Amino acid dipepetide frequency for Mycobacterium Phage Rachaly

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.535AlaAla: 11.535 ± 0.965
0.496AlaCys: 0.496 ± 0.168
5.023AlaAsp: 5.023 ± 0.519
8.186AlaGlu: 8.186 ± 0.679
3.473AlaPhe: 3.473 ± 0.576
8.558AlaGly: 8.558 ± 0.879
1.55AlaHis: 1.55 ± 0.299
4.031AlaIle: 4.031 ± 0.473
4.899AlaLys: 4.899 ± 0.635
8.868AlaLeu: 8.868 ± 1.06
2.481AlaMet: 2.481 ± 0.348
3.349AlaAsn: 3.349 ± 0.639
4.589AlaPro: 4.589 ± 0.572
3.721AlaGln: 3.721 ± 0.657
6.14AlaArg: 6.14 ± 0.636
4.961AlaSer: 4.961 ± 0.423
4.899AlaThr: 4.899 ± 0.496
7.876AlaVal: 7.876 ± 0.789
1.674AlaTrp: 1.674 ± 0.281
3.163AlaTyr: 3.163 ± 0.494
0.0AlaXaa: 0.0 ± 0.0
Cys
0.744CysAla: 0.744 ± 0.237
0.31CysCys: 0.31 ± 0.169
0.93CysAsp: 0.93 ± 0.232
0.372CysGlu: 0.372 ± 0.139
0.186CysPhe: 0.186 ± 0.09
0.868CysGly: 0.868 ± 0.239
0.248CysHis: 0.248 ± 0.138
0.31CysIle: 0.31 ± 0.17
0.62CysLys: 0.62 ± 0.195
0.744CysLeu: 0.744 ± 0.197
0.186CysMet: 0.186 ± 0.113
0.31CysAsn: 0.31 ± 0.115
0.62CysPro: 0.62 ± 0.268
0.124CysGln: 0.124 ± 0.09
0.434CysArg: 0.434 ± 0.158
0.434CysSer: 0.434 ± 0.165
0.682CysThr: 0.682 ± 0.203
0.558CysVal: 0.558 ± 0.147
0.372CysTrp: 0.372 ± 0.15
0.372CysTyr: 0.372 ± 0.159
0.0CysXaa: 0.0 ± 0.0
Asp
6.822AspAla: 6.822 ± 0.606
0.496AspCys: 0.496 ± 0.168
3.969AspAsp: 3.969 ± 0.484
4.279AspGlu: 4.279 ± 0.651
2.481AspPhe: 2.481 ± 0.402
5.643AspGly: 5.643 ± 0.636
1.302AspHis: 1.302 ± 0.292
3.225AspIle: 3.225 ± 0.426
2.419AspLys: 2.419 ± 0.388
5.829AspLeu: 5.829 ± 0.691
1.488AspMet: 1.488 ± 0.35
0.93AspAsn: 0.93 ± 0.254
5.023AspPro: 5.023 ± 0.606
2.295AspGln: 2.295 ± 0.32
2.915AspArg: 2.915 ± 0.455
2.667AspSer: 2.667 ± 0.422
3.287AspThr: 3.287 ± 0.449
3.907AspVal: 3.907 ± 0.479
1.24AspTrp: 1.24 ± 0.247
2.419AspTyr: 2.419 ± 0.283
0.0AspXaa: 0.0 ± 0.0
Glu
6.636GluAla: 6.636 ± 0.929
0.31GluCys: 0.31 ± 0.126
3.845GluAsp: 3.845 ± 0.589
4.155GluGlu: 4.155 ± 0.576
2.853GluPhe: 2.853 ± 0.434
5.395GluGly: 5.395 ± 0.689
1.426GluHis: 1.426 ± 0.346
3.659GluIle: 3.659 ± 0.543
2.233GluLys: 2.233 ± 0.337
6.698GluLeu: 6.698 ± 0.779
2.295GluMet: 2.295 ± 0.332
2.171GluAsn: 2.171 ± 0.318
2.853GluPro: 2.853 ± 0.482
2.729GluGln: 2.729 ± 0.347
4.217GluArg: 4.217 ± 0.559
2.977GluSer: 2.977 ± 0.487
4.155GluThr: 4.155 ± 0.5
5.147GluVal: 5.147 ± 0.56
1.364GluTrp: 1.364 ± 0.305
1.55GluTyr: 1.55 ± 0.296
0.0GluXaa: 0.0 ± 0.0
Phe
3.597PheAla: 3.597 ± 0.433
0.496PheCys: 0.496 ± 0.192
2.481PheAsp: 2.481 ± 0.458
2.419PheGlu: 2.419 ± 0.371
0.744PhePhe: 0.744 ± 0.187
2.853PheGly: 2.853 ± 0.452
0.868PheHis: 0.868 ± 0.264
1.426PheIle: 1.426 ± 0.32
1.054PheLys: 1.054 ± 0.251
2.543PheLeu: 2.543 ± 0.661
0.496PheMet: 0.496 ± 0.144
1.984PheAsn: 1.984 ± 0.393
1.55PhePro: 1.55 ± 0.338
1.364PheGln: 1.364 ± 0.253
1.984PheArg: 1.984 ± 0.317
1.984PheSer: 1.984 ± 0.367
2.233PheThr: 2.233 ± 0.301
2.543PheVal: 2.543 ± 0.371
0.372PheTrp: 0.372 ± 0.147
0.682PheTyr: 0.682 ± 0.198
0.0PheXaa: 0.0 ± 0.0
Gly
6.822GlyAla: 6.822 ± 1.015
0.682GlyCys: 0.682 ± 0.231
6.264GlyAsp: 6.264 ± 0.619
4.093GlyGlu: 4.093 ± 0.575
3.411GlyPhe: 3.411 ± 0.619
6.946GlyGly: 6.946 ± 1.363
1.674GlyHis: 1.674 ± 0.312
4.775GlyIle: 4.775 ± 0.627
4.403GlyLys: 4.403 ± 0.592
6.884GlyLeu: 6.884 ± 1.139
1.86GlyMet: 1.86 ± 0.28
3.659GlyAsn: 3.659 ± 0.613
4.279GlyPro: 4.279 ± 1.041
3.225GlyGln: 3.225 ± 0.407
4.093GlyArg: 4.093 ± 0.509
4.465GlySer: 4.465 ± 0.514
5.333GlyThr: 5.333 ± 0.699
6.698GlyVal: 6.698 ± 0.674
1.302GlyTrp: 1.302 ± 0.254
2.419GlyTyr: 2.419 ± 0.354
0.0GlyXaa: 0.0 ± 0.0
His
1.674HisAla: 1.674 ± 0.342
0.248HisCys: 0.248 ± 0.114
1.178HisAsp: 1.178 ± 0.275
1.488HisGlu: 1.488 ± 0.331
0.31HisPhe: 0.31 ± 0.147
1.798HisGly: 1.798 ± 0.411
0.434HisHis: 0.434 ± 0.155
1.364HisIle: 1.364 ± 0.269
0.806HisLys: 0.806 ± 0.257
1.86HisLeu: 1.86 ± 0.405
0.31HisMet: 0.31 ± 0.117
0.682HisAsn: 0.682 ± 0.187
1.054HisPro: 1.054 ± 0.227
0.744HisGln: 0.744 ± 0.222
1.55HisArg: 1.55 ± 0.377
1.178HisSer: 1.178 ± 0.38
0.93HisThr: 0.93 ± 0.241
1.054HisVal: 1.054 ± 0.28
0.62HisTrp: 0.62 ± 0.189
0.682HisTyr: 0.682 ± 0.271
0.0HisXaa: 0.0 ± 0.0
Ile
4.899IleAla: 4.899 ± 0.567
0.558IleCys: 0.558 ± 0.186
4.031IleAsp: 4.031 ± 0.487
4.961IleGlu: 4.961 ± 0.626
1.488IlePhe: 1.488 ± 0.301
4.217IleGly: 4.217 ± 0.741
0.992IleHis: 0.992 ± 0.273
2.357IleIle: 2.357 ± 0.351
2.791IleLys: 2.791 ± 0.491
3.349IleLeu: 3.349 ± 0.352
0.372IleMet: 0.372 ± 0.169
2.295IleAsn: 2.295 ± 0.431
3.225IlePro: 3.225 ± 0.421
2.171IleGln: 2.171 ± 0.527
3.101IleArg: 3.101 ± 0.371
2.419IleSer: 2.419 ± 0.539
3.411IleThr: 3.411 ± 0.416
2.605IleVal: 2.605 ± 0.397
0.868IleTrp: 0.868 ± 0.213
0.992IleTyr: 0.992 ± 0.21
0.0IleXaa: 0.0 ± 0.0
Lys
5.085LysAla: 5.085 ± 0.876
0.248LysCys: 0.248 ± 0.112
2.419LysAsp: 2.419 ± 0.366
2.667LysGlu: 2.667 ± 0.382
1.178LysPhe: 1.178 ± 0.264
3.535LysGly: 3.535 ± 0.683
0.806LysHis: 0.806 ± 0.214
1.984LysIle: 1.984 ± 0.416
2.729LysLys: 2.729 ± 0.507
3.659LysLeu: 3.659 ± 0.51
0.93LysMet: 0.93 ± 0.237
1.55LysAsn: 1.55 ± 0.332
2.977LysPro: 2.977 ± 0.502
1.612LysGln: 1.612 ± 0.394
3.287LysArg: 3.287 ± 0.469
2.729LysSer: 2.729 ± 0.377
2.977LysThr: 2.977 ± 0.42
3.783LysVal: 3.783 ± 0.434
0.806LysTrp: 0.806 ± 0.209
1.302LysTyr: 1.302 ± 0.31
0.0LysXaa: 0.0 ± 0.0
Leu
9.054LeuAla: 9.054 ± 0.868
0.682LeuCys: 0.682 ± 0.211
5.209LeuAsp: 5.209 ± 0.598
5.271LeuGlu: 5.271 ± 0.734
2.915LeuPhe: 2.915 ± 0.346
5.953LeuGly: 5.953 ± 0.932
1.922LeuHis: 1.922 ± 0.323
4.651LeuIle: 4.651 ± 0.586
3.597LeuLys: 3.597 ± 0.522
5.767LeuLeu: 5.767 ± 0.572
2.047LeuMet: 2.047 ± 0.314
2.419LeuAsn: 2.419 ± 0.402
4.775LeuPro: 4.775 ± 0.507
2.543LeuGln: 2.543 ± 0.416
6.45LeuArg: 6.45 ± 0.849
5.395LeuSer: 5.395 ± 0.612
4.651LeuThr: 4.651 ± 0.658
4.775LeuVal: 4.775 ± 0.77
1.24LeuTrp: 1.24 ± 0.265
2.171LeuTyr: 2.171 ± 0.373
0.0LeuXaa: 0.0 ± 0.0
Met
2.357MetAla: 2.357 ± 0.345
0.062MetCys: 0.062 ± 0.057
1.054MetAsp: 1.054 ± 0.227
1.054MetGlu: 1.054 ± 0.226
0.62MetPhe: 0.62 ± 0.198
1.364MetGly: 1.364 ± 0.271
0.434MetHis: 0.434 ± 0.178
1.24MetIle: 1.24 ± 0.266
1.116MetLys: 1.116 ± 0.236
1.736MetLeu: 1.736 ± 0.324
0.682MetMet: 0.682 ± 0.248
0.992MetAsn: 0.992 ± 0.255
1.24MetPro: 1.24 ± 0.274
0.868MetGln: 0.868 ± 0.242
1.364MetArg: 1.364 ± 0.29
2.171MetSer: 2.171 ± 0.341
2.481MetThr: 2.481 ± 0.372
1.054MetVal: 1.054 ± 0.228
0.248MetTrp: 0.248 ± 0.121
0.744MetTyr: 0.744 ± 0.223
0.0MetXaa: 0.0 ± 0.0
Asn
3.597AsnAla: 3.597 ± 0.657
0.62AsnCys: 0.62 ± 0.216
1.736AsnAsp: 1.736 ± 0.288
1.488AsnGlu: 1.488 ± 0.302
0.868AsnPhe: 0.868 ± 0.295
3.907AsnGly: 3.907 ± 0.563
1.054AsnHis: 1.054 ± 0.233
1.55AsnIle: 1.55 ± 0.358
1.24AsnLys: 1.24 ± 0.281
2.915AsnLeu: 2.915 ± 0.454
0.93AsnMet: 0.93 ± 0.201
0.682AsnAsn: 0.682 ± 0.187
2.233AsnPro: 2.233 ± 0.419
1.302AsnGln: 1.302 ± 0.27
1.674AsnArg: 1.674 ± 0.358
1.488AsnSer: 1.488 ± 0.266
1.612AsnThr: 1.612 ± 0.321
2.419AsnVal: 2.419 ± 0.444
0.93AsnTrp: 0.93 ± 0.217
0.682AsnTyr: 0.682 ± 0.177
0.0AsnXaa: 0.0 ± 0.0
Pro
5.953ProAla: 5.953 ± 0.67
0.434ProCys: 0.434 ± 0.181
3.473ProAsp: 3.473 ± 0.47
4.651ProGlu: 4.651 ± 0.641
1.922ProPhe: 1.922 ± 0.411
4.589ProGly: 4.589 ± 0.641
0.992ProHis: 0.992 ± 0.27
3.163ProIle: 3.163 ± 0.357
3.039ProLys: 3.039 ± 0.547
3.101ProLeu: 3.101 ± 0.51
0.93ProMet: 0.93 ± 0.224
1.736ProAsn: 1.736 ± 0.314
2.543ProPro: 2.543 ± 0.496
2.233ProGln: 2.233 ± 0.571
3.845ProArg: 3.845 ± 0.606
3.163ProSer: 3.163 ± 0.398
3.659ProThr: 3.659 ± 0.532
3.845ProVal: 3.845 ± 0.46
1.116ProTrp: 1.116 ± 0.374
1.302ProTyr: 1.302 ± 0.242
0.0ProXaa: 0.0 ± 0.0
Gln
4.775GlnAla: 4.775 ± 0.75
0.124GlnCys: 0.124 ± 0.086
1.488GlnAsp: 1.488 ± 0.258
2.109GlnGlu: 2.109 ± 0.372
1.302GlnPhe: 1.302 ± 0.294
4.589GlnGly: 4.589 ± 1.443
0.868GlnHis: 0.868 ± 0.184
2.729GlnIle: 2.729 ± 0.466
1.55GlnLys: 1.55 ± 0.332
3.163GlnLeu: 3.163 ± 0.82
1.178GlnMet: 1.178 ± 0.255
0.992GlnAsn: 0.992 ± 0.207
1.488GlnPro: 1.488 ± 0.357
1.922GlnGln: 1.922 ± 0.37
2.357GlnArg: 2.357 ± 0.376
1.612GlnSer: 1.612 ± 0.292
2.419GlnThr: 2.419 ± 0.464
2.419GlnVal: 2.419 ± 0.418
0.62GlnTrp: 0.62 ± 0.233
0.868GlnTyr: 0.868 ± 0.212
0.0GlnXaa: 0.0 ± 0.0
Arg
4.899ArgAla: 4.899 ± 0.667
0.93ArgCys: 0.93 ± 0.296
3.349ArgAsp: 3.349 ± 0.465
5.209ArgGlu: 5.209 ± 0.734
2.295ArgPhe: 2.295 ± 0.368
4.465ArgGly: 4.465 ± 0.516
1.426ArgHis: 1.426 ± 0.264
3.659ArgIle: 3.659 ± 0.488
3.287ArgLys: 3.287 ± 0.56
5.953ArgLeu: 5.953 ± 0.772
1.736ArgMet: 1.736 ± 0.339
2.233ArgAsn: 2.233 ± 0.386
2.729ArgPro: 2.729 ± 0.46
1.86ArgGln: 1.86 ± 0.345
4.837ArgArg: 4.837 ± 0.603
2.605ArgSer: 2.605 ± 0.407
3.039ArgThr: 3.039 ± 0.469
4.465ArgVal: 4.465 ± 0.456
1.426ArgTrp: 1.426 ± 0.296
1.798ArgTyr: 1.798 ± 0.378
0.0ArgXaa: 0.0 ± 0.0
Ser
4.217SerAla: 4.217 ± 0.502
0.62SerCys: 0.62 ± 0.179
3.969SerAsp: 3.969 ± 0.473
3.597SerGlu: 3.597 ± 0.422
1.86SerPhe: 1.86 ± 0.415
4.527SerGly: 4.527 ± 0.64
0.93SerHis: 0.93 ± 0.22
2.357SerIle: 2.357 ± 0.346
2.295SerLys: 2.295 ± 0.459
4.403SerLeu: 4.403 ± 0.738
1.302SerMet: 1.302 ± 0.272
1.116SerAsn: 1.116 ± 0.216
3.845SerPro: 3.845 ± 0.499
2.233SerGln: 2.233 ± 0.36
3.721SerArg: 3.721 ± 0.443
2.915SerSer: 2.915 ± 0.484
3.659SerThr: 3.659 ± 0.386
4.093SerVal: 4.093 ± 0.628
1.116SerTrp: 1.116 ± 0.232
1.612SerTyr: 1.612 ± 0.293
0.0SerXaa: 0.0 ± 0.0
Thr
6.14ThrAla: 6.14 ± 0.497
0.806ThrCys: 0.806 ± 0.213
3.659ThrAsp: 3.659 ± 0.568
3.473ThrGlu: 3.473 ± 0.515
2.047ThrPhe: 2.047 ± 0.314
5.271ThrGly: 5.271 ± 0.609
0.93ThrHis: 0.93 ± 0.248
2.791ThrIle: 2.791 ± 0.401
3.039ThrLys: 3.039 ± 0.487
5.519ThrLeu: 5.519 ± 0.696
1.178ThrMet: 1.178 ± 0.295
1.798ThrAsn: 1.798 ± 0.382
3.721ThrPro: 3.721 ± 0.457
2.605ThrGln: 2.605 ± 0.37
2.791ThrArg: 2.791 ± 0.467
3.597ThrSer: 3.597 ± 0.537
3.349ThrThr: 3.349 ± 0.52
5.023ThrVal: 5.023 ± 0.711
1.054ThrTrp: 1.054 ± 0.257
2.357ThrTyr: 2.357 ± 0.356
0.0ThrXaa: 0.0 ± 0.0
Val
6.388ValAla: 6.388 ± 0.87
0.868ValCys: 0.868 ± 0.244
5.643ValAsp: 5.643 ± 0.667
4.341ValGlu: 4.341 ± 0.513
2.419ValPhe: 2.419 ± 0.516
5.395ValGly: 5.395 ± 0.653
1.054ValHis: 1.054 ± 0.257
3.597ValIle: 3.597 ± 0.502
3.287ValLys: 3.287 ± 0.445
4.713ValLeu: 4.713 ± 0.62
1.178ValMet: 1.178 ± 0.249
2.667ValAsn: 2.667 ± 0.39
4.093ValPro: 4.093 ± 0.503
2.667ValGln: 2.667 ± 0.41
4.465ValArg: 4.465 ± 0.666
4.713ValSer: 4.713 ± 0.607
5.209ValThr: 5.209 ± 0.616
5.705ValVal: 5.705 ± 0.528
1.178ValTrp: 1.178 ± 0.315
1.86ValTyr: 1.86 ± 0.462
0.0ValXaa: 0.0 ± 0.0
Trp
1.984TrpAla: 1.984 ± 0.415
0.31TrpCys: 0.31 ± 0.138
0.868TrpAsp: 0.868 ± 0.224
0.992TrpGlu: 0.992 ± 0.252
0.62TrpPhe: 0.62 ± 0.222
1.116TrpGly: 1.116 ± 0.273
0.496TrpHis: 0.496 ± 0.201
1.054TrpIle: 1.054 ± 0.243
0.93TrpLys: 0.93 ± 0.268
1.116TrpLeu: 1.116 ± 0.325
0.496TrpMet: 0.496 ± 0.177
0.62TrpAsn: 0.62 ± 0.213
1.116TrpPro: 1.116 ± 0.297
1.178TrpGln: 1.178 ± 0.289
1.178TrpArg: 1.178 ± 0.271
1.364TrpSer: 1.364 ± 0.327
1.55TrpThr: 1.55 ± 0.294
0.992TrpVal: 0.992 ± 0.212
0.372TrpTrp: 0.372 ± 0.158
0.248TrpTyr: 0.248 ± 0.104
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.295TyrAla: 2.295 ± 0.421
0.124TyrCys: 0.124 ± 0.091
2.047TyrAsp: 2.047 ± 0.372
1.86TyrGlu: 1.86 ± 0.325
0.682TyrPhe: 0.682 ± 0.178
2.295TyrGly: 2.295 ± 0.44
0.558TyrHis: 0.558 ± 0.181
1.178TyrIle: 1.178 ± 0.23
0.93TyrLys: 0.93 ± 0.262
2.667TyrLeu: 2.667 ± 0.374
0.744TyrMet: 0.744 ± 0.22
0.744TyrAsn: 0.744 ± 0.205
1.736TyrPro: 1.736 ± 0.383
1.178TyrGln: 1.178 ± 0.245
1.86TyrArg: 1.86 ± 0.392
1.55TyrSer: 1.55 ± 0.306
1.612TyrThr: 1.612 ± 0.289
2.481TyrVal: 2.481 ± 0.43
0.682TyrTrp: 0.682 ± 0.221
0.93TyrTyr: 0.93 ± 0.253
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 91 proteins (16126 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski