Amino acid dipepetide frequency for Halovirus HHTV-2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.95AlaAla: 8.95 ± 1.088
0.477AlaCys: 0.477 ± 0.159
7.876AlaAsp: 7.876 ± 0.717
10.143AlaGlu: 10.143 ± 0.864
2.506AlaPhe: 2.506 ± 0.375
7.816AlaGly: 7.816 ± 0.728
2.208AlaHis: 2.208 ± 0.384
3.043AlaIle: 3.043 ± 0.511
2.327AlaLys: 2.327 ± 0.331
7.1AlaLeu: 7.1 ± 0.777
1.671AlaMet: 1.671 ± 0.334
2.625AlaAsn: 2.625 ± 0.5
3.341AlaPro: 3.341 ± 0.476
3.103AlaGln: 3.103 ± 0.506
5.609AlaArg: 5.609 ± 0.603
5.489AlaSer: 5.489 ± 0.763
4.654AlaThr: 4.654 ± 0.552
6.802AlaVal: 6.802 ± 0.629
2.029AlaTrp: 2.029 ± 0.306
2.625AlaTyr: 2.625 ± 0.428
0.0AlaXaa: 0.0 ± 0.0
Cys
0.776CysAla: 0.776 ± 0.261
0.06CysCys: 0.06 ± 0.062
0.656CysAsp: 0.656 ± 0.241
0.955CysGlu: 0.955 ± 0.204
0.119CysPhe: 0.119 ± 0.089
1.671CysGly: 1.671 ± 0.455
0.179CysHis: 0.179 ± 0.106
0.179CysIle: 0.179 ± 0.098
0.179CysLys: 0.179 ± 0.095
0.418CysLeu: 0.418 ± 0.171
0.06CysMet: 0.06 ± 0.057
0.179CysAsn: 0.179 ± 0.099
0.835CysPro: 0.835 ± 0.272
0.119CysGln: 0.119 ± 0.084
0.597CysArg: 0.597 ± 0.202
0.179CysSer: 0.179 ± 0.124
0.298CysThr: 0.298 ± 0.14
0.537CysVal: 0.537 ± 0.188
0.179CysTrp: 0.179 ± 0.116
0.358CysTyr: 0.358 ± 0.138
0.0CysXaa: 0.0 ± 0.0
Asp
9.248AspAla: 9.248 ± 0.651
0.895AspCys: 0.895 ± 0.262
8.294AspAsp: 8.294 ± 0.672
8.652AspGlu: 8.652 ± 0.87
2.924AspPhe: 2.924 ± 0.385
9.308AspGly: 9.308 ± 0.939
1.671AspHis: 1.671 ± 0.288
2.208AspIle: 2.208 ± 0.4
1.372AspLys: 1.372 ± 0.282
10.143AspLeu: 10.143 ± 0.724
1.85AspMet: 1.85 ± 0.265
2.446AspAsn: 2.446 ± 0.377
5.251AspPro: 5.251 ± 0.739
2.804AspGln: 2.804 ± 0.404
5.668AspArg: 5.668 ± 0.636
4.833AspSer: 4.833 ± 0.533
5.609AspThr: 5.609 ± 0.614
6.802AspVal: 6.802 ± 0.651
1.73AspTrp: 1.73 ± 0.425
2.506AspTyr: 2.506 ± 0.449
0.0AspXaa: 0.0 ± 0.0
Glu
10.442GluAla: 10.442 ± 0.8
1.014GluCys: 1.014 ± 0.317
13.007GluAsp: 13.007 ± 1.215
6.802GluGlu: 6.802 ± 0.768
1.492GluPhe: 1.492 ± 0.291
7.279GluGly: 7.279 ± 0.807
1.611GluHis: 1.611 ± 0.341
2.029GluIle: 2.029 ± 0.323
3.461GluLys: 3.461 ± 0.485
4.475GluLeu: 4.475 ± 0.564
2.327GluMet: 2.327 ± 0.388
2.267GluAsn: 2.267 ± 0.353
4.594GluPro: 4.594 ± 0.614
3.58GluGln: 3.58 ± 0.531
6.802GluArg: 6.802 ± 0.635
4.773GluSer: 4.773 ± 0.557
5.489GluThr: 5.489 ± 0.655
8.652GluVal: 8.652 ± 0.723
2.685GluTrp: 2.685 ± 0.377
2.983GluTyr: 2.983 ± 0.453
0.0GluXaa: 0.0 ± 0.0
Phe
1.551PheAla: 1.551 ± 0.28
0.179PheCys: 0.179 ± 0.111
2.625PheAsp: 2.625 ± 0.397
2.804PheGlu: 2.804 ± 0.433
0.179PhePhe: 0.179 ± 0.107
1.79PheGly: 1.79 ± 0.3
0.298PheHis: 0.298 ± 0.125
1.193PheIle: 1.193 ± 0.261
0.418PheLys: 0.418 ± 0.156
1.611PheLeu: 1.611 ± 0.344
0.418PheMet: 0.418 ± 0.178
0.955PheAsn: 0.955 ± 0.268
0.835PhePro: 0.835 ± 0.235
1.014PheGln: 1.014 ± 0.273
1.611PheArg: 1.611 ± 0.315
2.148PheSer: 2.148 ± 0.361
2.267PheThr: 2.267 ± 0.267
2.029PheVal: 2.029 ± 0.312
0.119PheTrp: 0.119 ± 0.08
0.537PheTyr: 0.537 ± 0.205
0.0PheXaa: 0.0 ± 0.0
Gly
7.816GlyAla: 7.816 ± 0.612
0.955GlyCys: 0.955 ± 0.227
7.936GlyAsp: 7.936 ± 0.63
8.771GlyGlu: 8.771 ± 0.813
2.506GlyPhe: 2.506 ± 0.412
9.845GlyGly: 9.845 ± 1.036
1.73GlyHis: 1.73 ± 0.336
2.506GlyIle: 2.506 ± 0.409
2.267GlyLys: 2.267 ± 0.406
4.773GlyLeu: 4.773 ± 0.592
1.551GlyMet: 1.551 ± 0.332
2.566GlyAsn: 2.566 ± 0.413
3.282GlyPro: 3.282 ± 0.496
2.148GlyGln: 2.148 ± 0.341
4.952GlyArg: 4.952 ± 0.655
6.325GlySer: 6.325 ± 0.739
6.683GlyThr: 6.683 ± 0.732
6.862GlyVal: 6.862 ± 0.699
1.492GlyTrp: 1.492 ± 0.257
2.446GlyTyr: 2.446 ± 0.445
0.0GlyXaa: 0.0 ± 0.0
His
1.492HisAla: 1.492 ± 0.257
0.0HisCys: 0.0 ± 0.0
1.611HisAsp: 1.611 ± 0.33
1.969HisGlu: 1.969 ± 0.32
0.358HisPhe: 0.358 ± 0.141
2.088HisGly: 2.088 ± 0.415
0.597HisHis: 0.597 ± 0.185
0.895HisIle: 0.895 ± 0.253
0.298HisLys: 0.298 ± 0.133
1.372HisLeu: 1.372 ± 0.257
0.06HisMet: 0.06 ± 0.054
0.477HisAsn: 0.477 ± 0.178
1.372HisPro: 1.372 ± 0.284
0.597HisGln: 0.597 ± 0.18
1.372HisArg: 1.372 ± 0.282
0.895HisSer: 0.895 ± 0.221
1.432HisThr: 1.432 ± 0.282
1.551HisVal: 1.551 ± 0.301
0.298HisTrp: 0.298 ± 0.13
0.955HisTyr: 0.955 ± 0.284
0.0HisXaa: 0.0 ± 0.0
Ile
2.387IleAla: 2.387 ± 0.364
0.358IleCys: 0.358 ± 0.154
3.043IleAsp: 3.043 ± 0.401
3.282IleGlu: 3.282 ± 0.529
0.716IlePhe: 0.716 ± 0.213
2.864IleGly: 2.864 ± 0.659
0.537IleHis: 0.537 ± 0.187
1.014IleIle: 1.014 ± 0.219
0.895IleLys: 0.895 ± 0.263
1.671IleLeu: 1.671 ± 0.313
0.418IleMet: 0.418 ± 0.141
0.895IleAsn: 0.895 ± 0.226
2.267IlePro: 2.267 ± 0.303
1.313IleGln: 1.313 ± 0.264
2.566IleArg: 2.566 ± 0.437
1.313IleSer: 1.313 ± 0.326
3.043IleThr: 3.043 ± 0.55
2.625IleVal: 2.625 ± 0.467
0.597IleTrp: 0.597 ± 0.161
0.955IleTyr: 0.955 ± 0.272
0.0IleXaa: 0.0 ± 0.0
Lys
3.64LysAla: 3.64 ± 0.419
0.179LysCys: 0.179 ± 0.104
2.446LysAsp: 2.446 ± 0.453
1.909LysGlu: 1.909 ± 0.536
0.298LysPhe: 0.298 ± 0.138
2.148LysGly: 2.148 ± 0.337
0.477LysHis: 0.477 ± 0.18
0.537LysIle: 0.537 ± 0.174
0.477LysLys: 0.477 ± 0.147
1.134LysLeu: 1.134 ± 0.372
0.597LysMet: 0.597 ± 0.19
0.656LysAsn: 0.656 ± 0.18
1.969LysPro: 1.969 ± 0.382
1.551LysGln: 1.551 ± 0.35
3.103LysArg: 3.103 ± 0.343
1.492LysSer: 1.492 ± 0.262
1.73LysThr: 1.73 ± 0.376
2.208LysVal: 2.208 ± 0.351
0.239LysTrp: 0.239 ± 0.121
0.597LysTyr: 0.597 ± 0.208
0.0LysXaa: 0.0 ± 0.0
Leu
6.265LeuAla: 6.265 ± 0.659
0.716LeuCys: 0.716 ± 0.282
5.072LeuAsp: 5.072 ± 0.512
6.623LeuGlu: 6.623 ± 0.682
1.193LeuPhe: 1.193 ± 0.258
5.31LeuGly: 5.31 ± 0.592
1.551LeuHis: 1.551 ± 0.289
2.267LeuIle: 2.267 ± 0.399
2.804LeuLys: 2.804 ± 0.498
4.594LeuLeu: 4.594 ± 0.493
1.551LeuMet: 1.551 ± 0.33
1.671LeuAsn: 1.671 ± 0.285
3.819LeuPro: 3.819 ± 0.483
2.685LeuGln: 2.685 ± 0.385
6.146LeuArg: 6.146 ± 0.662
4.833LeuSer: 4.833 ± 0.515
5.43LeuThr: 5.43 ± 0.557
3.938LeuVal: 3.938 ± 0.508
1.014LeuTrp: 1.014 ± 0.233
2.267LeuTyr: 2.267 ± 0.477
0.0LeuXaa: 0.0 ± 0.0
Met
2.446MetAla: 2.446 ± 0.349
0.06MetCys: 0.06 ± 0.056
2.088MetAsp: 2.088 ± 0.316
1.73MetGlu: 1.73 ± 0.365
0.418MetPhe: 0.418 ± 0.165
1.611MetGly: 1.611 ± 0.333
0.179MetHis: 0.179 ± 0.102
0.358MetIle: 0.358 ± 0.175
0.835MetLys: 0.835 ± 0.212
0.895MetLeu: 0.895 ± 0.212
0.298MetMet: 0.298 ± 0.12
0.776MetAsn: 0.776 ± 0.19
1.074MetPro: 1.074 ± 0.212
0.298MetGln: 0.298 ± 0.131
0.716MetArg: 0.716 ± 0.24
2.148MetSer: 2.148 ± 0.348
2.029MetThr: 2.029 ± 0.323
1.074MetVal: 1.074 ± 0.236
0.119MetTrp: 0.119 ± 0.079
0.298MetTyr: 0.298 ± 0.156
0.0MetXaa: 0.0 ± 0.0
Asn
2.327AsnAla: 2.327 ± 0.424
0.358AsnCys: 0.358 ± 0.148
2.924AsnAsp: 2.924 ± 0.341
2.029AsnGlu: 2.029 ± 0.256
1.014AsnPhe: 1.014 ± 0.295
2.387AsnGly: 2.387 ± 0.366
0.776AsnHis: 0.776 ± 0.241
0.835AsnIle: 0.835 ± 0.229
0.835AsnLys: 0.835 ± 0.219
2.029AsnLeu: 2.029 ± 0.293
0.358AsnMet: 0.358 ± 0.169
1.074AsnAsn: 1.074 ± 0.285
1.372AsnPro: 1.372 ± 0.311
0.955AsnGln: 0.955 ± 0.238
1.85AsnArg: 1.85 ± 0.283
1.611AsnSer: 1.611 ± 0.43
1.671AsnThr: 1.671 ± 0.354
2.327AsnVal: 2.327 ± 0.357
0.656AsnTrp: 0.656 ± 0.2
1.014AsnTyr: 1.014 ± 0.255
0.0AsnXaa: 0.0 ± 0.0
Pro
3.282ProAla: 3.282 ± 0.439
0.298ProCys: 0.298 ± 0.169
5.967ProAsp: 5.967 ± 0.765
6.862ProGlu: 6.862 ± 0.821
1.611ProPhe: 1.611 ± 0.242
4.415ProGly: 4.415 ± 0.536
0.358ProHis: 0.358 ± 0.164
1.551ProIle: 1.551 ± 0.303
1.134ProLys: 1.134 ± 0.271
3.103ProLeu: 3.103 ± 0.499
1.611ProMet: 1.611 ± 0.368
1.253ProAsn: 1.253 ± 0.244
3.103ProPro: 3.103 ± 0.509
1.85ProGln: 1.85 ± 0.263
2.387ProArg: 2.387 ± 0.382
3.043ProSer: 3.043 ± 0.476
3.282ProThr: 3.282 ± 0.502
4.177ProVal: 4.177 ± 0.457
0.955ProTrp: 0.955 ± 0.263
1.014ProTyr: 1.014 ± 0.267
0.0ProXaa: 0.0 ± 0.0
Gln
3.222GlnAla: 3.222 ± 0.56
0.0GlnCys: 0.0 ± 0.0
2.864GlnAsp: 2.864 ± 0.411
3.282GlnGlu: 3.282 ± 0.456
1.432GlnPhe: 1.432 ± 0.273
2.864GlnGly: 2.864 ± 0.375
0.716GlnHis: 0.716 ± 0.203
1.074GlnIle: 1.074 ± 0.262
1.313GlnLys: 1.313 ± 0.38
1.492GlnLeu: 1.492 ± 0.301
1.074GlnMet: 1.074 ± 0.252
1.253GlnAsn: 1.253 ± 0.266
1.551GlnPro: 1.551 ± 0.283
1.134GlnGln: 1.134 ± 0.235
2.387GlnArg: 2.387 ± 0.375
1.73GlnSer: 1.73 ± 0.301
2.924GlnThr: 2.924 ± 0.429
2.208GlnVal: 2.208 ± 0.408
0.477GlnTrp: 0.477 ± 0.144
0.716GlnTyr: 0.716 ± 0.188
0.0GlnXaa: 0.0 ± 0.0
Arg
6.026ArgAla: 6.026 ± 0.583
0.716ArgCys: 0.716 ± 0.248
5.012ArgAsp: 5.012 ± 0.505
6.862ArgGlu: 6.862 ± 0.589
1.313ArgPhe: 1.313 ± 0.316
4.952ArgGly: 4.952 ± 0.587
1.79ArgHis: 1.79 ± 0.325
2.566ArgIle: 2.566 ± 0.417
2.148ArgLys: 2.148 ± 0.379
5.907ArgLeu: 5.907 ± 0.549
1.73ArgMet: 1.73 ± 0.348
1.909ArgAsn: 1.909 ± 0.395
2.208ArgPro: 2.208 ± 0.362
2.267ArgGln: 2.267 ± 0.388
4.415ArgArg: 4.415 ± 0.624
3.878ArgSer: 3.878 ± 0.579
3.819ArgThr: 3.819 ± 0.459
4.952ArgVal: 4.952 ± 0.562
0.656ArgTrp: 0.656 ± 0.197
1.85ArgTyr: 1.85 ± 0.383
0.0ArgXaa: 0.0 ± 0.0
Ser
6.026SerAla: 6.026 ± 0.606
0.597SerCys: 0.597 ± 0.205
5.251SerAsp: 5.251 ± 0.605
4.833SerGlu: 4.833 ± 0.446
1.671SerPhe: 1.671 ± 0.429
6.146SerGly: 6.146 ± 0.616
1.134SerHis: 1.134 ± 0.262
2.566SerIle: 2.566 ± 0.41
1.313SerLys: 1.313 ± 0.277
4.236SerLeu: 4.236 ± 0.53
0.716SerMet: 0.716 ± 0.188
1.909SerAsn: 1.909 ± 0.286
3.282SerPro: 3.282 ± 0.405
2.148SerGln: 2.148 ± 0.318
2.685SerArg: 2.685 ± 0.4
4.057SerSer: 4.057 ± 0.536
4.236SerThr: 4.236 ± 0.462
4.773SerVal: 4.773 ± 0.525
1.253SerTrp: 1.253 ± 0.307
2.029SerTyr: 2.029 ± 0.349
0.0SerXaa: 0.0 ± 0.0
Thr
5.609ThrAla: 5.609 ± 0.649
0.477ThrCys: 0.477 ± 0.195
6.205ThrAsp: 6.205 ± 0.494
6.146ThrGlu: 6.146 ± 0.652
2.148ThrPhe: 2.148 ± 0.351
5.967ThrGly: 5.967 ± 0.589
1.014ThrHis: 1.014 ± 0.261
3.222ThrIle: 3.222 ± 0.585
1.492ThrLys: 1.492 ± 0.287
6.026ThrLeu: 6.026 ± 0.608
1.193ThrMet: 1.193 ± 0.217
1.73ThrAsn: 1.73 ± 0.31
4.117ThrPro: 4.117 ± 0.533
1.671ThrGln: 1.671 ± 0.304
3.401ThrArg: 3.401 ± 0.404
3.938ThrSer: 3.938 ± 0.488
4.117ThrThr: 4.117 ± 0.766
5.728ThrVal: 5.728 ± 0.572
1.313ThrTrp: 1.313 ± 0.276
1.909ThrTyr: 1.909 ± 0.375
0.0ThrXaa: 0.0 ± 0.0
Val
5.549ValAla: 5.549 ± 0.521
0.656ValCys: 0.656 ± 0.238
6.504ValAsp: 6.504 ± 0.665
7.16ValGlu: 7.16 ± 0.695
1.671ValPhe: 1.671 ± 0.434
4.236ValGly: 4.236 ± 0.582
2.148ValHis: 2.148 ± 0.329
2.804ValIle: 2.804 ± 0.417
2.327ValLys: 2.327 ± 0.378
5.31ValLeu: 5.31 ± 0.568
1.193ValMet: 1.193 ± 0.253
2.566ValAsn: 2.566 ± 0.376
4.654ValPro: 4.654 ± 0.558
3.461ValGln: 3.461 ± 0.541
5.191ValArg: 5.191 ± 0.608
5.549ValSer: 5.549 ± 0.735
5.847ValThr: 5.847 ± 0.674
4.773ValVal: 4.773 ± 0.629
1.73ValTrp: 1.73 ± 0.322
2.745ValTyr: 2.745 ± 0.422
0.0ValXaa: 0.0 ± 0.0
Trp
1.492TrpAla: 1.492 ± 0.273
0.298TrpCys: 0.298 ± 0.138
1.73TrpAsp: 1.73 ± 0.33
1.551TrpGlu: 1.551 ± 0.352
0.358TrpPhe: 0.358 ± 0.158
1.492TrpGly: 1.492 ± 0.358
0.239TrpHis: 0.239 ± 0.15
0.358TrpIle: 0.358 ± 0.147
0.895TrpLys: 0.895 ± 0.22
1.253TrpLeu: 1.253 ± 0.305
0.418TrpMet: 0.418 ± 0.172
0.477TrpAsn: 0.477 ± 0.158
1.193TrpPro: 1.193 ± 0.245
0.537TrpGln: 0.537 ± 0.139
1.193TrpArg: 1.193 ± 0.268
0.895TrpSer: 0.895 ± 0.247
1.313TrpThr: 1.313 ± 0.228
1.372TrpVal: 1.372 ± 0.296
0.298TrpTrp: 0.298 ± 0.118
0.716TrpTyr: 0.716 ± 0.233
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.85TyrAla: 1.85 ± 0.302
0.239TyrCys: 0.239 ± 0.134
3.103TyrAsp: 3.103 ± 0.449
3.401TyrGlu: 3.401 ± 0.451
0.656TyrPhe: 0.656 ± 0.193
3.222TyrGly: 3.222 ± 0.415
0.477TyrHis: 0.477 ± 0.209
1.551TyrIle: 1.551 ± 0.31
0.597TyrLys: 0.597 ± 0.192
2.208TyrLeu: 2.208 ± 0.439
0.298TyrMet: 0.298 ± 0.153
0.716TyrAsn: 0.716 ± 0.21
1.134TyrPro: 1.134 ± 0.327
0.477TyrGln: 0.477 ± 0.176
2.327TyrArg: 2.327 ± 0.389
1.73TyrSer: 1.73 ± 0.348
1.551TyrThr: 1.551 ± 0.393
2.745TyrVal: 2.745 ± 0.39
0.239TyrTrp: 0.239 ± 0.115
0.776TyrTyr: 0.776 ± 0.219
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 88 proteins (16761 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski