Amino acid dipepetide frequency for Xylanimicrobium sp. FW10M-9

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
25.149AlaAla: 25.149 ± 0.227
0.873AlaCys: 0.873 ± 0.033
9.266AlaAsp: 9.266 ± 0.11
7.664AlaGlu: 7.664 ± 0.1
3.689AlaPhe: 3.689 ± 0.056
14.186AlaGly: 14.186 ± 0.129
2.9AlaHis: 2.9 ± 0.051
4.076AlaIle: 4.076 ± 0.074
2.242AlaLys: 2.242 ± 0.063
15.295AlaLeu: 15.295 ± 0.148
2.749AlaMet: 2.749 ± 0.049
1.968AlaAsn: 1.968 ± 0.046
7.899AlaPro: 7.899 ± 0.134
4.167AlaGln: 4.167 ± 0.065
11.347AlaArg: 11.347 ± 0.134
6.918AlaSer: 6.918 ± 0.096
8.79AlaThr: 8.79 ± 0.094
14.123AlaVal: 14.123 ± 0.166
2.492AlaTrp: 2.492 ± 0.048
2.406AlaTyr: 2.406 ± 0.047
0.0AlaXaa: 0.0 ± 0.0
Cys
0.76CysAla: 0.76 ± 0.031
0.056CysCys: 0.056 ± 0.009
0.335CysAsp: 0.335 ± 0.018
0.283CysGlu: 0.283 ± 0.015
0.158CysPhe: 0.158 ± 0.012
0.628CysGly: 0.628 ± 0.027
0.111CysHis: 0.111 ± 0.01
0.13CysIle: 0.13 ± 0.01
0.063CysLys: 0.063 ± 0.008
0.466CysLeu: 0.466 ± 0.022
0.074CysMet: 0.074 ± 0.008
0.095CysAsn: 0.095 ± 0.009
0.361CysPro: 0.361 ± 0.02
0.119CysGln: 0.119 ± 0.011
0.388CysArg: 0.388 ± 0.018
0.352CysSer: 0.352 ± 0.018
0.381CysThr: 0.381 ± 0.019
0.499CysVal: 0.499 ± 0.021
0.09CysTrp: 0.09 ± 0.009
0.113CysTyr: 0.113 ± 0.01
0.0CysXaa: 0.0 ± 0.0
Asp
9.956AspAla: 9.956 ± 0.11
0.268AspCys: 0.268 ± 0.016
4.996AspAsp: 4.996 ± 0.087
3.665AspGlu: 3.665 ± 0.062
1.362AspPhe: 1.362 ± 0.041
6.961AspGly: 6.961 ± 0.085
1.375AspHis: 1.375 ± 0.042
1.449AspIle: 1.449 ± 0.046
0.911AspLys: 0.911 ± 0.036
6.797AspLeu: 6.797 ± 0.077
0.625AspMet: 0.625 ± 0.025
0.776AspAsn: 0.776 ± 0.029
4.545AspPro: 4.545 ± 0.079
1.522AspGln: 1.522 ± 0.043
4.415AspArg: 4.415 ± 0.076
1.906AspSer: 1.906 ± 0.047
2.751AspThr: 2.751 ± 0.053
7.219AspVal: 7.219 ± 0.09
0.863AspTrp: 0.863 ± 0.028
1.048AspTyr: 1.048 ± 0.034
0.0AspXaa: 0.0 ± 0.0
Glu
7.137GluAla: 7.137 ± 0.105
0.225GluCys: 0.225 ± 0.016
2.474GluAsp: 2.474 ± 0.053
2.36GluGlu: 2.36 ± 0.058
1.174GluPhe: 1.174 ± 0.035
3.599GluGly: 3.599 ± 0.065
1.58GluHis: 1.58 ± 0.042
2.094GluIle: 2.094 ± 0.048
1.116GluLys: 1.116 ± 0.037
5.837GluLeu: 5.837 ± 0.075
0.675GluMet: 0.675 ± 0.023
0.846GluAsn: 0.846 ± 0.03
3.222GluPro: 3.222 ± 0.065
1.944GluGln: 1.944 ± 0.044
4.993GluArg: 4.993 ± 0.074
2.082GluSer: 2.082 ± 0.05
2.667GluThr: 2.667 ± 0.051
4.583GluVal: 4.583 ± 0.071
0.663GluTrp: 0.663 ± 0.029
0.876GluTyr: 0.876 ± 0.031
0.0GluXaa: 0.0 ± 0.0
Phe
3.767PheAla: 3.767 ± 0.066
0.187PheCys: 0.187 ± 0.013
1.968PheAsp: 1.968 ± 0.051
1.449PheGlu: 1.449 ± 0.037
0.865PhePhe: 0.865 ± 0.033
2.875PheGly: 2.875 ± 0.063
0.542PheHis: 0.542 ± 0.025
0.601PheIle: 0.601 ± 0.028
0.41PheLys: 0.41 ± 0.021
2.633PheLeu: 2.633 ± 0.055
0.372PheMet: 0.372 ± 0.02
0.488PheAsn: 0.488 ± 0.023
1.244PhePro: 1.244 ± 0.039
0.68PheGln: 0.68 ± 0.026
1.661PheArg: 1.661 ± 0.036
1.321PheSer: 1.321 ± 0.038
1.776PheThr: 1.776 ± 0.042
2.718PheVal: 2.718 ± 0.057
0.482PheTrp: 0.482 ± 0.027
0.544PheTyr: 0.544 ± 0.026
0.0PheXaa: 0.0 ± 0.0
Gly
12.12GlyAla: 12.12 ± 0.12
0.567GlyCys: 0.567 ± 0.026
5.279GlyAsp: 5.279 ± 0.073
4.495GlyGlu: 4.495 ± 0.058
2.88GlyPhe: 2.88 ± 0.055
8.355GlyGly: 8.355 ± 0.121
2.03GlyHis: 2.03 ± 0.047
3.355GlyIle: 3.355 ± 0.062
1.989GlyLys: 1.989 ± 0.047
9.473GlyLeu: 9.473 ± 0.101
1.819GlyMet: 1.819 ± 0.046
1.535GlyAsn: 1.535 ± 0.038
4.893GlyPro: 4.893 ± 0.078
2.551GlyGln: 2.551 ± 0.053
7.176GlyArg: 7.176 ± 0.094
5.039GlySer: 5.039 ± 0.064
6.496GlyThr: 6.496 ± 0.105
9.024GlyVal: 9.024 ± 0.103
1.889GlyTrp: 1.889 ± 0.048
2.095GlyTyr: 2.095 ± 0.052
0.0GlyXaa: 0.0 ± 0.0
His
2.954HisAla: 2.954 ± 0.058
0.084HisCys: 0.084 ± 0.008
1.551HisAsp: 1.551 ± 0.035
1.159HisGlu: 1.159 ± 0.037
0.493HisPhe: 0.493 ± 0.024
2.256HisGly: 2.256 ± 0.049
0.613HisHis: 0.613 ± 0.027
0.417HisIle: 0.417 ± 0.02
0.279HisLys: 0.279 ± 0.017
2.391HisLeu: 2.391 ± 0.053
0.258HisMet: 0.258 ± 0.017
0.344HisAsn: 0.344 ± 0.018
1.543HisPro: 1.543 ± 0.044
0.561HisGln: 0.561 ± 0.021
1.814HisArg: 1.814 ± 0.047
0.728HisSer: 0.728 ± 0.025
1.082HisThr: 1.082 ± 0.034
2.21HisVal: 2.21 ± 0.051
0.313HisTrp: 0.313 ± 0.017
0.368HisTyr: 0.368 ± 0.019
0.0HisXaa: 0.0 ± 0.0
Ile
4.572IleAla: 4.572 ± 0.077
0.164IleCys: 0.164 ± 0.011
2.23IleAsp: 2.23 ± 0.044
1.8IleGlu: 1.8 ± 0.044
0.71IlePhe: 0.71 ± 0.031
3.031IleGly: 3.031 ± 0.062
0.504IleHis: 0.504 ± 0.022
0.947IleIle: 0.947 ± 0.041
0.59IleLys: 0.59 ± 0.029
2.606IleLeu: 2.606 ± 0.056
0.417IleMet: 0.417 ± 0.02
0.561IleAsn: 0.561 ± 0.023
1.65IlePro: 1.65 ± 0.042
0.639IleGln: 0.639 ± 0.026
1.661IleArg: 1.661 ± 0.038
1.42IleSer: 1.42 ± 0.036
2.151IleThr: 2.151 ± 0.052
3.051IleVal: 3.051 ± 0.058
0.346IleTrp: 0.346 ± 0.019
0.499IleTyr: 0.499 ± 0.025
0.0IleXaa: 0.0 ± 0.0
Lys
2.395LysAla: 2.395 ± 0.059
0.066LysCys: 0.066 ± 0.007
1.054LysAsp: 1.054 ± 0.039
0.872LysGlu: 0.872 ± 0.03
0.347LysPhe: 0.347 ± 0.019
1.321LysGly: 1.321 ± 0.043
0.409LysHis: 0.409 ± 0.02
0.674LysIle: 0.674 ± 0.029
0.556LysLys: 0.556 ± 0.026
1.367LysLeu: 1.367 ± 0.038
0.255LysMet: 0.255 ± 0.014
0.413LysAsn: 0.413 ± 0.019
1.027LysPro: 1.027 ± 0.036
0.532LysGln: 0.532 ± 0.022
1.168LysArg: 1.168 ± 0.036
0.84LysSer: 0.84 ± 0.032
1.069LysThr: 1.069 ± 0.035
1.623LysVal: 1.623 ± 0.044
0.159LysTrp: 0.159 ± 0.013
0.352LysTyr: 0.352 ± 0.02
0.0LysXaa: 0.0 ± 0.0
Leu
16.751LeuAla: 16.751 ± 0.161
0.538LeuCys: 0.538 ± 0.023
7.298LeuAsp: 7.298 ± 0.089
4.727LeuGlu: 4.727 ± 0.075
2.472LeuPhe: 2.472 ± 0.058
9.892LeuGly: 9.892 ± 0.111
2.089LeuHis: 2.089 ± 0.044
2.36LeuIle: 2.36 ± 0.056
1.372LeuLys: 1.372 ± 0.043
10.575LeuLeu: 10.575 ± 0.137
1.427LeuMet: 1.427 ± 0.045
1.367LeuAsn: 1.367 ± 0.038
6.014LeuPro: 6.014 ± 0.069
2.234LeuGln: 2.234 ± 0.048
8.192LeuArg: 8.192 ± 0.095
4.525LeuSer: 4.525 ± 0.068
6.711LeuThr: 6.711 ± 0.084
10.917LeuVal: 10.917 ± 0.137
1.352LeuTrp: 1.352 ± 0.038
1.525LeuTyr: 1.525 ± 0.038
0.0LeuXaa: 0.0 ± 0.0
Met
2.076MetAla: 2.076 ± 0.05
0.086MetCys: 0.086 ± 0.008
0.772MetAsp: 0.772 ± 0.028
0.552MetGlu: 0.552 ± 0.026
0.461MetPhe: 0.461 ± 0.02
1.074MetGly: 1.074 ± 0.037
0.357MetHis: 0.357 ± 0.019
0.552MetIle: 0.552 ± 0.024
0.32MetLys: 0.32 ± 0.018
1.608MetLeu: 1.608 ± 0.044
0.229MetMet: 0.229 ± 0.015
0.378MetAsn: 0.378 ± 0.02
1.088MetPro: 1.088 ± 0.034
0.37MetGln: 0.37 ± 0.017
1.226MetArg: 1.226 ± 0.035
1.288MetSer: 1.288 ± 0.032
1.683MetThr: 1.683 ± 0.042
1.39MetVal: 1.39 ± 0.036
0.182MetTrp: 0.182 ± 0.011
0.247MetTyr: 0.247 ± 0.017
0.0MetXaa: 0.0 ± 0.0
Asn
1.978AsnAla: 1.978 ± 0.047
0.094AsnCys: 0.094 ± 0.009
0.916AsnAsp: 0.916 ± 0.034
0.706AsnGlu: 0.706 ± 0.026
0.443AsnPhe: 0.443 ± 0.023
1.478AsnGly: 1.478 ± 0.044
0.353AsnHis: 0.353 ± 0.018
0.553AsnIle: 0.553 ± 0.027
0.276AsnLys: 0.276 ± 0.016
1.692AsnLeu: 1.692 ± 0.044
0.242AsnMet: 0.242 ± 0.014
0.368AsnAsn: 0.368 ± 0.022
1.388AsnPro: 1.388 ± 0.044
0.499AsnGln: 0.499 ± 0.024
1.036AsnArg: 1.036 ± 0.033
0.616AsnSer: 0.616 ± 0.023
0.958AsnThr: 0.958 ± 0.033
1.565AsnVal: 1.565 ± 0.04
0.228AsnTrp: 0.228 ± 0.015
0.362AsnTyr: 0.362 ± 0.021
0.0AsnXaa: 0.0 ± 0.0
Pro
9.44ProAla: 9.44 ± 0.141
0.246ProCys: 0.246 ± 0.015
4.463ProAsp: 4.463 ± 0.076
3.549ProGlu: 3.549 ± 0.063
1.573ProPhe: 1.573 ± 0.037
6.389ProGly: 6.389 ± 0.089
1.223ProHis: 1.223 ± 0.037
1.307ProIle: 1.307 ± 0.036
0.762ProLys: 0.762 ± 0.029
5.136ProLeu: 5.136 ± 0.078
0.898ProMet: 0.898 ± 0.029
0.838ProAsn: 0.838 ± 0.032
3.037ProPro: 3.037 ± 0.075
1.614ProGln: 1.614 ± 0.038
4.175ProArg: 4.175 ± 0.076
3.264ProSer: 3.264 ± 0.078
3.78ProThr: 3.78 ± 0.068
5.751ProVal: 5.751 ± 0.08
0.99ProTrp: 0.99 ± 0.034
1.049ProTyr: 1.049 ± 0.036
0.0ProXaa: 0.0 ± 0.0
Gln
3.815GlnAla: 3.815 ± 0.071
0.141GlnCys: 0.141 ± 0.011
1.335GlnAsp: 1.335 ± 0.041
1.189GlnGlu: 1.189 ± 0.035
0.696GlnPhe: 0.696 ± 0.026
2.178GlnGly: 2.178 ± 0.042
0.675GlnHis: 0.675 ± 0.024
1.024GlnIle: 1.024 ± 0.032
0.484GlnLys: 0.484 ± 0.02
2.615GlnLeu: 2.615 ± 0.053
0.451GlnMet: 0.451 ± 0.02
0.515GlnAsn: 0.515 ± 0.023
1.552GlnPro: 1.552 ± 0.041
1.106GlnGln: 1.106 ± 0.04
2.341GlnArg: 2.341 ± 0.042
1.086GlnSer: 1.086 ± 0.036
1.44GlnThr: 1.44 ± 0.044
3.102GlnVal: 3.102 ± 0.056
0.462GlnTrp: 0.462 ± 0.02
0.571GlnTyr: 0.571 ± 0.025
0.0GlnXaa: 0.0 ± 0.0
Arg
10.446ArgAla: 10.446 ± 0.124
0.429ArgCys: 0.429 ± 0.023
4.419ArgAsp: 4.419 ± 0.078
4.092ArgGlu: 4.092 ± 0.068
2.175ArgPhe: 2.175 ± 0.044
6.009ArgGly: 6.009 ± 0.082
1.806ArgHis: 1.806 ± 0.049
2.532ArgIle: 2.532 ± 0.049
1.31ArgLys: 1.31 ± 0.034
8.096ArgLeu: 8.096 ± 0.098
1.507ArgMet: 1.507 ± 0.036
1.109ArgAsn: 1.109 ± 0.033
4.621ArgPro: 4.621 ± 0.084
2.066ArgGln: 2.066 ± 0.045
7.731ArgArg: 7.731 ± 0.115
3.919ArgSer: 3.919 ± 0.061
5.242ArgThr: 5.242 ± 0.078
6.724ArgVal: 6.724 ± 0.087
1.524ArgTrp: 1.524 ± 0.036
1.671ArgTyr: 1.671 ± 0.042
0.0ArgXaa: 0.0 ± 0.0
Ser
6.524SerAla: 6.524 ± 0.087
0.258SerCys: 0.258 ± 0.017
2.68SerAsp: 2.68 ± 0.056
1.938SerGlu: 1.938 ± 0.041
1.541SerPhe: 1.541 ± 0.039
5.165SerGly: 5.165 ± 0.085
0.897SerHis: 0.897 ± 0.031
1.545SerIle: 1.545 ± 0.038
0.795SerLys: 0.795 ± 0.028
4.729SerLeu: 4.729 ± 0.064
0.955SerMet: 0.955 ± 0.029
0.824SerAsn: 0.824 ± 0.03
2.966SerPro: 2.966 ± 0.077
1.213SerGln: 1.213 ± 0.036
3.463SerArg: 3.463 ± 0.065
2.72SerSer: 2.72 ± 0.071
3.325SerThr: 3.325 ± 0.071
4.39SerVal: 4.39 ± 0.067
0.896SerTrp: 0.896 ± 0.029
0.926SerTyr: 0.926 ± 0.03
0.0SerXaa: 0.0 ± 0.0
Thr
8.761ThrAla: 8.761 ± 0.105
0.366ThrCys: 0.366 ± 0.018
3.586ThrAsp: 3.586 ± 0.065
2.616ThrGlu: 2.616 ± 0.05
1.982ThrPhe: 1.982 ± 0.047
6.253ThrGly: 6.253 ± 0.076
1.252ThrHis: 1.252 ± 0.037
2.234ThrIle: 2.234 ± 0.047
0.953ThrLys: 0.953 ± 0.034
6.399ThrLeu: 6.399 ± 0.086
0.979ThrMet: 0.979 ± 0.033
1.029ThrAsn: 1.029 ± 0.031
4.609ThrPro: 4.609 ± 0.076
1.614ThrGln: 1.614 ± 0.038
4.149ThrArg: 4.149 ± 0.064
3.454ThrSer: 3.454 ± 0.066
4.848ThrThr: 4.848 ± 0.101
6.633ThrVal: 6.633 ± 0.102
1.163ThrTrp: 1.163 ± 0.034
1.316ThrTyr: 1.316 ± 0.041
0.0ThrXaa: 0.0 ± 0.0
Val
15.119ValAla: 15.119 ± 0.168
0.566ValCys: 0.566 ± 0.022
6.525ValAsp: 6.525 ± 0.075
5.335ValGlu: 5.335 ± 0.08
2.443ValPhe: 2.443 ± 0.048
8.523ValGly: 8.523 ± 0.099
1.991ValHis: 1.991 ± 0.043
2.826ValIle: 2.826 ± 0.053
1.505ValLys: 1.505 ± 0.041
10.798ValLeu: 10.798 ± 0.12
1.499ValMet: 1.499 ± 0.043
1.58ValAsn: 1.58 ± 0.039
6.013ValPro: 6.013 ± 0.094
2.211ValGln: 2.211 ± 0.05
7.666ValArg: 7.666 ± 0.098
4.502ValSer: 4.502 ± 0.073
6.84ValThr: 6.84 ± 0.101
12.961ValVal: 12.961 ± 0.163
1.332ValTrp: 1.332 ± 0.039
1.504ValTyr: 1.504 ± 0.039
0.0ValXaa: 0.0 ± 0.0
Trp
1.964TrpAla: 1.964 ± 0.041
0.129TrpCys: 0.129 ± 0.011
0.965TrpAsp: 0.965 ± 0.033
0.7TrpGlu: 0.7 ± 0.028
0.574TrpPhe: 0.574 ± 0.023
1.15TrpGly: 1.15 ± 0.037
0.408TrpHis: 0.408 ± 0.022
0.477TrpIle: 0.477 ± 0.02
0.269TrpLys: 0.269 ± 0.016
1.837TrpLeu: 1.837 ± 0.047
0.291TrpMet: 0.291 ± 0.017
0.387TrpAsn: 0.387 ± 0.019
0.817TrpPro: 0.817 ± 0.033
0.59TrpGln: 0.59 ± 0.026
1.311TrpArg: 1.311 ± 0.036
0.971TrpSer: 0.971 ± 0.033
1.131TrpThr: 1.131 ± 0.038
1.461TrpVal: 1.461 ± 0.034
0.394TrpTrp: 0.394 ± 0.023
0.294TrpTyr: 0.294 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.515TyrAla: 2.515 ± 0.042
0.119TyrCys: 0.119 ± 0.01
1.298TyrAsp: 1.298 ± 0.043
0.996TyrGlu: 0.996 ± 0.029
0.544TyrPhe: 0.544 ± 0.025
1.739TyrGly: 1.739 ± 0.042
0.304TyrHis: 0.304 ± 0.016
0.394TyrIle: 0.394 ± 0.021
0.301TyrLys: 0.301 ± 0.016
1.987TyrLeu: 1.987 ± 0.049
0.218TyrMet: 0.218 ± 0.015
0.33TyrAsn: 0.33 ± 0.016
0.996TyrPro: 0.996 ± 0.036
0.546TyrGln: 0.546 ± 0.025
1.511TyrArg: 1.511 ± 0.04
0.797TyrSer: 0.797 ± 0.031
1.074TyrThr: 1.074 ± 0.037
1.795TyrVal: 1.795 ± 0.039
0.301TyrTrp: 0.301 ± 0.018
0.382TyrTyr: 0.382 ± 0.023
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3305 proteins (1091220 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski