034	4.142GluVal: 4.142 ± 0.049	0.662GluTrp: 0.662 ± 0.015	0.877GluTyr: 0.877 ± 0.018	0.0GluXaa: 0.0 ± 0.0
Phe	3.72PheAla: 3.72 ± 0.039	0.261PheCys: 0.261 ± 0.01	1.953PheAsp: 1.953 ± 0.028	1.176PheGlu: 1.176 ± 0.022	0.844PhePhe: 0.844 ± 0.021	3.038PheGly: 3.038 ± 0.035	0.637PheHis: 0.637 ± 0.019	0.68PheIle: 0.68 ± 0.018	0.433PheLys: 0.433 ± 0.014	2.441PheLeu: 2.441 ± 0.036	0.37PheMet: 0.37 ± 0.012	0.542PheAsn: 0.542 ± 0.014	1.39PhePro: 1.39 ± 0.024	0.71PheGln: 0.71 ± 0.018	1.787PheArg: 1.787 ± 0.03	1.475PheSer: 1.475 ± 0.025	2.116PheThr: 2.116 ± 0.031	2.072PheVal: 2.072 ± 0.029	0.403PheTrp: 0.403 ± 0.013	0.57PheTyr: 0.57 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	11.761GlyAla: 11.761 ± 0.076	0.865GlyCys: 0.865 ± 0.021	5.328GlyAsp: 5.328 ± 0.048	4.565GlyGlu: 4.565 ± 0.055	2.87GlyPhe: 2.87 ± 0.033	9.854GlyGly: 9.854 ± 0.091	2.461GlyHis: 2.461 ± 0.036	3.25GlyIle: 3.25 ± 0.037	2.261GlyLys: 2.261 ± 0.042	9.459GlyLeu: 9.459 ± 0.064	1.958GlyMet: 1.958 ± 0.027	1.831GlyAsn: 1.831 ± 0.037	5.494GlyPro: 5.494 ± 0.057	2.862GlyGln: 2.862 ± 0.045	7.946GlyArg: 7.946 ± 0.06	5.85GlySer: 5.85 ± 0.063	7.033GlyThr: 7.033 ± 0.077	7.517GlyVal: 7.517 ± 0.061	1.803GlyTrp: 1.803 ± 0.033	2.47GlyTyr: 2.47 ± 0.033	0.0GlyXaa: 0.0 ± 0.0
His	2.79HisAla: 2.79 ± 0.041	0.201HisCys: 0.201 ± 0.009	1.37HisAsp: 1.37 ± 0.023	1.073HisGlu: 1.073 ± 0.025	0.67HisPhe: 0.67 ± 0.016	2.506HisGly: 2.506 ± 0.037	0.686HisHis: 0.686 ± 0.016	0.662HisIle: 0.662 ± 0.018	0.331HisLys: 0.331 ± 0.012	2.454HisLeu: 2.454 ± 0.034	0.317HisMet: 0.317 ± 0.012	0.38HisAsn: 0.38 ± 0.012	1.912HisPro: 1.912 ± 0.03	0.705HisGln: 0.705 ± 0.02	2.124HisArg: 2.124 ± 0.032	1.081HisSer: 1.081 ± 0.02	1.417HisThr: 1.417 ± 0.026	1.665HisVal: 1.665 ± 0.028	0.392HisTrp: 0.392 ± 0.014	0.496HisTyr: 0.496 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	4.684IleAla: 4.684 ± 0.047	0.262IleCys: 0.262 ± 0.01	2.167IleAsp: 2.167 ± 0.031	1.767IleGlu: 1.767 ± 0.033	0.663IlePhe: 0.663 ± 0.019	3.474IleGly: 3.474 ± 0.042	0.596IleHis: 0.596 ± 0.017	0.792IleIle: 0.792 ± 0.022	0.638IleLys: 0.638 ± 0.02	2.233IleLeu: 2.233 ± 0.037	0.399IleMet: 0.399 ± 0.015	0.663IleAsn: 0.663 ± 0.017	1.718IlePro: 1.718 ± 0.025	0.691IleGln: 0.691 ± 0.017	2.123IleArg: 2.123 ± 0.029	1.667IleSer: 1.667 ± 0.03	2.209IleThr: 2.209 ± 0.032	2.458IleVal: 2.458 ± 0.038	0.335IleTrp: 0.335 ± 0.014	0.54IleTyr: 0.54 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	2.714LysAla: 2.714 ± 0.04	0.122LysCys: 0.122 ± 0.009	1.159LysAsp: 1.159 ± 0.023	0.841LysGlu: 0.841 ± 0.022	0.397LysPhe: 0.397 ± 0.013	1.586LysGly: 1.586 ± 0.03	0.387LysHis: 0.387 ± 0.013	0.749LysIle: 0.749 ± 0.023	0.61LysLys: 0.61 ± 0.026	1.708LysLeu: 1.708 ± 0.03	0.312LysMet: 0.312 ± 0.013	0.457LysAsn: 0.457 ± 0.014	1.21LysPro: 1.21 ± 0.03	0.648LysGln: 0.648 ± 0.017	1.184LysArg: 1.184 ± 0.025	1.06LysSer: 1.06 ± 0.024	1.131LysThr: 1.131 ± 0.026	1.702LysVal: 1.702 ± 0.03	0.243LysTrp: 0.243 ± 0.01	0.406LysTyr: 0.406 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	15.751LeuAla: 15.751 ± 0.112	0.806LeuCys: 0.806 ± 0.018	6.741LeuAsp: 6.741 ± 0.074	4.041LeuGlu: 4.041 ± 0.052	2.46LeuPhe: 2.46 ± 0.034	9.079LeuGly: 9.079 ± 0.071	2.434LeuHis: 2.434 ± 0.035	3.132LeuIle: 3.132 ± 0.044	1.605LeuLys: 1.605 ± 0.029	11.147LeuLeu: 11.147 ± 0.101	1.502LeuMet: 1.502 ± 0.025	1.628LeuAsn: 1.628 ± 0.028	6.771LeuPro: 6.771 ± 0.063	2.246LeuGln: 2.246 ± 0.031	8.685LeuArg: 8.685 ± 0.072	5.314LeuSer: 5.314 ± 0.052	6.818LeuThr: 6.818 ± 0.055	8.453LeuVal: 8.453 ± 0.067	1.29LeuTrp: 1.29 ± 0.023	1.82LeuTyr: 1.82 ± 0.028	0.0LeuXaa: 0.0 ± 0.0
Met	2.251MetAla: 2.251 ± 0.031	0.135MetCys: 0.135 ± 0.008	0.885MetAsp: 0.885 ± 0.022	0.633MetGlu: 0.633 ± 0.017	0.427MetPhe: 0.427 ± 0.015	1.266MetGly: 1.266 ± 0.025	0.334MetHis: 0.334 ± 0.012	0.569MetIle: 0.569 ± 0.016	0.363MetLys: 0.363 ± 0.013	1.618MetLeu: 1.618 ± 0.026	0.258MetMet: 0.258 ± 0.01	0.419MetAsn: 0.419 ± 0.013	1.11MetPro: 1.11 ± 0.02	0.457MetGln: 0.457 ± 0.015	1.387MetArg: 1.387 ± 0.023	1.268MetSer: 1.268 ± 0.023	1.477MetThr: 1.477 ± 0.025	1.216MetVal: 1.216 ± 0.024	0.203MetTrp: 0.203 ± 0.008	0.294MetTyr: 0.294 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.275AsnAla: 2.275 ± 0.039	0.163AsnCys: 0.163 ± 0.009	0.92AsnAsp: 0.92 ± 0.02	0.704AsnGlu: 0.704 ± 0.017	0.462AsnPhe: 0.462 ± 0.014	2.105AsnGly: 2.105 ± 0.05	0.381AsnHis: 0.381 ± 0.013	0.618AsnIle: 0.618 ± 0.019	0.369AsnLys: 0.369 ± 0.013	1.678AsnLeu: 1.678 ± 0.028	0.286AsnMet: 0.286 ± 0.011	0.463AsnAsn: 0.463 ± 0.019	1.371AsnPro: 1.371 ± 0.025	0.597AsnGln: 0.597 ± 0.02	1.219AsnArg: 1.219 ± 0.025	1.063AsnSer: 1.063 ± 0.029	1.162AsnThr: 1.162 ± 0.028	1.406AsnVal: 1.406 ± 0.026	0.32AsnTrp: 0.32 ± 0.014	0.446AsnTyr: 0.446 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	10.27ProAla: 10.27 ± 0.101	0.345ProCys: 0.345 ± 0.012	4.539ProAsp: 4.539 ± 0.051	3.684ProGlu: 3.684 ± 0.044	1.473ProPhe: 1.473 ± 0.022	7.143ProGly: 7.143 ± 0.069	1.449ProHis: 1.449 ± 0.025	1.317ProIle: 1.317 ± 0.022	1.032ProLys: 1.032 ± 0.022	5.447ProLeu: 5.447 ± 0.053	0.967ProMet: 0.967 ± 0.024	0.946ProAsn: 0.946 ± 0.018	4.262ProPro: 4.262 ± 0.072	1.964ProGln: 1.964 ± 0.041	4.123ProArg: 4.123 ± 0.049	3.272ProSer: 3.272 ± 0.042	3.406ProThr: 3.406 ± 0.047	5.319ProVal: 5.319 ± 0.052	0.934ProTrp: 0.934 ± 0.021	1.422ProTyr: 1.422 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	4.102GlnAla: 4.102 ± 0.046	0.167GlnCys: 0.167 ± 0.008	1.57GlnAsp: 1.57 ± 0.027	1.321GlnGlu: 1.321 ± 0.026	0.703GlnPhe: 0.703 ± 0.017	2.394GlnGly: 2.394 ± 0.031	0.706GlnHis: 0.706 ± 0.017	1.104GlnIle: 1.104 ± 0.025	0.56GlnLys: 0.56 ± 0.018	3.098GlnLeu: 3.098 ± 0.041	0.47GlnMet: 0.47 ± 0.014	0.539GlnAsn: 0.539 ± 0.016	1.891GlnPro: 1.891 ± 0.036	1.438GlnGln: 1.438 ± 0.039	2.429GlnArg: 2.429 ± 0.032	1.39GlnSer: 1.39 ± 0.026	1.472GlnThr: 1.472 ± 0.025	2.551GlnVal: 2.551 ± 0.035	0.511GlnTrp: 0.511 ± 0.016	0.617GlnTyr: 0.617 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	9.763ArgAla: 9.763 ± 0.09	0.575ArgCys: 0.575 ± 0.018	4.248ArgAsp: 4.248 ± 0.052	4.189ArgGlu: 4.189 ± 0.049	2.201ArgPhe: 2.201 ± 0.026	5.858ArgGly: 5.858 ± 0.058	2.169ArgHis: 2.169 ± 0.034	3.09ArgIle: 3.09 ± 0.036	1.514ArgLys: 1.514 ± 0.032	8.845ArgLeu: 8.845 ± 0.078	1.683ArgMet: 1.683 ± 0.027	1.318ArgAsn: 1.318 ± 0.026	5.076ArgPro: 5.076 ± 0.053	2.43ArgGln: 2.43 ± 0.029	7.736ArgArg: 7.736 ± 0.078	3.98ArgSer: 3.98 ± 0.04	5.312ArgThr: 5.312 ± 0.049	5.517ArgVal: 5.517 ± 0.053	1.369ArgTrp: 1.369 ± 0.024	1.798ArgTyr: 1.798 ± 0.03	0.0ArgXaa: 0.0 ± 0.0
Ser	7.343SerAla: 7.343 ± 0.06	0.429SerCys: 0.429 ± 0.014	2.779SerAsp: 2.779 ± 0.038	1.971SerGlu: 1.971 ± 0.032	1.541SerPhe: 1.541 ± 0.025	6.275SerGly: 6.275 ± 0.071	1.013SerHis: 1.013 ± 0.023	1.352SerIle: 1.352 ± 0.026	0.917SerLys: 0.917 ± 0.021	4.731SerLeu: 4.731 ± 0.053	1.027SerMet: 1.027 ± 0.022	0.956SerAsn: 0.956 ± 0.027	3.316SerPro: 3.316 ± 0.044	1.376SerGln: 1.376 ± 0.025	3.744SerArg: 3.744 ± 0.043	3.096SerSer: 3.096 ± 0.051	3.438SerThr: 3.438 ± 0.051	4.21SerVal: 4.21 ± 0.045	0.958SerTrp: 0.958 ± 0.022	1.318SerTyr: 1.318 ± 0.027	0.0SerXaa: 0.0 ± 0.0
Thr	10.113ThrAla: 10.113 ± 0.08	0.429ThrCys: 0.429 ± 0.014	3.626ThrAsp: 3.626 ± 0.042	2.735ThrGlu: 2.735 ± 0.038	1.65ThrPhe: 1.65 ± 0.027	7.237ThrGly: 7.237 ± 0.074	1.214ThrHis: 1.214 ± 0.021	1.612ThrIle: 1.612 ± 0.028	1.049ThrLys: 1.049 ± 0.025	5.717ThrLeu: 5.717 ± 0.053	0.963ThrMet: 0.963 ± 0.022	1.094ThrAsn: 1.094 ± 0.028	4.288ThrPro: 4.288 ± 0.05	1.424ThrGln: 1.424 ± 0.025	3.916ThrArg: 3.916 ± 0.05	3.491ThrSer: 3.491 ± 0.055	4.319ThrThr: 4.319 ± 0.067	6.398ThrVal: 6.398 ± 0.067	0.949ThrTrp: 0.949 ± 0.021	1.448ThrTyr: 1.448 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	11.025ValAla: 11.025 ± 0.077	0.751ValCys: 0.751 ± 0.018	4.895ValAsp: 4.895 ± 0.045	4.144ValGlu: 4.144 ± 0.04	2.365ValPhe: 2.365 ± 0.036	6.527ValGly: 6.527 ± 0.058	1.969ValHis: 1.969 ± 0.036	2.812ValIle: 2.812 ± 0.038	1.57ValLys: 1.57 ± 0.031	9.375ValLeu: 9.375 ± 0.073	1.344ValMet: 1.344 ± 0.024	1.723ValAsn: 1.723 ± 0.034	5.287ValPro: 5.287 ± 0.047	2.171ValGln: 2.171 ± 0.032	6.75ValArg: 6.75 ± 0.062	4.311ValSer: 4.311 ± 0.047	5.815ValThr: 5.815 ± 0.054	7.717ValVal: 7.717 ± 0.073	1.127ValTrp: 1.127 ± 0.025	1.613ValTyr: 1.613 ± 0.029	0.0ValXaa: 0.0 ± 0.0
Trp	1.673TrpAla: 1.673 ± 0.028	0.159TrpCys: 0.159 ± 0.008	0.823TrpAsp: 0.823 ± 0.021	0.68TrpGlu: 0.68 ± 0.017	0.482TrpPhe: 0.482 ± 0.015	1.062TrpGly: 1.062 ± 0.021	0.427TrpHis: 0.427 ± 0.013	0.52TrpIle: 0.52 ± 0.015	0.325TrpLys: 0.325 ± 0.012	1.706TrpLeu: 1.706 ± 0.031	0.271TrpMet: 0.271 ± 0.01	0.44TrpAsn: 0.44 ± 0.016	0.853TrpPro: 0.853 ± 0.02	0.651TrpGln: 0.651 ± 0.017	1.295TrpArg: 1.295 ± 0.024	1.046TrpSer: 1.046 ± 0.021	1.159TrpThr: 1.159 ± 0.024	0.947TrpVal: 0.947 ± 0.022	0.353TrpTrp: 0.353 ± 0.011	0.368TrpTyr: 0.368 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.873TyrAla: 2.873 ± 0.033	0.175TyrCys: 0.175 ± 0.007	1.581TyrAsp: 1.581 ± 0.039	1.097TyrGlu: 1.097 ± 0.022	0.618TyrPhe: 0.618 ± 0.018	2.351TyrGly: 2.351 ± 0.037	0.415TyrHis: 0.415 ± 0.013	0.473TyrIle: 0.473 ± 0.013	0.343TyrLys: 0.343 ± 0.014	2.086TyrLeu: 2.086 ± 0.029	0.232TyrMet: 0.232 ± 0.01	0.492TyrAsn: 0.492 ± 0.019	1.157TyrPro: 1.157 ± 0.026	0.704TyrGln: 0.704 ± 0.024	1.836TyrArg: 1.836 ± 0.028	1.044TyrSer: 1.044 ± 0.027	1.275TyrThr: 1.275 ± 0.031	1.694TyrVal: 1.694 ± 0.029	0.366TyrTrp: 0.366 ± 0.013	0.475TyrTyr: 0.475 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.002XaaXaa: 0.002 ± 0.001

Statistics based on 7034 proteins (2374895 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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