Amino acid dipepetide frequency for Nocardioides alpinus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.925AlaAla: 18.925 ± 0.18
0.938AlaCys: 0.938 ± 0.025
8.633AlaAsp: 8.633 ± 0.105
7.75AlaGlu: 7.75 ± 0.093
3.53AlaPhe: 3.53 ± 0.054
11.968AlaGly: 11.968 ± 0.099
2.628AlaHis: 2.628 ± 0.05
4.568AlaIle: 4.568 ± 0.06
2.351AlaLys: 2.351 ± 0.06
13.266AlaLeu: 13.266 ± 0.129
2.806AlaMet: 2.806 ± 0.041
1.961AlaAsn: 1.961 ± 0.042
6.218AlaPro: 6.218 ± 0.079
3.493AlaGln: 3.493 ± 0.065
9.239AlaArg: 9.239 ± 0.1
6.795AlaSer: 6.795 ± 0.072
7.975AlaThr: 7.975 ± 0.095
11.493AlaVal: 11.493 ± 0.109
2.161AlaTrp: 2.161 ± 0.041
2.546AlaTyr: 2.546 ± 0.043
0.001AlaXaa: 0.001 ± 0.001
Cys
0.816CysAla: 0.816 ± 0.023
0.082CysCys: 0.082 ± 0.007
0.482CysAsp: 0.482 ± 0.018
0.359CysGlu: 0.359 ± 0.017
0.222CysPhe: 0.222 ± 0.012
0.799CysGly: 0.799 ± 0.023
0.183CysHis: 0.183 ± 0.012
0.195CysIle: 0.195 ± 0.012
0.1CysLys: 0.1 ± 0.008
0.658CysLeu: 0.658 ± 0.021
0.106CysMet: 0.106 ± 0.009
0.135CysAsn: 0.135 ± 0.009
0.428CysPro: 0.428 ± 0.021
0.179CysGln: 0.179 ± 0.011
0.521CysArg: 0.521 ± 0.021
0.435CysSer: 0.435 ± 0.019
0.459CysThr: 0.459 ± 0.018
0.589CysVal: 0.589 ± 0.021
0.1CysTrp: 0.1 ± 0.008
0.133CysTyr: 0.133 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
8.249AspAla: 8.249 ± 0.088
0.346AspCys: 0.346 ± 0.016
5.012AspAsp: 5.012 ± 0.063
4.557AspGlu: 4.557 ± 0.066
1.806AspPhe: 1.806 ± 0.037
6.504AspGly: 6.504 ± 0.083
1.661AspHis: 1.661 ± 0.036
2.081AspIle: 2.081 ± 0.04
1.113AspLys: 1.113 ± 0.031
7.705AspLeu: 7.705 ± 0.085
0.969AspMet: 0.969 ± 0.028
1.127AspAsn: 1.127 ± 0.035
4.521AspPro: 4.521 ± 0.061
1.922AspGln: 1.922 ± 0.038
5.015AspArg: 5.015 ± 0.064
2.766AspSer: 2.766 ± 0.044
3.197AspThr: 3.197 ± 0.052
6.477AspVal: 6.477 ± 0.075
1.061AspTrp: 1.061 ± 0.026
1.304AspTyr: 1.304 ± 0.031
0.0AspXaa: 0.0 ± 0.0
Glu
7.248GluAla: 7.248 ± 0.077
0.326GluCys: 0.326 ± 0.016
3.251GluAsp: 3.251 ± 0.055
3.23GluGlu: 3.23 ± 0.067
1.449GluPhe: 1.449 ± 0.032
4.271GluGly: 4.271 ± 0.059
1.67GluHis: 1.67 ± 0.035
2.418GluIle: 2.418 ± 0.044
1.287GluLys: 1.287 ± 0.033
6.337GluLeu: 6.337 ± 0.074
1.125GluMet: 1.125 ± 0.031
0.859GluAsn: 0.859 ± 0.026
3.064GluPro: 3.064 ± 0.054
2.211GluGln: 2.211 ± 0.045
4.849GluArg: 4.849 ± 0.073
2.974GluSer: 2.974 ± 0.049
2.991GluThr: 2.991 ± 0.049
5.671GluVal: 5.671 ± 0.072
0.89GluTrp: 0.89 ± 0.025
0.841GluTyr: 0.841 ± 0.027
0.0GluXaa: 0.0 ± 0.0
Phe
3.681PheAla: 3.681 ± 0.047
0.263PheCys: 0.263 ± 0.013
2.158PheAsp: 2.158 ± 0.036
1.553PheGlu: 1.553 ± 0.039
0.923PhePhe: 0.923 ± 0.033
3.048PheGly: 3.048 ± 0.053
0.603PheHis: 0.603 ± 0.02
0.859PheIle: 0.859 ± 0.028
0.485PheLys: 0.485 ± 0.023
2.595PheLeu: 2.595 ± 0.05
0.462PheMet: 0.462 ± 0.018
0.588PheAsn: 0.588 ± 0.021
1.326PhePro: 1.326 ± 0.031
0.608PheGln: 0.608 ± 0.022
1.744PheArg: 1.744 ± 0.035
1.508PheSer: 1.508 ± 0.032
1.999PheThr: 1.999 ± 0.043
2.701PheVal: 2.701 ± 0.052
0.436PheTrp: 0.436 ± 0.016
0.615PheTyr: 0.615 ± 0.023
0.0PheXaa: 0.0 ± 0.0
Gly
10.301GlyAla: 10.301 ± 0.091
0.808GlyCys: 0.808 ± 0.02
5.767GlyAsp: 5.767 ± 0.068
5.071GlyGlu: 5.071 ± 0.058
2.976GlyPhe: 2.976 ± 0.049
8.007GlyGly: 8.007 ± 0.113
2.143GlyHis: 2.143 ± 0.04
3.768GlyIle: 3.768 ± 0.056
2.066GlyLys: 2.066 ± 0.042
9.285GlyLeu: 9.285 ± 0.1
2.027GlyMet: 2.027 ± 0.045
1.776GlyAsn: 1.776 ± 0.048
4.393GlyPro: 4.393 ± 0.056
2.63GlyGln: 2.63 ± 0.045
6.989GlyArg: 6.989 ± 0.067
5.551GlySer: 5.551 ± 0.077
6.023GlyThr: 6.023 ± 0.092
7.974GlyVal: 7.974 ± 0.073
1.829GlyTrp: 1.829 ± 0.037
2.04GlyTyr: 2.04 ± 0.04
0.0GlyXaa: 0.0 ± 0.0
His
2.601HisAla: 2.601 ± 0.05
0.179HisCys: 0.179 ± 0.011
1.676HisAsp: 1.676 ± 0.036
1.345HisGlu: 1.345 ± 0.032
0.596HisPhe: 0.596 ± 0.023
2.213HisGly: 2.213 ± 0.048
0.725HisHis: 0.725 ± 0.028
0.555HisIle: 0.555 ± 0.019
0.315HisLys: 0.315 ± 0.016
2.512HisLeu: 2.512 ± 0.043
0.317HisMet: 0.317 ± 0.017
0.369HisAsn: 0.369 ± 0.014
1.584HisPro: 1.584 ± 0.038
0.662HisGln: 0.662 ± 0.023
1.923HisArg: 1.923 ± 0.045
0.957HisSer: 0.957 ± 0.03
1.189HisThr: 1.189 ± 0.036
2.067HisVal: 2.067 ± 0.044
0.354HisTrp: 0.354 ± 0.017
0.45HisTyr: 0.45 ± 0.018
0.0HisXaa: 0.0 ± 0.0
Ile
5.065IleAla: 5.065 ± 0.072
0.288IleCys: 0.288 ± 0.014
2.837IleAsp: 2.837 ± 0.048
2.415IleGlu: 2.415 ± 0.04
0.873IlePhe: 0.873 ± 0.028
3.92IleGly: 3.92 ± 0.061
0.709IleHis: 0.709 ± 0.023
1.142IleIle: 1.142 ± 0.03
0.763IleLys: 0.763 ± 0.027
2.618IleLeu: 2.618 ± 0.052
0.492IleMet: 0.492 ± 0.02
0.795IleAsn: 0.795 ± 0.023
1.777IlePro: 1.777 ± 0.038
0.746IleGln: 0.746 ± 0.025
2.258IleArg: 2.258 ± 0.044
2.007IleSer: 2.007 ± 0.043
2.405IleThr: 2.405 ± 0.041
3.228IleVal: 3.228 ± 0.047
0.435IleTrp: 0.435 ± 0.018
0.583IleTyr: 0.583 ± 0.021
0.0IleXaa: 0.0 ± 0.0
Lys
2.47LysAla: 2.47 ± 0.048
0.101LysCys: 0.101 ± 0.009
1.183LysAsp: 1.183 ± 0.03
0.945LysGlu: 0.945 ± 0.028
0.459LysPhe: 0.459 ± 0.018
1.578LysGly: 1.578 ± 0.04
0.392LysHis: 0.392 ± 0.018
0.802LysIle: 0.802 ± 0.027
0.758LysLys: 0.758 ± 0.038
1.559LysLeu: 1.559 ± 0.035
0.389LysMet: 0.389 ± 0.017
0.428LysAsn: 0.428 ± 0.02
1.063LysPro: 1.063 ± 0.032
0.632LysGln: 0.632 ± 0.021
1.33LysArg: 1.33 ± 0.032
1.039LysSer: 1.039 ± 0.031
1.12LysThr: 1.12 ± 0.033
2.016LysVal: 2.016 ± 0.052
0.231LysTrp: 0.231 ± 0.012
0.404LysTyr: 0.404 ± 0.019
0.0LysXaa: 0.0 ± 0.0
Leu
14.958LeuAla: 14.958 ± 0.136
0.648LeuCys: 0.648 ± 0.022
7.252LeuAsp: 7.252 ± 0.078
5.4LeuGlu: 5.4 ± 0.07
2.459LeuPhe: 2.459 ± 0.051
9.54LeuGly: 9.54 ± 0.09
2.12LeuHis: 2.12 ± 0.047
2.987LeuIle: 2.987 ± 0.056
1.664LeuLys: 1.664 ± 0.039
10.363LeuLeu: 10.363 ± 0.132
1.747LeuMet: 1.747 ± 0.042
1.562LeuAsn: 1.562 ± 0.034
5.715LeuPro: 5.715 ± 0.069
2.271LeuGln: 2.271 ± 0.037
7.461LeuArg: 7.461 ± 0.081
5.305LeuSer: 5.305 ± 0.069
6.589LeuThr: 6.589 ± 0.068
10.647LeuVal: 10.647 ± 0.107
1.238LeuTrp: 1.238 ± 0.03
1.447LeuTyr: 1.447 ± 0.036
0.001LeuXaa: 0.001 ± 0.001
Met
2.389MetAla: 2.389 ± 0.034
0.138MetCys: 0.138 ± 0.009
0.985MetAsp: 0.985 ± 0.026
0.802MetGlu: 0.802 ± 0.026
0.508MetPhe: 0.508 ± 0.019
1.465MetGly: 1.465 ± 0.033
0.377MetHis: 0.377 ± 0.018
0.709MetIle: 0.709 ± 0.023
0.483MetLys: 0.483 ± 0.019
1.909MetLeu: 1.909 ± 0.042
0.35MetMet: 0.35 ± 0.018
0.423MetAsn: 0.423 ± 0.016
1.188MetPro: 1.188 ± 0.029
0.506MetGln: 0.506 ± 0.019
1.485MetArg: 1.485 ± 0.032
1.583MetSer: 1.583 ± 0.033
1.787MetThr: 1.787 ± 0.035
1.623MetVal: 1.623 ± 0.035
0.223MetTrp: 0.223 ± 0.012
0.265MetTyr: 0.265 ± 0.013
0.0MetXaa: 0.0 ± 0.0
Asn
2.156AsnAla: 2.156 ± 0.041
0.133AsnCys: 0.133 ± 0.01
1.134AsnAsp: 1.134 ± 0.03
0.833AsnGlu: 0.833 ± 0.025
0.532AsnPhe: 0.532 ± 0.022
1.728AsnGly: 1.728 ± 0.044
0.374AsnHis: 0.374 ± 0.017
0.682AsnIle: 0.682 ± 0.025
0.364AsnLys: 0.364 ± 0.018
1.787AsnLeu: 1.787 ± 0.038
0.294AsnMet: 0.294 ± 0.014
0.438AsnAsn: 0.438 ± 0.024
1.359AsnPro: 1.359 ± 0.033
0.545AsnGln: 0.545 ± 0.022
1.168AsnArg: 1.168 ± 0.032
0.825AsnSer: 0.825 ± 0.03
1.027AsnThr: 1.027 ± 0.032
1.465AsnVal: 1.465 ± 0.037
0.247AsnTrp: 0.247 ± 0.012
0.382AsnTyr: 0.382 ± 0.02
0.0AsnXaa: 0.0 ± 0.0
Pro
7.094ProAla: 7.094 ± 0.096
0.303ProCys: 0.303 ± 0.016
4.619ProAsp: 4.619 ± 0.053
3.75ProGlu: 3.75 ± 0.06
1.501ProPhe: 1.501 ± 0.029
5.515ProGly: 5.515 ± 0.076
1.247ProHis: 1.247 ± 0.033
1.715ProIle: 1.715 ± 0.032
0.87ProLys: 0.87 ± 0.026
4.664ProLeu: 4.664 ± 0.052
1.118ProMet: 1.118 ± 0.027
0.78ProAsn: 0.78 ± 0.025
2.786ProPro: 2.786 ± 0.052
1.507ProGln: 1.507 ± 0.039
3.52ProArg: 3.52 ± 0.056
3.271ProSer: 3.271 ± 0.049
3.803ProThr: 3.803 ± 0.082
5.076ProVal: 5.076 ± 0.063
0.956ProTrp: 0.956 ± 0.028
1.065ProTyr: 1.065 ± 0.028
0.0ProXaa: 0.0 ± 0.0
Gln
3.486GlnAla: 3.486 ± 0.056
0.166GlnCys: 0.166 ± 0.01
1.389GlnAsp: 1.389 ± 0.032
1.298GlnGlu: 1.298 ± 0.033
0.703GlnPhe: 0.703 ± 0.023
2.175GlnGly: 2.175 ± 0.041
0.694GlnHis: 0.694 ± 0.025
1.015GlnIle: 1.015 ± 0.029
0.551GlnLys: 0.551 ± 0.021
2.917GlnLeu: 2.917 ± 0.049
0.569GlnMet: 0.569 ± 0.022
0.416GlnAsn: 0.416 ± 0.019
1.611GlnPro: 1.611 ± 0.044
1.207GlnGln: 1.207 ± 0.033
2.419GlnArg: 2.419 ± 0.045
1.269GlnSer: 1.269 ± 0.029
1.441GlnThr: 1.441 ± 0.03
3.008GlnVal: 3.008 ± 0.051
0.483GlnTrp: 0.483 ± 0.018
0.481GlnTyr: 0.481 ± 0.019
0.0GlnXaa: 0.0 ± 0.0
Arg
8.688ArgAla: 8.688 ± 0.094
0.436ArgCys: 0.436 ± 0.02
4.659ArgAsp: 4.659 ± 0.064
4.448ArgGlu: 4.448 ± 0.068
2.245ArgPhe: 2.245 ± 0.036
5.559ArgGly: 5.559 ± 0.076
1.852ArgHis: 1.852 ± 0.038
3.187ArgIle: 3.187 ± 0.051
1.387ArgLys: 1.387 ± 0.035
8.035ArgLeu: 8.035 ± 0.086
1.738ArgMet: 1.738 ± 0.04
1.306ArgAsn: 1.306 ± 0.028
4.011ArgPro: 4.011 ± 0.06
2.048ArgGln: 2.048 ± 0.042
6.924ArgArg: 6.924 ± 0.088
4.25ArgSer: 4.25 ± 0.069
4.863ArgThr: 4.863 ± 0.063
6.161ArgVal: 6.161 ± 0.073
1.374ArgTrp: 1.374 ± 0.03
1.434ArgTyr: 1.434 ± 0.03
0.0ArgXaa: 0.0 ± 0.0
Ser
6.694SerAla: 6.694 ± 0.079
0.378SerCys: 0.378 ± 0.017
3.285SerAsp: 3.285 ± 0.052
2.655SerGlu: 2.655 ± 0.048
1.719SerPhe: 1.719 ± 0.038
5.946SerGly: 5.946 ± 0.074
1.145SerHis: 1.145 ± 0.035
1.936SerIle: 1.936 ± 0.037
0.912SerLys: 0.912 ± 0.027
5.233SerLeu: 5.233 ± 0.062
1.308SerMet: 1.308 ± 0.036
0.967SerAsn: 0.967 ± 0.03
3.251SerPro: 3.251 ± 0.057
1.446SerGln: 1.446 ± 0.034
3.918SerArg: 3.918 ± 0.056
3.361SerSer: 3.361 ± 0.053
3.8SerThr: 3.8 ± 0.066
4.717SerVal: 4.717 ± 0.058
0.995SerTrp: 0.995 ± 0.028
1.288SerTyr: 1.288 ± 0.03
0.0SerXaa: 0.0 ± 0.0
Thr
7.648ThrAla: 7.648 ± 0.093
0.446ThrCys: 0.446 ± 0.019
3.973ThrAsp: 3.973 ± 0.056
3.133ThrGlu: 3.133 ± 0.055
1.987ThrPhe: 1.987 ± 0.041
6.329ThrGly: 6.329 ± 0.075
1.3ThrHis: 1.3 ± 0.031
2.414ThrIle: 2.414 ± 0.046
1.156ThrLys: 1.156 ± 0.03
5.999ThrLeu: 5.999 ± 0.064
1.132ThrMet: 1.132 ± 0.025
1.187ThrAsn: 1.187 ± 0.037
4.108ThrPro: 4.108 ± 0.074
1.531ThrGln: 1.531 ± 0.033
4.094ThrArg: 4.094 ± 0.051
4.036ThrSer: 4.036 ± 0.054
4.53ThrThr: 4.53 ± 0.082
5.832ThrVal: 5.832 ± 0.082
1.073ThrTrp: 1.073 ± 0.03
1.534ThrTyr: 1.534 ± 0.034
0.0ThrXaa: 0.0 ± 0.0
Val
12.549ValAla: 12.549 ± 0.119
0.691ValCys: 0.691 ± 0.022
6.457ValAsp: 6.457 ± 0.065
5.674ValGlu: 5.674 ± 0.067
2.458ValPhe: 2.458 ± 0.045
7.897ValGly: 7.897 ± 0.074
2.061ValHis: 2.061 ± 0.04
3.251ValIle: 3.251 ± 0.049
1.644ValLys: 1.644 ± 0.04
10.074ValLeu: 10.074 ± 0.103
1.717ValMet: 1.717 ± 0.037
1.638ValAsn: 1.638 ± 0.039
5.083ValPro: 5.083 ± 0.06
2.127ValGln: 2.127 ± 0.036
7.033ValArg: 7.033 ± 0.086
4.966ValSer: 4.966 ± 0.062
6.096ValThr: 6.096 ± 0.08
10.581ValVal: 10.581 ± 0.103
1.232ValTrp: 1.232 ± 0.032
1.353ValTyr: 1.353 ± 0.03
0.0ValXaa: 0.0 ± 0.0
Trp
1.652TrpAla: 1.652 ± 0.031
0.169TrpCys: 0.169 ± 0.011
0.907TrpAsp: 0.907 ± 0.028
0.744TrpGlu: 0.744 ± 0.025
0.581TrpPhe: 0.581 ± 0.022
1.118TrpGly: 1.118 ± 0.027
0.385TrpHis: 0.385 ± 0.017
0.624TrpIle: 0.624 ± 0.019
0.3TrpLys: 0.3 ± 0.017
1.942TrpLeu: 1.942 ± 0.043
0.319TrpMet: 0.319 ± 0.015
0.362TrpAsn: 0.362 ± 0.019
0.743TrpPro: 0.743 ± 0.023
0.574TrpGln: 0.574 ± 0.021
1.315TrpArg: 1.315 ± 0.037
1.135TrpSer: 1.135 ± 0.031
1.136TrpThr: 1.136 ± 0.033
1.334TrpVal: 1.334 ± 0.028
0.423TrpTrp: 0.423 ± 0.017
0.281TrpTyr: 0.281 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.573TyrAla: 2.573 ± 0.039
0.144TyrCys: 0.144 ± 0.011
1.733TyrAsp: 1.733 ± 0.039
0.998TyrGlu: 0.998 ± 0.029
0.629TyrPhe: 0.629 ± 0.024
1.845TyrGly: 1.845 ± 0.042
0.318TyrHis: 0.318 ± 0.014
0.448TyrIle: 0.448 ± 0.019
0.331TyrLys: 0.331 ± 0.018
1.916TyrLeu: 1.916 ± 0.041
0.215TyrMet: 0.215 ± 0.012
0.353TyrAsn: 0.353 ± 0.018
0.93TyrPro: 0.93 ± 0.028
0.456TyrGln: 0.456 ± 0.019
1.4TyrArg: 1.4 ± 0.032
0.922TyrSer: 0.922 ± 0.025
1.012TyrThr: 1.012 ± 0.032
1.919TyrVal: 1.919 ± 0.039
0.303TyrTrp: 0.303 ± 0.015
0.418TyrTyr: 0.418 ± 0.018
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.001XaaPro: 0.001 ± 0.001
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.004XaaXaa: 0.004 ± 0.002
Statistics based on 4347 proteins (1417320 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski