Amino acid dipepetide frequency for Verrucomicrobiales bacterium T37

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.175AlaAla: 12.175 ± 0.175	0.958AlaCys: 0.958 ± 0.035	6.181AlaAsp: 6.181 ± 0.092	6.9AlaGlu: 6.9 ± 0.115	3.55AlaPhe: 3.55 ± 0.067	8.463AlaGly: 8.463 ± 0.141	1.897AlaHis: 1.897 ± 0.053	5.191AlaIle: 5.191 ± 0.087	4.422AlaLys: 4.422 ± 0.086	10.361AlaLeu: 10.361 ± 0.13	2.679AlaMet: 2.679 ± 0.068	3.089AlaAsn: 3.089 ± 0.066	4.536AlaPro: 4.536 ± 0.086	3.111AlaGln: 3.111 ± 0.062	5.473AlaArg: 5.473 ± 0.111	5.944AlaSer: 5.944 ± 0.09	5.613AlaThr: 5.613 ± 0.111	7.873AlaVal: 7.873 ± 0.108	1.349AlaTrp: 1.349 ± 0.038	2.261AlaTyr: 2.261 ± 0.056	0.0AlaXaa: 0.0 ± 0.0
Cys	0.943CysAla: 0.943 ± 0.032	0.173CysCys: 0.173 ± 0.015	0.586CysAsp: 0.586 ± 0.028	0.526CysGlu: 0.526 ± 0.022	0.367CysPhe: 0.367 ± 0.019	1.037CysGly: 1.037 ± 0.038	0.289CysHis: 0.289 ± 0.021	0.402CysIle: 0.402 ± 0.018	0.272CysLys: 0.272 ± 0.019	0.832CysLeu: 0.832 ± 0.033	0.18CysMet: 0.18 ± 0.013	0.234CysAsn: 0.234 ± 0.015	0.54CysPro: 0.54 ± 0.026	0.266CysGln: 0.266 ± 0.016	0.583CysArg: 0.583 ± 0.023	0.594CysSer: 0.594 ± 0.026	0.405CysThr: 0.405 ± 0.019	0.723CysVal: 0.723 ± 0.029	0.168CysTrp: 0.168 ± 0.013	0.279CysTyr: 0.279 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	6.754AspAla: 6.754 ± 0.1	0.542AspCys: 0.542 ± 0.026	3.992AspAsp: 3.992 ± 0.194	4.678AspGlu: 4.678 ± 0.125	2.513AspPhe: 2.513 ± 0.082	6.086AspGly: 6.086 ± 0.266	1.616AspHis: 1.616 ± 0.056	2.502AspIle: 2.502 ± 0.057	2.0AspLys: 2.0 ± 0.056	5.868AspLeu: 5.868 ± 0.14	1.096AspMet: 1.096 ± 0.038	1.691AspAsn: 1.691 ± 0.041	3.396AspPro: 3.396 ± 0.065	2.446AspGln: 2.446 ± 0.07	3.555AspArg: 3.555 ± 0.076	3.149AspSer: 3.149 ± 0.066	2.84AspThr: 2.84 ± 0.109	4.622AspVal: 4.622 ± 0.101	1.08AspTrp: 1.08 ± 0.036	1.85AspTyr: 1.85 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	6.636GluAla: 6.636 ± 0.093	0.496GluCys: 0.496 ± 0.024	3.421GluAsp: 3.421 ± 0.077	4.351GluGlu: 4.351 ± 0.089	2.422GluPhe: 2.422 ± 0.056	4.639GluGly: 4.639 ± 0.068	1.298GluHis: 1.298 ± 0.042	3.76GluIle: 3.76 ± 0.066	3.297GluLys: 3.297 ± 0.08	7.004GluLeu: 7.004 ± 0.107	1.773GluMet: 1.773 ± 0.049	2.181GluAsn: 2.181 ± 0.058	2.733GluPro: 2.733 ± 0.069	2.509GluGln: 2.509 ± 0.053	4.555GluArg: 4.555 ± 0.091	3.913GluSer: 3.913 ± 0.074	3.212GluThr: 3.212 ± 0.056	5.282GluVal: 5.282 ± 0.12	1.013GluTrp: 1.013 ± 0.034	1.457GluTyr: 1.457 ± 0.05	0.0GluXaa: 0.0 ± 0.0
Phe	3.739PheAla: 3.739 ± 0.071	0.457PheCys: 0.457 ± 0.022	2.911PheAsp: 2.911 ± 0.096	2.404PheGlu: 2.404 ± 0.048	1.709PhePhe: 1.709 ± 0.053	3.41PheGly: 3.41 ± 0.068	0.858PheHis: 0.858 ± 0.031	1.816PheIle: 1.816 ± 0.045	1.431PheLys: 1.431 ± 0.044	3.502PheLeu: 3.502 ± 0.075	0.695PheMet: 0.695 ± 0.029	1.231PheAsn: 1.231 ± 0.032	1.682PhePro: 1.682 ± 0.051	1.044PheGln: 1.044 ± 0.03	2.063PheArg: 2.063 ± 0.047	2.777PheSer: 2.777 ± 0.054	2.427PheThr: 2.427 ± 0.14	2.762PheVal: 2.762 ± 0.061	0.581PheTrp: 0.581 ± 0.026	1.082PheTyr: 1.082 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	7.531GlyAla: 7.531 ± 0.115	0.904GlyCys: 0.904 ± 0.033	5.267GlyAsp: 5.267 ± 0.196	5.238GlyGlu: 5.238 ± 0.08	3.329GlyPhe: 3.329 ± 0.064	7.59GlyGly: 7.59 ± 0.163	1.635GlyHis: 1.635 ± 0.048	4.302GlyIle: 4.302 ± 0.067	3.901GlyLys: 3.901 ± 0.09	7.17GlyLeu: 7.17 ± 0.094	2.323GlyMet: 2.323 ± 0.06	2.882GlyAsn: 2.882 ± 0.131	2.362GlyPro: 2.362 ± 0.051	2.528GlyGln: 2.528 ± 0.058	4.766GlyArg: 4.766 ± 0.074	5.289GlySer: 5.289 ± 0.198	4.47GlyThr: 4.47 ± 0.101	6.47GlyVal: 6.47 ± 0.107	1.455GlyTrp: 1.455 ± 0.04	2.375GlyTyr: 2.375 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	1.947HisAla: 1.947 ± 0.057	0.297HisCys: 0.297 ± 0.018	1.15HisAsp: 1.15 ± 0.036	1.242HisGlu: 1.242 ± 0.033	0.978HisPhe: 0.978 ± 0.029	1.815HisGly: 1.815 ± 0.049	0.725HisHis: 0.725 ± 0.033	1.047HisIle: 1.047 ± 0.032	0.721HisLys: 0.721 ± 0.027	2.169HisLeu: 2.169 ± 0.052	0.41HisMet: 0.41 ± 0.021	0.612HisAsn: 0.612 ± 0.024	1.408HisPro: 1.408 ± 0.042	0.802HisGln: 0.802 ± 0.031	1.404HisArg: 1.404 ± 0.04	1.177HisSer: 1.177 ± 0.032	1.005HisThr: 1.005 ± 0.035	1.459HisVal: 1.459 ± 0.047	0.392HisTrp: 0.392 ± 0.021	0.743HisTyr: 0.743 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.699IleAla: 5.699 ± 0.088	0.529IleCys: 0.529 ± 0.024	4.021IleAsp: 4.021 ± 0.074	3.796IleGlu: 3.796 ± 0.072	1.762IlePhe: 1.762 ± 0.05	4.37IleGly: 4.37 ± 0.075	1.166IleHis: 1.166 ± 0.037	2.233IleIle: 2.233 ± 0.051	1.898IleLys: 1.898 ± 0.052	4.098IleLeu: 4.098 ± 0.079	0.756IleMet: 0.756 ± 0.03	1.794IleAsn: 1.794 ± 0.045	2.553IlePro: 2.553 ± 0.06	1.501IleGln: 1.501 ± 0.045	2.833IleArg: 2.833 ± 0.055	3.083IleSer: 3.083 ± 0.063	3.186IleThr: 3.186 ± 0.082	3.668IleVal: 3.668 ± 0.07	0.547IleTrp: 0.547 ± 0.022	1.19IleTyr: 1.19 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	4.046LysAla: 4.046 ± 0.078	0.238LysCys: 0.238 ± 0.015	2.26LysAsp: 2.26 ± 0.054	2.726LysGlu: 2.726 ± 0.064	1.442LysPhe: 1.442 ± 0.045	2.934LysGly: 2.934 ± 0.062	0.858LysHis: 0.858 ± 0.03	2.156LysIle: 2.156 ± 0.058	2.217LysLys: 2.217 ± 0.065	4.169LysLeu: 4.169 ± 0.078	1.196LysMet: 1.196 ± 0.037	1.313LysAsn: 1.313 ± 0.041	2.311LysPro: 2.311 ± 0.06	1.571LysGln: 1.571 ± 0.043	2.976LysArg: 2.976 ± 0.074	2.568LysSer: 2.568 ± 0.069	2.134LysThr: 2.134 ± 0.055	3.193LysVal: 3.193 ± 0.066	0.557LysTrp: 0.557 ± 0.024	0.912LysTyr: 0.912 ± 0.03	0.0LysXaa: 0.0 ± 0.0
Leu	10.389LeuAla: 10.389 ± 0.125	1.008LeuCys: 1.008 ± 0.031	5.898LeuAsp: 5.898 ± 0.112	6.311LeuGlu: 6.311 ± 0.093	3.476LeuPhe: 3.476 ± 0.093	7.338LeuGly: 7.338 ± 0.114	1.932LeuHis: 1.932 ± 0.049	4.881LeuIle: 4.881 ± 0.095	4.075LeuLys: 4.075 ± 0.073	8.86LeuLeu: 8.86 ± 0.143	2.202LeuMet: 2.202 ± 0.049	3.117LeuAsn: 3.117 ± 0.065	5.03LeuPro: 5.03 ± 0.089	2.93LeuGln: 2.93 ± 0.056	5.854LeuArg: 5.854 ± 0.105	5.78LeuSer: 5.78 ± 0.104	5.643LeuThr: 5.643 ± 0.091	7.489LeuVal: 7.489 ± 0.114	1.215LeuTrp: 1.215 ± 0.04	1.993LeuTyr: 1.993 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	2.357MetAla: 2.357 ± 0.057	0.172MetCys: 0.172 ± 0.015	1.228MetAsp: 1.228 ± 0.04	1.34MetGlu: 1.34 ± 0.035	0.7MetPhe: 0.7 ± 0.028	1.673MetGly: 1.673 ± 0.043	0.439MetHis: 0.439 ± 0.021	1.333MetIle: 1.333 ± 0.041	1.35MetLys: 1.35 ± 0.036	2.252MetLeu: 2.252 ± 0.061	0.743MetMet: 0.743 ± 0.03	0.89MetAsn: 0.89 ± 0.028	1.214MetPro: 1.214 ± 0.035	0.701MetGln: 0.701 ± 0.026	1.634MetArg: 1.634 ± 0.048	1.63MetSer: 1.63 ± 0.047	1.466MetThr: 1.466 ± 0.036	1.854MetVal: 1.854 ± 0.046	0.263MetTrp: 0.263 ± 0.016	0.295MetTyr: 0.295 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.221AsnAla: 3.221 ± 0.054	0.27AsnCys: 0.27 ± 0.015	2.042AsnAsp: 2.042 ± 0.099	1.973AsnGlu: 1.973 ± 0.044	1.241AsnPhe: 1.241 ± 0.05	3.043AsnGly: 3.043 ± 0.066	0.813AsnHis: 0.813 ± 0.031	1.451AsnIle: 1.451 ± 0.043	1.086AsnLys: 1.086 ± 0.051	2.874AsnLeu: 2.874 ± 0.055	0.586AsnMet: 0.586 ± 0.026	0.974AsnAsn: 0.974 ± 0.043	2.07AsnPro: 2.07 ± 0.051	1.278AsnGln: 1.278 ± 0.041	2.013AsnArg: 2.013 ± 0.054	1.68AsnSer: 1.68 ± 0.045	1.694AsnThr: 1.694 ± 0.058	2.368AsnVal: 2.368 ± 0.066	0.563AsnTrp: 0.563 ± 0.027	0.907AsnTyr: 0.907 ± 0.031	0.0AsnXaa: 0.0 ± 0.0
Pro	5.202ProAla: 5.202 ± 0.101	0.317ProCys: 0.317 ± 0.02	3.395ProAsp: 3.395 ± 0.084	4.142ProGlu: 4.142 ± 0.09	1.83ProPhe: 1.83 ± 0.045	3.588ProGly: 3.588 ± 0.066	1.054ProHis: 1.054 ± 0.035	2.151ProIle: 2.151 ± 0.054	1.987ProLys: 1.987 ± 0.057	4.179ProLeu: 4.179 ± 0.072	1.036ProMet: 1.036 ± 0.034	1.582ProAsn: 1.582 ± 0.042	1.936ProPro: 1.936 ± 0.057	1.72ProGln: 1.72 ± 0.04	2.26ProArg: 2.26 ± 0.055	2.986ProSer: 2.986 ± 0.061	2.8ProThr: 2.8 ± 0.069	4.059ProVal: 4.059 ± 0.078	0.642ProTrp: 0.642 ± 0.026	1.09ProTyr: 1.09 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	3.26GlnAla: 3.26 ± 0.067	0.257GlnCys: 0.257 ± 0.016	1.54GlnAsp: 1.54 ± 0.042	1.772GlnGlu: 1.772 ± 0.048	1.27GlnPhe: 1.27 ± 0.034	2.266GlnGly: 2.266 ± 0.05	0.737GlnHis: 0.737 ± 0.029	1.874GlnIle: 1.874 ± 0.039	1.352GlnLys: 1.352 ± 0.042	3.758GlnLeu: 3.758 ± 0.091	0.937GlnMet: 0.937 ± 0.031	0.97GlnAsn: 0.97 ± 0.035	1.795GlnPro: 1.795 ± 0.051	1.454GlnGln: 1.454 ± 0.052	2.554GlnArg: 2.554 ± 0.059	2.19GlnSer: 2.19 ± 0.063	1.611GlnThr: 1.611 ± 0.041	2.407GlnVal: 2.407 ± 0.044	0.636GlnTrp: 0.636 ± 0.025	0.703GlnTyr: 0.703 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	5.191ArgAla: 5.191 ± 0.108	0.566ArgCys: 0.566 ± 0.022	3.721ArgAsp: 3.721 ± 0.085	4.331ArgGlu: 4.331 ± 0.077	2.705ArgPhe: 2.705 ± 0.067	4.136ArgGly: 4.136 ± 0.084	1.296ArgHis: 1.296 ± 0.037	3.485ArgIle: 3.485 ± 0.086	2.929ArgLys: 2.929 ± 0.068	5.53ArgLeu: 5.53 ± 0.109	1.728ArgMet: 1.728 ± 0.053	2.017ArgAsn: 2.017 ± 0.056	2.638ArgPro: 2.638 ± 0.051	2.068ArgGln: 2.068 ± 0.053	4.229ArgArg: 4.229 ± 0.098	3.568ArgSer: 3.568 ± 0.08	2.896ArgThr: 2.896 ± 0.053	4.485ArgVal: 4.485 ± 0.074	1.09ArgTrp: 1.09 ± 0.043	1.774ArgTyr: 1.774 ± 0.054	0.0ArgXaa: 0.0 ± 0.0
Ser	5.985SerAla: 5.985 ± 0.096	0.538SerCys: 0.538 ± 0.024	3.905SerAsp: 3.905 ± 0.087	3.785SerGlu: 3.785 ± 0.071	2.4SerPhe: 2.4 ± 0.051	5.721SerGly: 5.721 ± 0.106	1.195SerHis: 1.195 ± 0.034	2.951SerIle: 2.951 ± 0.052	2.426SerLys: 2.426 ± 0.051	6.023SerLeu: 6.023 ± 0.13	1.37SerMet: 1.37 ± 0.038	1.856SerAsn: 1.856 ± 0.044	3.044SerPro: 3.044 ± 0.06	1.939SerGln: 1.939 ± 0.048	3.206SerArg: 3.206 ± 0.077	3.901SerSer: 3.901 ± 0.087	3.274SerThr: 3.274 ± 0.066	4.721SerVal: 4.721 ± 0.157	0.959SerTrp: 0.959 ± 0.051	1.654SerTyr: 1.654 ± 0.049	0.001SerXaa: 0.001 ± 0.001
Thr	5.417ThrAla: 5.417 ± 0.116	0.463ThrCys: 0.463 ± 0.023	3.363ThrAsp: 3.363 ± 0.114	3.005ThrGlu: 3.005 ± 0.059	2.119ThrPhe: 2.119 ± 0.044	4.734ThrGly: 4.734 ± 0.121	1.122ThrHis: 1.122 ± 0.037	3.043ThrIle: 3.043 ± 0.058	2.084ThrLys: 2.084 ± 0.06	5.621ThrLeu: 5.621 ± 0.089	1.068ThrMet: 1.068 ± 0.035	1.892ThrAsn: 1.892 ± 0.069	3.269ThrPro: 3.269 ± 0.066	1.611ThrGln: 1.611 ± 0.046	2.937ThrArg: 2.937 ± 0.068	3.399ThrSer: 3.399 ± 0.103	3.523ThrThr: 3.523 ± 0.099	4.241ThrVal: 4.241 ± 0.144	0.79ThrTrp: 0.79 ± 0.033	1.42ThrTyr: 1.42 ± 0.071	0.0ThrXaa: 0.0 ± 0.0
Val	8.2ValAla: 8.2 ± 0.155	0.774ValCys: 0.774 ± 0.027	4.985ValAsp: 4.985 ± 0.11	5.022ValGlu: 5.022 ± 0.084	2.951ValPhe: 2.951 ± 0.058	6.011ValGly: 6.011 ± 0.111	1.474ValHis: 1.474 ± 0.04	4.262ValIle: 4.262 ± 0.064	2.808ValLys: 2.808 ± 0.068	7.037ValLeu: 7.037 ± 0.107	1.845ValMet: 1.845 ± 0.048	2.351ValAsn: 2.351 ± 0.067	3.693ValPro: 3.693 ± 0.081	2.047ValGln: 2.047 ± 0.045	4.703ValArg: 4.703 ± 0.09	4.666ValSer: 4.666 ± 0.082	4.866ValThr: 4.866 ± 0.183	7.096ValVal: 7.096 ± 0.11	1.009ValTrp: 1.009 ± 0.034	1.648ValTyr: 1.648 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	1.143TrpAla: 1.143 ± 0.037	0.169TrpCys: 0.169 ± 0.013	0.801TrpAsp: 0.801 ± 0.03	0.803TrpGlu: 0.803 ± 0.03	0.675TrpPhe: 0.675 ± 0.028	0.905TrpGly: 0.905 ± 0.034	0.399TrpHis: 0.399 ± 0.019	0.87TrpIle: 0.87 ± 0.029	0.69TrpLys: 0.69 ± 0.03	1.637TrpLeu: 1.637 ± 0.048	0.461TrpMet: 0.461 ± 0.022	0.673TrpAsn: 0.673 ± 0.04	0.521TrpPro: 0.521 ± 0.025	0.722TrpGln: 0.722 ± 0.028	1.064TrpArg: 1.064 ± 0.038	1.003TrpSer: 1.003 ± 0.033	0.79TrpThr: 0.79 ± 0.034	1.046TrpVal: 1.046 ± 0.039	0.314TrpTrp: 0.314 ± 0.018	0.325TrpTyr: 0.325 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.192TyrAla: 2.192 ± 0.054	0.269TyrCys: 0.269 ± 0.018	1.608TyrAsp: 1.608 ± 0.041	1.607TyrGlu: 1.607 ± 0.047	1.141TyrPhe: 1.141 ± 0.035	2.027TyrGly: 2.027 ± 0.051	0.699TyrHis: 0.699 ± 0.029	0.974TyrIle: 0.974 ± 0.036	0.832TyrLys: 0.832 ± 0.029	2.477TyrLeu: 2.477 ± 0.063	0.449TyrMet: 0.449 ± 0.023	0.799TyrAsn: 0.799 ± 0.027	1.222TyrPro: 1.222 ± 0.035	1.095TyrGln: 1.095 ± 0.031	1.721TyrArg: 1.721 ± 0.044	1.561TyrSer: 1.561 ± 0.047	1.264TyrThr: 1.264 ± 0.04	1.633TyrVal: 1.633 ± 0.043	0.386TyrTrp: 0.386 ± 0.021	0.837TyrTyr: 0.837 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2971 proteins (1053078 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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