Amino acid dipepetide frequency for Rotavirus A (isolate RVA/Monkey/South Africa/SA11-H96/1958/G3P5B[2]) (RV-A) (Simian Agent 11 (isolate SI/South Africa/H96/58))

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.36AlaAla: 4.36 ± 0.551
1.13AlaCys: 1.13 ± 0.391
3.391AlaAsp: 3.391 ± 0.436
2.261AlaGlu: 2.261 ± 0.665
2.584AlaPhe: 2.584 ± 0.492
1.938AlaGly: 1.938 ± 0.558
0.969AlaHis: 0.969 ± 0.343
3.714AlaIle: 3.714 ± 0.815
3.391AlaLys: 3.391 ± 1.215
4.037AlaLeu: 4.037 ± 0.726
1.453AlaMet: 1.453 ± 0.516
5.006AlaAsn: 5.006 ± 0.751
1.776AlaPro: 1.776 ± 0.439
2.099AlaGln: 2.099 ± 0.419
2.261AlaArg: 2.261 ± 0.829
3.391AlaSer: 3.391 ± 0.57
4.198AlaThr: 4.198 ± 1.266
3.875AlaVal: 3.875 ± 0.823
0.161AlaTrp: 0.161 ± 0.149
1.453AlaTyr: 1.453 ± 0.421
0.0AlaXaa: 0.0 ± 0.0
Cys
0.161CysAla: 0.161 ± 0.152
0.484CysCys: 0.484 ± 0.281
0.807CysAsp: 0.807 ± 0.317
0.484CysGlu: 0.484 ± 0.281
0.807CysPhe: 0.807 ± 0.417
0.0CysGly: 0.0 ± 0.0
0.0CysHis: 0.0 ± 0.0
0.807CysIle: 0.807 ± 0.33
1.13CysLys: 1.13 ± 0.595
1.292CysLeu: 1.292 ± 0.629
0.484CysMet: 0.484 ± 0.267
1.13CysAsn: 1.13 ± 0.412
0.323CysPro: 0.323 ± 0.294
0.646CysGln: 0.646 ± 0.387
0.646CysArg: 0.646 ± 0.289
0.646CysSer: 0.646 ± 0.383
1.13CysThr: 1.13 ± 0.62
0.323CysVal: 0.323 ± 0.205
0.0CysTrp: 0.0 ± 0.0
0.646CysTyr: 0.646 ± 0.387
0.0CysXaa: 0.0 ± 0.0
Asp
3.875AspAla: 3.875 ± 0.817
0.323AspCys: 0.323 ± 0.233
4.037AspAsp: 4.037 ± 0.916
3.391AspGlu: 3.391 ± 0.634
3.552AspPhe: 3.552 ± 0.588
2.422AspGly: 2.422 ± 0.373
0.484AspHis: 0.484 ± 0.258
5.329AspIle: 5.329 ± 0.738
3.552AspLys: 3.552 ± 0.917
4.844AspLeu: 4.844 ± 0.546
1.938AspMet: 1.938 ± 0.345
3.391AspAsn: 3.391 ± 0.598
2.099AspPro: 2.099 ± 0.566
2.584AspGln: 2.584 ± 0.393
2.099AspArg: 2.099 ± 0.57
4.683AspSer: 4.683 ± 0.929
3.391AspThr: 3.391 ± 0.926
4.683AspVal: 4.683 ± 0.776
0.969AspTrp: 0.969 ± 0.297
3.229AspTyr: 3.229 ± 0.564
0.0AspXaa: 0.0 ± 0.0
Glu
2.584GluAla: 2.584 ± 0.517
0.161GluCys: 0.161 ± 0.178
2.099GluAsp: 2.099 ± 0.482
4.198GluGlu: 4.198 ± 0.675
2.422GluPhe: 2.422 ± 0.783
1.292GluGly: 1.292 ± 0.496
0.807GluHis: 0.807 ± 0.38
4.521GluIle: 4.521 ± 0.858
3.714GluLys: 3.714 ± 1.118
5.813GluLeu: 5.813 ± 1.194
2.422GluMet: 2.422 ± 0.457
4.037GluAsn: 4.037 ± 0.745
1.776GluPro: 1.776 ± 0.576
2.099GluGln: 2.099 ± 0.592
2.907GluArg: 2.907 ± 0.651
2.907GluSer: 2.907 ± 0.7
2.745GluThr: 2.745 ± 0.654
3.229GluVal: 3.229 ± 0.527
0.807GluTrp: 0.807 ± 0.398
3.714GluTyr: 3.714 ± 0.917
0.0GluXaa: 0.0 ± 0.0
Phe
1.776PheAla: 1.776 ± 0.586
0.484PheCys: 0.484 ± 0.25
3.068PheAsp: 3.068 ± 0.59
2.907PheGlu: 2.907 ± 0.548
1.292PhePhe: 1.292 ± 0.432
1.938PheGly: 1.938 ± 0.521
1.292PheHis: 1.292 ± 0.384
4.521PheIle: 4.521 ± 0.775
4.037PheLys: 4.037 ± 0.817
3.552PheLeu: 3.552 ± 1.202
0.484PheMet: 0.484 ± 0.257
3.552PheAsn: 3.552 ± 0.737
1.776PhePro: 1.776 ± 0.588
1.776PheGln: 1.776 ± 0.641
2.099PheArg: 2.099 ± 0.548
3.229PheSer: 3.229 ± 0.674
2.584PheThr: 2.584 ± 0.76
1.615PheVal: 1.615 ± 0.55
0.161PheTrp: 0.161 ± 0.135
1.776PheTyr: 1.776 ± 0.503
0.0PheXaa: 0.0 ± 0.0
Gly
1.292GlyAla: 1.292 ± 0.4
1.13GlyCys: 1.13 ± 0.381
0.969GlyAsp: 0.969 ± 0.421
1.453GlyGlu: 1.453 ± 0.442
0.969GlyPhe: 0.969 ± 0.319
1.615GlyGly: 1.615 ± 0.61
0.969GlyHis: 0.969 ± 0.46
4.198GlyIle: 4.198 ± 0.838
2.584GlyLys: 2.584 ± 0.552
2.745GlyLeu: 2.745 ± 0.578
0.969GlyMet: 0.969 ± 0.37
1.292GlyAsn: 1.292 ± 0.376
1.453GlyPro: 1.453 ± 0.648
1.453GlyGln: 1.453 ± 0.486
1.13GlyArg: 1.13 ± 0.487
3.714GlySer: 3.714 ± 1.285
1.776GlyThr: 1.776 ± 0.597
2.584GlyVal: 2.584 ± 0.564
0.646GlyTrp: 0.646 ± 0.315
1.13GlyTyr: 1.13 ± 0.494
0.0GlyXaa: 0.0 ± 0.0
His
0.807HisAla: 0.807 ± 0.277
0.484HisCys: 0.484 ± 0.533
1.292HisAsp: 1.292 ± 0.335
0.323HisGlu: 0.323 ± 0.271
0.323HisPhe: 0.323 ± 0.185
0.161HisGly: 0.161 ± 0.203
0.646HisHis: 0.646 ± 0.325
0.646HisIle: 0.646 ± 0.335
1.13HisLys: 1.13 ± 0.443
1.615HisLeu: 1.615 ± 0.545
0.484HisMet: 0.484 ± 0.39
0.807HisAsn: 0.807 ± 0.31
0.646HisPro: 0.646 ± 0.387
0.969HisGln: 0.969 ± 0.534
0.0HisArg: 0.0 ± 0.0
1.615HisSer: 1.615 ± 0.503
0.646HisThr: 0.646 ± 0.204
1.13HisVal: 1.13 ± 0.336
0.161HisTrp: 0.161 ± 0.143
1.615HisTyr: 1.615 ± 0.539
0.0HisXaa: 0.0 ± 0.0
Ile
5.329IleAla: 5.329 ± 0.78
0.484IleCys: 0.484 ± 0.286
3.714IleAsp: 3.714 ± 1.024
5.49IleGlu: 5.49 ± 0.934
2.422IlePhe: 2.422 ± 0.75
2.907IleGly: 2.907 ± 0.558
0.646IleHis: 0.646 ± 0.472
5.652IleIle: 5.652 ± 0.588
5.006IleLys: 5.006 ± 0.989
6.297IleLeu: 6.297 ± 1.353
1.292IleMet: 1.292 ± 0.257
6.943IleAsn: 6.943 ± 0.689
4.36IlePro: 4.36 ± 0.696
4.037IleGln: 4.037 ± 0.679
4.683IleArg: 4.683 ± 0.604
6.297IleSer: 6.297 ± 0.974
6.459IleThr: 6.459 ± 0.93
3.552IleVal: 3.552 ± 0.496
0.323IleTrp: 0.323 ± 0.261
4.683IleTyr: 4.683 ± 1.37
0.0IleXaa: 0.0 ± 0.0
Lys
1.776LysAla: 1.776 ± 0.764
1.13LysCys: 1.13 ± 0.311
2.422LysAsp: 2.422 ± 0.685
4.36LysGlu: 4.36 ± 1.068
2.907LysPhe: 2.907 ± 1.075
2.099LysGly: 2.099 ± 0.591
1.292LysHis: 1.292 ± 0.536
4.037LysIle: 4.037 ± 1.039
3.714LysLys: 3.714 ± 0.619
7.912LysLeu: 7.912 ± 1.154
2.745LysMet: 2.745 ± 0.84
3.714LysAsn: 3.714 ± 0.74
2.261LysPro: 2.261 ± 0.667
3.068LysGln: 3.068 ± 0.669
3.068LysArg: 3.068 ± 0.538
4.844LysSer: 4.844 ± 0.959
2.907LysThr: 2.907 ± 0.486
4.037LysVal: 4.037 ± 0.902
1.615LysTrp: 1.615 ± 0.708
3.552LysTyr: 3.552 ± 1.1
0.0LysXaa: 0.0 ± 0.0
Leu
4.037LeuAla: 4.037 ± 0.696
0.969LeuCys: 0.969 ± 0.561
6.136LeuAsp: 6.136 ± 0.727
5.49LeuGlu: 5.49 ± 1.454
4.198LeuPhe: 4.198 ± 0.917
2.261LeuGly: 2.261 ± 0.479
2.099LeuHis: 2.099 ± 0.568
7.428LeuIle: 7.428 ± 0.635
5.652LeuLys: 5.652 ± 1.007
8.235LeuLeu: 8.235 ± 1.358
3.391LeuMet: 3.391 ± 0.726
7.105LeuAsn: 7.105 ± 0.904
4.36LeuPro: 4.36 ± 0.859
3.875LeuGln: 3.875 ± 1.181
5.167LeuArg: 5.167 ± 0.497
8.074LeuSer: 8.074 ± 0.908
7.589LeuThr: 7.589 ± 0.799
3.552LeuVal: 3.552 ± 0.948
0.646LeuTrp: 0.646 ± 0.249
4.844LeuTyr: 4.844 ± 0.77
0.0LeuXaa: 0.0 ± 0.0
Met
1.938MetAla: 1.938 ± 0.459
0.161MetCys: 0.161 ± 0.149
3.229MetAsp: 3.229 ± 0.881
1.292MetGlu: 1.292 ± 0.638
1.292MetPhe: 1.292 ± 0.358
0.969MetGly: 0.969 ± 0.45
0.646MetHis: 0.646 ± 0.31
1.13MetIle: 1.13 ± 0.373
2.099MetLys: 2.099 ± 0.477
3.552MetLeu: 3.552 ± 0.715
0.807MetMet: 0.807 ± 0.397
1.776MetAsn: 1.776 ± 0.504
0.807MetPro: 0.807 ± 0.342
1.938MetGln: 1.938 ± 0.87
1.938MetArg: 1.938 ± 0.485
2.745MetSer: 2.745 ± 0.758
1.453MetThr: 1.453 ± 0.341
0.807MetVal: 0.807 ± 0.276
0.646MetTrp: 0.646 ± 0.247
0.807MetTyr: 0.807 ± 0.336
0.0MetXaa: 0.0 ± 0.0
Asn
3.714AsnAla: 3.714 ± 0.527
0.484AsnCys: 0.484 ± 0.34
4.683AsnAsp: 4.683 ± 0.87
4.198AsnGlu: 4.198 ± 0.644
3.068AsnPhe: 3.068 ± 0.875
2.745AsnGly: 2.745 ± 0.734
1.938AsnHis: 1.938 ± 0.919
3.391AsnIle: 3.391 ± 1.051
2.907AsnLys: 2.907 ± 0.949
6.782AsnLeu: 6.782 ± 0.975
2.422AsnMet: 2.422 ± 0.671
5.006AsnAsn: 5.006 ± 1.163
1.615AsnPro: 1.615 ± 0.633
2.099AsnGln: 2.099 ± 0.621
2.907AsnArg: 2.907 ± 0.522
5.652AsnSer: 5.652 ± 0.807
3.391AsnThr: 3.391 ± 0.666
6.136AsnVal: 6.136 ± 0.875
1.776AsnTrp: 1.776 ± 0.585
5.006AsnTyr: 5.006 ± 0.88
0.0AsnXaa: 0.0 ± 0.0
Pro
1.292ProAla: 1.292 ± 0.49
0.0ProCys: 0.0 ± 0.0
2.099ProAsp: 2.099 ± 0.525
0.807ProGlu: 0.807 ± 0.324
2.099ProPhe: 2.099 ± 0.421
1.776ProGly: 1.776 ± 0.446
0.969ProHis: 0.969 ± 0.448
3.875ProIle: 3.875 ± 0.562
1.453ProLys: 1.453 ± 0.443
2.422ProLeu: 2.422 ± 0.474
0.969ProMet: 0.969 ± 0.462
2.099ProAsn: 2.099 ± 0.937
1.13ProPro: 1.13 ± 0.545
1.615ProGln: 1.615 ± 0.669
1.453ProArg: 1.453 ± 0.414
2.261ProSer: 2.261 ± 0.607
3.068ProThr: 3.068 ± 0.817
2.745ProVal: 2.745 ± 0.755
0.0ProTrp: 0.0 ± 0.0
1.615ProTyr: 1.615 ± 0.392
0.0ProXaa: 0.0 ± 0.0
Gln
1.776GlnAla: 1.776 ± 0.533
0.484GlnCys: 0.484 ± 0.201
2.261GlnAsp: 2.261 ± 0.566
1.453GlnGlu: 1.453 ± 0.486
2.099GlnPhe: 2.099 ± 0.716
0.323GlnGly: 0.323 ± 0.229
0.969GlnHis: 0.969 ± 0.362
4.037GlnIle: 4.037 ± 0.824
2.261GlnLys: 2.261 ± 0.565
5.813GlnLeu: 5.813 ± 1.218
1.453GlnMet: 1.453 ± 0.619
2.422GlnAsn: 2.422 ± 0.634
1.13GlnPro: 1.13 ± 0.303
2.422GlnGln: 2.422 ± 0.824
2.261GlnArg: 2.261 ± 0.82
1.776GlnSer: 1.776 ± 0.378
4.037GlnThr: 4.037 ± 0.874
3.229GlnVal: 3.229 ± 0.965
0.646GlnTrp: 0.646 ± 0.337
2.099GlnTyr: 2.099 ± 0.448
0.0GlnXaa: 0.0 ± 0.0
Arg
1.938ArgAla: 1.938 ± 0.538
0.646ArgCys: 0.646 ± 0.248
3.068ArgAsp: 3.068 ± 0.631
2.584ArgGlu: 2.584 ± 0.609
2.261ArgPhe: 2.261 ± 0.544
1.615ArgGly: 1.615 ± 0.37
0.646ArgHis: 0.646 ± 0.326
4.037ArgIle: 4.037 ± 0.433
2.745ArgLys: 2.745 ± 0.679
4.844ArgLeu: 4.844 ± 1.258
2.099ArgMet: 2.099 ± 0.549
3.875ArgAsn: 3.875 ± 1.096
0.646ArgPro: 0.646 ± 0.341
1.938ArgGln: 1.938 ± 0.673
2.584ArgArg: 2.584 ± 0.56
4.037ArgSer: 4.037 ± 0.58
2.261ArgThr: 2.261 ± 0.522
2.907ArgVal: 2.907 ± 0.64
0.807ArgTrp: 0.807 ± 0.374
1.292ArgTyr: 1.292 ± 0.412
0.0ArgXaa: 0.0 ± 0.0
Ser
3.875SerAla: 3.875 ± 0.827
0.484SerCys: 0.484 ± 0.328
4.36SerAsp: 4.36 ± 1.009
4.36SerGlu: 4.36 ± 0.656
2.907SerPhe: 2.907 ± 0.76
2.584SerGly: 2.584 ± 0.596
0.323SerHis: 0.323 ± 0.158
7.266SerIle: 7.266 ± 1.211
4.521SerLys: 4.521 ± 0.688
7.751SerLeu: 7.751 ± 1.036
2.099SerMet: 2.099 ± 0.54
5.49SerAsn: 5.49 ± 1.029
2.584SerPro: 2.584 ± 0.63
3.552SerGln: 3.552 ± 0.68
3.714SerArg: 3.714 ± 0.695
5.974SerSer: 5.974 ± 1.485
5.49SerThr: 5.49 ± 1.294
4.683SerVal: 4.683 ± 0.726
0.646SerTrp: 0.646 ± 0.399
3.229SerTyr: 3.229 ± 0.989
0.0SerXaa: 0.0 ± 0.0
Thr
4.36ThrAla: 4.36 ± 1.321
0.646ThrCys: 0.646 ± 0.393
4.521ThrAsp: 4.521 ± 1.032
3.391ThrGlu: 3.391 ± 0.717
3.875ThrPhe: 3.875 ± 0.734
2.422ThrGly: 2.422 ± 0.646
0.484ThrHis: 0.484 ± 0.28
5.974ThrIle: 5.974 ± 0.835
4.037ThrLys: 4.037 ± 0.433
7.589ThrLeu: 7.589 ± 1.544
1.615ThrMet: 1.615 ± 0.523
3.552ThrAsn: 3.552 ± 0.376
1.292ThrPro: 1.292 ± 0.398
2.584ThrGln: 2.584 ± 0.74
2.261ThrArg: 2.261 ± 0.541
4.683ThrSer: 4.683 ± 0.504
5.49ThrThr: 5.49 ± 1.284
4.521ThrVal: 4.521 ± 0.607
0.646ThrTrp: 0.646 ± 0.278
2.261ThrTyr: 2.261 ± 0.667
0.0ThrXaa: 0.0 ± 0.0
Val
4.683ValAla: 4.683 ± 0.839
1.13ValCys: 1.13 ± 0.441
5.006ValAsp: 5.006 ± 1.018
3.391ValGlu: 3.391 ± 0.731
2.584ValPhe: 2.584 ± 0.506
2.584ValGly: 2.584 ± 0.413
0.323ValHis: 0.323 ± 0.248
5.329ValIle: 5.329 ± 0.632
4.037ValLys: 4.037 ± 0.794
5.652ValLeu: 5.652 ± 0.584
1.938ValMet: 1.938 ± 0.742
3.714ValAsn: 3.714 ± 0.713
1.776ValPro: 1.776 ± 0.39
1.615ValGln: 1.615 ± 0.462
1.938ValArg: 1.938 ± 0.446
4.198ValSer: 4.198 ± 1.028
3.714ValThr: 3.714 ± 0.857
3.552ValVal: 3.552 ± 0.81
0.0ValTrp: 0.0 ± 0.0
2.745ValTyr: 2.745 ± 0.48
0.0ValXaa: 0.0 ± 0.0
Trp
0.161TrpAla: 0.161 ± 0.135
0.484TrpCys: 0.484 ± 0.533
0.969TrpAsp: 0.969 ± 0.285
0.161TrpGlu: 0.161 ± 0.15
0.161TrpPhe: 0.161 ± 0.152
0.161TrpGly: 0.161 ± 0.149
0.0TrpHis: 0.0 ± 0.0
1.453TrpIle: 1.453 ± 0.639
1.938TrpLys: 1.938 ± 0.536
1.615TrpLeu: 1.615 ± 0.299
0.161TrpMet: 0.161 ± 0.149
0.484TrpAsn: 0.484 ± 0.3
0.484TrpPro: 0.484 ± 0.307
0.646TrpGln: 0.646 ± 0.481
0.484TrpArg: 0.484 ± 0.356
0.484TrpSer: 0.484 ± 0.201
0.484TrpThr: 0.484 ± 0.248
0.161TrpVal: 0.161 ± 0.171
0.323TrpTrp: 0.323 ± 0.294
0.807TrpTyr: 0.807 ± 0.417
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.714TyrAla: 3.714 ± 0.746
0.646TyrCys: 0.646 ± 0.366
2.745TyrAsp: 2.745 ± 0.599
2.261TyrGlu: 2.261 ± 0.451
2.099TyrPhe: 2.099 ± 0.579
2.261TyrGly: 2.261 ± 0.667
0.0TyrHis: 0.0 ± 0.0
3.229TyrIle: 3.229 ± 0.584
3.552TyrLys: 3.552 ± 0.676
2.745TyrLeu: 2.745 ± 1.001
0.646TyrMet: 0.646 ± 0.308
4.521TyrAsn: 4.521 ± 0.754
1.453TyrPro: 1.453 ± 0.342
1.938TyrGln: 1.938 ± 0.57
3.229TyrArg: 3.229 ± 0.619
4.683TyrSer: 4.683 ± 1.303
3.391TyrThr: 3.391 ± 0.914
2.745TyrVal: 2.745 ± 0.432
0.646TyrTrp: 0.646 ± 0.328
3.229TyrTyr: 3.229 ± 1.258
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 13 proteins (6194 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski