Amino acid dipepetide frequency for Alloactinosynnema sp. L-07

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
20.648AlaAla: 20.648 ± 0.166
1.093AlaCys: 1.093 ± 0.021
9.221AlaAsp: 9.221 ± 0.072
8.483AlaGlu: 8.483 ± 0.078
3.437AlaPhe: 3.437 ± 0.041
12.248AlaGly: 12.248 ± 0.097
2.701AlaHis: 2.701 ± 0.036
4.584AlaIle: 4.584 ± 0.05
3.269AlaLys: 3.269 ± 0.052
13.449AlaLeu: 13.449 ± 0.104
2.792AlaMet: 2.792 ± 0.039
2.532AlaAsn: 2.532 ± 0.039
6.163AlaPro: 6.163 ± 0.073
3.561AlaGln: 3.561 ± 0.046
9.563AlaArg: 9.563 ± 0.08
5.464AlaSer: 5.464 ± 0.052
7.867AlaThr: 7.867 ± 0.072
12.101AlaVal: 12.101 ± 0.097
1.831AlaTrp: 1.831 ± 0.032
2.381AlaTyr: 2.381 ± 0.034
0.0AlaXaa: 0.0 ± 0.0
Cys
1.162CysAla: 1.162 ± 0.024
0.106CysCys: 0.106 ± 0.008
0.517CysAsp: 0.517 ± 0.015
0.396CysGlu: 0.396 ± 0.012
0.22CysPhe: 0.22 ± 0.01
0.989CysGly: 0.989 ± 0.024
0.219CysHis: 0.219 ± 0.009
0.139CysIle: 0.139 ± 0.008
0.124CysLys: 0.124 ± 0.007
0.749CysLeu: 0.749 ± 0.02
0.119CysMet: 0.119 ± 0.008
0.136CysAsn: 0.136 ± 0.008
0.511CysPro: 0.511 ± 0.018
0.226CysGln: 0.226 ± 0.01
0.571CysArg: 0.571 ± 0.017
0.479CysSer: 0.479 ± 0.016
0.477CysThr: 0.477 ± 0.017
0.723CysVal: 0.723 ± 0.018
0.143CysTrp: 0.143 ± 0.008
0.16CysTyr: 0.16 ± 0.009
0.0CysXaa: 0.0 ± 0.0
Asp
7.724AspAla: 7.724 ± 0.075
0.464AspCys: 0.464 ± 0.016
3.926AspAsp: 3.926 ± 0.053
3.836AspGlu: 3.836 ± 0.05
1.699AspPhe: 1.699 ± 0.03
6.371AspGly: 6.371 ± 0.078
1.618AspHis: 1.618 ± 0.025
2.207AspIle: 2.207 ± 0.038
1.34AspLys: 1.34 ± 0.029
7.231AspLeu: 7.231 ± 0.065
0.872AspMet: 0.872 ± 0.02
1.227AspAsn: 1.227 ± 0.025
4.705AspPro: 4.705 ± 0.051
2.034AspGln: 2.034 ± 0.033
5.186AspArg: 5.186 ± 0.055
2.789AspSer: 2.789 ± 0.038
3.533AspThr: 3.533 ± 0.043
5.189AspVal: 5.189 ± 0.051
0.972AspTrp: 0.972 ± 0.02
1.305AspTyr: 1.305 ± 0.027
0.0AspXaa: 0.0 ± 0.0
Glu
5.841GluAla: 5.841 ± 0.058
0.395GluCys: 0.395 ± 0.015
2.508GluAsp: 2.508 ± 0.032
2.348GluGlu: 2.348 ± 0.043
1.73GluPhe: 1.73 ± 0.03
3.277GluGly: 3.277 ± 0.04
1.509GluHis: 1.509 ± 0.026
2.492GluIle: 2.492 ± 0.036
1.122GluLys: 1.122 ± 0.026
6.588GluLeu: 6.588 ± 0.072
0.889GluMet: 0.889 ± 0.017
0.996GluAsn: 0.996 ± 0.022
3.217GluPro: 3.217 ± 0.045
2.071GluGln: 2.071 ± 0.034
4.694GluArg: 4.694 ± 0.048
2.771GluSer: 2.771 ± 0.036
2.72GluThr: 2.72 ± 0.036
4.797GluVal: 4.797 ± 0.053
0.79GluTrp: 0.79 ± 0.02
0.983GluTyr: 0.983 ± 0.027
0.0GluXaa: 0.0 ± 0.0
Phe
3.987PheAla: 3.987 ± 0.041
0.273PheCys: 0.273 ± 0.01
2.27PheAsp: 2.27 ± 0.035
1.392PheGlu: 1.392 ± 0.024
0.826PhePhe: 0.826 ± 0.021
3.168PheGly: 3.168 ± 0.04
0.644PheHis: 0.644 ± 0.016
0.847PheIle: 0.847 ± 0.019
0.508PheLys: 0.508 ± 0.017
2.507PheLeu: 2.507 ± 0.038
0.398PheMet: 0.398 ± 0.015
0.583PheAsn: 0.583 ± 0.018
1.408PhePro: 1.408 ± 0.024
0.707PheGln: 0.707 ± 0.018
1.785PheArg: 1.785 ± 0.029
1.428PheSer: 1.428 ± 0.025
2.108PheThr: 2.108 ± 0.032
2.363PheVal: 2.363 ± 0.033
0.404PheTrp: 0.404 ± 0.016
0.602PheTyr: 0.602 ± 0.016
0.0PheXaa: 0.0 ± 0.0
Gly
10.131GlyAla: 10.131 ± 0.084
0.853GlyCys: 0.853 ± 0.023
5.329GlyAsp: 5.329 ± 0.052
4.608GlyGlu: 4.608 ± 0.047
2.877GlyPhe: 2.877 ± 0.044
8.277GlyGly: 8.277 ± 0.101
2.197GlyHis: 2.197 ± 0.041
3.528GlyIle: 3.528 ± 0.042
2.59GlyLys: 2.59 ± 0.036
8.974GlyLeu: 8.974 ± 0.078
2.008GlyMet: 2.008 ± 0.034
1.881GlyAsn: 1.881 ± 0.047
4.681GlyPro: 4.681 ± 0.057
2.725GlyGln: 2.725 ± 0.038
6.664GlyArg: 6.664 ± 0.065
5.055GlySer: 5.055 ± 0.071
5.844GlyThr: 5.844 ± 0.077
7.927GlyVal: 7.927 ± 0.076
1.677GlyTrp: 1.677 ± 0.031
2.253GlyTyr: 2.253 ± 0.036
0.0GlyXaa: 0.0 ± 0.0
His
2.614HisAla: 2.614 ± 0.04
0.225HisCys: 0.225 ± 0.011
1.373HisAsp: 1.373 ± 0.024
1.078HisGlu: 1.078 ± 0.021
0.595HisPhe: 0.595 ± 0.016
2.304HisGly: 2.304 ± 0.038
0.738HisHis: 0.738 ± 0.019
0.69HisIle: 0.69 ± 0.019
0.372HisLys: 0.372 ± 0.013
2.365HisLeu: 2.365 ± 0.039
0.304HisMet: 0.304 ± 0.011
0.454HisAsn: 0.454 ± 0.016
1.703HisPro: 1.703 ± 0.034
0.708HisGln: 0.708 ± 0.018
2.067HisArg: 2.067 ± 0.033
1.058HisSer: 1.058 ± 0.02
1.299HisThr: 1.299 ± 0.03
1.799HisVal: 1.799 ± 0.029
0.359HisTrp: 0.359 ± 0.013
0.484HisTyr: 0.484 ± 0.014
0.0HisXaa: 0.0 ± 0.0
Ile
5.626IleAla: 5.626 ± 0.057
0.276IleCys: 0.276 ± 0.012
3.061IleAsp: 3.061 ± 0.04
2.352IleGlu: 2.352 ± 0.038
0.755IlePhe: 0.755 ± 0.021
3.882IleGly: 3.882 ± 0.043
0.679IleHis: 0.679 ± 0.019
1.104IleIle: 1.104 ± 0.025
0.855IleLys: 0.855 ± 0.022
2.658IleLeu: 2.658 ± 0.045
0.514IleMet: 0.514 ± 0.017
0.857IleAsn: 0.857 ± 0.023
2.045IlePro: 2.045 ± 0.032
0.844IleGln: 0.844 ± 0.02
2.486IleArg: 2.486 ± 0.037
1.943IleSer: 1.943 ± 0.026
2.78IleThr: 2.78 ± 0.041
3.222IleVal: 3.222 ± 0.039
0.402IleTrp: 0.402 ± 0.014
0.626IleTyr: 0.626 ± 0.019
0.0IleXaa: 0.0 ± 0.0
Lys
2.818LysAla: 2.818 ± 0.036
0.119LysCys: 0.119 ± 0.007
1.125LysAsp: 1.125 ± 0.027
0.93LysGlu: 0.93 ± 0.023
0.59LysPhe: 0.59 ± 0.018
1.565LysGly: 1.565 ± 0.027
0.497LysHis: 0.497 ± 0.014
1.109LysIle: 1.109 ± 0.027
0.615LysLys: 0.615 ± 0.021
2.291LysLeu: 2.291 ± 0.036
0.4LysMet: 0.4 ± 0.013
0.472LysAsn: 0.472 ± 0.016
1.605LysPro: 1.605 ± 0.028
0.68LysGln: 0.68 ± 0.019
1.591LysArg: 1.591 ± 0.03
1.263LysSer: 1.263 ± 0.026
1.329LysThr: 1.329 ± 0.029
2.205LysVal: 2.205 ± 0.041
0.295LysTrp: 0.295 ± 0.011
0.44LysTyr: 0.44 ± 0.016
0.0LysXaa: 0.0 ± 0.0
Leu
15.156LeuAla: 15.156 ± 0.093
0.807LeuCys: 0.807 ± 0.019
7.136LeuAsp: 7.136 ± 0.07
3.927LeuGlu: 3.927 ± 0.05
2.653LeuPhe: 2.653 ± 0.045
8.913LeuGly: 8.913 ± 0.068
2.097LeuHis: 2.097 ± 0.032
3.839LeuIle: 3.839 ± 0.047
1.733LeuLys: 1.733 ± 0.033
10.235LeuLeu: 10.235 ± 0.104
1.519LeuMet: 1.519 ± 0.026
1.82LeuAsn: 1.82 ± 0.034
6.223LeuPro: 6.223 ± 0.056
1.883LeuGln: 1.883 ± 0.032
8.786LeuArg: 8.786 ± 0.08
5.431LeuSer: 5.431 ± 0.053
6.628LeuThr: 6.628 ± 0.055
9.267LeuVal: 9.267 ± 0.087
1.282LeuTrp: 1.282 ± 0.027
1.574LeuTyr: 1.574 ± 0.03
0.0LeuXaa: 0.0 ± 0.0
Met
2.412MetAla: 2.412 ± 0.031
0.133MetCys: 0.133 ± 0.007
0.899MetAsp: 0.899 ± 0.019
0.641MetGlu: 0.641 ± 0.017
0.533MetPhe: 0.533 ± 0.015
1.333MetGly: 1.333 ± 0.029
0.34MetHis: 0.34 ± 0.012
0.86MetIle: 0.86 ± 0.022
0.389MetLys: 0.389 ± 0.014
1.766MetLeu: 1.766 ± 0.027
0.322MetMet: 0.322 ± 0.012
0.45MetAsn: 0.45 ± 0.016
1.091MetPro: 1.091 ± 0.024
0.38MetGln: 0.38 ± 0.012
1.467MetArg: 1.467 ± 0.025
1.354MetSer: 1.354 ± 0.026
1.676MetThr: 1.676 ± 0.028
1.554MetVal: 1.554 ± 0.028
0.201MetTrp: 0.201 ± 0.01
0.26MetTyr: 0.26 ± 0.011
0.0MetXaa: 0.0 ± 0.0
Asn
2.39AsnAla: 2.39 ± 0.037
0.184AsnCys: 0.184 ± 0.008
1.092AsnAsp: 1.092 ± 0.026
0.847AsnGlu: 0.847 ± 0.02
0.533AsnPhe: 0.533 ± 0.016
2.088AsnGly: 2.088 ± 0.04
0.486AsnHis: 0.486 ± 0.015
0.705AsnIle: 0.705 ± 0.02
0.466AsnLys: 0.466 ± 0.015
1.965AsnLeu: 1.965 ± 0.034
0.295AsnMet: 0.295 ± 0.011
0.559AsnAsn: 0.559 ± 0.025
1.674AsnPro: 1.674 ± 0.035
0.601AsnGln: 0.601 ± 0.021
1.531AsnArg: 1.531 ± 0.029
1.055AsnSer: 1.055 ± 0.024
1.253AsnThr: 1.253 ± 0.028
1.525AsnVal: 1.525 ± 0.031
0.302AsnTrp: 0.302 ± 0.013
0.447AsnTyr: 0.447 ± 0.017
0.0AsnXaa: 0.0 ± 0.0
Pro
7.879ProAla: 7.879 ± 0.081
0.392ProCys: 0.392 ± 0.014
4.686ProAsp: 4.686 ± 0.062
3.568ProGlu: 3.568 ± 0.047
1.586ProPhe: 1.586 ± 0.027
5.943ProGly: 5.943 ± 0.062
1.238ProHis: 1.238 ± 0.023
1.937ProIle: 1.937 ± 0.031
1.283ProLys: 1.283 ± 0.028
4.896ProLeu: 4.896 ± 0.052
1.144ProMet: 1.144 ± 0.022
1.29ProAsn: 1.29 ± 0.026
3.479ProPro: 3.479 ± 0.061
1.515ProGln: 1.515 ± 0.03
3.834ProArg: 3.834 ± 0.047
3.182ProSer: 3.182 ± 0.038
3.986ProThr: 3.986 ± 0.058
5.27ProVal: 5.27 ± 0.052
0.912ProTrp: 0.912 ± 0.024
1.034ProTyr: 1.034 ± 0.022
0.0ProXaa: 0.0 ± 0.0
Gln
3.713GlnAla: 3.713 ± 0.052
0.195GlnCys: 0.195 ± 0.011
1.303GlnAsp: 1.303 ± 0.022
1.108GlnGlu: 1.108 ± 0.026
0.751GlnPhe: 0.751 ± 0.02
2.005GlnGly: 2.005 ± 0.038
0.645GlnHis: 0.645 ± 0.017
1.106GlnIle: 1.106 ± 0.022
0.541GlnLys: 0.541 ± 0.018
2.924GlnLeu: 2.924 ± 0.039
0.434GlnMet: 0.434 ± 0.014
0.495GlnAsn: 0.495 ± 0.015
1.833GlnPro: 1.833 ± 0.038
1.105GlnGln: 1.105 ± 0.032
2.491GlnArg: 2.491 ± 0.034
1.312GlnSer: 1.312 ± 0.027
1.489GlnThr: 1.489 ± 0.027
2.768GlnVal: 2.768 ± 0.032
0.476GlnTrp: 0.476 ± 0.014
0.532GlnTyr: 0.532 ± 0.017
0.0GlnXaa: 0.0 ± 0.0
Arg
9.689ArgAla: 9.689 ± 0.082
0.636ArgCys: 0.636 ± 0.019
4.519ArgAsp: 4.519 ± 0.051
4.101ArgGlu: 4.101 ± 0.044
2.483ArgPhe: 2.483 ± 0.039
5.659ArgGly: 5.659 ± 0.056
1.948ArgHis: 1.948 ± 0.031
3.081ArgIle: 3.081 ± 0.038
1.792ArgLys: 1.792 ± 0.033
8.281ArgLeu: 8.281 ± 0.069
1.862ArgMet: 1.862 ± 0.031
1.383ArgAsn: 1.383 ± 0.031
4.58ArgPro: 4.58 ± 0.053
2.23ArgGln: 2.23 ± 0.035
6.986ArgArg: 6.986 ± 0.079
3.998ArgSer: 3.998 ± 0.048
4.952ArgThr: 4.952 ± 0.055
6.319ArgVal: 6.319 ± 0.054
1.455ArgTrp: 1.455 ± 0.03
1.74ArgTyr: 1.74 ± 0.027
0.0ArgXaa: 0.0 ± 0.0
Ser
6.905SerAla: 6.905 ± 0.062
0.431SerCys: 0.431 ± 0.015
2.902SerAsp: 2.902 ± 0.037
2.245SerGlu: 2.245 ± 0.035
1.528SerPhe: 1.528 ± 0.026
5.642SerGly: 5.642 ± 0.069
0.999SerHis: 0.999 ± 0.021
1.872SerIle: 1.872 ± 0.034
1.055SerLys: 1.055 ± 0.024
4.663SerLeu: 4.663 ± 0.046
1.155SerMet: 1.155 ± 0.023
1.011SerAsn: 1.011 ± 0.023
3.104SerPro: 3.104 ± 0.039
1.265SerGln: 1.265 ± 0.024
3.667SerArg: 3.667 ± 0.048
2.792SerSer: 2.792 ± 0.05
3.604SerThr: 3.604 ± 0.045
4.53SerVal: 4.53 ± 0.048
0.927SerTrp: 0.927 ± 0.025
1.096SerTyr: 1.096 ± 0.022
0.0SerXaa: 0.0 ± 0.0
Thr
8.703ThrAla: 8.703 ± 0.077
0.485ThrCys: 0.485 ± 0.014
3.943ThrAsp: 3.943 ± 0.049
3.242ThrGlu: 3.242 ± 0.043
1.792ThrPhe: 1.792 ± 0.032
6.345ThrGly: 6.345 ± 0.065
1.255ThrHis: 1.255 ± 0.025
2.272ThrIle: 2.272 ± 0.033
1.436ThrLys: 1.436 ± 0.025
5.831ThrLeu: 5.831 ± 0.055
1.109ThrMet: 1.109 ± 0.024
1.239ThrAsn: 1.239 ± 0.027
4.097ThrPro: 4.097 ± 0.046
1.489ThrGln: 1.489 ± 0.028
4.21ThrArg: 4.21 ± 0.051
3.462ThrSer: 3.462 ± 0.048
4.703ThrThr: 4.703 ± 0.107
6.355ThrVal: 6.355 ± 0.068
1.044ThrTrp: 1.044 ± 0.025
1.337ThrTyr: 1.337 ± 0.038
0.0ThrXaa: 0.0 ± 0.0
Val
12.025ValAla: 12.025 ± 0.098
0.748ValCys: 0.748 ± 0.018
6.301ValAsp: 6.301 ± 0.059
5.009ValGlu: 5.009 ± 0.056
2.46ValPhe: 2.46 ± 0.034
7.222ValGly: 7.222 ± 0.064
1.968ValHis: 1.968 ± 0.035
3.491ValIle: 3.491 ± 0.047
1.773ValLys: 1.773 ± 0.032
9.507ValLeu: 9.507 ± 0.074
1.379ValMet: 1.379 ± 0.026
1.862ValAsn: 1.862 ± 0.038
5.021ValPro: 5.021 ± 0.053
1.956ValGln: 1.956 ± 0.027
6.889ValArg: 6.889 ± 0.062
4.614ValSer: 4.614 ± 0.05
5.821ValThr: 5.821 ± 0.058
8.677ValVal: 8.677 ± 0.084
1.119ValTrp: 1.119 ± 0.021
1.47ValTyr: 1.47 ± 0.029
0.0ValXaa: 0.0 ± 0.0
Trp
1.656TrpAla: 1.656 ± 0.029
0.171TrpCys: 0.171 ± 0.009
0.795TrpAsp: 0.795 ± 0.019
0.637TrpGlu: 0.637 ± 0.02
0.544TrpPhe: 0.544 ± 0.016
1.004TrpGly: 1.004 ± 0.023
0.405TrpHis: 0.405 ± 0.014
0.611TrpIle: 0.611 ± 0.017
0.336TrpLys: 0.336 ± 0.013
1.803TrpLeu: 1.803 ± 0.033
0.322TrpMet: 0.322 ± 0.012
0.36TrpAsn: 0.36 ± 0.014
0.812TrpPro: 0.812 ± 0.02
0.576TrpGln: 0.576 ± 0.017
1.436TrpArg: 1.436 ± 0.027
0.963TrpSer: 0.963 ± 0.026
1.078TrpThr: 1.078 ± 0.019
1.127TrpVal: 1.127 ± 0.024
0.361TrpTrp: 0.361 ± 0.015
0.278TrpTyr: 0.278 ± 0.01
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.309TyrAla: 2.309 ± 0.032
0.18TyrCys: 0.18 ± 0.011
1.323TyrAsp: 1.323 ± 0.037
0.99TyrGlu: 0.99 ± 0.023
0.615TyrPhe: 0.615 ± 0.017
1.845TyrGly: 1.845 ± 0.031
0.405TyrHis: 0.405 ± 0.013
0.492TyrIle: 0.492 ± 0.016
0.34TyrLys: 0.34 ± 0.013
2.229TyrLeu: 2.229 ± 0.035
0.224TyrMet: 0.224 ± 0.01
0.392TyrAsn: 0.392 ± 0.015
1.099TyrPro: 1.099 ± 0.024
0.67TyrGln: 0.67 ± 0.018
1.789TyrArg: 1.789 ± 0.028
0.983TyrSer: 0.983 ± 0.025
1.201TyrThr: 1.201 ± 0.026
1.592TyrVal: 1.592 ± 0.031
0.323TyrTrp: 0.323 ± 0.011
0.43TyrTyr: 0.43 ± 0.013
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7267 proteins (2223605 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski