Amino acid dipepetide frequency for Halarchaeum sp. CBA1220

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
15.606AlaAla: 15.606 ± 0.253
0.886AlaCys: 0.886 ± 0.032
11.205AlaAsp: 11.205 ± 0.139
9.19AlaGlu: 9.19 ± 0.127
4.42AlaPhe: 4.42 ± 0.08
10.258AlaGly: 10.258 ± 0.141
2.25AlaHis: 2.25 ± 0.057
4.002AlaIle: 4.002 ± 0.065
1.931AlaLys: 1.931 ± 0.051
13.151AlaLeu: 13.151 ± 0.169
2.14AlaMet: 2.14 ± 0.05
2.775AlaAsn: 2.775 ± 0.067
4.394AlaPro: 4.394 ± 0.079
2.168AlaGln: 2.168 ± 0.056
7.449AlaArg: 7.449 ± 0.121
6.614AlaSer: 6.614 ± 0.099
7.409AlaThr: 7.409 ± 0.12
12.103AlaVal: 12.103 ± 0.17
1.284AlaTrp: 1.284 ± 0.041
3.251AlaTyr: 3.251 ± 0.064
0.0AlaXaa: 0.0 ± 0.0
Cys
0.755CysAla: 0.755 ± 0.031
0.085CysCys: 0.085 ± 0.009
0.515CysAsp: 0.515 ± 0.026
0.658CysGlu: 0.658 ± 0.031
0.184CysPhe: 0.184 ± 0.014
0.865CysGly: 0.865 ± 0.034
0.186CysHis: 0.186 ± 0.014
0.225CysIle: 0.225 ± 0.014
0.104CysLys: 0.104 ± 0.011
0.589CysLeu: 0.589 ± 0.023
0.087CysMet: 0.087 ± 0.009
0.168CysAsn: 0.168 ± 0.014
0.53CysPro: 0.53 ± 0.027
0.13CysGln: 0.13 ± 0.013
0.448CysArg: 0.448 ± 0.022
0.387CysSer: 0.387 ± 0.02
0.437CysThr: 0.437 ± 0.023
0.576CysVal: 0.576 ± 0.026
0.103CysTrp: 0.103 ± 0.01
0.214CysTyr: 0.214 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
13.696AspAla: 13.696 ± 0.175
0.628AspCys: 0.628 ± 0.029
7.732AspAsp: 7.732 ± 0.133
6.931AspGlu: 6.931 ± 0.124
1.995AspPhe: 1.995 ± 0.053
7.987AspGly: 7.987 ± 0.12
1.634AspHis: 1.634 ± 0.046
2.611AspIle: 2.611 ± 0.064
0.78AspLys: 0.78 ± 0.029
7.395AspLeu: 7.395 ± 0.107
1.087AspMet: 1.087 ± 0.035
0.998AspAsn: 0.998 ± 0.039
4.622AspPro: 4.622 ± 0.08
1.314AspGln: 1.314 ± 0.04
4.669AspArg: 4.669 ± 0.081
3.133AspSer: 3.133 ± 0.067
3.982AspThr: 3.982 ± 0.065
9.747AspVal: 9.747 ± 0.142
1.02AspTrp: 1.02 ± 0.038
2.381AspTyr: 2.381 ± 0.06
0.0AspXaa: 0.0 ± 0.0
Glu
9.178GluAla: 9.178 ± 0.131
0.517GluCys: 0.517 ± 0.024
5.714GluAsp: 5.714 ± 0.102
7.081GluGlu: 7.081 ± 0.141
2.652GluPhe: 2.652 ± 0.059
5.447GluGly: 5.447 ± 0.087
2.446GluHis: 2.446 ± 0.05
2.795GluIle: 2.795 ± 0.064
1.846GluLys: 1.846 ± 0.052
6.722GluLeu: 6.722 ± 0.109
1.683GluMet: 1.683 ± 0.045
2.191GluAsn: 2.191 ± 0.05
3.114GluPro: 3.114 ± 0.06
2.214GluGln: 2.214 ± 0.057
9.523GluArg: 9.523 ± 0.153
4.847GluSer: 4.847 ± 0.084
6.207GluThr: 6.207 ± 0.098
5.286GluVal: 5.286 ± 0.094
1.089GluTrp: 1.089 ± 0.035
2.506GluTyr: 2.506 ± 0.058
0.0GluXaa: 0.0 ± 0.0
Phe
3.916PheAla: 3.916 ± 0.08
0.302PheCys: 0.302 ± 0.016
3.184PheAsp: 3.184 ± 0.056
2.889PheGlu: 2.889 ± 0.065
1.012PhePhe: 1.012 ± 0.037
2.958PheGly: 2.958 ± 0.065
0.597PheHis: 0.597 ± 0.025
0.833PheIle: 0.833 ± 0.032
0.428PheLys: 0.428 ± 0.024
2.826PheLeu: 2.826 ± 0.07
0.448PheMet: 0.448 ± 0.024
0.631PheAsn: 0.631 ± 0.027
1.299PhePro: 1.299 ± 0.036
0.681PheGln: 0.681 ± 0.026
1.796PheArg: 1.796 ± 0.046
1.623PheSer: 1.623 ± 0.04
1.756PheThr: 1.756 ± 0.042
3.265PheVal: 3.265 ± 0.059
0.34PheTrp: 0.34 ± 0.02
0.848PheTyr: 0.848 ± 0.028
0.0PheXaa: 0.0 ± 0.0
Gly
9.179GlyAla: 9.179 ± 0.133
0.645GlyCys: 0.645 ± 0.026
6.987GlyAsp: 6.987 ± 0.09
7.0GlyGlu: 7.0 ± 0.097
3.173GlyPhe: 3.173 ± 0.071
7.368GlyGly: 7.368 ± 0.134
1.818GlyHis: 1.818 ± 0.053
3.338GlyIle: 3.338 ± 0.068
1.783GlyLys: 1.783 ± 0.052
7.179GlyLeu: 7.179 ± 0.125
1.496GlyMet: 1.496 ± 0.04
1.729GlyAsn: 1.729 ± 0.049
3.28GlyPro: 3.28 ± 0.059
1.671GlyGln: 1.671 ± 0.047
5.134GlyArg: 5.134 ± 0.085
4.653GlySer: 4.653 ± 0.079
5.528GlyThr: 5.528 ± 0.092
8.879GlyVal: 8.879 ± 0.122
1.12GlyTrp: 1.12 ± 0.032
2.671GlyTyr: 2.671 ± 0.055
0.0GlyXaa: 0.0 ± 0.0
His
2.586HisAla: 2.586 ± 0.057
0.171HisCys: 0.171 ± 0.015
2.057HisAsp: 2.057 ± 0.051
1.749HisGlu: 1.749 ± 0.048
0.554HisPhe: 0.554 ± 0.026
2.033HisGly: 2.033 ± 0.049
0.579HisHis: 0.579 ± 0.028
0.529HisIle: 0.529 ± 0.024
0.26HisLys: 0.26 ± 0.016
1.844HisLeu: 1.844 ± 0.041
0.274HisMet: 0.274 ± 0.018
0.414HisAsn: 0.414 ± 0.021
1.344HisPro: 1.344 ± 0.041
0.465HisGln: 0.465 ± 0.023
1.299HisArg: 1.299 ± 0.041
0.868HisSer: 0.868 ± 0.031
1.109HisThr: 1.109 ± 0.036
2.205HisVal: 2.205 ± 0.051
0.214HisTrp: 0.214 ± 0.015
0.678HisTyr: 0.678 ± 0.029
0.0HisXaa: 0.0 ± 0.0
Ile
3.937IleAla: 3.937 ± 0.074
0.178IleCys: 0.178 ± 0.015
3.104IleAsp: 3.104 ± 0.071
3.314IleGlu: 3.314 ± 0.072
0.656IlePhe: 0.656 ± 0.027
2.956IleGly: 2.956 ± 0.067
0.688IleHis: 0.688 ± 0.023
0.979IleIle: 0.979 ± 0.044
0.566IleLys: 0.566 ± 0.024
2.304IleLeu: 2.304 ± 0.063
0.351IleMet: 0.351 ± 0.02
0.72IleAsn: 0.72 ± 0.031
1.731IlePro: 1.731 ± 0.043
0.874IleGln: 0.874 ± 0.035
2.079IleArg: 2.079 ± 0.044
1.569IleSer: 1.569 ± 0.044
2.141IleThr: 2.141 ± 0.052
2.795IleVal: 2.795 ± 0.057
0.229IleTrp: 0.229 ± 0.017
0.736IleTyr: 0.736 ± 0.031
0.0IleXaa: 0.0 ± 0.0
Lys
1.685LysAla: 1.685 ± 0.046
0.117LysCys: 0.117 ± 0.012
0.983LysAsp: 0.983 ± 0.037
1.256LysGlu: 1.256 ± 0.044
0.471LysPhe: 0.471 ± 0.027
1.296LysGly: 1.296 ± 0.04
0.469LysHis: 0.469 ± 0.022
0.64LysIle: 0.64 ± 0.033
0.497LysLys: 0.497 ± 0.028
1.531LysLeu: 1.531 ± 0.047
0.317LysMet: 0.317 ± 0.02
0.531LysAsn: 0.531 ± 0.023
0.89LysPro: 0.89 ± 0.03
0.672LysGln: 0.672 ± 0.028
1.587LysArg: 1.587 ± 0.051
1.007LysSer: 1.007 ± 0.031
1.267LysThr: 1.267 ± 0.041
1.237LysVal: 1.237 ± 0.041
0.214LysTrp: 0.214 ± 0.016
0.575LysTyr: 0.575 ± 0.024
0.0LysXaa: 0.0 ± 0.0
Leu
12.84LeuAla: 12.84 ± 0.165
0.745LeuCys: 0.745 ± 0.031
8.295LeuAsp: 8.295 ± 0.132
6.686LeuGlu: 6.686 ± 0.11
2.743LeuPhe: 2.743 ± 0.062
7.981LeuGly: 7.981 ± 0.144
1.629LeuHis: 1.629 ± 0.043
2.174LeuIle: 2.174 ± 0.063
1.5LeuLys: 1.5 ± 0.046
8.692LeuLeu: 8.692 ± 0.146
1.236LeuMet: 1.236 ± 0.038
1.776LeuAsn: 1.776 ± 0.04
4.36LeuPro: 4.36 ± 0.077
1.894LeuGln: 1.894 ± 0.054
5.911LeuArg: 5.911 ± 0.1
5.03LeuSer: 5.03 ± 0.078
5.407LeuThr: 5.407 ± 0.08
9.094LeuVal: 9.094 ± 0.131
0.842LeuTrp: 0.842 ± 0.036
2.26LeuTyr: 2.26 ± 0.054
0.0LeuXaa: 0.0 ± 0.0
Met
1.742MetAla: 1.742 ± 0.048
0.102MetCys: 0.102 ± 0.011
1.144MetAsp: 1.144 ± 0.041
1.021MetGlu: 1.021 ± 0.034
0.427MetPhe: 0.427 ± 0.023
1.355MetGly: 1.355 ± 0.046
0.352MetHis: 0.352 ± 0.02
0.445MetIle: 0.445 ± 0.022
0.386MetLys: 0.386 ± 0.021
1.345MetLeu: 1.345 ± 0.04
0.293MetMet: 0.293 ± 0.017
0.514MetAsn: 0.514 ± 0.023
0.829MetPro: 0.829 ± 0.028
0.453MetGln: 0.453 ± 0.025
1.181MetArg: 1.181 ± 0.037
1.477MetSer: 1.477 ± 0.043
1.319MetThr: 1.319 ± 0.037
1.172MetVal: 1.172 ± 0.037
0.137MetTrp: 0.137 ± 0.012
0.362MetTyr: 0.362 ± 0.021
0.0MetXaa: 0.0 ± 0.0
Asn
2.936AsnAla: 2.936 ± 0.077
0.21AsnCys: 0.21 ± 0.015
1.605AsnAsp: 1.605 ± 0.047
1.548AsnGlu: 1.548 ± 0.045
0.602AsnPhe: 0.602 ± 0.027
1.827AsnGly: 1.827 ± 0.044
0.481AsnHis: 0.481 ± 0.022
0.708AsnIle: 0.708 ± 0.029
0.404AsnLys: 0.404 ± 0.023
1.826AsnLeu: 1.826 ± 0.041
0.356AsnMet: 0.356 ± 0.019
0.484AsnAsn: 0.484 ± 0.025
1.498AsnPro: 1.498 ± 0.045
0.588AsnGln: 0.588 ± 0.023
1.439AsnArg: 1.439 ± 0.04
0.908AsnSer: 0.908 ± 0.034
1.314AsnThr: 1.314 ± 0.037
2.246AsnVal: 2.246 ± 0.057
0.313AsnTrp: 0.313 ± 0.019
0.641AsnTyr: 0.641 ± 0.025
0.0AsnXaa: 0.0 ± 0.0
Pro
5.037ProAla: 5.037 ± 0.088
0.225ProCys: 0.225 ± 0.016
4.779ProAsp: 4.779 ± 0.078
4.658ProGlu: 4.658 ± 0.079
1.495ProPhe: 1.495 ± 0.038
3.64ProGly: 3.64 ± 0.067
0.914ProHis: 0.914 ± 0.032
1.502ProIle: 1.502 ± 0.044
0.793ProLys: 0.793 ± 0.028
3.824ProLeu: 3.824 ± 0.068
0.822ProMet: 0.822 ± 0.034
1.074ProAsn: 1.074 ± 0.031
2.058ProPro: 2.058 ± 0.046
0.867ProGln: 0.867 ± 0.032
2.393ProArg: 2.393 ± 0.049
2.629ProSer: 2.629 ± 0.053
3.02ProThr: 3.02 ± 0.056
4.389ProVal: 4.389 ± 0.072
0.55ProTrp: 0.55 ± 0.023
1.208ProTyr: 1.208 ± 0.038
0.0ProXaa: 0.0 ± 0.0
Gln
2.164GlnAla: 2.164 ± 0.053
0.139GlnCys: 0.139 ± 0.013
1.254GlnAsp: 1.254 ± 0.041
1.457GlnGlu: 1.457 ± 0.049
0.851GlnPhe: 0.851 ± 0.03
1.492GlnGly: 1.492 ± 0.045
0.536GlnHis: 0.536 ± 0.023
0.808GlnIle: 0.808 ± 0.03
0.56GlnLys: 0.56 ± 0.028
2.025GlnLeu: 2.025 ± 0.054
0.453GlnMet: 0.453 ± 0.022
0.729GlnAsn: 0.729 ± 0.029
1.0GlnPro: 1.0 ± 0.04
0.933GlnGln: 0.933 ± 0.035
1.837GlnArg: 1.837 ± 0.042
1.45GlnSer: 1.45 ± 0.041
1.451GlnThr: 1.451 ± 0.04
1.6GlnVal: 1.6 ± 0.048
0.34GlnTrp: 0.34 ± 0.019
0.87GlnTyr: 0.87 ± 0.03
0.0GlnXaa: 0.0 ± 0.0
Arg
7.76ArgAla: 7.76 ± 0.111
0.45ArgCys: 0.45 ± 0.026
6.088ArgAsp: 6.088 ± 0.088
7.174ArgGlu: 7.174 ± 0.12
2.215ArgPhe: 2.215 ± 0.053
4.625ArgGly: 4.625 ± 0.082
1.421ArgHis: 1.421 ± 0.042
2.496ArgIle: 2.496 ± 0.053
1.299ArgLys: 1.299 ± 0.043
6.156ArgLeu: 6.156 ± 0.09
1.214ArgMet: 1.214 ± 0.038
1.474ArgAsn: 1.474 ± 0.04
2.64ArgPro: 2.64 ± 0.058
1.502ArgGln: 1.502 ± 0.043
4.921ArgArg: 4.921 ± 0.091
3.164ArgSer: 3.164 ± 0.069
3.93ArgThr: 3.93 ± 0.071
6.31ArgVal: 6.31 ± 0.098
0.83ArgTrp: 0.83 ± 0.035
2.118ArgTyr: 2.118 ± 0.055
0.0ArgXaa: 0.0 ± 0.0
Ser
5.67SerAla: 5.67 ± 0.101
0.324SerCys: 0.324 ± 0.021
4.074SerAsp: 4.074 ± 0.076
4.173SerGlu: 4.173 ± 0.067
1.784SerPhe: 1.784 ± 0.047
5.29SerGly: 5.29 ± 0.091
0.972SerHis: 0.972 ± 0.034
1.892SerIle: 1.892 ± 0.044
1.131SerLys: 1.131 ± 0.038
4.774SerLeu: 4.774 ± 0.07
0.993SerMet: 0.993 ± 0.035
1.272SerAsn: 1.272 ± 0.043
2.34SerPro: 2.34 ± 0.05
1.255SerGln: 1.255 ± 0.042
3.146SerArg: 3.146 ± 0.065
2.778SerSer: 2.778 ± 0.073
3.349SerThr: 3.349 ± 0.07
4.905SerVal: 4.905 ± 0.081
0.594SerTrp: 0.594 ± 0.026
1.397SerTyr: 1.397 ± 0.043
0.0SerXaa: 0.0 ± 0.0
Thr
6.74ThrAla: 6.74 ± 0.102
0.36ThrCys: 0.36 ± 0.022
4.922ThrAsp: 4.922 ± 0.077
4.417ThrGlu: 4.417 ± 0.078
2.003ThrPhe: 2.003 ± 0.055
5.617ThrGly: 5.617 ± 0.081
1.421ThrHis: 1.421 ± 0.04
2.218ThrIle: 2.218 ± 0.054
1.006ThrLys: 1.006 ± 0.04
6.251ThrLeu: 6.251 ± 0.088
0.971ThrMet: 0.971 ± 0.035
1.44ThrAsn: 1.44 ± 0.046
3.601ThrPro: 3.601 ± 0.062
1.342ThrGln: 1.342 ± 0.041
3.612ThrArg: 3.612 ± 0.069
3.02ThrSer: 3.02 ± 0.068
4.587ThrThr: 4.587 ± 0.121
7.028ThrVal: 7.028 ± 0.141
0.668ThrTrp: 0.668 ± 0.028
1.926ThrTyr: 1.926 ± 0.047
0.0ThrXaa: 0.0 ± 0.0
Val
12.603ValAla: 12.603 ± 0.16
0.798ValCys: 0.798 ± 0.025
7.308ValAsp: 7.308 ± 0.101
8.549ValGlu: 8.549 ± 0.116
3.089ValPhe: 3.089 ± 0.069
8.258ValGly: 8.258 ± 0.14
1.938ValHis: 1.938 ± 0.048
2.66ValIle: 2.66 ± 0.072
1.31ValLys: 1.31 ± 0.041
8.926ValLeu: 8.926 ± 0.139
1.248ValMet: 1.248 ± 0.037
2.013ValAsn: 2.013 ± 0.048
4.597ValPro: 4.597 ± 0.073
1.865ValGln: 1.865 ± 0.05
6.351ValArg: 6.351 ± 0.101
5.188ValSer: 5.188 ± 0.09
6.476ValThr: 6.476 ± 0.11
10.266ValVal: 10.266 ± 0.142
0.841ValTrp: 0.841 ± 0.029
2.375ValTyr: 2.375 ± 0.06
0.0ValXaa: 0.0 ± 0.0
Trp
1.087TrpAla: 1.087 ± 0.033
0.095TrpCys: 0.095 ± 0.012
0.7TrpAsp: 0.7 ± 0.03
0.866TrpGlu: 0.866 ± 0.032
0.473TrpPhe: 0.473 ± 0.024
0.846TrpGly: 0.846 ± 0.034
0.239TrpHis: 0.239 ± 0.017
0.356TrpIle: 0.356 ± 0.019
0.266TrpLys: 0.266 ± 0.017
1.179TrpLeu: 1.179 ± 0.043
0.219TrpMet: 0.219 ± 0.015
0.364TrpAsn: 0.364 ± 0.023
0.441TrpPro: 0.441 ± 0.023
0.34TrpGln: 0.34 ± 0.02
0.914TrpArg: 0.914 ± 0.031
0.583TrpSer: 0.583 ± 0.028
0.861TrpThr: 0.861 ± 0.033
0.894TrpVal: 0.894 ± 0.029
0.216TrpTrp: 0.216 ± 0.017
0.367TrpTyr: 0.367 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.37TyrAla: 3.37 ± 0.066
0.268TyrCys: 0.268 ± 0.018
2.694TyrAsp: 2.694 ± 0.062
2.441TyrGlu: 2.441 ± 0.063
0.836TyrPhe: 0.836 ± 0.025
2.531TyrGly: 2.531 ± 0.055
0.663TyrHis: 0.663 ± 0.027
0.695TyrIle: 0.695 ± 0.028
0.392TyrLys: 0.392 ± 0.021
2.559TyrLeu: 2.559 ± 0.057
0.365TyrMet: 0.365 ± 0.02
0.637TyrAsn: 0.637 ± 0.025
1.308TyrPro: 1.308 ± 0.043
0.72TyrGln: 0.72 ± 0.033
2.101TyrArg: 2.101 ± 0.051
1.185TyrSer: 1.185 ± 0.031
1.598TyrThr: 1.598 ± 0.044
2.66TyrVal: 2.66 ± 0.057
0.362TyrTrp: 0.362 ± 0.022
0.92TyrTyr: 0.92 ± 0.033
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3110 proteins (920609 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski