Amino acid dipepetide frequency for Perca fluviatilis (European perch)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.529AlaAla: 6.529 ± 0.041	1.291AlaCys: 1.291 ± 0.012	3.256AlaAsp: 3.256 ± 0.018	4.725AlaGlu: 4.725 ± 0.028	2.311AlaPhe: 2.311 ± 0.016	4.513AlaGly: 4.513 ± 0.027	1.504AlaHis: 1.504 ± 0.011	2.641AlaIle: 2.641 ± 0.018	3.389AlaLys: 3.389 ± 0.021	6.502AlaLeu: 6.502 ± 0.032	1.607AlaMet: 1.607 ± 0.012	2.227AlaAsn: 2.227 ± 0.015	3.632AlaPro: 3.632 ± 0.027	2.981AlaGln: 2.981 ± 0.021	3.157AlaArg: 3.157 ± 0.019	5.61AlaSer: 5.61 ± 0.026	3.65AlaThr: 3.65 ± 0.021	5.009AlaVal: 5.009 ± 0.022	0.656AlaTrp: 0.656 ± 0.009	1.462AlaTyr: 1.462 ± 0.011	0.0AlaXaa: 0.0 ± 0.0
Cys	1.179CysAla: 1.179 ± 0.011	0.657CysCys: 0.657 ± 0.01	1.14CysAsp: 1.14 ± 0.014	1.251CysGlu: 1.251 ± 0.016	0.837CysPhe: 0.837 ± 0.008	1.536CysGly: 1.536 ± 0.018	0.662CysHis: 0.662 ± 0.01	0.929CysIle: 0.929 ± 0.01	1.112CysLys: 1.112 ± 0.013	2.126CysLeu: 2.126 ± 0.017	0.468CysMet: 0.468 ± 0.006	0.846CysAsn: 0.846 ± 0.01	1.34CysPro: 1.34 ± 0.024	1.082CysGln: 1.082 ± 0.013	1.314CysArg: 1.314 ± 0.013	2.179CysSer: 2.179 ± 0.02	1.179CysThr: 1.179 ± 0.011	1.555CysVal: 1.555 ± 0.017	0.301CysTrp: 0.301 ± 0.005	0.604CysTyr: 0.604 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	3.003AspAla: 3.003 ± 0.018	1.176AspCys: 1.176 ± 0.013	3.163AspAsp: 3.163 ± 0.024	3.754AspGlu: 3.754 ± 0.024	2.066AspPhe: 2.066 ± 0.015	3.715AspGly: 3.715 ± 0.021	1.185AspHis: 1.185 ± 0.011	2.676AspIle: 2.676 ± 0.021	2.716AspLys: 2.716 ± 0.019	4.855AspLeu: 4.855 ± 0.021	1.323AspMet: 1.323 ± 0.011	2.016AspAsn: 2.016 ± 0.017	2.863AspPro: 2.863 ± 0.017	2.032AspGln: 2.032 ± 0.014	2.825AspArg: 2.825 ± 0.021	4.629AspSer: 4.629 ± 0.024	2.77AspThr: 2.77 ± 0.015	3.31AspVal: 3.31 ± 0.021	0.69AspTrp: 0.69 ± 0.009	1.51AspTyr: 1.51 ± 0.013	0.0AspXaa: 0.0 ± 0.0
Glu	4.779GluAla: 4.779 ± 0.029	1.233GluCys: 1.233 ± 0.013	4.512GluAsp: 4.512 ± 0.026	8.245GluGlu: 8.245 ± 0.065	1.851GluPhe: 1.851 ± 0.013	4.26GluGly: 4.26 ± 0.029	1.451GluHis: 1.451 ± 0.012	2.759GluIle: 2.759 ± 0.019	4.666GluLys: 4.666 ± 0.033	6.101GluLeu: 6.101 ± 0.035	1.775GluMet: 1.775 ± 0.015	2.675GluAsn: 2.675 ± 0.017	2.927GluPro: 2.927 ± 0.02	3.12GluGln: 3.12 ± 0.021	4.35GluArg: 4.35 ± 0.035	4.457GluSer: 4.457 ± 0.023	3.56GluThr: 3.56 ± 0.022	4.311GluVal: 4.311 ± 0.021	0.675GluTrp: 0.675 ± 0.008	1.538GluTyr: 1.538 ± 0.015	0.0GluXaa: 0.0 ± 0.0
Phe	1.823PheAla: 1.823 ± 0.014	0.899PheCys: 0.899 ± 0.01	1.69PheAsp: 1.69 ± 0.013	1.783PheGlu: 1.783 ± 0.014	1.482PhePhe: 1.482 ± 0.014	2.136PheGly: 2.136 ± 0.016	0.983PheHis: 0.983 ± 0.008	1.783PheIle: 1.783 ± 0.014	1.756PheLys: 1.756 ± 0.014	3.667PheLeu: 3.667 ± 0.024	0.791PheMet: 0.791 ± 0.008	1.441PheAsn: 1.441 ± 0.012	1.795PhePro: 1.795 ± 0.015	1.567PheGln: 1.567 ± 0.013	1.814PheArg: 1.814 ± 0.015	3.313PheSer: 3.313 ± 0.017	2.248PheThr: 2.248 ± 0.016	2.093PheVal: 2.093 ± 0.015	0.448PheTrp: 0.448 ± 0.006	1.153PheTyr: 1.153 ± 0.01	0.0PheXaa: 0.0 ± 0.0
Gly	4.168GlyAla: 4.168 ± 0.026	1.301GlyCys: 1.301 ± 0.012	3.318GlyAsp: 3.318 ± 0.02	4.264GlyGlu: 4.264 ± 0.026	2.382GlyPhe: 2.382 ± 0.018	5.697GlyGly: 5.697 ± 0.047	1.686GlyHis: 1.686 ± 0.015	2.55GlyIle: 2.55 ± 0.016	3.544GlyLys: 3.544 ± 0.029	5.594GlyLeu: 5.594 ± 0.028	1.483GlyMet: 1.483 ± 0.015	2.509GlyAsn: 2.509 ± 0.016	3.463GlyPro: 3.463 ± 0.042	2.867GlyGln: 2.867 ± 0.019	3.748GlyArg: 3.748 ± 0.026	5.86GlySer: 5.86 ± 0.033	3.396GlyThr: 3.396 ± 0.02	4.049GlyVal: 4.049 ± 0.022	0.777GlyTrp: 0.777 ± 0.01	1.828GlyTyr: 1.828 ± 0.015	0.0GlyXaa: 0.0 ± 0.0
His	1.369HisAla: 1.369 ± 0.011	0.754HisCys: 0.754 ± 0.009	0.985HisAsp: 0.985 ± 0.01	1.162HisGlu: 1.162 ± 0.009	1.035HisPhe: 1.035 ± 0.008	1.587HisGly: 1.587 ± 0.013	1.112HisHis: 1.112 ± 0.017	1.287HisIle: 1.287 ± 0.01	1.27HisLys: 1.27 ± 0.012	2.645HisLeu: 2.645 ± 0.017	0.674HisMet: 0.674 ± 0.008	1.043HisAsn: 1.043 ± 0.009	1.629HisPro: 1.629 ± 0.015	1.318HisGln: 1.318 ± 0.012	1.665HisArg: 1.665 ± 0.012	2.502HisSer: 2.502 ± 0.017	1.655HisThr: 1.655 ± 0.017	1.427HisVal: 1.427 ± 0.011	0.339HisTrp: 0.339 ± 0.005	0.833HisTyr: 0.833 ± 0.009	0.0HisXaa: 0.0 ± 0.0
Ile	2.425IleAla: 2.425 ± 0.017	1.018IleCys: 1.018 ± 0.012	2.031IleAsp: 2.031 ± 0.017	2.317IleGlu: 2.317 ± 0.02	1.668IlePhe: 1.668 ± 0.015	2.28IleGly: 2.28 ± 0.016	1.228IleHis: 1.228 ± 0.009	2.267IleIle: 2.267 ± 0.017	2.462IleLys: 2.462 ± 0.022	4.075IleLeu: 4.075 ± 0.023	1.03IleMet: 1.03 ± 0.01	1.884IleAsn: 1.884 ± 0.015	2.45IlePro: 2.45 ± 0.017	2.173IleGln: 2.173 ± 0.015	2.346IleArg: 2.346 ± 0.014	3.711IleSer: 3.711 ± 0.02	2.764IleThr: 2.764 ± 0.02	2.468IleVal: 2.468 ± 0.017	0.454IleTrp: 0.454 ± 0.006	1.299IleTyr: 1.299 ± 0.011	0.0IleXaa: 0.0 ± 0.0
Lys	3.792LysAla: 3.792 ± 0.024	0.989LysCys: 0.989 ± 0.011	3.249LysAsp: 3.249 ± 0.02	4.726LysGlu: 4.726 ± 0.032	1.491LysPhe: 1.491 ± 0.015	3.273LysGly: 3.273 ± 0.031	1.391LysHis: 1.391 ± 0.011	2.358LysIle: 2.358 ± 0.019	4.477LysLys: 4.477 ± 0.037	4.826LysLeu: 4.826 ± 0.024	1.512LysMet: 1.512 ± 0.017	2.16LysAsn: 2.16 ± 0.014	2.942LysPro: 2.942 ± 0.022	2.523LysGln: 2.523 ± 0.017	3.489LysArg: 3.489 ± 0.022	3.793LysSer: 3.793 ± 0.022	3.269LysThr: 3.269 ± 0.021	3.461LysVal: 3.461 ± 0.018	0.57LysTrp: 0.57 ± 0.007	1.424LysTyr: 1.424 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	6.071LeuAla: 6.071 ± 0.03	2.184LeuCys: 2.184 ± 0.018	4.83LeuAsp: 4.83 ± 0.024	6.268LeuGlu: 6.268 ± 0.035	3.237LeuPhe: 3.237 ± 0.021	5.141LeuGly: 5.141 ± 0.023	2.702LeuHis: 2.702 ± 0.018	3.643LeuIle: 3.643 ± 0.022	5.487LeuLys: 5.487 ± 0.03	9.987LeuLeu: 9.987 ± 0.051	2.106LeuMet: 2.106 ± 0.014	3.518LeuAsn: 3.518 ± 0.018	5.394LeuPro: 5.394 ± 0.027	5.48LeuGln: 5.48 ± 0.038	5.606LeuArg: 5.606 ± 0.025	8.463LeuSer: 8.463 ± 0.037	5.243LeuThr: 5.243 ± 0.025	5.393LeuVal: 5.393 ± 0.026	1.061LeuTrp: 1.061 ± 0.011	2.512LeuTyr: 2.512 ± 0.017	0.0LeuXaa: 0.0 ± 0.0
Met	1.983MetAla: 1.983 ± 0.014	0.476MetCys: 0.476 ± 0.007	1.499MetAsp: 1.499 ± 0.013	2.024MetGlu: 2.024 ± 0.014	0.836MetPhe: 0.836 ± 0.009	1.46MetGly: 1.46 ± 0.013	0.493MetHis: 0.493 ± 0.007	0.854MetIle: 0.854 ± 0.008	1.474MetLys: 1.474 ± 0.012	2.076MetLeu: 2.076 ± 0.014	0.734MetMet: 0.734 ± 0.009	0.882MetAsn: 0.882 ± 0.008	1.105MetPro: 1.105 ± 0.016	0.996MetGln: 0.996 ± 0.01	1.19MetArg: 1.19 ± 0.01	1.942MetSer: 1.942 ± 0.014	1.296MetThr: 1.296 ± 0.011	1.541MetVal: 1.541 ± 0.013	0.267MetTrp: 0.267 ± 0.005	0.617MetTyr: 0.617 ± 0.008	0.0MetXaa: 0.0 ± 0.0
Asn	2.166AsnAla: 2.166 ± 0.014	0.864AsnCys: 0.864 ± 0.012	1.67AsnAsp: 1.67 ± 0.014	2.034AsnGlu: 2.034 ± 0.013	1.35AsnPhe: 1.35 ± 0.012	2.765AsnGly: 2.765 ± 0.02	1.02AsnHis: 1.02 ± 0.009	2.079AsnIle: 2.079 ± 0.014	2.209AsnLys: 2.209 ± 0.016	3.519AsnLeu: 3.519 ± 0.02	1.065AsnMet: 1.065 ± 0.01	1.872AsnAsn: 1.872 ± 0.015	2.226AsnPro: 2.226 ± 0.014	1.762AsnGln: 1.762 ± 0.013	2.0AsnArg: 2.0 ± 0.014	3.233AsnSer: 3.233 ± 0.017	2.319AsnThr: 2.319 ± 0.017	2.314AsnVal: 2.314 ± 0.016	0.435AsnTrp: 0.435 ± 0.005	1.111AsnTyr: 1.111 ± 0.01	0.0AsnXaa: 0.0 ± 0.0
Pro	4.395ProAla: 4.395 ± 0.027	1.126ProCys: 1.126 ± 0.016	2.926ProAsp: 2.926 ± 0.016	3.844ProGlu: 3.844 ± 0.022	1.764ProPhe: 1.764 ± 0.012	4.279ProGly: 4.279 ± 0.056	1.537ProHis: 1.537 ± 0.015	1.877ProIle: 1.877 ± 0.012	2.609ProLys: 2.609 ± 0.025	4.922ProLeu: 4.922 ± 0.025	1.064ProMet: 1.064 ± 0.011	1.954ProAsn: 1.954 ± 0.015	5.664ProPro: 5.664 ± 0.052	2.75ProGln: 2.75 ± 0.025	2.823ProArg: 2.823 ± 0.017	5.777ProSer: 5.777 ± 0.038	3.211ProThr: 3.211 ± 0.025	3.83ProVal: 3.83 ± 0.021	0.551ProTrp: 0.551 ± 0.006	1.4ProTyr: 1.4 ± 0.013	0.0ProXaa: 0.0 ± 0.0
Gln	3.203GlnAla: 3.203 ± 0.019	0.998GlnCys: 0.998 ± 0.014	2.396GlnAsp: 2.396 ± 0.016	3.52GlnGlu: 3.52 ± 0.026	1.308GlnPhe: 1.308 ± 0.012	2.826GlnGly: 2.826 ± 0.023	1.428GlnHis: 1.428 ± 0.014	1.877GlnIle: 1.877 ± 0.012	2.555GlnLys: 2.555 ± 0.018	4.531GlnLeu: 4.531 ± 0.03	1.146GlnMet: 1.146 ± 0.012	1.745GlnAsn: 1.745 ± 0.012	2.77GlnPro: 2.77 ± 0.024	3.564GlnGln: 3.564 ± 0.052	3.229GlnArg: 3.229 ± 0.022	3.684GlnSer: 3.684 ± 0.024	2.735GlnThr: 2.735 ± 0.018	2.708GlnVal: 2.708 ± 0.016	0.551GlnTrp: 0.551 ± 0.007	1.201GlnTyr: 1.201 ± 0.012	0.0GlnXaa: 0.0 ± 0.0
Arg	3.511ArgAla: 3.511 ± 0.02	1.299ArgCys: 1.299 ± 0.014	2.98ArgAsp: 2.98 ± 0.021	4.034ArgGlu: 4.034 ± 0.028	1.868ArgPhe: 1.868 ± 0.013	3.701ArgGly: 3.701 ± 0.029	1.591ArgHis: 1.591 ± 0.013	2.289ArgIle: 2.289 ± 0.015	3.536ArgLys: 3.536 ± 0.019	5.327ArgLeu: 5.327 ± 0.027	1.321ArgMet: 1.321 ± 0.01	2.086ArgAsn: 2.086 ± 0.013	3.036ArgPro: 3.036 ± 0.022	2.722ArgGln: 2.722 ± 0.017	4.542ArgArg: 4.542 ± 0.027	4.601ArgSer: 4.601 ± 0.027	2.937ArgThr: 2.937 ± 0.015	3.307ArgVal: 3.307 ± 0.017	0.697ArgTrp: 0.697 ± 0.008	1.516ArgTyr: 1.516 ± 0.011	0.0ArgXaa: 0.0 ± 0.0
Ser	5.8SerAla: 5.8 ± 0.024	2.043SerCys: 2.043 ± 0.019	4.446SerAsp: 4.446 ± 0.023	4.995SerGlu: 4.995 ± 0.029	3.026SerPhe: 3.026 ± 0.018	5.716SerGly: 5.716 ± 0.027	2.275SerHis: 2.275 ± 0.017	3.298SerIle: 3.298 ± 0.019	4.0SerLys: 4.0 ± 0.022	8.366SerLeu: 8.366 ± 0.037	1.867SerMet: 1.867 ± 0.013	3.028SerAsn: 3.028 ± 0.019	6.206SerPro: 6.206 ± 0.044	4.067SerGln: 4.067 ± 0.026	4.61SerArg: 4.61 ± 0.023	10.747SerSer: 10.747 ± 0.063	5.0SerThr: 5.0 ± 0.028	5.534SerVal: 5.534 ± 0.021	0.994SerTrp: 0.994 ± 0.01	2.15SerTyr: 2.15 ± 0.016	0.0SerXaa: 0.0 ± 0.0
Thr	4.212ThrAla: 4.212 ± 0.02	1.344ThrCys: 1.344 ± 0.017	2.999ThrAsp: 2.999 ± 0.02	3.907ThrGlu: 3.907 ± 0.024	2.054ThrPhe: 2.054 ± 0.017	3.81ThrGly: 3.81 ± 0.025	1.451ThrHis: 1.451 ± 0.016	2.378ThrIle: 2.378 ± 0.018	2.745ThrLys: 2.745 ± 0.019	5.436ThrLeu: 5.436 ± 0.023	1.252ThrMet: 1.252 ± 0.012	2.009ThrAsn: 2.009 ± 0.015	3.732ThrPro: 3.732 ± 0.025	2.464ThrGln: 2.464 ± 0.017	2.536ThrArg: 2.536 ± 0.016	4.992ThrSer: 4.992 ± 0.025	3.654ThrThr: 3.654 ± 0.046	4.275ThrVal: 4.275 ± 0.023	0.667ThrTrp: 0.667 ± 0.009	1.399ThrTyr: 1.399 ± 0.01	0.0ThrXaa: 0.0 ± 0.0
Val	4.198ValAla: 4.198 ± 0.022	1.712ValCys: 1.712 ± 0.018	3.203ValAsp: 3.203 ± 0.017	4.142ValGlu: 4.142 ± 0.023	2.552ValPhe: 2.552 ± 0.017	3.529ValGly: 3.529 ± 0.018	1.545ValHis: 1.545 ± 0.013	2.876ValIle: 2.876 ± 0.019	3.589ValLys: 3.589 ± 0.021	6.089ValLeu: 6.089 ± 0.028	1.526ValMet: 1.526 ± 0.012	2.447ValAsn: 2.447 ± 0.016	3.351ValPro: 3.351 ± 0.019	2.784ValGln: 2.784 ± 0.017	3.24ValArg: 3.24 ± 0.018	5.382ValSer: 5.382 ± 0.026	4.068ValThr: 4.068 ± 0.025	4.401ValVal: 4.401 ± 0.021	0.77ValTrp: 0.77 ± 0.008	1.784ValTyr: 1.784 ± 0.013	0.0ValXaa: 0.0 ± 0.0
Trp	0.678TrpAla: 0.678 ± 0.008	0.246TrpCys: 0.246 ± 0.004	0.649TrpAsp: 0.649 ± 0.008	0.739TrpGlu: 0.739 ± 0.008	0.441TrpPhe: 0.441 ± 0.007	0.626TrpGly: 0.626 ± 0.009	0.266TrpHis: 0.266 ± 0.005	0.542TrpIle: 0.542 ± 0.006	0.712TrpLys: 0.712 ± 0.007	1.158TrpLeu: 1.158 ± 0.011	0.34TrpMet: 0.34 ± 0.005	0.482TrpAsn: 0.482 ± 0.006	0.439TrpPro: 0.439 ± 0.006	0.476TrpGln: 0.476 ± 0.006	0.78TrpArg: 0.78 ± 0.008	0.962TrpSer: 0.962 ± 0.011	0.723TrpThr: 0.723 ± 0.009	0.679TrpVal: 0.679 ± 0.009	0.191TrpTrp: 0.191 ± 0.004	0.337TrpTyr: 0.337 ± 0.006	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.368TyrAla: 1.368 ± 0.011	0.687TyrCys: 0.687 ± 0.01	1.336TyrAsp: 1.336 ± 0.011	1.512TyrGlu: 1.512 ± 0.013	1.107TyrPhe: 1.107 ± 0.011	1.637TyrGly: 1.637 ± 0.014	0.781TyrHis: 0.781 ± 0.008	1.386TyrIle: 1.386 ± 0.012	1.407TyrLys: 1.407 ± 0.014	2.525TyrLeu: 2.525 ± 0.02	0.662TyrMet: 0.662 ± 0.008	1.189TyrAsn: 1.189 ± 0.013	1.336TyrPro: 1.336 ± 0.014	1.248TyrGln: 1.248 ± 0.01	1.636TyrArg: 1.636 ± 0.012	2.334TyrSer: 2.334 ± 0.014	1.633TyrThr: 1.633 ± 0.013	1.523TyrVal: 1.523 ± 0.014	0.371TyrTrp: 0.371 ± 0.007	0.946TyrTyr: 0.946 ± 0.01	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 24123 proteins (13420900 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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