Amino acid dipepetide frequency for Acinetobacter phage Ab105-2phi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.0AlaAla: 7.0 ± 1.304
0.547AlaCys: 0.547 ± 0.212
4.593AlaAsp: 4.593 ± 0.532
6.289AlaGlu: 6.289 ± 0.689
2.734AlaPhe: 2.734 ± 0.383
4.539AlaGly: 4.539 ± 0.542
1.422AlaHis: 1.422 ± 0.281
5.906AlaIle: 5.906 ± 0.585
7.273AlaLys: 7.273 ± 1.045
8.749AlaLeu: 8.749 ± 0.785
2.625AlaMet: 2.625 ± 0.396
3.828AlaAsn: 3.828 ± 0.467
1.586AlaPro: 1.586 ± 0.309
4.812AlaGln: 4.812 ± 1.108
3.773AlaArg: 3.773 ± 0.437
4.757AlaSer: 4.757 ± 0.593
4.484AlaThr: 4.484 ± 0.773
5.796AlaVal: 5.796 ± 0.532
0.875AlaTrp: 0.875 ± 0.167
2.789AlaTyr: 2.789 ± 0.353
0.0AlaXaa: 0.0 ± 0.0
Cys
0.766CysAla: 0.766 ± 0.245
0.219CysCys: 0.219 ± 0.116
0.383CysAsp: 0.383 ± 0.147
1.039CysGlu: 1.039 ± 0.265
0.437CysPhe: 0.437 ± 0.149
0.93CysGly: 0.93 ± 0.278
0.109CysHis: 0.109 ± 0.075
0.711CysIle: 0.711 ± 0.188
0.875CysLys: 0.875 ± 0.226
0.656CysLeu: 0.656 ± 0.202
0.164CysMet: 0.164 ± 0.101
0.273CysAsn: 0.273 ± 0.126
0.273CysPro: 0.273 ± 0.14
0.328CysGln: 0.328 ± 0.147
0.273CysArg: 0.273 ± 0.126
0.602CysSer: 0.602 ± 0.214
0.602CysThr: 0.602 ± 0.207
0.437CysVal: 0.437 ± 0.139
0.055CysTrp: 0.055 ± 0.056
0.273CysTyr: 0.273 ± 0.108
0.0CysXaa: 0.0 ± 0.0
Asp
4.593AspAla: 4.593 ± 0.431
0.656AspCys: 0.656 ± 0.238
3.992AspAsp: 3.992 ± 0.65
4.101AspGlu: 4.101 ± 0.467
2.515AspPhe: 2.515 ± 0.339
4.265AspGly: 4.265 ± 0.521
1.039AspHis: 1.039 ± 0.321
4.32AspIle: 4.32 ± 0.533
4.539AspLys: 4.539 ± 0.524
6.617AspLeu: 6.617 ± 0.513
0.984AspMet: 0.984 ± 0.214
2.023AspAsn: 2.023 ± 0.255
1.695AspPro: 1.695 ± 0.305
2.515AspGln: 2.515 ± 0.393
2.406AspArg: 2.406 ± 0.373
3.5AspSer: 3.5 ± 0.52
2.57AspThr: 2.57 ± 0.34
3.554AspVal: 3.554 ± 0.45
0.875AspTrp: 0.875 ± 0.284
2.351AspTyr: 2.351 ± 0.349
0.0AspXaa: 0.0 ± 0.0
Glu
5.906GluAla: 5.906 ± 0.862
0.711GluCys: 0.711 ± 0.207
3.172GluAsp: 3.172 ± 0.497
5.414GluGlu: 5.414 ± 0.677
3.554GluPhe: 3.554 ± 0.454
2.625GluGly: 2.625 ± 0.345
1.312GluHis: 1.312 ± 0.297
4.922GluIle: 4.922 ± 0.458
6.289GluLys: 6.289 ± 0.666
7.492GluLeu: 7.492 ± 0.719
1.148GluMet: 1.148 ± 0.231
4.265GluAsn: 4.265 ± 0.528
2.078GluPro: 2.078 ± 0.447
3.718GluGln: 3.718 ± 0.577
3.773GluArg: 3.773 ± 0.503
3.39GluSer: 3.39 ± 0.482
3.773GluThr: 3.773 ± 0.404
4.375GluVal: 4.375 ± 0.428
0.656GluTrp: 0.656 ± 0.193
1.969GluTyr: 1.969 ± 0.324
0.0GluXaa: 0.0 ± 0.0
Phe
2.789PheAla: 2.789 ± 0.285
0.437PheCys: 0.437 ± 0.167
2.679PheAsp: 2.679 ± 0.389
2.734PheGlu: 2.734 ± 0.357
1.367PhePhe: 1.367 ± 0.318
3.172PheGly: 3.172 ± 0.475
0.875PheHis: 0.875 ± 0.195
2.953PheIle: 2.953 ± 0.43
2.898PheLys: 2.898 ± 0.463
2.406PheLeu: 2.406 ± 0.331
0.656PheMet: 0.656 ± 0.154
3.008PheAsn: 3.008 ± 0.409
1.039PhePro: 1.039 ± 0.191
1.75PheGln: 1.75 ± 0.291
1.969PheArg: 1.969 ± 0.306
2.461PheSer: 2.461 ± 0.337
2.187PheThr: 2.187 ± 0.424
2.461PheVal: 2.461 ± 0.351
0.328PheTrp: 0.328 ± 0.126
0.82PheTyr: 0.82 ± 0.173
0.0PheXaa: 0.0 ± 0.0
Gly
5.086GlyAla: 5.086 ± 0.666
0.766GlyCys: 0.766 ± 0.188
3.609GlyAsp: 3.609 ± 0.494
4.429GlyGlu: 4.429 ± 0.385
2.406GlyPhe: 2.406 ± 0.36
4.484GlyGly: 4.484 ± 0.677
1.148GlyHis: 1.148 ± 0.291
3.609GlyIle: 3.609 ± 0.492
4.593GlyLys: 4.593 ± 0.475
5.796GlyLeu: 5.796 ± 0.552
1.914GlyMet: 1.914 ± 0.337
2.734GlyAsn: 2.734 ± 0.343
1.094GlyPro: 1.094 ± 0.256
3.062GlyGln: 3.062 ± 0.36
2.351GlyArg: 2.351 ± 0.4
4.429GlySer: 4.429 ± 0.468
3.609GlyThr: 3.609 ± 0.563
4.265GlyVal: 4.265 ± 0.427
1.367GlyTrp: 1.367 ± 0.238
1.75GlyTyr: 1.75 ± 0.307
0.0GlyXaa: 0.0 ± 0.0
His
0.984HisAla: 0.984 ± 0.217
0.164HisCys: 0.164 ± 0.081
1.039HisAsp: 1.039 ± 0.272
1.531HisGlu: 1.531 ± 0.309
0.766HisPhe: 0.766 ± 0.186
0.547HisGly: 0.547 ± 0.168
0.383HisHis: 0.383 ± 0.157
1.148HisIle: 1.148 ± 0.291
0.984HisLys: 0.984 ± 0.186
2.242HisLeu: 2.242 ± 0.451
0.711HisMet: 0.711 ± 0.169
0.602HisAsn: 0.602 ± 0.161
1.476HisPro: 1.476 ± 0.319
0.875HisGln: 0.875 ± 0.202
0.492HisArg: 0.492 ± 0.188
0.984HisSer: 0.984 ± 0.241
0.383HisThr: 0.383 ± 0.147
0.711HisVal: 0.711 ± 0.2
0.273HisTrp: 0.273 ± 0.119
0.602HisTyr: 0.602 ± 0.201
0.0HisXaa: 0.0 ± 0.0
Ile
5.851IleAla: 5.851 ± 0.684
0.492IleCys: 0.492 ± 0.165
4.101IleAsp: 4.101 ± 0.452
6.89IleGlu: 6.89 ± 0.526
1.586IlePhe: 1.586 ± 0.328
4.375IleGly: 4.375 ± 0.446
0.656IleHis: 0.656 ± 0.202
3.718IleIle: 3.718 ± 0.468
4.211IleLys: 4.211 ± 0.516
3.609IleLeu: 3.609 ± 0.388
0.875IleMet: 0.875 ± 0.234
3.172IleAsn: 3.172 ± 0.453
2.023IlePro: 2.023 ± 0.292
2.844IleGln: 2.844 ± 0.458
2.515IleArg: 2.515 ± 0.415
5.25IleSer: 5.25 ± 0.525
3.937IleThr: 3.937 ± 0.42
3.5IleVal: 3.5 ± 0.386
0.93IleTrp: 0.93 ± 0.201
2.461IleTyr: 2.461 ± 0.435
0.0IleXaa: 0.0 ± 0.0
Lys
8.093LysAla: 8.093 ± 1.108
0.547LysCys: 0.547 ± 0.165
4.429LysAsp: 4.429 ± 0.491
4.593LysGlu: 4.593 ± 0.595
2.187LysPhe: 2.187 ± 0.314
4.156LysGly: 4.156 ± 0.479
1.203LysHis: 1.203 ± 0.263
5.304LysIle: 5.304 ± 0.529
5.25LysLys: 5.25 ± 0.71
8.203LysLeu: 8.203 ± 0.819
2.133LysMet: 2.133 ± 0.309
3.336LysAsn: 3.336 ± 0.481
3.281LysPro: 3.281 ± 0.553
4.484LysGln: 4.484 ± 0.555
3.718LysArg: 3.718 ± 0.452
5.195LysSer: 5.195 ± 0.597
5.031LysThr: 5.031 ± 0.476
4.703LysVal: 4.703 ± 0.544
1.148LysTrp: 1.148 ± 0.278
2.515LysTyr: 2.515 ± 0.424
0.0LysXaa: 0.0 ± 0.0
Leu
7.546LeuAla: 7.546 ± 0.721
0.875LeuCys: 0.875 ± 0.228
5.687LeuAsp: 5.687 ± 0.573
6.234LeuGlu: 6.234 ± 0.627
2.789LeuPhe: 2.789 ± 0.347
5.304LeuGly: 5.304 ± 0.452
1.422LeuHis: 1.422 ± 0.281
5.961LeuIle: 5.961 ± 0.464
8.476LeuLys: 8.476 ± 0.727
6.617LeuLeu: 6.617 ± 0.541
2.023LeuMet: 2.023 ± 0.321
5.851LeuAsn: 5.851 ± 0.626
3.008LeuPro: 3.008 ± 0.407
3.226LeuGln: 3.226 ± 0.441
3.773LeuArg: 3.773 ± 0.494
6.453LeuSer: 6.453 ± 0.719
6.179LeuThr: 6.179 ± 0.646
5.742LeuVal: 5.742 ± 0.604
0.711LeuTrp: 0.711 ± 0.188
2.242LeuTyr: 2.242 ± 0.309
0.0LeuXaa: 0.0 ± 0.0
Met
2.351MetAla: 2.351 ± 0.277
0.383MetCys: 0.383 ± 0.139
2.297MetAsp: 2.297 ± 0.314
0.82MetGlu: 0.82 ± 0.161
1.094MetPhe: 1.094 ± 0.261
1.258MetGly: 1.258 ± 0.253
0.273MetHis: 0.273 ± 0.109
0.984MetIle: 0.984 ± 0.223
2.023MetLys: 2.023 ± 0.387
1.695MetLeu: 1.695 ± 0.333
0.437MetMet: 0.437 ± 0.13
1.258MetAsn: 1.258 ± 0.261
1.094MetPro: 1.094 ± 0.214
0.875MetGln: 0.875 ± 0.181
0.93MetArg: 0.93 ± 0.22
2.515MetSer: 2.515 ± 0.361
2.023MetThr: 2.023 ± 0.332
0.766MetVal: 0.766 ± 0.204
0.055MetTrp: 0.055 ± 0.059
0.602MetTyr: 0.602 ± 0.157
0.0MetXaa: 0.0 ± 0.0
Asn
3.992AsnAla: 3.992 ± 0.685
0.602AsnCys: 0.602 ± 0.186
2.679AsnAsp: 2.679 ± 0.333
3.445AsnGlu: 3.445 ± 0.426
2.242AsnPhe: 2.242 ± 0.358
4.047AsnGly: 4.047 ± 0.598
0.82AsnHis: 0.82 ± 0.218
2.953AsnIle: 2.953 ± 0.424
3.445AsnLys: 3.445 ± 0.528
5.632AsnLeu: 5.632 ± 0.628
1.039AsnMet: 1.039 ± 0.21
3.39AsnAsn: 3.39 ± 0.475
2.57AsnPro: 2.57 ± 0.451
2.515AsnGln: 2.515 ± 0.321
2.351AsnArg: 2.351 ± 0.348
3.117AsnSer: 3.117 ± 0.458
2.461AsnThr: 2.461 ± 0.367
2.679AsnVal: 2.679 ± 0.411
0.875AsnTrp: 0.875 ± 0.213
1.859AsnTyr: 1.859 ± 0.312
0.0AsnXaa: 0.0 ± 0.0
Pro
1.969ProAla: 1.969 ± 0.339
0.219ProCys: 0.219 ± 0.117
2.297ProAsp: 2.297 ± 0.409
3.226ProGlu: 3.226 ± 0.53
1.312ProPhe: 1.312 ± 0.274
0.984ProGly: 0.984 ± 0.338
0.766ProHis: 0.766 ± 0.232
1.859ProIle: 1.859 ± 0.304
2.515ProLys: 2.515 ± 0.402
2.844ProLeu: 2.844 ± 0.49
0.656ProMet: 0.656 ± 0.184
2.406ProAsn: 2.406 ± 0.4
1.531ProPro: 1.531 ± 0.298
1.148ProGln: 1.148 ± 0.259
0.984ProArg: 0.984 ± 0.242
1.75ProSer: 1.75 ± 0.3
2.844ProThr: 2.844 ± 0.381
2.515ProVal: 2.515 ± 0.444
0.219ProTrp: 0.219 ± 0.109
1.531ProTyr: 1.531 ± 0.298
0.0ProXaa: 0.0 ± 0.0
Gln
5.414GlnAla: 5.414 ± 0.928
0.328GlnCys: 0.328 ± 0.149
2.625GlnAsp: 2.625 ± 0.577
3.609GlnGlu: 3.609 ± 0.558
1.75GlnPhe: 1.75 ± 0.217
2.898GlnGly: 2.898 ± 0.504
0.984GlnHis: 0.984 ± 0.21
2.898GlnIle: 2.898 ± 0.382
3.664GlnLys: 3.664 ± 0.605
3.554GlnLeu: 3.554 ± 0.444
0.93GlnMet: 0.93 ± 0.185
2.187GlnAsn: 2.187 ± 0.33
1.422GlnPro: 1.422 ± 0.293
2.406GlnGln: 2.406 ± 0.455
2.078GlnArg: 2.078 ± 0.313
2.461GlnSer: 2.461 ± 0.32
2.953GlnThr: 2.953 ± 0.334
2.679GlnVal: 2.679 ± 0.416
0.547GlnTrp: 0.547 ± 0.163
1.476GlnTyr: 1.476 ± 0.348
0.0GlnXaa: 0.0 ± 0.0
Arg
3.39ArgAla: 3.39 ± 0.36
0.547ArgCys: 0.547 ± 0.153
2.351ArgAsp: 2.351 ± 0.304
1.969ArgGlu: 1.969 ± 0.342
1.641ArgPhe: 1.641 ± 0.273
2.789ArgGly: 2.789 ± 0.441
0.82ArgHis: 0.82 ± 0.201
2.625ArgIle: 2.625 ± 0.395
3.992ArgLys: 3.992 ± 0.428
4.32ArgLeu: 4.32 ± 0.608
1.312ArgMet: 1.312 ± 0.247
2.57ArgAsn: 2.57 ± 0.362
1.367ArgPro: 1.367 ± 0.337
2.297ArgGln: 2.297 ± 0.371
1.859ArgArg: 1.859 ± 0.381
1.805ArgSer: 1.805 ± 0.327
2.133ArgThr: 2.133 ± 0.293
2.789ArgVal: 2.789 ± 0.31
0.602ArgTrp: 0.602 ± 0.148
1.695ArgTyr: 1.695 ± 0.26
0.0ArgXaa: 0.0 ± 0.0
Ser
4.32SerAla: 4.32 ± 0.564
0.383SerCys: 0.383 ± 0.14
3.554SerAsp: 3.554 ± 0.475
3.828SerGlu: 3.828 ± 0.357
3.117SerPhe: 3.117 ± 0.464
5.031SerGly: 5.031 ± 0.478
0.875SerHis: 0.875 ± 0.167
4.101SerIle: 4.101 ± 0.402
5.742SerLys: 5.742 ± 0.722
5.195SerLeu: 5.195 ± 0.541
2.297SerMet: 2.297 ± 0.297
3.336SerAsn: 3.336 ± 0.388
1.805SerPro: 1.805 ± 0.335
2.515SerGln: 2.515 ± 0.354
2.351SerArg: 2.351 ± 0.323
4.703SerSer: 4.703 ± 0.662
2.515SerThr: 2.515 ± 0.388
5.468SerVal: 5.468 ± 0.624
0.602SerTrp: 0.602 ± 0.16
2.406SerTyr: 2.406 ± 0.299
0.0SerXaa: 0.0 ± 0.0
Thr
5.25ThrAla: 5.25 ± 0.602
0.383ThrCys: 0.383 ± 0.138
3.008ThrAsp: 3.008 ± 0.35
3.718ThrGlu: 3.718 ± 0.483
3.39ThrPhe: 3.39 ± 0.497
3.828ThrGly: 3.828 ± 0.436
0.93ThrHis: 0.93 ± 0.24
3.554ThrIle: 3.554 ± 0.514
3.828ThrLys: 3.828 ± 0.393
4.32ThrLeu: 4.32 ± 0.468
0.875ThrMet: 0.875 ± 0.208
3.062ThrAsn: 3.062 ± 0.422
3.172ThrPro: 3.172 ± 0.48
2.351ThrGln: 2.351 ± 0.298
2.023ThrArg: 2.023 ± 0.291
3.39ThrSer: 3.39 ± 0.484
2.734ThrThr: 2.734 ± 0.505
3.828ThrVal: 3.828 ± 0.386
0.328ThrTrp: 0.328 ± 0.125
1.859ThrTyr: 1.859 ± 0.31
0.0ThrXaa: 0.0 ± 0.0
Val
5.742ValAla: 5.742 ± 0.576
0.602ValCys: 0.602 ± 0.172
3.664ValAsp: 3.664 ± 0.487
4.265ValGlu: 4.265 ± 0.401
2.187ValPhe: 2.187 ± 0.375
4.101ValGly: 4.101 ± 0.538
1.094ValHis: 1.094 ± 0.24
3.226ValIle: 3.226 ± 0.384
4.484ValLys: 4.484 ± 0.485
5.687ValLeu: 5.687 ± 0.551
1.805ValMet: 1.805 ± 0.268
3.609ValAsn: 3.609 ± 0.476
1.641ValPro: 1.641 ± 0.298
2.625ValGln: 2.625 ± 0.332
3.117ValArg: 3.117 ± 0.4
4.703ValSer: 4.703 ± 0.457
3.172ValThr: 3.172 ± 0.459
4.211ValVal: 4.211 ± 0.555
0.656ValTrp: 0.656 ± 0.167
1.695ValTyr: 1.695 ± 0.257
0.0ValXaa: 0.0 ± 0.0
Trp
0.93TrpAla: 0.93 ± 0.188
0.383TrpCys: 0.383 ± 0.132
0.383TrpAsp: 0.383 ± 0.16
0.547TrpGlu: 0.547 ± 0.17
0.602TrpPhe: 0.602 ± 0.152
0.984TrpGly: 0.984 ± 0.248
0.109TrpHis: 0.109 ± 0.069
0.875TrpIle: 0.875 ± 0.197
0.875TrpLys: 0.875 ± 0.207
1.422TrpLeu: 1.422 ± 0.238
0.492TrpMet: 0.492 ± 0.199
0.437TrpAsn: 0.437 ± 0.16
0.164TrpPro: 0.164 ± 0.103
0.875TrpGln: 0.875 ± 0.195
0.383TrpArg: 0.383 ± 0.152
0.711TrpSer: 0.711 ± 0.212
0.273TrpThr: 0.273 ± 0.111
0.656TrpVal: 0.656 ± 0.175
0.055TrpTrp: 0.055 ± 0.052
0.383TrpTyr: 0.383 ± 0.142
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.406TyrAla: 2.406 ± 0.294
0.164TyrCys: 0.164 ± 0.088
2.57TyrAsp: 2.57 ± 0.359
1.859TyrGlu: 1.859 ± 0.312
1.312TyrPhe: 1.312 ± 0.266
2.187TyrGly: 2.187 ± 0.33
0.656TyrHis: 0.656 ± 0.181
1.367TyrIle: 1.367 ± 0.235
3.554TyrLys: 3.554 ± 0.388
3.117TyrLeu: 3.117 ± 0.49
0.602TyrMet: 0.602 ± 0.175
1.367TyrAsn: 1.367 ± 0.268
1.258TyrPro: 1.258 ± 0.308
1.641TyrGln: 1.641 ± 0.306
1.75TyrArg: 1.75 ± 0.339
1.969TyrSer: 1.969 ± 0.283
1.969TyrThr: 1.969 ± 0.326
1.148TyrVal: 1.148 ± 0.247
0.383TyrTrp: 0.383 ± 0.134
0.711TyrTyr: 0.711 ± 0.192
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 93 proteins (18288 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski