Amino acid dipepetide frequency for Porphyromonas sp. COT-290 OH860

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.697AlaAla: 5.697 ± 0.122	0.887AlaCys: 0.887 ± 0.047	4.588AlaAsp: 4.588 ± 0.092	6.024AlaGlu: 6.024 ± 0.138	3.026AlaPhe: 3.026 ± 0.078	5.574AlaGly: 5.574 ± 0.097	1.722AlaHis: 1.722 ± 0.053	5.13AlaIle: 5.13 ± 0.093	4.531AlaLys: 4.531 ± 0.105	9.055AlaLeu: 9.055 ± 0.163	2.163AlaMet: 2.163 ± 0.069	2.889AlaAsn: 2.889 ± 0.073	3.166AlaPro: 3.166 ± 0.088	3.732AlaGln: 3.732 ± 0.077	4.396AlaArg: 4.396 ± 0.089	5.411AlaSer: 5.411 ± 0.104	4.33AlaThr: 4.33 ± 0.091	4.794AlaVal: 4.794 ± 0.094	0.853AlaTrp: 0.853 ± 0.038	3.327AlaTyr: 3.327 ± 0.076	0.0AlaXaa: 0.0 ± 0.0
Cys	0.704CysAla: 0.704 ± 0.033	0.127CysCys: 0.127 ± 0.015	0.488CysAsp: 0.488 ± 0.036	0.45CysGlu: 0.45 ± 0.03	0.38CysPhe: 0.38 ± 0.026	0.785CysGly: 0.785 ± 0.038	0.271CysHis: 0.271 ± 0.025	0.64CysIle: 0.64 ± 0.035	0.42CysLys: 0.42 ± 0.027	1.008CysLeu: 1.008 ± 0.043	0.205CysMet: 0.205 ± 0.017	0.337CysAsn: 0.337 ± 0.025	0.502CysPro: 0.502 ± 0.032	0.377CysGln: 0.377 ± 0.028	0.593CysArg: 0.593 ± 0.031	0.724CysSer: 0.724 ± 0.04	0.474CysThr: 0.474 ± 0.028	0.597CysVal: 0.597 ± 0.035	0.122CysTrp: 0.122 ± 0.014	0.387CysTyr: 0.387 ± 0.026	0.002CysXaa: 0.002 ± 0.002
Asp	4.097AspAla: 4.097 ± 0.072	0.529AspCys: 0.529 ± 0.029	2.238AspAsp: 2.238 ± 0.062	3.892AspGlu: 3.892 ± 0.088	2.504AspPhe: 2.504 ± 0.058	3.728AspGly: 3.728 ± 0.085	1.018AspHis: 1.018 ± 0.042	3.447AspIle: 3.447 ± 0.082	3.128AspLys: 3.128 ± 0.085	5.668AspLeu: 5.668 ± 0.102	1.406AspMet: 1.406 ± 0.056	2.003AspAsn: 2.003 ± 0.06	2.122AspPro: 2.122 ± 0.061	1.639AspGln: 1.639 ± 0.049	3.262AspArg: 3.262 ± 0.08	2.839AspSer: 2.839 ± 0.08	2.563AspThr: 2.563 ± 0.072	3.147AspVal: 3.147 ± 0.081	0.798AspTrp: 0.798 ± 0.039	2.595AspTyr: 2.595 ± 0.078	0.0AspXaa: 0.0 ± 0.0
Glu	6.921GluAla: 6.921 ± 0.144	0.479GluCys: 0.479 ± 0.029	3.312GluAsp: 3.312 ± 0.078	5.105GluGlu: 5.105 ± 0.133	2.107GluPhe: 2.107 ± 0.064	4.773GluGly: 4.773 ± 0.083	1.744GluHis: 1.744 ± 0.058	4.3GluIle: 4.3 ± 0.1	2.955GluLys: 2.955 ± 0.087	7.787GluLeu: 7.787 ± 0.146	1.702GluMet: 1.702 ± 0.051	1.952GluAsn: 1.952 ± 0.055	2.173GluPro: 2.173 ± 0.067	3.887GluGln: 3.887 ± 0.093	4.763GluArg: 4.763 ± 0.092	3.165GluSer: 3.165 ± 0.081	2.358GluThr: 2.358 ± 0.07	4.96GluVal: 4.96 ± 0.103	0.681GluTrp: 0.681 ± 0.038	2.421GluTyr: 2.421 ± 0.066	0.0GluXaa: 0.0 ± 0.0
Phe	3.241PheAla: 3.241 ± 0.087	0.398PheCys: 0.398 ± 0.026	2.598PheAsp: 2.598 ± 0.063	2.125PheGlu: 2.125 ± 0.056	1.81PhePhe: 1.81 ± 0.068	3.214PheGly: 3.214 ± 0.081	0.702PheHis: 0.702 ± 0.037	2.471PheIle: 2.471 ± 0.082	1.625PheLys: 1.625 ± 0.06	3.251PheLeu: 3.251 ± 0.082	0.886PheMet: 0.886 ± 0.039	1.547PheAsn: 1.547 ± 0.058	1.484PhePro: 1.484 ± 0.049	0.858PheGln: 0.858 ± 0.036	2.188PheArg: 2.188 ± 0.058	2.915PheSer: 2.915 ± 0.075	2.16PheThr: 2.16 ± 0.057	3.122PheVal: 3.122 ± 0.076	0.423PheTrp: 0.423 ± 0.028	1.448PheTyr: 1.448 ± 0.05	0.0PheXaa: 0.0 ± 0.0
Gly	5.736GlyAla: 5.736 ± 0.108	0.734GlyCys: 0.734 ± 0.039	3.449GlyAsp: 3.449 ± 0.083	4.631GlyGlu: 4.631 ± 0.079	2.957GlyPhe: 2.957 ± 0.073	5.245GlyGly: 5.245 ± 0.118	1.618GlyHis: 1.618 ± 0.053	4.968GlyIle: 4.968 ± 0.093	4.484GlyLys: 4.484 ± 0.09	7.452GlyLeu: 7.452 ± 0.127	1.877GlyMet: 1.877 ± 0.058	2.618GlyAsn: 2.618 ± 0.083	1.342GlyPro: 1.342 ± 0.048	2.938GlyGln: 2.938 ± 0.074	4.411GlyArg: 4.411 ± 0.104	4.373GlySer: 4.373 ± 0.096	3.599GlyThr: 3.599 ± 0.083	5.245GlyVal: 5.245 ± 0.095	0.927GlyTrp: 0.927 ± 0.047	3.614GlyTyr: 3.614 ± 0.081	0.0GlyXaa: 0.0 ± 0.0
His	1.387HisAla: 1.387 ± 0.048	0.279HisCys: 0.279 ± 0.023	1.005HisAsp: 1.005 ± 0.044	1.193HisGlu: 1.193 ± 0.042	0.925HisPhe: 0.925 ± 0.036	1.472HisGly: 1.472 ± 0.051	0.61HisHis: 0.61 ± 0.043	1.686HisIle: 1.686 ± 0.05	1.104HisLys: 1.104 ± 0.046	2.451HisLeu: 2.451 ± 0.071	0.344HisMet: 0.344 ± 0.025	0.929HisAsn: 0.929 ± 0.044	1.104HisPro: 1.104 ± 0.043	0.922HisGln: 0.922 ± 0.036	1.294HisArg: 1.294 ± 0.053	1.456HisSer: 1.456 ± 0.049	1.201HisThr: 1.201 ± 0.045	1.025HisVal: 1.025 ± 0.041	0.299HisTrp: 0.299 ± 0.022	1.026HisTyr: 1.026 ± 0.044	0.0HisXaa: 0.0 ± 0.0
Ile	5.607IleAla: 5.607 ± 0.119	0.706IleCys: 0.706 ± 0.039	4.206IleAsp: 4.206 ± 0.082	4.495IleGlu: 4.495 ± 0.102	2.345IlePhe: 2.345 ± 0.075	4.621IleGly: 4.621 ± 0.096	1.292IleHis: 1.292 ± 0.044	3.867IleIle: 3.867 ± 0.097	3.591IleLys: 3.591 ± 0.08	5.45IleLeu: 5.45 ± 0.106	1.271IleMet: 1.271 ± 0.053	2.814IleAsn: 2.814 ± 0.07	3.023IlePro: 3.023 ± 0.072	2.006IleGln: 2.006 ± 0.066	3.715IleArg: 3.715 ± 0.08	4.5IleSer: 4.5 ± 0.097	3.325IleThr: 3.325 ± 0.074	4.201IleVal: 4.201 ± 0.091	0.58IleTrp: 0.58 ± 0.034	2.451IleTyr: 2.451 ± 0.065	0.003IleXaa: 0.003 ± 0.002
Lys	4.502LysAla: 4.502 ± 0.097	0.293LysCys: 0.293 ± 0.024	2.77LysAsp: 2.77 ± 0.075	3.684LysGlu: 3.684 ± 0.085	1.565LysPhe: 1.565 ± 0.047	3.575LysGly: 3.575 ± 0.079	1.365LysHis: 1.365 ± 0.055	3.239LysIle: 3.239 ± 0.089	3.234LysLys: 3.234 ± 0.095	5.169LysLeu: 5.169 ± 0.091	1.535LysMet: 1.535 ± 0.055	1.957LysAsn: 1.957 ± 0.061	2.277LysPro: 2.277 ± 0.078	2.348LysGln: 2.348 ± 0.062	3.327LysArg: 3.327 ± 0.08	2.978LysSer: 2.978 ± 0.069	2.975LysThr: 2.975 ± 0.075	3.228LysVal: 3.228 ± 0.078	0.552LysTrp: 0.552 ± 0.034	2.034LysTyr: 2.034 ± 0.058	0.0LysXaa: 0.0 ± 0.0
Leu	8.389LeuAla: 8.389 ± 0.147	1.147LeuCys: 1.147 ± 0.049	5.419LeuAsp: 5.419 ± 0.106	6.915LeuGlu: 6.915 ± 0.136	3.875LeuPhe: 3.875 ± 0.086	7.964LeuGly: 7.964 ± 0.131	2.218LeuHis: 2.218 ± 0.067	5.835LeuIle: 5.835 ± 0.117	5.26LeuLys: 5.26 ± 0.103	10.451LeuLeu: 10.451 ± 0.194	2.714LeuMet: 2.714 ± 0.066	3.642LeuAsn: 3.642 ± 0.085	4.852LeuPro: 4.852 ± 0.095	3.538LeuGln: 3.538 ± 0.087	6.485LeuArg: 6.485 ± 0.105	8.379LeuSer: 8.379 ± 0.161	5.247LeuThr: 5.247 ± 0.097	6.399LeuVal: 6.399 ± 0.128	1.162LeuTrp: 1.162 ± 0.046	3.884LeuTyr: 3.884 ± 0.099	0.0LeuXaa: 0.0 ± 0.0
Met	2.215MetAla: 2.215 ± 0.067	0.198MetCys: 0.198 ± 0.018	1.213MetAsp: 1.213 ± 0.045	1.342MetGlu: 1.342 ± 0.049	0.687MetPhe: 0.687 ± 0.04	1.929MetGly: 1.929 ± 0.066	0.514MetHis: 0.514 ± 0.026	1.56MetIle: 1.56 ± 0.051	1.506MetLys: 1.506 ± 0.052	2.707MetLeu: 2.707 ± 0.068	0.735MetMet: 0.735 ± 0.032	1.168MetAsn: 1.168 ± 0.043	1.32MetPro: 1.32 ± 0.05	1.193MetGln: 1.193 ± 0.046	1.62MetArg: 1.62 ± 0.049	1.722MetSer: 1.722 ± 0.059	1.439MetThr: 1.439 ± 0.047	1.349MetVal: 1.349 ± 0.052	0.193MetTrp: 0.193 ± 0.018	0.686MetTyr: 0.686 ± 0.035	0.0MetXaa: 0.0 ± 0.0
Asn	2.895AsnAla: 2.895 ± 0.073	0.309AsnCys: 0.309 ± 0.026	1.623AsnAsp: 1.623 ± 0.055	2.13AsnGlu: 2.13 ± 0.07	1.489AsnPhe: 1.489 ± 0.051	2.53AsnGly: 2.53 ± 0.084	0.77AsnHis: 0.77 ± 0.034	2.464AsnIle: 2.464 ± 0.064	2.163AsnLys: 2.163 ± 0.058	3.885AsnLeu: 3.885 ± 0.087	0.993AsnMet: 0.993 ± 0.041	1.631AsnAsn: 1.631 ± 0.066	2.289AsnPro: 2.289 ± 0.069	1.466AsnGln: 1.466 ± 0.053	2.16AsnArg: 2.16 ± 0.062	2.062AsnSer: 2.062 ± 0.055	2.033AsnThr: 2.033 ± 0.057	2.281AsnVal: 2.281 ± 0.074	0.511AsnTrp: 0.511 ± 0.032	1.618AsnTyr: 1.618 ± 0.06	0.002AsnXaa: 0.002 ± 0.002
Pro	3.077ProAla: 3.077 ± 0.072	0.306ProCys: 0.306 ± 0.021	2.333ProAsp: 2.333 ± 0.072	3.745ProGlu: 3.745 ± 0.089	1.588ProPhe: 1.588 ± 0.052	2.127ProGly: 2.127 ± 0.059	0.937ProHis: 0.937 ± 0.043	2.928ProIle: 2.928 ± 0.073	2.386ProLys: 2.386 ± 0.065	3.846ProLeu: 3.846 ± 0.091	1.114ProMet: 1.114 ± 0.047	1.858ProAsn: 1.858 ± 0.06	0.978ProPro: 0.978 ± 0.045	1.682ProGln: 1.682 ± 0.062	2.097ProArg: 2.097 ± 0.06	2.94ProSer: 2.94 ± 0.067	2.418ProThr: 2.418 ± 0.058	2.487ProVal: 2.487 ± 0.078	0.522ProTrp: 0.522 ± 0.033	1.697ProTyr: 1.697 ± 0.044	0.0ProXaa: 0.0 ± 0.0
Gln	3.437GlnAla: 3.437 ± 0.067	0.302GlnCys: 0.302 ± 0.024	1.96GlnAsp: 1.96 ± 0.059	2.833GlnGlu: 2.833 ± 0.076	1.274GlnPhe: 1.274 ± 0.048	2.775GlnGly: 2.775 ± 0.062	0.798GlnHis: 0.798 ± 0.038	2.834GlnIle: 2.834 ± 0.082	1.824GlnLys: 1.824 ± 0.071	3.768GlnLeu: 3.768 ± 0.085	1.248GlnMet: 1.248 ± 0.044	1.279GlnAsn: 1.279 ± 0.045	1.514GlnPro: 1.514 ± 0.051	1.644GlnGln: 1.644 ± 0.064	2.335GlnArg: 2.335 ± 0.068	2.405GlnSer: 2.405 ± 0.062	2.547GlnThr: 2.547 ± 0.066	2.443GlnVal: 2.443 ± 0.067	0.506GlnTrp: 0.506 ± 0.034	1.403GlnTyr: 1.403 ± 0.046	0.0GlnXaa: 0.0 ± 0.0
Arg	4.469ArgAla: 4.469 ± 0.095	0.511ArgCys: 0.511 ± 0.034	2.59ArgAsp: 2.59 ± 0.067	4.204ArgGlu: 4.204 ± 0.1	2.34ArgPhe: 2.34 ± 0.061	4.014ArgGly: 4.014 ± 0.083	1.324ArgHis: 1.324 ± 0.046	4.181ArgIle: 4.181 ± 0.07	2.867ArgLys: 2.867 ± 0.075	6.999ArgLeu: 6.999 ± 0.128	1.663ArgMet: 1.663 ± 0.054	2.038ArgAsn: 2.038 ± 0.052	2.414ArgPro: 2.414 ± 0.078	2.35ArgGln: 2.35 ± 0.066	3.604ArgArg: 3.604 ± 0.096	3.72ArgSer: 3.72 ± 0.081	3.092ArgThr: 3.092 ± 0.08	3.522ArgVal: 3.522 ± 0.074	0.788ArgTrp: 0.788 ± 0.037	2.704ArgTyr: 2.704 ± 0.084	0.0ArgXaa: 0.0 ± 0.0
Ser	5.183SerAla: 5.183 ± 0.114	0.678SerCys: 0.678 ± 0.036	3.178SerAsp: 3.178 ± 0.065	3.851SerGlu: 3.851 ± 0.089	2.862SerPhe: 2.862 ± 0.078	5.293SerGly: 5.293 ± 0.106	1.193SerHis: 1.193 ± 0.044	4.305SerIle: 4.305 ± 0.092	3.132SerLys: 3.132 ± 0.082	7.339SerLeu: 7.339 ± 0.127	1.535SerMet: 1.535 ± 0.056	2.224SerAsn: 2.224 ± 0.063	2.831SerPro: 2.831 ± 0.067	2.198SerGln: 2.198 ± 0.064	3.479SerArg: 3.479 ± 0.078	4.54SerSer: 4.54 ± 0.114	3.371SerThr: 3.371 ± 0.079	4.12SerVal: 4.12 ± 0.091	0.876SerTrp: 0.876 ± 0.038	2.828SerTyr: 2.828 ± 0.094	0.0SerXaa: 0.0 ± 0.0
Thr	4.034ThrAla: 4.034 ± 0.096	0.42ThrCys: 0.42 ± 0.026	2.95ThrAsp: 2.95 ± 0.069	3.299ThrGlu: 3.299 ± 0.077	2.181ThrPhe: 2.181 ± 0.061	3.761ThrGly: 3.761 ± 0.07	1.13ThrHis: 1.13 ± 0.042	3.444ThrIle: 3.444 ± 0.078	2.634ThrLys: 2.634 ± 0.07	5.862ThrLeu: 5.862 ± 0.097	1.154ThrMet: 1.154 ± 0.046	1.907ThrAsn: 1.907 ± 0.062	3.077ThrPro: 3.077 ± 0.071	1.879ThrGln: 1.879 ± 0.062	2.347ThrArg: 2.347 ± 0.064	3.538ThrSer: 3.538 ± 0.083	3.008ThrThr: 3.008 ± 0.075	2.958ThrVal: 2.958 ± 0.086	0.529ThrTrp: 0.529 ± 0.031	2.228ThrTyr: 2.228 ± 0.067	0.0ThrXaa: 0.0 ± 0.0
Val	5.634ValAla: 5.634 ± 0.102	0.729ValCys: 0.729 ± 0.035	3.761ValAsp: 3.761 ± 0.086	4.578ValGlu: 4.578 ± 0.086	2.388ValPhe: 2.388 ± 0.066	4.907ValGly: 4.907 ± 0.102	1.236ValHis: 1.236 ± 0.044	3.637ValIle: 3.637 ± 0.081	3.15ValLys: 3.15 ± 0.085	6.179ValLeu: 6.179 ± 0.126	1.544ValMet: 1.544 ± 0.048	2.271ValAsn: 2.271 ± 0.07	2.484ValPro: 2.484 ± 0.071	2.224ValGln: 2.224 ± 0.073	3.746ValArg: 3.746 ± 0.083	3.965ValSer: 3.965 ± 0.084	3.079ValThr: 3.079 ± 0.074	4.682ValVal: 4.682 ± 0.1	0.755ValTrp: 0.755 ± 0.041	2.59ValTyr: 2.59 ± 0.058	0.0ValXaa: 0.0 ± 0.0
Trp	0.902TrpAla: 0.902 ± 0.036	0.136TrpCys: 0.136 ± 0.015	0.618TrpAsp: 0.618 ± 0.033	0.721TrpGlu: 0.721 ± 0.033	0.469TrpPhe: 0.469 ± 0.026	1.031TrpGly: 1.031 ± 0.045	0.317TrpHis: 0.317 ± 0.024	0.64TrpIle: 0.64 ± 0.032	0.451TrpLys: 0.451 ± 0.027	1.284TrpLeu: 1.284 ± 0.048	0.304TrpMet: 0.304 ± 0.024	0.438TrpAsn: 0.438 ± 0.028	0.276TrpPro: 0.276 ± 0.023	0.63TrpGln: 0.63 ± 0.034	0.826TrpArg: 0.826 ± 0.04	0.818TrpSer: 0.818 ± 0.035	0.549TrpThr: 0.549 ± 0.034	0.739TrpVal: 0.739 ± 0.039	0.187TrpTrp: 0.187 ± 0.021	0.446TrpTyr: 0.446 ± 0.031	0.002TrpXaa: 0.002 ± 0.002
Tyr	3.168TyrAla: 3.168 ± 0.073	0.425TyrCys: 0.425 ± 0.027	2.325TyrAsp: 2.325 ± 0.058	2.33TyrGlu: 2.33 ± 0.063	1.691TyrPhe: 1.691 ± 0.054	2.897TyrGly: 2.897 ± 0.083	0.932TyrHis: 0.932 ± 0.039	2.494TyrIle: 2.494 ± 0.066	2.16TyrLys: 2.16 ± 0.057	4.161TyrLeu: 4.161 ± 0.079	0.902TyrMet: 0.902 ± 0.039	1.803TyrAsn: 1.803 ± 0.059	1.838TyrPro: 1.838 ± 0.052	1.616TyrGln: 1.616 ± 0.052	2.745TyrArg: 2.745 ± 0.079	2.567TyrSer: 2.567 ± 0.069	2.57TyrThr: 2.57 ± 0.071	2.243TyrVal: 2.243 ± 0.057	0.519TyrTrp: 0.519 ± 0.031	1.839TyrTyr: 1.839 ± 0.07	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.002XaaAsp: 0.002 ± 0.002	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.002XaaGly: 0.002 ± 0.002	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.002XaaLeu: 0.002 ± 0.002	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.002XaaArg: 0.002 ± 0.002	0.0XaaSer: 0.0 ± 0.0	0.002XaaThr: 0.002 ± 0.002	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1618 proteins (605102 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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