Amino acid dipepetide frequency for Vibrio viridaestus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.762AlaAla: 6.762 ± 0.092	0.917AlaCys: 0.917 ± 0.027	4.084AlaAsp: 4.084 ± 0.06	4.941AlaGlu: 4.941 ± 0.071	3.246AlaPhe: 3.246 ± 0.048	5.507AlaGly: 5.507 ± 0.071	1.557AlaHis: 1.557 ± 0.034	6.095AlaIle: 6.095 ± 0.068	4.884AlaLys: 4.884 ± 0.072	8.997AlaLeu: 8.997 ± 0.083	2.454AlaMet: 2.454 ± 0.04	3.197AlaAsn: 3.197 ± 0.052	2.481AlaPro: 2.481 ± 0.05	3.385AlaGln: 3.385 ± 0.056	3.339AlaArg: 3.339 ± 0.056	5.096AlaSer: 5.096 ± 0.066	4.188AlaThr: 4.188 ± 0.058	5.489AlaVal: 5.489 ± 0.076	0.897AlaTrp: 0.897 ± 0.027	2.277AlaTyr: 2.277 ± 0.048	0.006AlaXaa: 0.006 ± 0.002
Cys	0.823CysAla: 0.823 ± 0.025	0.184CysCys: 0.184 ± 0.013	0.66CysAsp: 0.66 ± 0.022	0.636CysGlu: 0.636 ± 0.023	0.529CysPhe: 0.529 ± 0.021	0.987CysGly: 0.987 ± 0.029	0.358CysHis: 0.358 ± 0.017	0.683CysIle: 0.683 ± 0.025	0.449CysLys: 0.449 ± 0.019	1.051CysLeu: 1.051 ± 0.03	0.245CysMet: 0.245 ± 0.013	0.406CysAsn: 0.406 ± 0.019	0.461CysPro: 0.461 ± 0.018	0.437CysGln: 0.437 ± 0.019	0.508CysArg: 0.508 ± 0.023	0.831CysSer: 0.831 ± 0.022	0.507CysThr: 0.507 ± 0.02	0.72CysVal: 0.72 ± 0.026	0.136CysTrp: 0.136 ± 0.01	0.349CysTyr: 0.349 ± 0.016	0.003CysXaa: 0.003 ± 0.001
Asp	4.125AspAla: 4.125 ± 0.066	0.548AspCys: 0.548 ± 0.02	3.22AspAsp: 3.22 ± 0.057	3.904AspGlu: 3.904 ± 0.066	2.349AspPhe: 2.349 ± 0.044	3.59AspGly: 3.59 ± 0.057	1.095AspHis: 1.095 ± 0.028	4.576AspIle: 4.576 ± 0.056	3.389AspLys: 3.389 ± 0.056	5.117AspLeu: 5.117 ± 0.061	1.436AspMet: 1.436 ± 0.031	2.453AspAsn: 2.453 ± 0.043	1.995AspPro: 1.995 ± 0.038	1.919AspGln: 1.919 ± 0.037	2.218AspArg: 2.218 ± 0.041	3.556AspSer: 3.556 ± 0.053	2.771AspThr: 2.771 ± 0.047	4.047AspVal: 4.047 ± 0.059	0.83AspTrp: 0.83 ± 0.023	2.107AspTyr: 2.107 ± 0.039	0.01AspXaa: 0.01 ± 0.003
Glu	4.631GluAla: 4.631 ± 0.069	0.557GluCys: 0.557 ± 0.023	2.875GluAsp: 2.875 ± 0.058	4.052GluGlu: 4.052 ± 0.071	2.538GluPhe: 2.538 ± 0.046	3.349GluGly: 3.349 ± 0.056	1.604GluHis: 1.604 ± 0.033	3.942GluIle: 3.942 ± 0.062	4.182GluLys: 4.182 ± 0.056	7.124GluLeu: 7.124 ± 0.097	1.759GluMet: 1.759 ± 0.037	2.886GluAsn: 2.886 ± 0.043	2.018GluPro: 2.018 ± 0.043	3.593GluGln: 3.593 ± 0.055	3.235GluArg: 3.235 ± 0.054	3.997GluSer: 3.997 ± 0.058	3.164GluThr: 3.164 ± 0.05	4.035GluVal: 4.035 ± 0.057	0.815GluTrp: 0.815 ± 0.025	1.814GluTyr: 1.814 ± 0.037	0.01GluXaa: 0.01 ± 0.003
Phe	3.382PheAla: 3.382 ± 0.052	0.569PheCys: 0.569 ± 0.021	2.731PheAsp: 2.731 ± 0.049	2.329PheGlu: 2.329 ± 0.042	1.857PhePhe: 1.857 ± 0.042	3.333PheGly: 3.333 ± 0.06	0.874PheHis: 0.874 ± 0.023	3.173PheIle: 3.173 ± 0.053	2.071PheLys: 2.071 ± 0.039	3.703PheLeu: 3.703 ± 0.065	1.048PheMet: 1.048 ± 0.031	1.969PheAsn: 1.969 ± 0.042	1.493PhePro: 1.493 ± 0.032	1.289PheGln: 1.289 ± 0.026	1.583PheArg: 1.583 ± 0.034	3.537PheSer: 3.537 ± 0.056	2.381PheThr: 2.381 ± 0.044	2.88PheVal: 2.88 ± 0.046	0.565PheTrp: 0.565 ± 0.019	1.397PheTyr: 1.397 ± 0.037	0.01PheXaa: 0.01 ± 0.003
Gly	5.02GlyAla: 5.02 ± 0.077	0.951GlyCys: 0.951 ± 0.028	3.465GlyAsp: 3.465 ± 0.056	4.048GlyGlu: 4.048 ± 0.063	3.34GlyPhe: 3.34 ± 0.057	4.666GlyGly: 4.666 ± 0.072	1.558GlyHis: 1.558 ± 0.035	5.278GlyIle: 5.278 ± 0.079	4.123GlyLys: 4.123 ± 0.063	6.897GlyLeu: 6.897 ± 0.082	2.032GlyMet: 2.032 ± 0.038	2.487GlyAsn: 2.487 ± 0.044	1.749GlyPro: 1.749 ± 0.037	2.594GlyGln: 2.594 ± 0.041	2.975GlyArg: 2.975 ± 0.045	4.129GlySer: 4.129 ± 0.056	3.369GlyThr: 3.369 ± 0.059	5.096GlyVal: 5.096 ± 0.067	0.98GlyTrp: 0.98 ± 0.028	2.62GlyTyr: 2.62 ± 0.042	0.01GlyXaa: 0.01 ± 0.003
His	1.523HisAla: 1.523 ± 0.033	0.344HisCys: 0.344 ± 0.017	1.179HisAsp: 1.179 ± 0.036	1.21HisGlu: 1.21 ± 0.035	1.123HisPhe: 1.123 ± 0.03	1.49HisGly: 1.49 ± 0.033	0.712HisHis: 0.712 ± 0.03	1.558HisIle: 1.558 ± 0.033	1.055HisLys: 1.055 ± 0.026	2.308HisLeu: 2.308 ± 0.045	0.528HisMet: 0.528 ± 0.021	0.973HisAsn: 0.973 ± 0.033	1.123HisPro: 1.123 ± 0.029	1.119HisGln: 1.119 ± 0.031	1.021HisArg: 1.021 ± 0.032	1.559HisSer: 1.559 ± 0.033	1.013HisThr: 1.013 ± 0.028	1.327HisVal: 1.327 ± 0.034	0.358HisTrp: 0.358 ± 0.017	0.895HisTyr: 0.895 ± 0.025	0.004HisXaa: 0.004 ± 0.002
Ile	6.463IleAla: 6.463 ± 0.069	0.831IleCys: 0.831 ± 0.027	4.587IleAsp: 4.587 ± 0.057	4.998IleGlu: 4.998 ± 0.06	2.543IlePhe: 2.543 ± 0.052	5.153IleGly: 5.153 ± 0.072	1.466IleHis: 1.466 ± 0.039	4.438IleIle: 4.438 ± 0.07	3.64IleLys: 3.64 ± 0.062	6.057IleLeu: 6.057 ± 0.07	1.438IleMet: 1.438 ± 0.033	3.288IleAsn: 3.288 ± 0.048	2.971IlePro: 2.971 ± 0.046	2.554IleGln: 2.554 ± 0.046	3.092IleArg: 3.092 ± 0.051	5.394IleSer: 5.394 ± 0.069	3.88IleThr: 3.88 ± 0.05	4.673IleVal: 4.673 ± 0.065	0.676IleTrp: 0.676 ± 0.025	1.915IleTyr: 1.915 ± 0.038	0.016IleXaa: 0.016 ± 0.004
Lys	4.668LysAla: 4.668 ± 0.067	0.396LysCys: 0.396 ± 0.02	3.036LysAsp: 3.036 ± 0.048	3.823LysGlu: 3.823 ± 0.048	1.707LysPhe: 1.707 ± 0.035	3.518LysGly: 3.518 ± 0.054	1.275LysHis: 1.275 ± 0.03	3.346LysIle: 3.346 ± 0.052	3.3LysLys: 3.3 ± 0.055	5.592LysLeu: 5.592 ± 0.062	1.543LysMet: 1.543 ± 0.037	2.536LysAsn: 2.536 ± 0.046	2.354LysPro: 2.354 ± 0.039	2.911LysGln: 2.911 ± 0.055	2.861LysArg: 2.861 ± 0.046	3.714LysSer: 3.714 ± 0.058	3.016LysThr: 3.016 ± 0.049	3.963LysVal: 3.963 ± 0.058	0.617LysTrp: 0.617 ± 0.023	1.629LysTyr: 1.629 ± 0.036	0.011LysXaa: 0.011 ± 0.003
Leu	9.182LeuAla: 9.182 ± 0.089	1.218LeuCys: 1.218 ± 0.034	5.687LeuAsp: 5.687 ± 0.079	5.973LeuGlu: 5.973 ± 0.074	4.438LeuPhe: 4.438 ± 0.074	6.9LeuGly: 6.9 ± 0.086	1.978LeuHis: 1.978 ± 0.046	6.912LeuIle: 6.912 ± 0.074	5.717LeuLys: 5.717 ± 0.066	10.115LeuLeu: 10.115 ± 0.117	2.726LeuMet: 2.726 ± 0.052	4.713LeuAsn: 4.713 ± 0.061	4.526LeuPro: 4.526 ± 0.058	3.243LeuGln: 3.243 ± 0.045	4.24LeuArg: 4.24 ± 0.065	8.428LeuSer: 8.428 ± 0.092	5.843LeuThr: 5.843 ± 0.071	6.992LeuVal: 6.992 ± 0.083	1.064LeuTrp: 1.064 ± 0.029	2.809LeuTyr: 2.809 ± 0.051	0.026LeuXaa: 0.026 ± 0.007
Met	2.377MetAla: 2.377 ± 0.042	0.235MetCys: 0.235 ± 0.013	1.321MetAsp: 1.321 ± 0.033	1.305MetGlu: 1.305 ± 0.03	0.978MetPhe: 0.978 ± 0.027	1.815MetGly: 1.815 ± 0.041	0.491MetHis: 0.491 ± 0.019	1.697MetIle: 1.697 ± 0.034	1.621MetLys: 1.621 ± 0.034	2.705MetLeu: 2.705 ± 0.045	0.818MetMet: 0.818 ± 0.027	1.246MetAsn: 1.246 ± 0.029	1.176MetPro: 1.176 ± 0.031	0.989MetGln: 0.989 ± 0.03	1.129MetArg: 1.129 ± 0.026	2.127MetSer: 2.127 ± 0.04	1.722MetThr: 1.722 ± 0.035	1.825MetVal: 1.825 ± 0.04	0.234MetTrp: 0.234 ± 0.013	0.603MetTyr: 0.603 ± 0.023	0.007MetXaa: 0.007 ± 0.002
Asn	3.313AsnAla: 3.313 ± 0.062	0.397AsnCys: 0.397 ± 0.019	2.482AsnAsp: 2.482 ± 0.041	2.557AsnGlu: 2.557 ± 0.045	1.522AsnPhe: 1.522 ± 0.033	2.963AsnGly: 2.963 ± 0.052	1.025AsnHis: 1.025 ± 0.027	3.204AsnIle: 3.204 ± 0.049	2.393AsnLys: 2.393 ± 0.044	4.051AsnLeu: 4.051 ± 0.059	1.057AsnMet: 1.057 ± 0.024	2.002AsnAsn: 2.002 ± 0.039	2.079AsnPro: 2.079 ± 0.036	2.127AsnGln: 2.127 ± 0.044	2.059AsnArg: 2.059 ± 0.039	2.81AsnSer: 2.81 ± 0.05	2.276AsnThr: 2.276 ± 0.044	2.875AsnVal: 2.875 ± 0.049	0.576AsnTrp: 0.576 ± 0.02	1.381AsnTyr: 1.381 ± 0.036	0.01AsnXaa: 0.01 ± 0.003
Pro	2.612ProAla: 2.612 ± 0.049	0.355ProCys: 0.355 ± 0.017	2.423ProAsp: 2.423 ± 0.042	3.04ProGlu: 3.04 ± 0.055	1.8ProPhe: 1.8 ± 0.036	2.288ProGly: 2.288 ± 0.046	0.866ProHis: 0.866 ± 0.027	2.745ProIle: 2.745 ± 0.045	2.104ProLys: 2.104 ± 0.046	3.85ProLeu: 3.85 ± 0.058	1.029ProMet: 1.029 ± 0.028	1.763ProAsn: 1.763 ± 0.035	1.067ProPro: 1.067 ± 0.033	1.501ProGln: 1.501 ± 0.034	1.302ProArg: 1.302 ± 0.032	2.494ProSer: 2.494 ± 0.044	2.176ProThr: 2.176 ± 0.043	2.914ProVal: 2.914 ± 0.046	0.502ProTrp: 0.502 ± 0.017	1.329ProTyr: 1.329 ± 0.033	0.003ProXaa: 0.003 ± 0.002
Gln	3.436GlnAla: 3.436 ± 0.055	0.421GlnCys: 0.421 ± 0.02	1.947GlnAsp: 1.947 ± 0.036	2.345GlnGlu: 2.345 ± 0.048	1.795GlnPhe: 1.795 ± 0.039	2.572GlnGly: 2.572 ± 0.038	1.064GlnHis: 1.064 ± 0.029	2.731GlnIle: 2.731 ± 0.056	2.315GlnLys: 2.315 ± 0.049	4.684GlnLeu: 4.684 ± 0.065	1.058GlnMet: 1.058 ± 0.024	1.67GlnAsn: 1.67 ± 0.036	1.572GlnPro: 1.572 ± 0.035	2.37GlnGln: 2.37 ± 0.051	2.108GlnArg: 2.108 ± 0.047	2.853GlnSer: 2.853 ± 0.053	2.139GlnThr: 2.139 ± 0.038	2.804GlnVal: 2.804 ± 0.051	0.586GlnTrp: 0.586 ± 0.022	1.471GlnTyr: 1.471 ± 0.035	0.01GlnXaa: 0.01 ± 0.003
Arg	3.077ArgAla: 3.077 ± 0.053	0.478ArgCys: 0.478 ± 0.019	2.342ArgAsp: 2.342 ± 0.045	2.899ArgGlu: 2.899 ± 0.05	2.144ArgPhe: 2.144 ± 0.04	2.508ArgGly: 2.508 ± 0.044	1.1ArgHis: 1.1 ± 0.03	3.139ArgIle: 3.139 ± 0.051	2.51ArgLys: 2.51 ± 0.045	4.811ArgLeu: 4.811 ± 0.073	1.188ArgMet: 1.188 ± 0.028	1.894ArgAsn: 1.894 ± 0.032	1.539ArgPro: 1.539 ± 0.036	2.015ArgGln: 2.015 ± 0.044	2.354ArgArg: 2.354 ± 0.048	2.787ArgSer: 2.787 ± 0.04	2.085ArgThr: 2.085 ± 0.041	3.05ArgVal: 3.05 ± 0.046	0.622ArgTrp: 0.622 ± 0.024	1.74ArgTyr: 1.74 ± 0.032	0.01ArgXaa: 0.01 ± 0.003
Ser	5.263SerAla: 5.263 ± 0.063	0.688SerCys: 0.688 ± 0.024	4.036SerAsp: 4.036 ± 0.056	4.411SerGlu: 4.411 ± 0.074	3.072SerPhe: 3.072 ± 0.049	5.187SerGly: 5.187 ± 0.07	1.651SerHis: 1.651 ± 0.036	4.94SerIle: 4.94 ± 0.059	3.487SerLys: 3.487 ± 0.053	7.46SerLeu: 7.46 ± 0.09	1.871SerMet: 1.871 ± 0.044	2.873SerAsn: 2.873 ± 0.046	2.57SerPro: 2.57 ± 0.049	3.03SerGln: 3.03 ± 0.057	3.013SerArg: 3.013 ± 0.045	5.101SerSer: 5.101 ± 0.092	3.575SerThr: 3.575 ± 0.06	5.059SerVal: 5.059 ± 0.064	0.883SerTrp: 0.883 ± 0.024	2.194SerTyr: 2.194 ± 0.041	0.015SerXaa: 0.015 ± 0.004
Thr	4.148ThrAla: 4.148 ± 0.055	0.493ThrCys: 0.493 ± 0.018	2.845ThrAsp: 2.845 ± 0.047	3.014ThrGlu: 3.014 ± 0.052	2.198ThrPhe: 2.198 ± 0.046	3.869ThrGly: 3.869 ± 0.058	1.26ThrHis: 1.26 ± 0.032	3.726ThrIle: 3.726 ± 0.047	2.603ThrLys: 2.603 ± 0.047	6.28ThrLeu: 6.28 ± 0.07	1.213ThrMet: 1.213 ± 0.032	2.121ThrAsn: 2.121 ± 0.041	2.513ThrPro: 2.513 ± 0.04	2.29ThrGln: 2.29 ± 0.046	2.086ThrArg: 2.086 ± 0.046	3.632ThrSer: 3.632 ± 0.061	2.939ThrThr: 2.939 ± 0.05	3.766ThrVal: 3.766 ± 0.058	0.572ThrTrp: 0.572 ± 0.023	1.566ThrTyr: 1.566 ± 0.034	0.008ThrXaa: 0.008 ± 0.003
Val	5.97ValAla: 5.97 ± 0.071	0.796ValCys: 0.796 ± 0.024	3.961ValAsp: 3.961 ± 0.056	4.386ValGlu: 4.386 ± 0.064	2.919ValPhe: 2.919 ± 0.049	4.76ValGly: 4.76 ± 0.066	1.308ValHis: 1.308 ± 0.028	5.173ValIle: 5.173 ± 0.069	3.861ValLys: 3.861 ± 0.051	6.77ValLeu: 6.77 ± 0.076	1.965ValMet: 1.965 ± 0.04	2.994ValAsn: 2.994 ± 0.049	2.589ValPro: 2.589 ± 0.05	2.065ValGln: 2.065 ± 0.039	2.849ValArg: 2.849 ± 0.053	5.26ValSer: 5.26 ± 0.061	4.069ValThr: 4.069 ± 0.061	5.322ValVal: 5.322 ± 0.068	0.788ValTrp: 0.788 ± 0.027	1.855ValTyr: 1.855 ± 0.039	0.008ValXaa: 0.008 ± 0.003
Trp	0.788TrpAla: 0.788 ± 0.025	0.162TrpCys: 0.162 ± 0.011	0.596TrpAsp: 0.596 ± 0.023	0.595TrpGlu: 0.595 ± 0.024	0.603TrpPhe: 0.603 ± 0.02	0.793TrpGly: 0.793 ± 0.028	0.32TrpHis: 0.32 ± 0.016	0.819TrpIle: 0.819 ± 0.025	0.631TrpLys: 0.631 ± 0.024	1.684TrpLeu: 1.684 ± 0.042	0.343TrpMet: 0.343 ± 0.016	0.536TrpAsn: 0.536 ± 0.02	0.446TrpPro: 0.446 ± 0.019	0.722TrpGln: 0.722 ± 0.025	0.608TrpArg: 0.608 ± 0.022	0.791TrpSer: 0.791 ± 0.023	0.526TrpThr: 0.526 ± 0.021	0.852TrpVal: 0.852 ± 0.022	0.178TrpTrp: 0.178 ± 0.012	0.396TrpTyr: 0.396 ± 0.016	0.004TrpXaa: 0.004 ± 0.002
Tyr	2.229TyrAla: 2.229 ± 0.042	0.418TyrCys: 0.418 ± 0.019	1.765TyrAsp: 1.765 ± 0.041	1.705TyrGlu: 1.705 ± 0.039	1.464TyrPhe: 1.464 ± 0.039	2.13TyrGly: 2.13 ± 0.047	0.854TyrHis: 0.854 ± 0.027	1.882TyrIle: 1.882 ± 0.036	1.471TyrLys: 1.471 ± 0.034	3.461TyrLeu: 3.461 ± 0.059	0.661TyrMet: 0.661 ± 0.019	1.144TyrAsn: 1.144 ± 0.029	1.435TyrPro: 1.435 ± 0.035	1.79TyrGln: 1.79 ± 0.039	1.698TyrArg: 1.698 ± 0.038	2.271TyrSer: 2.271 ± 0.044	1.493TyrThr: 1.493 ± 0.036	1.97TyrVal: 1.97 ± 0.036	0.508TyrTrp: 0.508 ± 0.02	1.062TyrTyr: 1.062 ± 0.03	0.005TyrXaa: 0.005 ± 0.002
Xaa	0.01XaaAla: 0.01 ± 0.003	0.002XaaCys: 0.002 ± 0.001	0.011XaaAsp: 0.011 ± 0.003	0.01XaaGlu: 0.01 ± 0.003	0.011XaaPhe: 0.011 ± 0.003	0.009XaaGly: 0.009 ± 0.002	0.006XaaHis: 0.006 ± 0.002	0.017XaaIle: 0.017 ± 0.005	0.011XaaLys: 0.011 ± 0.004	0.012XaaLeu: 0.012 ± 0.003	0.008XaaMet: 0.008 ± 0.003	0.01XaaAsn: 0.01 ± 0.003	0.005XaaPro: 0.005 ± 0.002	0.009XaaGln: 0.009 ± 0.003	0.015XaaArg: 0.015 ± 0.004	0.012XaaSer: 0.012 ± 0.003	0.009XaaThr: 0.009 ± 0.003	0.008XaaVal: 0.008 ± 0.003	0.004XaaTrp: 0.004 ± 0.002	0.009XaaTyr: 0.009 ± 0.002	0.029XaaXaa: 0.029 ± 0.007

Statistics based on 4277 proteins (1367418 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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