Amino acid dipepetide frequency for Rhizobium yanglingense

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.643AlaAla: 14.643 ± 0.227
1.438AlaCys: 1.438 ± 0.048
6.189AlaAsp: 6.189 ± 0.102
6.718AlaGlu: 6.718 ± 0.107
4.373AlaPhe: 4.373 ± 0.086
8.966AlaGly: 8.966 ± 0.14
2.161AlaHis: 2.161 ± 0.062
6.446AlaIle: 6.446 ± 0.112
4.315AlaLys: 4.315 ± 0.095
11.066AlaLeu: 11.066 ± 0.148
3.373AlaMet: 3.373 ± 0.076
2.985AlaAsn: 2.985 ± 0.08
4.864AlaPro: 4.864 ± 0.088
3.418AlaGln: 3.418 ± 0.073
8.437AlaArg: 8.437 ± 0.122
7.157AlaSer: 7.157 ± 0.113
5.433AlaThr: 5.433 ± 0.1
8.01AlaVal: 8.01 ± 0.12
1.419AlaTrp: 1.419 ± 0.054
2.263AlaTyr: 2.263 ± 0.059
0.0AlaXaa: 0.0 ± 0.0
Cys
1.324CysAla: 1.324 ± 0.042
0.329CysCys: 0.329 ± 0.024
0.688CysAsp: 0.688 ± 0.034
0.608CysGlu: 0.608 ± 0.027
0.508CysPhe: 0.508 ± 0.03
1.236CysGly: 1.236 ± 0.044
0.394CysHis: 0.394 ± 0.027
0.585CysIle: 0.585 ± 0.029
0.361CysLys: 0.361 ± 0.025
1.138CysLeu: 1.138 ± 0.044
0.33CysMet: 0.33 ± 0.022
0.292CysAsn: 0.292 ± 0.022
0.664CysPro: 0.664 ± 0.032
0.428CysGln: 0.428 ± 0.028
1.486CysArg: 1.486 ± 0.054
0.946CysSer: 0.946 ± 0.038
0.452CysThr: 0.452 ± 0.026
0.733CysVal: 0.733 ± 0.036
0.234CysTrp: 0.234 ± 0.021
0.236CysTyr: 0.236 ± 0.02
0.0CysXaa: 0.0 ± 0.0
Asp
6.098AspAla: 6.098 ± 0.103
0.636AspCys: 0.636 ± 0.036
3.498AspAsp: 3.498 ± 0.09
3.65AspGlu: 3.65 ± 0.078
2.153AspPhe: 2.153 ± 0.056
4.936AspGly: 4.936 ± 0.091
1.322AspHis: 1.322 ± 0.055
3.102AspIle: 3.102 ± 0.081
1.723AspLys: 1.723 ± 0.055
5.53AspLeu: 5.53 ± 0.103
1.241AspMet: 1.241 ± 0.047
1.369AspAsn: 1.369 ± 0.049
3.046AspPro: 3.046 ± 0.065
1.807AspGln: 1.807 ± 0.062
4.78AspArg: 4.78 ± 0.08
2.089AspSer: 2.089 ± 0.062
2.296AspThr: 2.296 ± 0.067
3.689AspVal: 3.689 ± 0.076
0.811AspTrp: 0.811 ± 0.039
1.23AspTyr: 1.23 ± 0.042
0.0AspXaa: 0.0 ± 0.0
Glu
6.818GluAla: 6.818 ± 0.116
0.516GluCys: 0.516 ± 0.031
2.796GluAsp: 2.796 ± 0.07
3.434GluGlu: 3.434 ± 0.07
2.004GluPhe: 2.004 ± 0.067
3.916GluGly: 3.916 ± 0.069
1.35GluHis: 1.35 ± 0.053
3.724GluIle: 3.724 ± 0.082
2.68GluLys: 2.68 ± 0.078
5.344GluLeu: 5.344 ± 0.095
1.563GluMet: 1.563 ± 0.047
1.872GluAsn: 1.872 ± 0.054
2.72GluPro: 2.72 ± 0.068
2.196GluGln: 2.196 ± 0.063
5.195GluArg: 5.195 ± 0.099
2.422GluSer: 2.422 ± 0.067
3.365GluThr: 3.365 ± 0.081
3.53GluVal: 3.53 ± 0.073
0.64GluTrp: 0.64 ± 0.038
1.047GluTyr: 1.047 ± 0.042
0.0GluXaa: 0.0 ± 0.0
Phe
4.275PheAla: 4.275 ± 0.083
0.567PheCys: 0.567 ± 0.031
2.605PheAsp: 2.605 ± 0.058
2.31PheGlu: 2.31 ± 0.053
1.524PhePhe: 1.524 ± 0.054
3.48PheGly: 3.48 ± 0.077
0.886PheHis: 0.886 ± 0.04
1.786PheIle: 1.786 ± 0.053
1.127PheLys: 1.127 ± 0.041
3.371PheLeu: 3.371 ± 0.082
0.821PheMet: 0.821 ± 0.034
1.076PheAsn: 1.076 ± 0.043
1.717PhePro: 1.717 ± 0.054
1.101PheGln: 1.101 ± 0.044
2.937PheArg: 2.937 ± 0.071
2.624PheSer: 2.624 ± 0.067
1.944PheThr: 1.944 ± 0.056
2.695PheVal: 2.695 ± 0.068
0.5PheTrp: 0.5 ± 0.03
0.87PheTyr: 0.87 ± 0.042
0.0PheXaa: 0.0 ± 0.0
Gly
7.534GlyAla: 7.534 ± 0.117
1.106GlyCys: 1.106 ± 0.042
4.014GlyAsp: 4.014 ± 0.082
4.466GlyGlu: 4.466 ± 0.085
3.321GlyPhe: 3.321 ± 0.077
5.484GlyGly: 5.484 ± 0.107
1.755GlyHis: 1.755 ± 0.051
4.269GlyIle: 4.269 ± 0.088
3.722GlyLys: 3.722 ± 0.084
7.326GlyLeu: 7.326 ± 0.109
2.066GlyMet: 2.066 ± 0.055
2.31GlyAsn: 2.31 ± 0.062
2.94GlyPro: 2.94 ± 0.062
2.635GlyGln: 2.635 ± 0.059
6.329GlyArg: 6.329 ± 0.109
4.737GlySer: 4.737 ± 0.096
3.82GlyThr: 3.82 ± 0.08
4.944GlyVal: 4.944 ± 0.092
1.151GlyTrp: 1.151 ± 0.046
1.933GlyTyr: 1.933 ± 0.058
0.0GlyXaa: 0.0 ± 0.0
His
2.299HisAla: 2.299 ± 0.061
0.33HisCys: 0.33 ± 0.022
1.326HisAsp: 1.326 ± 0.043
1.204HisGlu: 1.204 ± 0.044
0.954HisPhe: 0.954 ± 0.038
1.9HisGly: 1.9 ± 0.059
0.726HisHis: 0.726 ± 0.042
1.02HisIle: 1.02 ± 0.046
0.579HisLys: 0.579 ± 0.032
2.206HisLeu: 2.206 ± 0.066
0.575HisMet: 0.575 ± 0.03
0.487HisAsn: 0.487 ± 0.028
1.281HisPro: 1.281 ± 0.044
0.793HisGln: 0.793 ± 0.036
1.983HisArg: 1.983 ± 0.062
1.225HisSer: 1.225 ± 0.047
0.888HisThr: 0.888 ± 0.039
1.532HisVal: 1.532 ± 0.054
0.313HisTrp: 0.313 ± 0.026
0.51HisTyr: 0.51 ± 0.024
0.0HisXaa: 0.0 ± 0.0
Ile
6.925IleAla: 6.925 ± 0.104
0.785IleCys: 0.785 ± 0.036
3.693IleAsp: 3.693 ± 0.082
3.745IleGlu: 3.745 ± 0.086
1.906IlePhe: 1.906 ± 0.06
4.812IleGly: 4.812 ± 0.099
0.975IleHis: 0.975 ± 0.036
2.413IleIle: 2.413 ± 0.071
1.784IleLys: 1.784 ± 0.054
4.362IleLeu: 4.362 ± 0.087
1.154IleMet: 1.154 ± 0.043
1.475IleAsn: 1.475 ± 0.053
2.344IlePro: 2.344 ± 0.066
1.42IleGln: 1.42 ± 0.046
3.923IleArg: 3.923 ± 0.082
3.68IleSer: 3.68 ± 0.073
2.445IleThr: 2.445 ± 0.076
4.128IleVal: 4.128 ± 0.079
0.736IleTrp: 0.736 ± 0.036
1.01IleTyr: 1.01 ± 0.046
0.0IleXaa: 0.0 ± 0.0
Lys
4.641LysAla: 4.641 ± 0.089
0.34LysCys: 0.34 ± 0.023
1.925LysAsp: 1.925 ± 0.064
1.944LysGlu: 1.944 ± 0.063
1.061LysPhe: 1.061 ± 0.042
2.754LysGly: 2.754 ± 0.078
0.755LysHis: 0.755 ± 0.031
2.053LysIle: 2.053 ± 0.056
1.68LysLys: 1.68 ± 0.063
3.773LysLeu: 3.773 ± 0.075
0.997LysMet: 0.997 ± 0.042
1.032LysAsn: 1.032 ± 0.045
2.336LysPro: 2.336 ± 0.068
1.202LysGln: 1.202 ± 0.049
3.267LysArg: 3.267 ± 0.072
2.462LysSer: 2.462 ± 0.068
2.353LysThr: 2.353 ± 0.064
2.518LysVal: 2.518 ± 0.069
0.43LysTrp: 0.43 ± 0.027
0.715LysTyr: 0.715 ± 0.035
0.0LysXaa: 0.0 ± 0.0
Leu
11.527LeuAla: 11.527 ± 0.173
1.199LeuCys: 1.199 ± 0.043
5.461LeuAsp: 5.461 ± 0.091
5.144LeuGlu: 5.144 ± 0.091
3.539LeuPhe: 3.539 ± 0.077
6.827LeuGly: 6.827 ± 0.093
1.928LeuHis: 1.928 ± 0.059
4.719LeuIle: 4.719 ± 0.098
3.854LeuLys: 3.854 ± 0.086
8.377LeuLeu: 8.377 ± 0.125
2.164LeuMet: 2.164 ± 0.066
2.544LeuAsn: 2.544 ± 0.075
5.356LeuPro: 5.356 ± 0.083
3.174LeuGln: 3.174 ± 0.077
7.316LeuArg: 7.316 ± 0.127
6.681LeuSer: 6.681 ± 0.1
5.014LeuThr: 5.014 ± 0.096
6.66LeuVal: 6.66 ± 0.107
1.096LeuTrp: 1.096 ± 0.043
1.8LeuTyr: 1.8 ± 0.044
0.0LeuXaa: 0.0 ± 0.0
Met
3.041MetAla: 3.041 ± 0.077
0.2MetCys: 0.2 ± 0.018
1.138MetAsp: 1.138 ± 0.037
1.305MetGlu: 1.305 ± 0.05
0.829MetPhe: 0.829 ± 0.041
1.552MetGly: 1.552 ± 0.047
0.508MetHis: 0.508 ± 0.028
1.54MetIle: 1.54 ± 0.048
1.34MetLys: 1.34 ± 0.049
2.568MetLeu: 2.568 ± 0.061
0.662MetMet: 0.662 ± 0.041
0.923MetAsn: 0.923 ± 0.039
1.672MetPro: 1.672 ± 0.055
0.915MetGln: 0.915 ± 0.042
2.246MetArg: 2.246 ± 0.065
1.876MetSer: 1.876 ± 0.061
1.943MetThr: 1.943 ± 0.055
1.661MetVal: 1.661 ± 0.05
0.226MetTrp: 0.226 ± 0.019
0.313MetTyr: 0.313 ± 0.022
0.0MetXaa: 0.0 ± 0.0
Asn
3.209AsnAla: 3.209 ± 0.072
0.386AsnCys: 0.386 ± 0.022
1.601AsnAsp: 1.601 ± 0.055
1.486AsnGlu: 1.486 ± 0.051
1.056AsnPhe: 1.056 ± 0.041
2.501AsnGly: 2.501 ± 0.062
0.611AsnHis: 0.611 ± 0.03
1.407AsnIle: 1.407 ± 0.051
0.811AsnLys: 0.811 ± 0.04
2.637AsnLeu: 2.637 ± 0.064
0.709AsnMet: 0.709 ± 0.035
0.819AsnAsn: 0.819 ± 0.041
1.752AsnPro: 1.752 ± 0.052
0.877AsnGln: 0.877 ± 0.036
2.233AsnArg: 2.233 ± 0.055
1.638AsnSer: 1.638 ± 0.056
1.286AsnThr: 1.286 ± 0.044
1.789AsnVal: 1.789 ± 0.062
0.457AsnTrp: 0.457 ± 0.027
0.648AsnTyr: 0.648 ± 0.038
0.0AsnXaa: 0.0 ± 0.0
Pro
5.987ProAla: 5.987 ± 0.114
0.608ProCys: 0.608 ± 0.032
3.22ProAsp: 3.22 ± 0.082
3.254ProGlu: 3.254 ± 0.085
1.96ProPhe: 1.96 ± 0.054
3.89ProGly: 3.89 ± 0.078
1.063ProHis: 1.063 ± 0.044
2.496ProIle: 2.496 ± 0.067
1.89ProLys: 1.89 ± 0.053
4.318ProLeu: 4.318 ± 0.081
1.428ProMet: 1.428 ± 0.048
1.403ProAsn: 1.403 ± 0.043
2.69ProPro: 2.69 ± 0.073
1.733ProGln: 1.733 ± 0.058
3.554ProArg: 3.554 ± 0.083
3.81ProSer: 3.81 ± 0.081
2.528ProThr: 2.528 ± 0.074
3.866ProVal: 3.866 ± 0.089
0.632ProTrp: 0.632 ± 0.036
1.064ProTyr: 1.064 ± 0.044
0.0ProXaa: 0.0 ± 0.0
Gln
3.823GlnAla: 3.823 ± 0.088
0.402GlnCys: 0.402 ± 0.025
1.414GlnAsp: 1.414 ± 0.049
1.714GlnGlu: 1.714 ± 0.044
1.169GlnPhe: 1.169 ± 0.038
2.061GlnGly: 2.061 ± 0.06
0.816GlnHis: 0.816 ± 0.037
1.977GlnIle: 1.977 ± 0.057
1.353GlnLys: 1.353 ± 0.049
3.031GlnLeu: 3.031 ± 0.079
0.971GlnMet: 0.971 ± 0.039
1.028GlnAsn: 1.028 ± 0.035
1.916GlnPro: 1.916 ± 0.059
1.507GlnGln: 1.507 ± 0.053
2.905GlnArg: 2.905 ± 0.066
2.113GlnSer: 2.113 ± 0.066
1.834GlnThr: 1.834 ± 0.057
2.061GlnVal: 2.061 ± 0.067
0.463GlnTrp: 0.463 ± 0.028
0.673GlnTyr: 0.673 ± 0.032
0.0GlnXaa: 0.0 ± 0.0
Arg
7.642ArgAla: 7.642 ± 0.125
1.221ArgCys: 1.221 ± 0.046
3.959ArgAsp: 3.959 ± 0.075
4.051ArgGlu: 4.051 ± 0.094
3.305ArgPhe: 3.305 ± 0.071
4.694ArgGly: 4.694 ± 0.091
2.462ArgHis: 2.462 ± 0.072
4.32ArgIle: 4.32 ± 0.086
3.366ArgLys: 3.366 ± 0.074
8.49ArgLeu: 8.49 ± 0.132
2.504ArgMet: 2.504 ± 0.064
2.555ArgAsn: 2.555 ± 0.067
4.601ArgPro: 4.601 ± 0.098
3.438ArgGln: 3.438 ± 0.083
8.408ArgArg: 8.408 ± 0.126
5.942ArgSer: 5.942 ± 0.102
3.943ArgThr: 3.943 ± 0.082
4.375ArgVal: 4.375 ± 0.077
1.273ArgTrp: 1.273 ± 0.048
1.808ArgTyr: 1.808 ± 0.057
0.0ArgXaa: 0.0 ± 0.0
Ser
7.064SerAla: 7.064 ± 0.112
0.936SerCys: 0.936 ± 0.041
3.209SerAsp: 3.209 ± 0.07
3.184SerGlu: 3.184 ± 0.07
2.582SerPhe: 2.582 ± 0.056
5.493SerGly: 5.493 ± 0.103
1.185SerHis: 1.185 ± 0.038
3.403SerIle: 3.403 ± 0.076
2.164SerLys: 2.164 ± 0.061
5.947SerLeu: 5.947 ± 0.098
2.009SerMet: 2.009 ± 0.059
1.691SerAsn: 1.691 ± 0.057
3.483SerPro: 3.483 ± 0.083
1.97SerGln: 1.97 ± 0.052
5.558SerArg: 5.558 ± 0.09
5.07SerSer: 5.07 ± 0.111
3.419SerThr: 3.419 ± 0.087
4.158SerVal: 4.158 ± 0.08
0.933SerTrp: 0.933 ± 0.042
1.339SerTyr: 1.339 ± 0.047
0.0SerXaa: 0.0 ± 0.0
Thr
5.958ThrAla: 5.958 ± 0.112
0.736ThrCys: 0.736 ± 0.034
2.677ThrAsp: 2.677 ± 0.073
2.695ThrGlu: 2.695 ± 0.073
1.933ThrPhe: 1.933 ± 0.056
4.299ThrGly: 4.299 ± 0.089
0.949ThrHis: 0.949 ± 0.043
3.113ThrIle: 3.113 ± 0.07
1.69ThrLys: 1.69 ± 0.054
4.982ThrLeu: 4.982 ± 0.085
1.35ThrMet: 1.35 ± 0.05
1.327ThrAsn: 1.327 ± 0.045
2.815ThrPro: 2.815 ± 0.074
1.332ThrGln: 1.332 ± 0.052
3.531ThrArg: 3.531 ± 0.079
3.461ThrSer: 3.461 ± 0.074
2.687ThrThr: 2.687 ± 0.074
3.822ThrVal: 3.822 ± 0.071
0.665ThrTrp: 0.665 ± 0.038
1.084ThrTyr: 1.084 ± 0.038
0.0ThrXaa: 0.0 ± 0.0
Val
7.672ValAla: 7.672 ± 0.113
0.811ValCys: 0.811 ± 0.036
3.844ValAsp: 3.844 ± 0.085
4.504ValGlu: 4.504 ± 0.074
2.611ValPhe: 2.611 ± 0.071
4.737ValGly: 4.737 ± 0.09
1.414ValHis: 1.414 ± 0.039
3.636ValIle: 3.636 ± 0.085
2.504ValLys: 2.504 ± 0.065
6.382ValLeu: 6.382 ± 0.098
1.701ValMet: 1.701 ± 0.057
1.763ValAsn: 1.763 ± 0.052
3.321ValPro: 3.321 ± 0.069
1.994ValGln: 1.994 ± 0.066
4.923ValArg: 4.923 ± 0.087
4.623ValSer: 4.623 ± 0.094
3.749ValThr: 3.749 ± 0.076
5.147ValVal: 5.147 ± 0.108
0.776ValTrp: 0.776 ± 0.041
1.335ValTyr: 1.335 ± 0.048
0.0ValXaa: 0.0 ± 0.0
Trp
1.04TrpAla: 1.04 ± 0.041
0.159TrpCys: 0.159 ± 0.014
0.551TrpAsp: 0.551 ± 0.03
0.559TrpGlu: 0.559 ± 0.029
0.531TrpPhe: 0.531 ± 0.029
0.689TrpGly: 0.689 ± 0.036
0.401TrpHis: 0.401 ± 0.024
0.712TrpIle: 0.712 ± 0.037
0.593TrpLys: 0.593 ± 0.03
1.422TrpLeu: 1.422 ± 0.054
0.418TrpMet: 0.418 ± 0.028
0.473TrpAsn: 0.473 ± 0.029
0.824TrpPro: 0.824 ± 0.037
0.558TrpGln: 0.558 ± 0.031
1.369TrpArg: 1.369 ± 0.044
1.021TrpSer: 1.021 ± 0.041
0.806TrpThr: 0.806 ± 0.037
0.697TrpVal: 0.697 ± 0.035
0.234TrpTrp: 0.234 ± 0.017
0.239TrpTyr: 0.239 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.151TyrAla: 2.151 ± 0.056
0.263TyrCys: 0.263 ± 0.021
1.196TyrAsp: 1.196 ± 0.048
1.157TyrGlu: 1.157 ± 0.042
0.896TyrPhe: 0.896 ± 0.04
1.635TyrGly: 1.635 ± 0.055
0.468TyrHis: 0.468 ± 0.027
0.994TyrIle: 0.994 ± 0.04
0.704TyrLys: 0.704 ± 0.035
2.113TyrLeu: 2.113 ± 0.054
0.42TyrMet: 0.42 ± 0.025
0.489TyrAsn: 0.489 ± 0.029
1.056TyrPro: 1.056 ± 0.041
0.731TyrGln: 0.731 ± 0.038
1.98TyrArg: 1.98 ± 0.053
1.22TyrSer: 1.22 ± 0.048
0.901TyrThr: 0.901 ± 0.038
1.433TyrVal: 1.433 ± 0.05
0.309TyrTrp: 0.309 ± 0.026
0.559TyrTyr: 0.559 ± 0.032
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4086 proteins (623830 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski