Amino acid dipepetide frequency for Actinobacillus succinogenes (strain ATCC 55618 / DSM 22257 / 130Z)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.085AlaAla: 8.085 ± 0.154	1.044AlaCys: 1.044 ± 0.037	5.203AlaAsp: 5.203 ± 0.09	6.379AlaGlu: 6.379 ± 0.117	3.673AlaPhe: 3.673 ± 0.083	6.497AlaGly: 6.497 ± 0.121	1.53AlaHis: 1.53 ± 0.053	5.598AlaIle: 5.598 ± 0.099	5.453AlaLys: 5.453 ± 0.101	10.318AlaLeu: 10.318 ± 0.13	2.508AlaMet: 2.508 ± 0.064	3.666AlaAsn: 3.666 ± 0.148	2.636AlaPro: 2.636 ± 0.063	3.998AlaGln: 3.998 ± 0.095	3.871AlaArg: 3.871 ± 0.083	4.072AlaSer: 4.072 ± 0.103	4.237AlaThr: 4.237 ± 0.13	7.414AlaVal: 7.414 ± 0.123	0.96AlaTrp: 0.96 ± 0.039	2.434AlaTyr: 2.434 ± 0.062	0.0AlaXaa: 0.0 ± 0.0
Cys	0.842CysAla: 0.842 ± 0.039	0.17CysCys: 0.17 ± 0.017	0.558CysAsp: 0.558 ± 0.031	0.62CysGlu: 0.62 ± 0.033	0.425CysPhe: 0.425 ± 0.024	1.103CysGly: 1.103 ± 0.045	0.312CysHis: 0.312 ± 0.024	0.622CysIle: 0.622 ± 0.031	0.436CysLys: 0.436 ± 0.029	1.025CysLeu: 1.025 ± 0.036	0.192CysMet: 0.192 ± 0.016	0.328CysAsn: 0.328 ± 0.026	0.501CysPro: 0.501 ± 0.032	0.383CysGln: 0.383 ± 0.024	0.58CysArg: 0.58 ± 0.032	0.606CysSer: 0.606 ± 0.032	0.53CysThr: 0.53 ± 0.028	0.666CysVal: 0.666 ± 0.034	0.121CysTrp: 0.121 ± 0.014	0.372CysTyr: 0.372 ± 0.023	0.0CysXaa: 0.0 ± 0.0
Asp	3.923AspAla: 3.923 ± 0.095	0.551AspCys: 0.551 ± 0.028	2.617AspAsp: 2.617 ± 0.066	3.914AspGlu: 3.914 ± 0.1	2.681AspPhe: 2.681 ± 0.062	3.697AspGly: 3.697 ± 0.132	0.861AspHis: 0.861 ± 0.034	3.811AspIle: 3.811 ± 0.078	3.394AspLys: 3.394 ± 0.076	5.11AspLeu: 5.11 ± 0.086	1.269AspMet: 1.269 ± 0.046	2.49AspAsn: 2.49 ± 0.073	1.979AspPro: 1.979 ± 0.057	1.536AspGln: 1.536 ± 0.044	2.266AspArg: 2.266 ± 0.062	2.598AspSer: 2.598 ± 0.083	2.331AspThr: 2.331 ± 0.072	3.697AspVal: 3.697 ± 0.086	0.843AspTrp: 0.843 ± 0.037	2.167AspTyr: 2.167 ± 0.06	0.0AspXaa: 0.0 ± 0.0
Glu	4.491GluAla: 4.491 ± 0.11	0.484GluCys: 0.484 ± 0.03	2.537GluAsp: 2.537 ± 0.068	3.623GluGlu: 3.623 ± 0.094	2.486GluPhe: 2.486 ± 0.07	3.23GluGly: 3.23 ± 0.084	1.31GluHis: 1.31 ± 0.043	4.586GluIle: 4.586 ± 0.093	4.908GluLys: 4.908 ± 0.096	6.398GluLeu: 6.398 ± 0.115	1.784GluMet: 1.784 ± 0.059	3.757GluAsn: 3.757 ± 0.086	1.902GluPro: 1.902 ± 0.063	3.791GluGln: 3.791 ± 0.083	3.7GluArg: 3.7 ± 0.079	2.839GluSer: 2.839 ± 0.077	3.211GluThr: 3.211 ± 0.074	3.759GluVal: 3.759 ± 0.089	0.703GluTrp: 0.703 ± 0.033	1.734GluTyr: 1.734 ± 0.05	0.0GluXaa: 0.0 ± 0.0
Phe	3.938PheAla: 3.938 ± 0.084	0.566PheCys: 0.566 ± 0.028	2.8PheAsp: 2.8 ± 0.056	2.471PheGlu: 2.471 ± 0.067	2.044PhePhe: 2.044 ± 0.071	3.588PheGly: 3.588 ± 0.082	0.871PheHis: 0.871 ± 0.042	3.137PheIle: 3.137 ± 0.08	1.985PheLys: 1.985 ± 0.056	3.921PheLeu: 3.921 ± 0.094	1.093PheMet: 1.093 ± 0.041	2.217PheAsn: 2.217 ± 0.062	1.54PhePro: 1.54 ± 0.043	1.326PheGln: 1.326 ± 0.047	1.837PheArg: 1.837 ± 0.052	3.096PheSer: 3.096 ± 0.08	2.499PheThr: 2.499 ± 0.057	3.097PheVal: 3.097 ± 0.071	0.566PheTrp: 0.566 ± 0.033	1.495PheTyr: 1.495 ± 0.053	0.0PheXaa: 0.0 ± 0.0
Gly	5.515GlyAla: 5.515 ± 0.108	0.882GlyCys: 0.882 ± 0.046	3.452GlyAsp: 3.452 ± 0.094	4.447GlyGlu: 4.447 ± 0.093	3.272GlyPhe: 3.272 ± 0.074	5.054GlyGly: 5.054 ± 0.13	1.4GlyHis: 1.4 ± 0.056	5.428GlyIle: 5.428 ± 0.111	5.038GlyLys: 5.038 ± 0.09	7.187GlyLeu: 7.187 ± 0.128	2.003GlyMet: 2.003 ± 0.068	2.905GlyAsn: 2.905 ± 0.116	1.266GlyPro: 1.266 ± 0.047	2.52GlyGln: 2.52 ± 0.065	3.082GlyArg: 3.082 ± 0.07	3.828GlySer: 3.828 ± 0.099	3.666GlyThr: 3.666 ± 0.149	5.542GlyVal: 5.542 ± 0.108	0.908GlyTrp: 0.908 ± 0.04	2.707GlyTyr: 2.707 ± 0.064	0.0GlyXaa: 0.0 ± 0.0
His	1.493HisAla: 1.493 ± 0.046	0.35HisCys: 0.35 ± 0.023	0.911HisAsp: 0.911 ± 0.038	1.044HisGlu: 1.044 ± 0.039	1.171HisPhe: 1.171 ± 0.042	1.481HisGly: 1.481 ± 0.049	0.651HisHis: 0.651 ± 0.033	1.498HisIle: 1.498 ± 0.048	0.997HisLys: 0.997 ± 0.038	2.119HisLeu: 2.119 ± 0.057	0.399HisMet: 0.399 ± 0.025	0.846HisAsn: 0.846 ± 0.042	1.115HisPro: 1.115 ± 0.048	0.951HisGln: 0.951 ± 0.036	1.071HisArg: 1.071 ± 0.035	1.251HisSer: 1.251 ± 0.044	0.941HisThr: 0.941 ± 0.036	1.068HisVal: 1.068 ± 0.04	0.322HisTrp: 0.322 ± 0.023	0.793HisTyr: 0.793 ± 0.033	0.0HisXaa: 0.0 ± 0.0
Ile	6.72IleAla: 6.72 ± 0.096	0.772IleCys: 0.772 ± 0.034	3.818IleAsp: 3.818 ± 0.074	4.137IleGlu: 4.137 ± 0.089	2.743IlePhe: 2.743 ± 0.074	5.251IleGly: 5.251 ± 0.121	1.295IleHis: 1.295 ± 0.039	4.283IleIle: 4.283 ± 0.098	3.449IleLys: 3.449 ± 0.072	6.189IleLeu: 6.189 ± 0.137	1.439IleMet: 1.439 ± 0.046	2.97IleAsn: 2.97 ± 0.08	2.889IlePro: 2.889 ± 0.081	2.421IleGln: 2.421 ± 0.063	3.415IleArg: 3.415 ± 0.077	4.384IleSer: 4.384 ± 0.083	3.715IleThr: 3.715 ± 0.103	4.548IleVal: 4.548 ± 0.087	0.637IleTrp: 0.637 ± 0.031	1.93IleTyr: 1.93 ± 0.057	0.0IleXaa: 0.0 ± 0.0
Lys	5.353LysAla: 5.353 ± 0.103	0.456LysCys: 0.456 ± 0.026	2.904LysAsp: 2.904 ± 0.075	3.401LysGlu: 3.401 ± 0.082	2.111LysPhe: 2.111 ± 0.052	3.576LysGly: 3.576 ± 0.081	1.078LysHis: 1.078 ± 0.045	4.029LysIle: 4.029 ± 0.08	3.471LysLys: 3.471 ± 0.091	5.875LysLeu: 5.875 ± 0.091	1.768LysMet: 1.768 ± 0.058	3.057LysAsn: 3.057 ± 0.07	2.424LysPro: 2.424 ± 0.072	2.69LysGln: 2.69 ± 0.066	2.849LysArg: 2.849 ± 0.068	3.266LysSer: 3.266 ± 0.074	3.462LysThr: 3.462 ± 0.075	3.734LysVal: 3.734 ± 0.09	0.58LysTrp: 0.58 ± 0.031	1.659LysTyr: 1.659 ± 0.053	0.0LysXaa: 0.0 ± 0.0
Leu	9.857LeuAla: 9.857 ± 0.138	1.145LeuCys: 1.145 ± 0.043	5.615LeuAsp: 5.615 ± 0.104	5.61LeuGlu: 5.61 ± 0.115	4.642LeuPhe: 4.642 ± 0.105	7.284LeuGly: 7.284 ± 0.126	2.065LeuHis: 2.065 ± 0.056	6.726LeuIle: 6.726 ± 0.117	5.58LeuLys: 5.58 ± 0.096	10.518LeuLeu: 10.518 ± 0.203	2.458LeuMet: 2.458 ± 0.071	4.871LeuAsn: 4.871 ± 0.091	4.84LeuPro: 4.84 ± 0.099	4.276LeuGln: 4.276 ± 0.092	4.734LeuArg: 4.734 ± 0.093	6.89LeuSer: 6.89 ± 0.104	6.502LeuThr: 6.502 ± 0.109	6.304LeuVal: 6.304 ± 0.117	1.081LeuTrp: 1.081 ± 0.048	2.69LeuTyr: 2.69 ± 0.068	0.0LeuXaa: 0.0 ± 0.0
Met	2.47MetAla: 2.47 ± 0.062	0.214MetCys: 0.214 ± 0.021	1.041MetAsp: 1.041 ± 0.04	1.162MetGlu: 1.162 ± 0.047	0.91MetPhe: 0.91 ± 0.043	1.691MetGly: 1.691 ± 0.056	0.424MetHis: 0.424 ± 0.029	1.583MetIle: 1.583 ± 0.053	1.774MetLys: 1.774 ± 0.052	2.638MetLeu: 2.638 ± 0.073	0.725MetMet: 0.725 ± 0.035	1.229MetAsn: 1.229 ± 0.039	1.202MetPro: 1.202 ± 0.041	1.192MetGln: 1.192 ± 0.043	1.177MetArg: 1.177 ± 0.049	1.574MetSer: 1.574 ± 0.049	1.685MetThr: 1.685 ± 0.055	1.538MetVal: 1.538 ± 0.048	0.217MetTrp: 0.217 ± 0.018	0.511MetTyr: 0.511 ± 0.027	0.0MetXaa: 0.0 ± 0.0
Asn	4.274AsnAla: 4.274 ± 0.155	0.412AsnCys: 0.412 ± 0.026	2.186AsnAsp: 2.186 ± 0.066	2.614AsnGlu: 2.614 ± 0.071	1.82AsnPhe: 1.82 ± 0.058	3.495AsnGly: 3.495 ± 0.154	0.889AsnHis: 0.889 ± 0.039	3.202AsnIle: 3.202 ± 0.084	2.407AsnLys: 2.407 ± 0.061	4.654AsnLeu: 4.654 ± 0.091	1.137AsnMet: 1.137 ± 0.036	2.114AsnAsn: 2.114 ± 0.125	2.511AsnPro: 2.511 ± 0.066	2.012AsnGln: 2.012 ± 0.057	2.495AsnArg: 2.495 ± 0.067	2.325AsnSer: 2.325 ± 0.099	2.23AsnThr: 2.23 ± 0.089	3.19AsnVal: 3.19 ± 0.146	0.64AsnTrp: 0.64 ± 0.03	1.444AsnTyr: 1.444 ± 0.048	0.0AsnXaa: 0.0 ± 0.0
Pro	3.242ProAla: 3.242 ± 0.086	0.315ProCys: 0.315 ± 0.024	2.102ProAsp: 2.102 ± 0.055	3.285ProGlu: 3.285 ± 0.074	1.899ProPhe: 1.899 ± 0.054	1.789ProGly: 1.789 ± 0.055	1.043ProHis: 1.043 ± 0.045	2.27ProIle: 2.27 ± 0.067	2.071ProLys: 2.071 ± 0.054	4.038ProLeu: 4.038 ± 0.088	1.019ProMet: 1.019 ± 0.042	1.969ProAsn: 1.969 ± 0.057	1.139ProPro: 1.139 ± 0.041	1.833ProGln: 1.833 ± 0.053	1.43ProArg: 1.43 ± 0.05	2.081ProSer: 2.081 ± 0.062	2.136ProThr: 2.136 ± 0.057	3.171ProVal: 3.171 ± 0.069	0.408ProTrp: 0.408 ± 0.027	1.359ProTyr: 1.359 ± 0.046	0.0ProXaa: 0.0 ± 0.0
Gln	4.4GlnAla: 4.4 ± 0.096	0.359GlnCys: 0.359 ± 0.025	1.919GlnAsp: 1.919 ± 0.055	2.298GlnGlu: 2.298 ± 0.065	1.799GlnPhe: 1.799 ± 0.05	2.926GlnGly: 2.926 ± 0.072	0.932GlnHis: 0.932 ± 0.038	2.919GlnIle: 2.919 ± 0.073	2.577GlnLys: 2.577 ± 0.062	4.274GlnLeu: 4.274 ± 0.087	0.938GlnMet: 0.938 ± 0.034	2.202GlnAsn: 2.202 ± 0.063	1.709GlnPro: 1.709 ± 0.058	2.755GlnGln: 2.755 ± 0.083	2.235GlnArg: 2.235 ± 0.072	2.526GlnSer: 2.526 ± 0.059	2.399GlnThr: 2.399 ± 0.065	2.616GlnVal: 2.616 ± 0.07	0.616GlnTrp: 0.616 ± 0.034	1.409GlnTyr: 1.409 ± 0.049	0.0GlnXaa: 0.0 ± 0.0
Arg	3.632ArgAla: 3.632 ± 0.082	0.442ArgCys: 0.442 ± 0.029	2.304ArgAsp: 2.304 ± 0.061	3.248ArgGlu: 3.248 ± 0.076	2.533ArgPhe: 2.533 ± 0.075	2.818ArgGly: 2.818 ± 0.072	1.273ArgHis: 1.273 ± 0.049	3.396ArgIle: 3.396 ± 0.064	2.701ArgLys: 2.701 ± 0.062	5.423ArgLeu: 5.423 ± 0.118	1.162ArgMet: 1.162 ± 0.043	2.192ArgAsn: 2.192 ± 0.057	1.803ArgPro: 1.803 ± 0.054	2.534ArgGln: 2.534 ± 0.073	2.777ArgArg: 2.777 ± 0.077	2.436ArgSer: 2.436 ± 0.058	2.467ArgThr: 2.467 ± 0.066	2.95ArgVal: 2.95 ± 0.086	0.575ArgTrp: 0.575 ± 0.031	1.828ArgTyr: 1.828 ± 0.049	0.0ArgXaa: 0.0 ± 0.0
Ser	5.663SerAla: 5.663 ± 0.125	0.507SerCys: 0.507 ± 0.029	2.958SerAsp: 2.958 ± 0.091	3.196SerGlu: 3.196 ± 0.075	2.471SerPhe: 2.471 ± 0.061	4.611SerGly: 4.611 ± 0.088	1.236SerHis: 1.236 ± 0.043	3.248SerIle: 3.248 ± 0.071	2.715SerLys: 2.715 ± 0.072	5.955SerLeu: 5.955 ± 0.095	1.391SerMet: 1.391 ± 0.045	2.198SerAsn: 2.198 ± 0.081	2.229SerPro: 2.229 ± 0.061	2.3SerGln: 2.3 ± 0.07	2.797SerArg: 2.797 ± 0.071	3.174SerSer: 3.174 ± 0.09	2.743SerThr: 2.743 ± 0.091	4.264SerVal: 4.264 ± 0.082	0.666SerTrp: 0.666 ± 0.037	1.778SerTyr: 1.778 ± 0.056	0.0SerXaa: 0.0 ± 0.0
Thr	5.838ThrAla: 5.838 ± 0.122	0.436ThrCys: 0.436 ± 0.026	3.078ThrAsp: 3.078 ± 0.091	3.511ThrGlu: 3.511 ± 0.089	2.26ThrPhe: 2.26 ± 0.063	4.119ThrGly: 4.119 ± 0.088	1.078ThrHis: 1.078 ± 0.038	3.17ThrIle: 3.17 ± 0.101	2.54ThrLys: 2.54 ± 0.075	5.94ThrLeu: 5.94 ± 0.095	1.065ThrMet: 1.065 ± 0.039	2.018ThrAsn: 2.018 ± 0.157	2.481ThrPro: 2.481 ± 0.063	2.174ThrGln: 2.174 ± 0.057	2.207ThrArg: 2.207 ± 0.056	2.495ThrSer: 2.495 ± 0.086	2.737ThrThr: 2.737 ± 0.098	4.338ThrVal: 4.338 ± 0.126	0.567ThrTrp: 0.567 ± 0.031	1.421ThrTyr: 1.421 ± 0.051	0.0ThrXaa: 0.0 ± 0.0
Val	6.326ValAla: 6.326 ± 0.123	0.73ValCys: 0.73 ± 0.037	3.487ValAsp: 3.487 ± 0.092	4.257ValGlu: 4.257 ± 0.09	2.967ValPhe: 2.967 ± 0.08	4.79ValGly: 4.79 ± 0.095	1.159ValHis: 1.159 ± 0.044	5.035ValIle: 5.035 ± 0.093	4.302ValLys: 4.302 ± 0.095	7.005ValLeu: 7.005 ± 0.123	1.769ValMet: 1.769 ± 0.055	3.294ValAsn: 3.294 ± 0.114	2.769ValPro: 2.769 ± 0.063	2.511ValGln: 2.511 ± 0.057	3.373ValArg: 3.373 ± 0.075	4.271ValSer: 4.271 ± 0.088	3.944ValThr: 3.944 ± 0.119	5.075ValVal: 5.075 ± 0.09	0.684ValTrp: 0.684 ± 0.037	1.935ValTyr: 1.935 ± 0.055	0.0ValXaa: 0.0 ± 0.0
Trp	0.888TrpAla: 0.888 ± 0.037	0.13TrpCys: 0.13 ± 0.016	0.572TrpAsp: 0.572 ± 0.029	0.535TrpGlu: 0.535 ± 0.029	0.591TrpPhe: 0.591 ± 0.031	0.765TrpGly: 0.765 ± 0.038	0.272TrpHis: 0.272 ± 0.02	0.693TrpIle: 0.693 ± 0.035	0.622TrpLys: 0.622 ± 0.036	1.725TrpLeu: 1.725 ± 0.057	0.264TrpMet: 0.264 ± 0.02	0.507TrpAsn: 0.507 ± 0.03	0.176TrpPro: 0.176 ± 0.016	0.888TrpGln: 0.888 ± 0.041	0.668TrpArg: 0.668 ± 0.037	0.569TrpSer: 0.569 ± 0.031	0.56TrpThr: 0.56 ± 0.032	0.767TrpVal: 0.767 ± 0.036	0.18TrpTrp: 0.18 ± 0.017	0.353TrpTyr: 0.353 ± 0.025	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.629TyrAla: 2.629 ± 0.067	0.428TyrCys: 0.428 ± 0.026	1.67TyrAsp: 1.67 ± 0.06	1.483TyrGlu: 1.483 ± 0.051	1.591TyrPhe: 1.591 ± 0.052	2.337TyrGly: 2.337 ± 0.067	0.793TyrHis: 0.793 ± 0.035	1.771TyrIle: 1.771 ± 0.049	1.323TyrLys: 1.323 ± 0.048	3.372TyrLeu: 3.372 ± 0.075	0.573TyrMet: 0.573 ± 0.03	1.221TyrAsn: 1.221 ± 0.044	1.484TyrPro: 1.484 ± 0.046	1.716TyrGln: 1.716 ± 0.05	1.93TyrArg: 1.93 ± 0.055	1.821TyrSer: 1.821 ± 0.054	1.48TyrThr: 1.48 ± 0.049	1.948TyrVal: 1.948 ± 0.053	0.448TyrTrp: 0.448 ± 0.023	1.063TyrTyr: 1.063 ± 0.048	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2077 proteins (677060 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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