Amino acid dipepetide frequency for Enhydra lutris papillomavirus 1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.284AlaAla: 4.284 ± 1.076
1.714AlaCys: 1.714 ± 0.833
4.284AlaAsp: 4.284 ± 1.214
4.713AlaGlu: 4.713 ± 2.663
3.428AlaPhe: 3.428 ± 1.111
3.428AlaGly: 3.428 ± 1.19
0.0AlaHis: 0.0 ± 0.0
2.571AlaIle: 2.571 ± 1.158
2.999AlaLys: 2.999 ± 1.511
3.428AlaLeu: 3.428 ± 0.943
0.428AlaMet: 0.428 ± 0.366
2.571AlaAsn: 2.571 ± 1.217
3.856AlaPro: 3.856 ± 1.574
3.428AlaGln: 3.428 ± 0.816
3.856AlaArg: 3.856 ± 1.306
5.998AlaSer: 5.998 ± 1.511
2.999AlaThr: 2.999 ± 0.424
3.856AlaVal: 3.856 ± 1.089
0.428AlaTrp: 0.428 ± 0.366
0.857AlaTyr: 0.857 ± 0.646
0.0AlaXaa: 0.0 ± 0.0
Cys
1.285CysAla: 1.285 ± 0.567
1.285CysCys: 1.285 ± 0.99
0.0CysAsp: 0.0 ± 0.0
0.857CysGlu: 0.857 ± 0.692
1.714CysPhe: 1.714 ± 0.559
1.285CysGly: 1.285 ± 0.869
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
3.856CysLys: 3.856 ± 0.917
2.142CysLeu: 2.142 ± 1.16
0.0CysMet: 0.0 ± 0.0
0.428CysAsn: 0.428 ± 0.467
2.142CysPro: 2.142 ± 0.698
0.857CysGln: 0.857 ± 0.57
0.428CysArg: 0.428 ± 0.366
2.142CysSer: 2.142 ± 0.942
2.571CysThr: 2.571 ± 1.594
0.428CysVal: 0.428 ± 0.323
0.428CysTrp: 0.428 ± 0.323
1.285CysTyr: 1.285 ± 1.012
0.0CysXaa: 0.0 ± 0.0
Asp
2.999AspAla: 2.999 ± 0.602
1.714AspCys: 1.714 ± 1.011
5.57AspAsp: 5.57 ± 1.952
3.856AspGlu: 3.856 ± 0.735
1.285AspPhe: 1.285 ± 0.825
3.428AspGly: 3.428 ± 0.868
1.714AspHis: 1.714 ± 1.032
5.141AspIle: 5.141 ± 1.35
2.571AspLys: 2.571 ± 0.872
7.284AspLeu: 7.284 ± 2.206
0.428AspMet: 0.428 ± 0.366
4.713AspAsn: 4.713 ± 1.789
5.141AspPro: 5.141 ± 1.57
3.428AspGln: 3.428 ± 1.14
0.0AspArg: 0.0 ± 0.0
4.284AspSer: 4.284 ± 0.58
2.571AspThr: 2.571 ± 0.615
3.428AspVal: 3.428 ± 1.083
1.714AspTrp: 1.714 ± 0.976
1.285AspTyr: 1.285 ± 0.339
0.0AspXaa: 0.0 ± 0.0
Glu
4.713GluAla: 4.713 ± 1.422
0.428GluCys: 0.428 ± 0.323
4.713GluAsp: 4.713 ± 1.304
7.284GluGlu: 7.284 ± 2.648
1.714GluPhe: 1.714 ± 0.785
2.571GluGly: 2.571 ± 0.728
1.714GluHis: 1.714 ± 0.593
0.857GluIle: 0.857 ± 0.369
3.428GluLys: 3.428 ± 1.107
2.142GluLeu: 2.142 ± 0.635
0.857GluMet: 0.857 ± 0.546
4.284GluAsn: 4.284 ± 0.994
1.285GluPro: 1.285 ± 0.419
4.713GluGln: 4.713 ± 1.707
4.284GluArg: 4.284 ± 1.259
3.856GluSer: 3.856 ± 1.254
4.284GluThr: 4.284 ± 1.189
5.141GluVal: 5.141 ± 1.611
0.857GluTrp: 0.857 ± 0.646
1.285GluTyr: 1.285 ± 0.782
0.0GluXaa: 0.0 ± 0.0
Phe
2.571PheAla: 2.571 ± 0.705
1.714PheCys: 1.714 ± 1.079
2.571PheAsp: 2.571 ± 1.179
2.142PheGlu: 2.142 ± 1.503
2.142PhePhe: 2.142 ± 0.7
4.284PheGly: 4.284 ± 1.129
0.428PheHis: 0.428 ± 0.467
3.428PheIle: 3.428 ± 0.643
4.713PheLys: 4.713 ± 1.848
5.998PheLeu: 5.998 ± 1.558
0.428PheMet: 0.428 ± 0.364
0.428PheAsn: 0.428 ± 0.366
2.999PhePro: 2.999 ± 1.22
1.714PheGln: 1.714 ± 0.559
1.714PheArg: 1.714 ± 0.586
2.142PheSer: 2.142 ± 0.38
2.999PheThr: 2.999 ± 0.853
0.428PheVal: 0.428 ± 0.368
1.714PheTrp: 1.714 ± 0.976
1.714PheTyr: 1.714 ± 0.97
0.0PheXaa: 0.0 ± 0.0
Gly
3.428GlyAla: 3.428 ± 0.802
1.714GlyCys: 1.714 ± 0.535
5.141GlyAsp: 5.141 ± 0.83
4.284GlyGlu: 4.284 ± 1.995
1.714GlyPhe: 1.714 ± 0.549
5.57GlyGly: 5.57 ± 2.105
1.285GlyHis: 1.285 ± 1.098
2.999GlyIle: 2.999 ± 0.485
2.999GlyLys: 2.999 ± 0.804
4.713GlyLeu: 4.713 ± 1.086
1.714GlyMet: 1.714 ± 0.644
1.714GlyAsn: 1.714 ± 0.272
2.142GlyPro: 2.142 ± 1.058
4.284GlyGln: 4.284 ± 1.611
2.999GlyArg: 2.999 ± 1.691
5.141GlySer: 5.141 ± 1.115
3.856GlyThr: 3.856 ± 1.215
4.713GlyVal: 4.713 ± 0.949
0.0GlyTrp: 0.0 ± 0.0
0.857GlyTyr: 0.857 ± 0.544
0.0GlyXaa: 0.0 ± 0.0
His
1.285HisAla: 1.285 ± 0.339
0.857HisCys: 0.857 ± 0.742
0.857HisAsp: 0.857 ± 0.369
0.857HisGlu: 0.857 ± 0.51
0.0HisPhe: 0.0 ± 0.0
1.285HisGly: 1.285 ± 0.695
0.428HisHis: 0.428 ± 0.457
1.285HisIle: 1.285 ± 0.688
1.285HisLys: 1.285 ± 0.567
1.285HisLeu: 1.285 ± 0.686
0.857HisMet: 0.857 ± 0.66
0.857HisAsn: 0.857 ± 0.369
2.142HisPro: 2.142 ± 0.978
0.428HisGln: 0.428 ± 0.323
0.857HisArg: 0.857 ± 0.369
1.714HisSer: 1.714 ± 1.263
0.857HisThr: 0.857 ± 0.53
2.142HisVal: 2.142 ± 0.63
1.285HisTrp: 1.285 ± 0.669
1.285HisTyr: 1.285 ± 0.58
0.0HisXaa: 0.0 ± 0.0
Ile
4.284IleAla: 4.284 ± 1.448
0.0IleCys: 0.0 ± 0.0
1.714IleAsp: 1.714 ± 0.838
4.284IleGlu: 4.284 ± 0.943
2.142IlePhe: 2.142 ± 0.63
2.999IleGly: 2.999 ± 0.835
1.714IleHis: 1.714 ± 0.739
1.285IleIle: 1.285 ± 0.64
0.857IleLys: 0.857 ± 0.503
2.142IleLeu: 2.142 ± 1.183
0.857IleMet: 0.857 ± 0.55
0.857IleAsn: 0.857 ± 0.539
1.714IlePro: 1.714 ± 1.15
2.142IleGln: 2.142 ± 0.868
0.428IleArg: 0.428 ± 0.368
3.428IleSer: 3.428 ± 1.197
3.428IleThr: 3.428 ± 0.955
3.428IleVal: 3.428 ± 1.395
0.0IleTrp: 0.0 ± 0.0
1.285IleTyr: 1.285 ± 0.484
0.0IleXaa: 0.0 ± 0.0
Lys
3.428LysAla: 3.428 ± 1.169
2.571LysCys: 2.571 ± 0.828
0.857LysAsp: 0.857 ± 0.853
2.571LysGlu: 2.571 ± 0.815
3.428LysPhe: 3.428 ± 1.151
3.856LysGly: 3.856 ± 1.312
0.428LysHis: 0.428 ± 0.323
2.999LysIle: 2.999 ± 1.403
4.284LysLys: 4.284 ± 1.334
3.856LysLeu: 3.856 ± 1.652
1.714LysMet: 1.714 ± 1.068
2.999LysAsn: 2.999 ± 1.187
1.714LysPro: 1.714 ± 0.513
2.571LysGln: 2.571 ± 0.849
4.284LysArg: 4.284 ± 1.19
4.284LysSer: 4.284 ± 1.53
2.571LysThr: 2.571 ± 0.837
4.284LysVal: 4.284 ± 1.315
0.428LysTrp: 0.428 ± 0.426
2.999LysTyr: 2.999 ± 0.923
0.0LysXaa: 0.0 ± 0.0
Leu
2.571LeuAla: 2.571 ± 0.927
2.142LeuCys: 2.142 ± 1.126
5.57LeuAsp: 5.57 ± 1.271
4.713LeuGlu: 4.713 ± 1.34
6.427LeuPhe: 6.427 ± 1.259
6.427LeuGly: 6.427 ± 1.911
1.714LeuHis: 1.714 ± 1.885
2.571LeuIle: 2.571 ± 1.001
5.57LeuLys: 5.57 ± 0.854
9.854LeuLeu: 9.854 ± 1.807
0.857LeuMet: 0.857 ± 0.646
6.427LeuAsn: 6.427 ± 1.355
2.571LeuPro: 2.571 ± 0.523
4.713LeuGln: 4.713 ± 1.305
7.712LeuArg: 7.712 ± 1.836
6.427LeuSer: 6.427 ± 1.864
6.427LeuThr: 6.427 ± 1.742
4.713LeuVal: 4.713 ± 0.6
0.857LeuTrp: 0.857 ± 0.599
3.856LeuTyr: 3.856 ± 1.37
0.0LeuXaa: 0.0 ± 0.0
Met
2.142MetAla: 2.142 ± 0.7
0.428MetCys: 0.428 ± 0.366
0.428MetAsp: 0.428 ± 0.457
0.428MetGlu: 0.428 ± 0.426
1.285MetPhe: 1.285 ± 0.693
0.0MetGly: 0.0 ± 0.0
0.0MetHis: 0.0 ± 0.0
0.428MetIle: 0.428 ± 0.323
0.857MetLys: 0.857 ± 0.539
1.285MetLeu: 1.285 ± 0.419
0.428MetMet: 0.428 ± 0.323
0.857MetAsn: 0.857 ± 0.732
1.285MetPro: 1.285 ± 0.852
0.428MetGln: 0.428 ± 0.323
0.428MetArg: 0.428 ± 0.323
1.285MetSer: 1.285 ± 0.969
0.857MetThr: 0.857 ± 0.503
1.285MetVal: 1.285 ± 0.686
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
1.714AsnAla: 1.714 ± 1.292
0.857AsnCys: 0.857 ± 0.384
3.428AsnAsp: 3.428 ± 0.831
1.285AsnGlu: 1.285 ± 0.567
1.285AsnPhe: 1.285 ± 0.748
1.714AsnGly: 1.714 ± 0.691
1.285AsnHis: 1.285 ± 0.693
3.428AsnIle: 3.428 ± 1.101
0.857AsnLys: 0.857 ± 0.503
2.571AsnLeu: 2.571 ± 1.046
0.0AsnMet: 0.0 ± 0.0
2.571AsnAsn: 2.571 ± 0.944
3.856AsnPro: 3.856 ± 1.386
2.571AsnGln: 2.571 ± 0.815
2.999AsnArg: 2.999 ± 1.319
4.284AsnSer: 4.284 ± 1.19
3.428AsnThr: 3.428 ± 1.513
2.142AsnVal: 2.142 ± 1.17
0.428AsnTrp: 0.428 ± 0.323
1.285AsnTyr: 1.285 ± 0.77
0.0AsnXaa: 0.0 ± 0.0
Pro
5.57ProAla: 5.57 ± 1.898
0.857ProCys: 0.857 ± 0.384
2.999ProAsp: 2.999 ± 1.173
3.428ProGlu: 3.428 ± 0.745
1.714ProPhe: 1.714 ± 0.785
2.999ProGly: 2.999 ± 1.153
1.285ProHis: 1.285 ± 0.505
2.571ProIle: 2.571 ± 1.342
2.999ProLys: 2.999 ± 0.934
8.569ProLeu: 8.569 ± 1.175
0.0ProMet: 0.0 ± 0.303
2.999ProAsn: 2.999 ± 0.876
8.141ProPro: 8.141 ± 1.506
2.142ProGln: 2.142 ± 0.613
6.427ProArg: 6.427 ± 0.978
5.57ProSer: 5.57 ± 1.173
3.428ProThr: 3.428 ± 1.902
1.285ProVal: 1.285 ± 0.825
0.0ProTrp: 0.0 ± 0.0
1.714ProTyr: 1.714 ± 1.463
0.0ProXaa: 0.0 ± 0.0
Gln
2.571GlnAla: 2.571 ± 0.653
1.714GlnCys: 1.714 ± 0.789
2.571GlnAsp: 2.571 ± 0.668
2.571GlnGlu: 2.571 ± 0.713
2.142GlnPhe: 2.142 ± 1.282
2.142GlnGly: 2.142 ± 0.768
1.714GlnHis: 1.714 ± 1.258
2.142GlnIle: 2.142 ± 0.714
2.142GlnLys: 2.142 ± 0.74
5.998GlnLeu: 5.998 ± 2.328
0.428GlnMet: 0.428 ± 0.426
1.714GlnAsn: 1.714 ± 1.007
2.571GlnPro: 2.571 ± 1.207
2.999GlnGln: 2.999 ± 0.978
2.571GlnArg: 2.571 ± 0.736
2.999GlnSer: 2.999 ± 1.042
2.999GlnThr: 2.999 ± 1.338
3.428GlnVal: 3.428 ± 1.377
0.428GlnTrp: 0.428 ± 0.323
1.714GlnTyr: 1.714 ± 0.272
0.0GlnXaa: 0.0 ± 0.0
Arg
2.571ArgAla: 2.571 ± 0.449
0.428ArgCys: 0.428 ± 0.467
3.856ArgAsp: 3.856 ± 1.139
4.284ArgGlu: 4.284 ± 1.291
3.428ArgPhe: 3.428 ± 0.675
5.141ArgGly: 5.141 ± 1.89
1.285ArgHis: 1.285 ± 0.77
0.857ArgIle: 0.857 ± 0.445
3.856ArgLys: 3.856 ± 0.825
6.427ArgLeu: 6.427 ± 2.119
0.857ArgMet: 0.857 ± 0.384
1.285ArgAsn: 1.285 ± 0.748
5.141ArgPro: 5.141 ± 1.736
1.285ArgGln: 1.285 ± 0.527
5.141ArgArg: 5.141 ± 2.258
4.284ArgSer: 4.284 ± 0.667
3.428ArgThr: 3.428 ± 0.778
5.141ArgVal: 5.141 ± 1.289
1.285ArgTrp: 1.285 ± 0.422
1.285ArgTyr: 1.285 ± 0.744
0.0ArgXaa: 0.0 ± 0.0
Ser
5.57SerAla: 5.57 ± 1.325
2.142SerCys: 2.142 ± 0.755
4.284SerAsp: 4.284 ± 1.728
3.856SerGlu: 3.856 ± 1.096
5.141SerPhe: 5.141 ± 1.784
4.713SerGly: 4.713 ± 1.71
1.285SerHis: 1.285 ± 0.905
2.142SerIle: 2.142 ± 0.349
4.713SerLys: 4.713 ± 1.029
7.712SerLeu: 7.712 ± 0.76
1.285SerMet: 1.285 ± 0.72
2.571SerAsn: 2.571 ± 0.449
5.141SerPro: 5.141 ± 0.936
4.284SerGln: 4.284 ± 1.903
4.284SerArg: 4.284 ± 1.117
5.57SerSer: 5.57 ± 1.874
7.712SerThr: 7.712 ± 2.264
5.57SerVal: 5.57 ± 1.393
0.857SerTrp: 0.857 ± 0.384
1.714SerTyr: 1.714 ± 0.89
0.0SerXaa: 0.0 ± 0.0
Thr
2.142ThrAla: 2.142 ± 1.112
0.857ThrCys: 0.857 ± 0.392
4.713ThrAsp: 4.713 ± 1.855
2.999ThrGlu: 2.999 ± 0.59
2.999ThrPhe: 2.999 ± 1.197
2.571ThrGly: 2.571 ± 0.677
2.142ThrHis: 2.142 ± 0.819
0.857ThrIle: 0.857 ± 0.732
2.999ThrLys: 2.999 ± 1.06
7.712ThrLeu: 7.712 ± 2.059
0.857ThrMet: 0.857 ± 0.445
1.285ThrAsn: 1.285 ± 0.8
6.855ThrPro: 6.855 ± 1.881
2.571ThrGln: 2.571 ± 0.88
5.141ThrArg: 5.141 ± 1.251
7.712ThrSer: 7.712 ± 0.886
3.428ThrThr: 3.428 ± 1.144
2.999ThrVal: 2.999 ± 0.876
0.428ThrTrp: 0.428 ± 0.426
1.285ThrTyr: 1.285 ± 0.567
0.0ThrXaa: 0.0 ± 0.0
Val
2.142ValAla: 2.142 ± 0.63
1.285ValCys: 1.285 ± 0.879
6.427ValAsp: 6.427 ± 0.701
2.571ValGlu: 2.571 ± 0.677
2.142ValPhe: 2.142 ± 0.72
3.856ValGly: 3.856 ± 1.424
1.714ValHis: 1.714 ± 0.785
1.714ValIle: 1.714 ± 0.688
2.571ValLys: 2.571 ± 1.124
5.57ValLeu: 5.57 ± 0.976
0.857ValMet: 0.857 ± 0.392
1.714ValAsn: 1.714 ± 0.723
5.141ValPro: 5.141 ± 1.126
2.571ValGln: 2.571 ± 1.001
5.141ValArg: 5.141 ± 0.525
7.712ValSer: 7.712 ± 1.619
3.428ValThr: 3.428 ± 1.152
5.141ValVal: 5.141 ± 1.678
0.857ValTrp: 0.857 ± 0.732
0.428ValTyr: 0.428 ± 0.467
0.0ValXaa: 0.0 ± 0.0
Trp
2.142TrpAla: 2.142 ± 0.719
0.428TrpCys: 0.428 ± 0.366
0.857TrpAsp: 0.857 ± 0.445
0.857TrpGlu: 0.857 ± 0.503
0.0TrpPhe: 0.0 ± 0.0
0.857TrpGly: 0.857 ± 0.51
0.428TrpHis: 0.428 ± 0.366
1.285TrpIle: 1.285 ± 0.686
1.285TrpLys: 1.285 ± 0.567
0.857TrpLeu: 0.857 ± 0.445
0.0TrpMet: 0.0 ± 0.0
0.857TrpAsn: 0.857 ± 0.384
0.0TrpPro: 0.0 ± 0.0
0.428TrpGln: 0.428 ± 0.366
0.428TrpArg: 0.428 ± 0.467
0.0TrpSer: 0.0 ± 0.0
0.857TrpThr: 0.857 ± 0.384
0.857TrpVal: 0.857 ± 0.646
0.0TrpTrp: 0.0 ± 0.0
0.428TrpTyr: 0.428 ± 0.323
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.714TyrAla: 1.714 ± 0.559
0.0TyrCys: 0.0 ± 0.0
1.714TyrAsp: 1.714 ± 0.586
2.571TyrGlu: 2.571 ± 1.198
2.142TyrPhe: 2.142 ± 0.768
2.142TyrGly: 2.142 ± 0.662
1.285TyrHis: 1.285 ± 0.686
0.428TyrIle: 0.428 ± 0.366
1.285TyrLys: 1.285 ± 0.686
2.571TyrLeu: 2.571 ± 0.49
0.857TyrMet: 0.857 ± 0.646
0.857TyrAsn: 0.857 ± 0.539
1.285TyrPro: 1.285 ± 0.64
0.0TyrGln: 0.0 ± 0.0
2.142TyrArg: 2.142 ± 1.082
1.714TyrSer: 1.714 ± 0.958
0.428TyrThr: 0.428 ± 0.426
2.571TyrVal: 2.571 ± 0.498
0.857TyrTrp: 0.857 ± 0.445
2.999TyrTyr: 2.999 ± 1.098
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7 proteins (2335 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski