Amino acid dipepetide frequency for Granulicella mallensis (strain ATCC BAA-1857 / DSM 23137 / MP5ACTX8)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.959AlaAla: 12.959 ± 0.128
0.969AlaCys: 0.969 ± 0.027
4.872AlaAsp: 4.872 ± 0.058
5.947AlaGlu: 5.947 ± 0.08
3.853AlaPhe: 3.853 ± 0.044
8.834AlaGly: 8.834 ± 0.08
2.248AlaHis: 2.248 ± 0.038
5.521AlaIle: 5.521 ± 0.073
4.027AlaLys: 4.027 ± 0.06
10.63AlaLeu: 10.63 ± 0.101
2.541AlaMet: 2.541 ± 0.043
3.637AlaAsn: 3.637 ± 0.062
5.249AlaPro: 5.249 ± 0.064
4.51AlaGln: 4.51 ± 0.056
5.598AlaArg: 5.598 ± 0.069
6.816AlaSer: 6.816 ± 0.066
6.641AlaThr: 6.641 ± 0.084
7.305AlaVal: 7.305 ± 0.078
1.321AlaTrp: 1.321 ± 0.03
2.631AlaTyr: 2.631 ± 0.042
0.0AlaXaa: 0.0 ± 0.0
Cys
0.865CysAla: 0.865 ± 0.022
0.149CysCys: 0.149 ± 0.009
0.416CysAsp: 0.416 ± 0.016
0.415CysGlu: 0.415 ± 0.014
0.389CysPhe: 0.389 ± 0.016
0.881CysGly: 0.881 ± 0.026
0.223CysHis: 0.223 ± 0.015
0.426CysIle: 0.426 ± 0.019
0.232CysLys: 0.232 ± 0.011
0.82CysLeu: 0.82 ± 0.023
0.172CysMet: 0.172 ± 0.009
0.269CysAsn: 0.269 ± 0.011
0.443CysPro: 0.443 ± 0.019
0.196CysGln: 0.196 ± 0.012
0.443CysArg: 0.443 ± 0.015
0.638CysSer: 0.638 ± 0.02
0.543CysThr: 0.543 ± 0.017
0.637CysVal: 0.637 ± 0.019
0.118CysTrp: 0.118 ± 0.009
0.224CysTyr: 0.224 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
5.381AspAla: 5.381 ± 0.066
0.4AspCys: 0.4 ± 0.016
2.343AspAsp: 2.343 ± 0.041
2.842AspGlu: 2.842 ± 0.051
2.237AspPhe: 2.237 ± 0.037
4.415AspGly: 4.415 ± 0.06
1.21AspHis: 1.21 ± 0.029
2.44AspIle: 2.44 ± 0.039
1.736AspLys: 1.736 ± 0.038
5.116AspLeu: 5.116 ± 0.058
0.909AspMet: 0.909 ± 0.022
1.597AspAsn: 1.597 ± 0.033
3.244AspPro: 3.244 ± 0.043
1.731AspGln: 1.731 ± 0.031
2.976AspArg: 2.976 ± 0.044
3.018AspSer: 3.018 ± 0.035
2.762AspThr: 2.762 ± 0.043
3.542AspVal: 3.542 ± 0.051
0.867AspTrp: 0.867 ± 0.022
1.57AspTyr: 1.57 ± 0.027
0.0AspXaa: 0.0 ± 0.0
Glu
5.778GluAla: 5.778 ± 0.076
0.346GluCys: 0.346 ± 0.014
2.533GluAsp: 2.533 ± 0.045
3.047GluGlu: 3.047 ± 0.054
2.007GluPhe: 2.007 ± 0.035
3.721GluGly: 3.721 ± 0.049
1.404GluHis: 1.404 ± 0.028
2.998GluIle: 2.998 ± 0.043
2.214GluLys: 2.214 ± 0.042
5.391GluLeu: 5.391 ± 0.079
1.356GluMet: 1.356 ± 0.031
1.685GluAsn: 1.685 ± 0.033
2.311GluPro: 2.311 ± 0.038
2.46GluGln: 2.46 ± 0.038
3.711GluArg: 3.711 ± 0.062
3.025GluSer: 3.025 ± 0.047
3.095GluThr: 3.095 ± 0.046
3.593GluVal: 3.593 ± 0.052
0.689GluTrp: 0.689 ± 0.02
1.367GluTyr: 1.367 ± 0.029
0.0GluXaa: 0.0 ± 0.0
Phe
4.295PheAla: 4.295 ± 0.052
0.428PheCys: 0.428 ± 0.015
2.528PheAsp: 2.528 ± 0.039
1.993PheGlu: 1.993 ± 0.032
1.772PhePhe: 1.772 ± 0.037
3.749PheGly: 3.749 ± 0.05
1.047PheHis: 1.047 ± 0.023
1.588PheIle: 1.588 ± 0.034
1.077PheLys: 1.077 ± 0.027
3.772PheLeu: 3.772 ± 0.054
0.726PheMet: 0.726 ± 0.019
1.604PheAsn: 1.604 ± 0.038
1.855PhePro: 1.855 ± 0.035
1.357PheGln: 1.357 ± 0.027
2.201PheArg: 2.201 ± 0.033
2.98PheSer: 2.98 ± 0.049
2.593PheThr: 2.593 ± 0.044
2.754PheVal: 2.754 ± 0.04
0.557PheTrp: 0.557 ± 0.02
1.254PheTyr: 1.254 ± 0.033
0.0PheXaa: 0.0 ± 0.0
Gly
7.488GlyAla: 7.488 ± 0.078
0.801GlyCys: 0.801 ± 0.023
3.914GlyAsp: 3.914 ± 0.049
3.851GlyGlu: 3.851 ± 0.054
3.582GlyPhe: 3.582 ± 0.053
6.92GlyGly: 6.92 ± 0.103
1.859GlyHis: 1.859 ± 0.03
4.538GlyIle: 4.538 ± 0.052
3.555GlyLys: 3.555 ± 0.05
7.625GlyLeu: 7.625 ± 0.077
1.908GlyMet: 1.908 ± 0.036
3.197GlyAsn: 3.197 ± 0.071
3.266GlyPro: 3.266 ± 0.045
3.036GlyGln: 3.036 ± 0.051
4.286GlyArg: 4.286 ± 0.053
5.781GlySer: 5.781 ± 0.076
5.751GlyThr: 5.751 ± 0.097
5.789GlyVal: 5.789 ± 0.072
1.316GlyTrp: 1.316 ± 0.03
2.697GlyTyr: 2.697 ± 0.041
0.0GlyXaa: 0.0 ± 0.0
His
2.253HisAla: 2.253 ± 0.037
0.216HisCys: 0.216 ± 0.011
1.196HisAsp: 1.196 ± 0.028
1.238HisGlu: 1.238 ± 0.028
1.038HisPhe: 1.038 ± 0.025
2.101HisGly: 2.101 ± 0.036
0.706HisHis: 0.706 ± 0.021
1.157HisIle: 1.157 ± 0.031
0.667HisLys: 0.667 ± 0.018
2.479HisLeu: 2.479 ± 0.041
0.463HisMet: 0.463 ± 0.016
0.718HisAsn: 0.718 ± 0.02
1.549HisPro: 1.549 ± 0.035
0.771HisGln: 0.771 ± 0.018
1.37HisArg: 1.37 ± 0.029
1.384HisSer: 1.384 ± 0.03
1.309HisThr: 1.309 ± 0.029
1.575HisVal: 1.575 ± 0.031
0.386HisTrp: 0.386 ± 0.015
0.712HisTyr: 0.712 ± 0.02
0.0HisXaa: 0.0 ± 0.0
Ile
6.198IleAla: 6.198 ± 0.067
0.477IleCys: 0.477 ± 0.015
3.049IleAsp: 3.049 ± 0.046
3.002IleGlu: 3.002 ± 0.044
1.994IlePhe: 1.994 ± 0.037
4.215IleGly: 4.215 ± 0.053
1.139IleHis: 1.139 ± 0.027
1.788IleIle: 1.788 ± 0.037
1.438IleLys: 1.438 ± 0.033
4.482IleLeu: 4.482 ± 0.06
0.697IleMet: 0.697 ± 0.02
1.777IleAsn: 1.777 ± 0.041
2.869IlePro: 2.869 ± 0.041
1.639IleGln: 1.639 ± 0.032
2.763IleArg: 2.763 ± 0.043
3.366IleSer: 3.366 ± 0.044
3.326IleThr: 3.326 ± 0.048
3.815IleVal: 3.815 ± 0.052
0.574IleTrp: 0.574 ± 0.017
1.379IleTyr: 1.379 ± 0.028
0.0IleXaa: 0.0 ± 0.0
Lys
3.738LysAla: 3.738 ± 0.055
0.166LysCys: 0.166 ± 0.01
1.87LysAsp: 1.87 ± 0.038
1.853LysGlu: 1.853 ± 0.038
1.152LysPhe: 1.152 ± 0.028
2.47LysGly: 2.47 ± 0.039
0.802LysHis: 0.802 ± 0.02
1.881LysIle: 1.881 ± 0.032
1.644LysLys: 1.644 ± 0.041
3.864LysLeu: 3.864 ± 0.047
0.908LysMet: 0.908 ± 0.025
1.312LysAsn: 1.312 ± 0.031
2.214LysPro: 2.214 ± 0.043
1.535LysGln: 1.535 ± 0.033
2.138LysArg: 2.138 ± 0.042
2.219LysSer: 2.219 ± 0.041
2.446LysThr: 2.446 ± 0.042
2.42LysVal: 2.42 ± 0.041
0.403LysTrp: 0.403 ± 0.015
0.946LysTyr: 0.946 ± 0.024
0.0LysXaa: 0.0 ± 0.0
Leu
11.128LeuAla: 11.128 ± 0.109
0.964LeuCys: 0.964 ± 0.023
5.176LeuAsp: 5.176 ± 0.054
4.995LeuGlu: 4.995 ± 0.068
3.824LeuPhe: 3.824 ± 0.056
7.416LeuGly: 7.416 ± 0.08
2.523LeuHis: 2.523 ± 0.043
4.545LeuIle: 4.545 ± 0.058
3.673LeuLys: 3.673 ± 0.041
10.575LeuLeu: 10.575 ± 0.12
1.9LeuMet: 1.9 ± 0.034
3.535LeuAsn: 3.535 ± 0.055
5.858LeuPro: 5.858 ± 0.063
3.893LeuGln: 3.893 ± 0.056
6.543LeuArg: 6.543 ± 0.079
7.026LeuSer: 7.026 ± 0.081
6.324LeuThr: 6.324 ± 0.061
6.546LeuVal: 6.546 ± 0.078
1.354LeuTrp: 1.354 ± 0.037
2.533LeuTyr: 2.533 ± 0.039
0.0LeuXaa: 0.0 ± 0.0
Met
2.207MetAla: 2.207 ± 0.036
0.127MetCys: 0.127 ± 0.008
0.977MetAsp: 0.977 ± 0.024
1.05MetGlu: 1.05 ± 0.025
0.641MetPhe: 0.641 ± 0.018
1.467MetGly: 1.467 ± 0.033
0.504MetHis: 0.504 ± 0.016
1.01MetIle: 1.01 ± 0.028
1.009MetLys: 1.009 ± 0.026
2.206MetLeu: 2.206 ± 0.04
0.51MetMet: 0.51 ± 0.019
0.806MetAsn: 0.806 ± 0.023
1.357MetPro: 1.357 ± 0.029
0.991MetGln: 0.991 ± 0.025
1.409MetArg: 1.409 ± 0.029
1.468MetSer: 1.468 ± 0.026
1.363MetThr: 1.363 ± 0.031
1.425MetVal: 1.425 ± 0.03
0.189MetTrp: 0.189 ± 0.01
0.424MetTyr: 0.424 ± 0.015
0.0MetXaa: 0.0 ± 0.0
Asn
3.602AsnAla: 3.602 ± 0.063
0.32AsnCys: 0.32 ± 0.015
1.754AsnAsp: 1.754 ± 0.034
1.593AsnGlu: 1.593 ± 0.033
1.629AsnPhe: 1.629 ± 0.038
3.518AsnGly: 3.518 ± 0.068
0.785AsnHis: 0.785 ± 0.024
1.857AsnIle: 1.857 ± 0.039
1.027AsnLys: 1.027 ± 0.023
3.552AsnLeu: 3.552 ± 0.063
0.641AsnMet: 0.641 ± 0.017
1.498AsnAsn: 1.498 ± 0.051
2.51AsnPro: 2.51 ± 0.046
1.403AsnGln: 1.403 ± 0.035
1.787AsnArg: 1.787 ± 0.033
2.39AsnSer: 2.39 ± 0.059
2.249AsnThr: 2.249 ± 0.045
2.539AsnVal: 2.539 ± 0.049
0.504AsnTrp: 0.504 ± 0.02
1.255AsnTyr: 1.255 ± 0.041
0.0AsnXaa: 0.0 ± 0.0
Pro
5.964ProAla: 5.964 ± 0.066
0.357ProCys: 0.357 ± 0.014
3.0ProAsp: 3.0 ± 0.049
3.569ProGlu: 3.569 ± 0.062
2.064ProPhe: 2.064 ± 0.039
4.621ProGly: 4.621 ± 0.053
1.218ProHis: 1.218 ± 0.026
2.488ProIle: 2.488 ± 0.036
1.991ProLys: 1.991 ± 0.039
4.996ProLeu: 4.996 ± 0.058
1.059ProMet: 1.059 ± 0.027
2.111ProAsn: 2.111 ± 0.044
2.59ProPro: 2.59 ± 0.047
2.26ProGln: 2.26 ± 0.035
2.436ProArg: 2.436 ± 0.041
3.752ProSer: 3.752 ± 0.056
3.352ProThr: 3.352 ± 0.048
4.148ProVal: 4.148 ± 0.053
0.71ProTrp: 0.71 ± 0.019
1.5ProTyr: 1.5 ± 0.031
0.0ProXaa: 0.0 ± 0.0
Gln
4.065GlnAla: 4.065 ± 0.054
0.23GlnCys: 0.23 ± 0.011
1.729GlnAsp: 1.729 ± 0.03
1.784GlnGlu: 1.784 ± 0.035
1.546GlnPhe: 1.546 ± 0.036
2.647GlnGly: 2.647 ± 0.039
0.95GlnHis: 0.95 ± 0.023
2.176GlnIle: 2.176 ± 0.043
1.384GlnLys: 1.384 ± 0.031
3.748GlnLeu: 3.748 ± 0.049
0.971GlnMet: 0.971 ± 0.027
1.443GlnAsn: 1.443 ± 0.041
2.29GlnPro: 2.29 ± 0.044
2.228GlnGln: 2.228 ± 0.042
2.572GlnArg: 2.572 ± 0.037
2.542GlnSer: 2.542 ± 0.042
2.556GlnThr: 2.556 ± 0.042
2.661GlnVal: 2.661 ± 0.043
0.581GlnTrp: 0.581 ± 0.019
1.127GlnTyr: 1.127 ± 0.031
0.0GlnXaa: 0.0 ± 0.0
Arg
5.263ArgAla: 5.263 ± 0.066
0.455ArgCys: 0.455 ± 0.019
2.802ArgAsp: 2.802 ± 0.051
3.602ArgGlu: 3.602 ± 0.059
2.485ArgPhe: 2.485 ± 0.037
3.739ArgGly: 3.739 ± 0.056
1.358ArgHis: 1.358 ± 0.029
3.368ArgIle: 3.368 ± 0.05
2.261ArgLys: 2.261 ± 0.037
5.911ArgLeu: 5.911 ± 0.069
1.494ArgMet: 1.494 ± 0.03
2.007ArgAsn: 2.007 ± 0.034
2.662ArgPro: 2.662 ± 0.042
2.164ArgGln: 2.164 ± 0.039
3.727ArgArg: 3.727 ± 0.053
3.742ArgSer: 3.742 ± 0.054
3.251ArgThr: 3.251 ± 0.042
4.033ArgVal: 4.033 ± 0.059
0.934ArgTrp: 0.934 ± 0.024
1.8ArgTyr: 1.8 ± 0.033
0.0ArgXaa: 0.0 ± 0.0
Ser
6.76SerAla: 6.76 ± 0.063
0.562SerCys: 0.562 ± 0.018
3.153SerAsp: 3.153 ± 0.037
3.102SerGlu: 3.102 ± 0.045
2.907SerPhe: 2.907 ± 0.048
6.406SerGly: 6.406 ± 0.085
1.432SerHis: 1.432 ± 0.027
3.538SerIle: 3.538 ± 0.044
2.232SerLys: 2.232 ± 0.039
6.896SerLeu: 6.896 ± 0.079
1.374SerMet: 1.374 ± 0.028
2.564SerAsn: 2.564 ± 0.061
3.687SerPro: 3.687 ± 0.053
2.379SerGln: 2.379 ± 0.037
3.362SerArg: 3.362 ± 0.05
5.134SerSer: 5.134 ± 0.078
4.309SerThr: 4.309 ± 0.066
4.6SerVal: 4.6 ± 0.066
0.904SerTrp: 0.904 ± 0.028
1.976SerTyr: 1.976 ± 0.039
0.0SerXaa: 0.0 ± 0.0
Thr
6.687ThrAla: 6.687 ± 0.081
0.511ThrCys: 0.511 ± 0.018
2.956ThrAsp: 2.956 ± 0.041
2.851ThrGlu: 2.851 ± 0.04
2.469ThrPhe: 2.469 ± 0.043
5.743ThrGly: 5.743 ± 0.086
1.334ThrHis: 1.334 ± 0.027
3.307ThrIle: 3.307 ± 0.048
1.919ThrLys: 1.919 ± 0.037
6.583ThrLeu: 6.583 ± 0.063
1.162ThrMet: 1.162 ± 0.025
2.354ThrAsn: 2.354 ± 0.054
4.372ThrPro: 4.372 ± 0.059
2.307ThrGln: 2.307 ± 0.042
2.93ThrArg: 2.93 ± 0.039
4.289ThrSer: 4.289 ± 0.064
4.176ThrThr: 4.176 ± 0.072
5.01ThrVal: 5.01 ± 0.067
0.841ThrTrp: 0.841 ± 0.023
1.778ThrTyr: 1.778 ± 0.037
0.0ThrXaa: 0.0 ± 0.0
Val
7.603ValAla: 7.603 ± 0.076
0.661ValCys: 0.661 ± 0.02
3.775ValAsp: 3.775 ± 0.043
3.977ValGlu: 3.977 ± 0.058
2.698ValPhe: 2.698 ± 0.049
4.968ValGly: 4.968 ± 0.059
1.562ValHis: 1.562 ± 0.027
3.404ValIle: 3.404 ± 0.047
2.363ValLys: 2.363 ± 0.042
7.445ValLeu: 7.445 ± 0.087
1.433ValMet: 1.433 ± 0.033
2.537ValAsn: 2.537 ± 0.049
3.825ValPro: 3.825 ± 0.047
2.631ValGln: 2.631 ± 0.037
4.054ValArg: 4.054 ± 0.048
4.799ValSer: 4.799 ± 0.056
4.694ValThr: 4.694 ± 0.059
5.249ValVal: 5.249 ± 0.062
0.926ValTrp: 0.926 ± 0.021
1.851ValTyr: 1.851 ± 0.031
0.0ValXaa: 0.0 ± 0.0
Trp
1.098TrpAla: 1.098 ± 0.027
0.121TrpCys: 0.121 ± 0.008
0.656TrpAsp: 0.656 ± 0.017
0.612TrpGlu: 0.612 ± 0.016
0.575TrpPhe: 0.575 ± 0.019
0.881TrpGly: 0.881 ± 0.026
0.379TrpHis: 0.379 ± 0.013
0.754TrpIle: 0.754 ± 0.023
0.645TrpLys: 0.645 ± 0.018
1.466TrpLeu: 1.466 ± 0.037
0.41TrpMet: 0.41 ± 0.014
0.657TrpAsn: 0.657 ± 0.022
0.58TrpPro: 0.58 ± 0.018
0.688TrpGln: 0.688 ± 0.018
0.9TrpArg: 0.9 ± 0.025
1.001TrpSer: 1.001 ± 0.028
0.901TrpThr: 0.901 ± 0.024
0.906TrpVal: 0.906 ± 0.023
0.232TrpTrp: 0.232 ± 0.012
0.391TrpTyr: 0.391 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.776TyrAla: 2.776 ± 0.038
0.24TyrCys: 0.24 ± 0.01
1.637TyrAsp: 1.637 ± 0.042
1.405TyrGlu: 1.405 ± 0.026
1.269TyrPhe: 1.269 ± 0.029
2.449TyrGly: 2.449 ± 0.04
0.602TyrHis: 0.602 ± 0.018
1.202TyrIle: 1.202 ± 0.029
0.89TyrLys: 0.89 ± 0.021
2.776TyrLeu: 2.776 ± 0.044
0.503TyrMet: 0.503 ± 0.018
1.104TyrAsn: 1.104 ± 0.036
1.453TyrPro: 1.453 ± 0.033
1.052TyrGln: 1.052 ± 0.029
1.856TyrArg: 1.856 ± 0.034
1.907TyrSer: 1.907 ± 0.042
1.939TyrThr: 1.939 ± 0.038
1.91TyrVal: 1.91 ± 0.037
0.444TyrTrp: 0.444 ± 0.017
0.851TyrTyr: 0.851 ± 0.025
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4804 proteins (1807496 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski