Amino acid dipepetide frequency for Streptococcus phage CHPC879

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.65AlaAla: 2.65 ± 1.15
0.274AlaCys: 0.274 ± 0.155
5.209AlaAsp: 5.209 ± 0.708
5.209AlaGlu: 5.209 ± 0.795
2.65AlaPhe: 2.65 ± 0.472
3.747AlaGly: 3.747 ± 0.781
0.822AlaHis: 0.822 ± 0.263
4.569AlaIle: 4.569 ± 0.846
6.305AlaLys: 6.305 ± 1.022
5.94AlaLeu: 5.94 ± 0.594
2.01AlaMet: 2.01 ± 0.461
4.386AlaAsn: 4.386 ± 0.797
1.554AlaPro: 1.554 ± 0.294
3.107AlaGln: 3.107 ± 0.426
2.559AlaArg: 2.559 ± 0.386
4.569AlaSer: 4.569 ± 0.706
4.021AlaThr: 4.021 ± 0.741
4.112AlaVal: 4.112 ± 0.661
0.457AlaTrp: 0.457 ± 0.175
2.833AlaTyr: 2.833 ± 0.56
0.0AlaXaa: 0.0 ± 0.0
Cys
0.274CysAla: 0.274 ± 0.134
0.0CysCys: 0.0 ± 0.0
0.731CysAsp: 0.731 ± 0.274
0.366CysGlu: 0.366 ± 0.19
0.274CysPhe: 0.274 ± 0.212
0.183CysGly: 0.183 ± 0.135
0.091CysHis: 0.091 ± 0.095
0.0CysIle: 0.0 ± 0.0
0.183CysLys: 0.183 ± 0.131
0.457CysLeu: 0.457 ± 0.269
0.091CysMet: 0.091 ± 0.097
0.366CysAsn: 0.366 ± 0.161
0.091CysPro: 0.091 ± 0.097
0.091CysGln: 0.091 ± 0.088
0.183CysArg: 0.183 ± 0.176
0.548CysSer: 0.548 ± 0.277
0.183CysThr: 0.183 ± 0.142
0.274CysVal: 0.274 ± 0.139
0.183CysTrp: 0.183 ± 0.113
0.183CysTyr: 0.183 ± 0.107
0.0CysXaa: 0.0 ± 0.0
Asp
3.564AspAla: 3.564 ± 0.834
0.366AspCys: 0.366 ± 0.176
3.655AspAsp: 3.655 ± 0.755
5.026AspGlu: 5.026 ± 0.776
3.747AspPhe: 3.747 ± 0.392
6.305AspGly: 6.305 ± 1.23
0.914AspHis: 0.914 ± 0.29
4.843AspIle: 4.843 ± 0.716
5.574AspLys: 5.574 ± 0.908
4.295AspLeu: 4.295 ± 0.751
2.01AspMet: 2.01 ± 0.505
4.569AspAsn: 4.569 ± 0.666
1.736AspPro: 1.736 ± 0.45
1.828AspGln: 1.828 ± 0.352
2.65AspArg: 2.65 ± 0.543
4.204AspSer: 4.204 ± 0.529
3.838AspThr: 3.838 ± 0.55
2.193AspVal: 2.193 ± 0.43
1.097AspTrp: 1.097 ± 0.376
2.376AspTyr: 2.376 ± 0.416
0.0AspXaa: 0.0 ± 0.0
Glu
4.386GluAla: 4.386 ± 0.582
0.274GluCys: 0.274 ± 0.139
3.747GluAsp: 3.747 ± 0.628
4.478GluGlu: 4.478 ± 1.21
2.193GluPhe: 2.193 ± 0.474
2.285GluGly: 2.285 ± 0.31
1.371GluHis: 1.371 ± 0.343
6.397GluIle: 6.397 ± 0.987
4.752GluLys: 4.752 ± 0.913
7.311GluLeu: 7.311 ± 1.209
2.741GluMet: 2.741 ± 0.633
4.021GluAsn: 4.021 ± 0.563
2.01GluPro: 2.01 ± 0.449
3.107GluGln: 3.107 ± 0.568
3.016GluArg: 3.016 ± 0.519
3.198GluSer: 3.198 ± 0.597
4.295GluThr: 4.295 ± 0.539
5.392GluVal: 5.392 ± 0.934
0.822GluTrp: 0.822 ± 0.244
3.29GluTyr: 3.29 ± 0.648
0.0GluXaa: 0.0 ± 0.0
Phe
3.198PheAla: 3.198 ± 0.604
0.274PheCys: 0.274 ± 0.115
3.838PheAsp: 3.838 ± 0.63
2.376PheGlu: 2.376 ± 0.598
1.736PhePhe: 1.736 ± 0.431
2.924PheGly: 2.924 ± 0.568
0.457PheHis: 0.457 ± 0.187
3.016PheIle: 3.016 ± 0.562
3.564PheLys: 3.564 ± 0.524
2.376PheLeu: 2.376 ± 0.486
0.731PheMet: 0.731 ± 0.27
3.29PheAsn: 3.29 ± 0.647
0.822PhePro: 0.822 ± 0.289
1.005PheGln: 1.005 ± 0.222
1.462PheArg: 1.462 ± 0.358
2.833PheSer: 2.833 ± 0.526
2.65PheThr: 2.65 ± 0.532
3.016PheVal: 3.016 ± 0.613
0.548PheTrp: 0.548 ± 0.286
2.01PheTyr: 2.01 ± 0.372
0.0PheXaa: 0.0 ± 0.0
Gly
3.381GlyAla: 3.381 ± 0.789
0.366GlyCys: 0.366 ± 0.183
4.021GlyAsp: 4.021 ± 0.736
3.838GlyGlu: 3.838 ± 0.531
2.833GlyPhe: 2.833 ± 0.46
4.112GlyGly: 4.112 ± 1.004
1.005GlyHis: 1.005 ± 0.268
5.392GlyIle: 5.392 ± 0.927
6.854GlyLys: 6.854 ± 0.957
5.757GlyLeu: 5.757 ± 0.727
1.005GlyMet: 1.005 ± 0.234
4.661GlyAsn: 4.661 ± 0.876
1.097GlyPro: 1.097 ± 0.443
2.833GlyGln: 2.833 ± 0.528
2.741GlyArg: 2.741 ± 0.44
4.386GlySer: 4.386 ± 0.633
3.929GlyThr: 3.929 ± 0.674
4.112GlyVal: 4.112 ± 0.793
1.279GlyTrp: 1.279 ± 0.392
2.924GlyTyr: 2.924 ± 0.434
0.0GlyXaa: 0.0 ± 0.0
His
0.64HisAla: 0.64 ± 0.253
0.0HisCys: 0.0 ± 0.0
0.64HisAsp: 0.64 ± 0.266
0.366HisGlu: 0.366 ± 0.252
1.279HisPhe: 1.279 ± 0.311
0.914HisGly: 0.914 ± 0.351
0.366HisHis: 0.366 ± 0.186
1.005HisIle: 1.005 ± 0.279
1.188HisLys: 1.188 ± 0.381
1.097HisLeu: 1.097 ± 0.274
0.64HisMet: 0.64 ± 0.287
0.822HisAsn: 0.822 ± 0.274
0.548HisPro: 0.548 ± 0.182
0.731HisGln: 0.731 ± 0.244
0.731HisArg: 0.731 ± 0.213
1.097HisSer: 1.097 ± 0.258
0.64HisThr: 0.64 ± 0.244
1.188HisVal: 1.188 ± 0.24
0.091HisTrp: 0.091 ± 0.077
0.731HisTyr: 0.731 ± 0.256
0.0HisXaa: 0.0 ± 0.0
Ile
5.3IleAla: 5.3 ± 0.932
0.274IleCys: 0.274 ± 0.154
4.752IleAsp: 4.752 ± 0.619
5.392IleGlu: 5.392 ± 0.915
1.828IlePhe: 1.828 ± 0.478
4.478IleGly: 4.478 ± 0.421
0.731IleHis: 0.731 ± 0.218
2.741IleIle: 2.741 ± 0.581
6.854IleLys: 6.854 ± 0.748
3.655IleLeu: 3.655 ± 0.621
1.828IleMet: 1.828 ± 0.482
4.843IleAsn: 4.843 ± 0.701
3.107IlePro: 3.107 ± 0.603
2.559IleGln: 2.559 ± 0.534
2.741IleArg: 2.741 ± 0.371
4.478IleSer: 4.478 ± 0.45
3.473IleThr: 3.473 ± 0.549
3.929IleVal: 3.929 ± 0.566
0.731IleTrp: 0.731 ± 0.243
2.01IleTyr: 2.01 ± 0.367
0.0IleXaa: 0.0 ± 0.0
Lys
6.671LysAla: 6.671 ± 0.848
0.274LysCys: 0.274 ± 0.166
5.392LysAsp: 5.392 ± 0.844
7.036LysGlu: 7.036 ± 1.361
3.564LysPhe: 3.564 ± 0.742
5.757LysGly: 5.757 ± 0.725
1.462LysHis: 1.462 ± 0.427
6.671LysIle: 6.671 ± 0.695
7.585LysLys: 7.585 ± 0.996
5.94LysLeu: 5.94 ± 0.803
2.924LysMet: 2.924 ± 0.515
4.386LysAsn: 4.386 ± 0.725
2.467LysPro: 2.467 ± 0.521
4.752LysGln: 4.752 ± 0.63
3.838LysArg: 3.838 ± 0.601
4.112LysSer: 4.112 ± 0.652
5.574LysThr: 5.574 ± 0.802
4.112LysVal: 4.112 ± 0.637
1.554LysTrp: 1.554 ± 0.278
3.564LysTyr: 3.564 ± 0.57
0.0LysXaa: 0.0 ± 0.0
Leu
6.214LeuAla: 6.214 ± 0.752
0.457LeuCys: 0.457 ± 0.279
5.574LeuAsp: 5.574 ± 0.779
6.488LeuGlu: 6.488 ± 1.033
3.29LeuPhe: 3.29 ± 0.423
5.209LeuGly: 5.209 ± 0.837
0.822LeuHis: 0.822 ± 0.247
3.655LeuIle: 3.655 ± 0.508
7.493LeuLys: 7.493 ± 0.706
4.569LeuLeu: 4.569 ± 0.759
2.559LeuMet: 2.559 ± 0.492
4.021LeuAsn: 4.021 ± 0.587
2.102LeuPro: 2.102 ± 0.352
2.65LeuGln: 2.65 ± 0.509
3.198LeuArg: 3.198 ± 0.825
4.386LeuSer: 4.386 ± 0.641
5.666LeuThr: 5.666 ± 0.95
4.021LeuVal: 4.021 ± 0.787
0.64LeuTrp: 0.64 ± 0.197
2.102LeuTyr: 2.102 ± 0.503
0.0LeuXaa: 0.0 ± 0.0
Met
1.736MetAla: 1.736 ± 0.396
0.091MetCys: 0.091 ± 0.095
0.822MetAsp: 0.822 ± 0.24
1.462MetGlu: 1.462 ± 0.437
0.914MetPhe: 0.914 ± 0.294
1.188MetGly: 1.188 ± 0.326
0.457MetHis: 0.457 ± 0.242
1.919MetIle: 1.919 ± 0.333
3.29MetLys: 3.29 ± 0.738
2.102MetLeu: 2.102 ± 0.375
0.822MetMet: 0.822 ± 0.246
1.371MetAsn: 1.371 ± 0.339
0.822MetPro: 0.822 ± 0.259
1.005MetGln: 1.005 ± 0.325
0.914MetArg: 0.914 ± 0.251
1.554MetSer: 1.554 ± 0.39
1.736MetThr: 1.736 ± 0.333
1.919MetVal: 1.919 ± 0.485
0.091MetTrp: 0.091 ± 0.077
1.554MetTyr: 1.554 ± 0.345
0.0MetXaa: 0.0 ± 0.0
Asn
5.209AsnAla: 5.209 ± 0.938
0.274AsnCys: 0.274 ± 0.136
3.929AsnAsp: 3.929 ± 0.538
3.929AsnGlu: 3.929 ± 0.684
2.924AsnPhe: 2.924 ± 0.38
6.671AsnGly: 6.671 ± 1.152
0.822AsnHis: 0.822 ± 0.21
3.29AsnIle: 3.29 ± 0.579
4.661AsnLys: 4.661 ± 0.962
4.935AsnLeu: 4.935 ± 0.631
0.914AsnMet: 0.914 ± 0.284
4.935AsnAsn: 4.935 ± 0.851
2.924AsnPro: 2.924 ± 0.681
3.564AsnGln: 3.564 ± 0.652
2.193AsnArg: 2.193 ± 0.56
4.204AsnSer: 4.204 ± 0.552
3.381AsnThr: 3.381 ± 0.688
3.473AsnVal: 3.473 ± 0.49
0.822AsnTrp: 0.822 ± 0.277
2.376AsnTyr: 2.376 ± 0.431
0.0AsnXaa: 0.0 ± 0.0
Pro
1.828ProAla: 1.828 ± 0.309
0.0ProCys: 0.0 ± 0.0
1.005ProAsp: 1.005 ± 0.326
1.828ProGlu: 1.828 ± 0.359
1.097ProPhe: 1.097 ± 0.343
1.188ProGly: 1.188 ± 0.472
0.457ProHis: 0.457 ± 0.194
1.462ProIle: 1.462 ± 0.328
3.929ProLys: 3.929 ± 0.692
2.376ProLeu: 2.376 ± 0.366
0.091ProMet: 0.091 ± 0.088
2.559ProAsn: 2.559 ± 0.506
0.457ProPro: 0.457 ± 0.209
1.462ProGln: 1.462 ± 0.306
0.822ProArg: 0.822 ± 0.403
2.193ProSer: 2.193 ± 0.353
2.467ProThr: 2.467 ± 0.443
1.188ProVal: 1.188 ± 0.366
0.548ProTrp: 0.548 ± 0.204
1.097ProTyr: 1.097 ± 0.379
0.0ProXaa: 0.0 ± 0.0
Gln
4.661GlnAla: 4.661 ± 0.643
0.183GlnCys: 0.183 ± 0.122
2.833GlnAsp: 2.833 ± 0.41
2.924GlnGlu: 2.924 ± 0.751
1.645GlnPhe: 1.645 ± 0.388
3.016GlnGly: 3.016 ± 0.415
0.731GlnHis: 0.731 ± 0.283
2.467GlnIle: 2.467 ± 0.521
3.198GlnLys: 3.198 ± 0.635
3.381GlnLeu: 3.381 ± 0.416
1.828GlnMet: 1.828 ± 0.401
2.193GlnAsn: 2.193 ± 0.442
0.731GlnPro: 0.731 ± 0.24
3.655GlnGln: 3.655 ± 0.79
2.01GlnArg: 2.01 ± 0.429
2.376GlnSer: 2.376 ± 0.362
2.65GlnThr: 2.65 ± 0.41
2.285GlnVal: 2.285 ± 0.478
0.731GlnTrp: 0.731 ± 0.225
1.919GlnTyr: 1.919 ± 0.323
0.0GlnXaa: 0.0 ± 0.0
Arg
2.376ArgAla: 2.376 ± 0.418
0.091ArgCys: 0.091 ± 0.088
2.467ArgAsp: 2.467 ± 0.576
3.016ArgGlu: 3.016 ± 0.562
1.462ArgPhe: 1.462 ± 0.321
2.467ArgGly: 2.467 ± 0.602
0.548ArgHis: 0.548 ± 0.206
2.376ArgIle: 2.376 ± 0.381
3.198ArgLys: 3.198 ± 0.543
3.655ArgLeu: 3.655 ± 0.524
0.914ArgMet: 0.914 ± 0.321
2.833ArgAsn: 2.833 ± 0.393
1.188ArgPro: 1.188 ± 0.302
2.376ArgGln: 2.376 ± 0.474
1.645ArgArg: 1.645 ± 0.473
1.645ArgSer: 1.645 ± 0.354
2.467ArgThr: 2.467 ± 0.607
2.833ArgVal: 2.833 ± 0.418
0.914ArgTrp: 0.914 ± 0.241
2.376ArgTyr: 2.376 ± 0.532
0.0ArgXaa: 0.0 ± 0.0
Ser
3.381SerAla: 3.381 ± 0.516
0.548SerCys: 0.548 ± 0.248
4.386SerAsp: 4.386 ± 0.692
3.381SerGlu: 3.381 ± 0.479
2.741SerPhe: 2.741 ± 0.448
4.386SerGly: 4.386 ± 0.814
0.822SerHis: 0.822 ± 0.269
4.478SerIle: 4.478 ± 0.56
5.117SerLys: 5.117 ± 0.719
3.655SerLeu: 3.655 ± 0.563
1.919SerMet: 1.919 ± 0.407
4.935SerAsn: 4.935 ± 0.571
1.736SerPro: 1.736 ± 0.435
2.833SerGln: 2.833 ± 0.56
2.376SerArg: 2.376 ± 0.505
2.924SerSer: 2.924 ± 0.595
4.204SerThr: 4.204 ± 0.628
4.843SerVal: 4.843 ± 0.456
0.914SerTrp: 0.914 ± 0.22
2.01SerTyr: 2.01 ± 0.455
0.0SerXaa: 0.0 ± 0.0
Thr
3.838ThrAla: 3.838 ± 0.521
0.183ThrCys: 0.183 ± 0.117
3.838ThrAsp: 3.838 ± 0.652
3.381ThrGlu: 3.381 ± 0.531
2.741ThrPhe: 2.741 ± 0.544
4.112ThrGly: 4.112 ± 0.53
1.188ThrHis: 1.188 ± 0.331
4.478ThrIle: 4.478 ± 0.667
4.752ThrLys: 4.752 ± 0.774
5.94ThrLeu: 5.94 ± 0.841
0.548ThrMet: 0.548 ± 0.196
5.117ThrAsn: 5.117 ± 0.686
1.371ThrPro: 1.371 ± 0.493
2.833ThrGln: 2.833 ± 0.513
2.559ThrArg: 2.559 ± 0.533
3.655ThrSer: 3.655 ± 0.745
3.929ThrThr: 3.929 ± 0.635
3.929ThrVal: 3.929 ± 0.789
0.914ThrTrp: 0.914 ± 0.27
3.016ThrTyr: 3.016 ± 0.648
0.0ThrXaa: 0.0 ± 0.0
Val
4.478ValAla: 4.478 ± 0.723
0.366ValCys: 0.366 ± 0.155
3.838ValAsp: 3.838 ± 0.44
4.752ValGlu: 4.752 ± 0.702
2.559ValPhe: 2.559 ± 0.378
4.661ValGly: 4.661 ± 0.742
0.822ValHis: 0.822 ± 0.337
3.747ValIle: 3.747 ± 0.456
5.483ValLys: 5.483 ± 0.561
3.29ValLeu: 3.29 ± 0.512
0.731ValMet: 0.731 ± 0.225
3.473ValAsn: 3.473 ± 0.704
1.919ValPro: 1.919 ± 0.389
2.193ValGln: 2.193 ± 0.479
1.919ValArg: 1.919 ± 0.456
5.026ValSer: 5.026 ± 0.724
4.204ValThr: 4.204 ± 0.736
3.381ValVal: 3.381 ± 0.582
1.005ValTrp: 1.005 ± 0.272
1.371ValTyr: 1.371 ± 0.425
0.0ValXaa: 0.0 ± 0.0
Trp
0.548TrpAla: 0.548 ± 0.193
0.0TrpCys: 0.0 ± 0.0
1.097TrpAsp: 1.097 ± 0.492
0.822TrpGlu: 0.822 ± 0.245
0.457TrpPhe: 0.457 ± 0.255
0.64TrpGly: 0.64 ± 0.232
0.366TrpHis: 0.366 ± 0.173
0.822TrpIle: 0.822 ± 0.269
0.548TrpLys: 0.548 ± 0.239
1.097TrpLeu: 1.097 ± 0.254
0.091TrpMet: 0.091 ± 0.111
1.005TrpAsn: 1.005 ± 0.308
0.091TrpPro: 0.091 ± 0.103
0.731TrpGln: 0.731 ± 0.228
0.914TrpArg: 0.914 ± 0.219
1.554TrpSer: 1.554 ± 0.576
1.097TrpThr: 1.097 ± 0.367
0.914TrpVal: 0.914 ± 0.239
0.274TrpTrp: 0.274 ± 0.194
0.64TrpTyr: 0.64 ± 0.247
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.65TyrAla: 2.65 ± 0.464
0.457TyrCys: 0.457 ± 0.265
3.107TyrAsp: 3.107 ± 0.544
3.016TyrGlu: 3.016 ± 0.618
2.193TyrPhe: 2.193 ± 0.391
2.285TyrGly: 2.285 ± 0.53
0.457TyrHis: 0.457 ± 0.219
2.376TyrIle: 2.376 ± 0.384
3.107TyrLys: 3.107 ± 0.533
3.29TyrLeu: 3.29 ± 0.598
1.279TyrMet: 1.279 ± 0.411
1.645TyrAsn: 1.645 ± 0.38
1.279TyrPro: 1.279 ± 0.35
2.102TyrGln: 2.102 ± 0.33
2.376TyrArg: 2.376 ± 0.315
2.65TyrSer: 2.65 ± 0.635
1.919TyrThr: 1.919 ± 0.413
2.102TyrVal: 2.102 ± 0.399
0.091TyrTrp: 0.091 ± 0.098
1.828TyrTyr: 1.828 ± 0.605
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 45 proteins (10944 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski