Amino acid dipepetide frequency for Mycoplasma parvum str. Indiana

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.764AlaAla: 1.764 ± 0.125
0.384AlaCys: 0.384 ± 0.041
1.128AlaAsp: 1.128 ± 0.088
2.489AlaGlu: 2.489 ± 0.125
2.01AlaPhe: 2.01 ± 0.125
2.327AlaGly: 2.327 ± 0.124
0.684AlaHis: 0.684 ± 0.063
3.965AlaIle: 3.965 ± 0.175
3.515AlaLys: 3.515 ± 0.151
4.451AlaLeu: 4.451 ± 0.215
0.672AlaMet: 0.672 ± 0.058
2.123AlaAsn: 2.123 ± 0.112
0.966AlaPro: 0.966 ± 0.091
1.296AlaGln: 1.296 ± 0.097
1.524AlaArg: 1.524 ± 0.101
2.879AlaSer: 2.879 ± 0.109
1.638AlaThr: 1.638 ± 0.105
1.758AlaVal: 1.758 ± 0.11
0.618AlaTrp: 0.618 ± 0.053
1.212AlaTyr: 1.212 ± 0.101
0.0AlaXaa: 0.0 ± 0.0
Cys
0.444CysAla: 0.444 ± 0.05
0.312CysCys: 0.312 ± 0.091
0.48CysAsp: 0.48 ± 0.053
0.966CysGlu: 0.966 ± 0.077
0.816CysPhe: 0.816 ± 0.07
0.708CysGly: 0.708 ± 0.073
0.15CysHis: 0.15 ± 0.03
0.738CysIle: 0.738 ± 0.067
1.278CysLys: 1.278 ± 0.104
1.194CysLeu: 1.194 ± 0.09
0.156CysMet: 0.156 ± 0.035
0.522CysAsn: 0.522 ± 0.048
0.438CysPro: 0.438 ± 0.055
0.426CysGln: 0.426 ± 0.055
0.354CysArg: 0.354 ± 0.05
1.02CysSer: 1.02 ± 0.078
0.45CysThr: 0.45 ± 0.053
0.378CysVal: 0.378 ± 0.047
0.174CysTrp: 0.174 ± 0.029
0.36CysTyr: 0.36 ± 0.046
0.0CysXaa: 0.0 ± 0.0
Asp
1.362AspAla: 1.362 ± 0.102
0.594AspCys: 0.594 ± 0.057
1.488AspAsp: 1.488 ± 0.102
3.239AspGlu: 3.239 ± 0.151
2.789AspPhe: 2.789 ± 0.144
2.147AspGly: 2.147 ± 0.118
0.618AspHis: 0.618 ± 0.071
3.641AspIle: 3.641 ± 0.174
4.541AspLys: 4.541 ± 0.152
4.925AspLeu: 4.925 ± 0.181
0.54AspMet: 0.54 ± 0.055
2.675AspAsn: 2.675 ± 0.13
0.972AspPro: 0.972 ± 0.077
1.404AspGln: 1.404 ± 0.084
1.614AspArg: 1.614 ± 0.106
3.851AspSer: 3.851 ± 0.159
1.068AspThr: 1.068 ± 0.076
1.446AspVal: 1.446 ± 0.095
1.08AspTrp: 1.08 ± 0.077
2.07AspTyr: 2.07 ± 0.126
0.0AspXaa: 0.0 ± 0.0
Glu
2.987GluAla: 2.987 ± 0.124
0.852GluCys: 0.852 ± 0.073
3.425GluAsp: 3.425 ± 0.155
8.662GluGlu: 8.662 ± 0.279
4.067GluPhe: 4.067 ± 0.156
3.845GluGly: 3.845 ± 0.158
0.894GluHis: 0.894 ± 0.073
8.734GluIle: 8.734 ± 0.234
11.781GluLys: 11.781 ± 0.312
8.41GluLeu: 8.41 ± 0.24
1.548GluMet: 1.548 ± 0.106
6.58GluAsn: 6.58 ± 0.237
0.912GluPro: 0.912 ± 0.074
2.735GluGln: 2.735 ± 0.152
2.825GluArg: 2.825 ± 0.153
4.715GluSer: 4.715 ± 0.209
2.537GluThr: 2.537 ± 0.113
3.815GluVal: 3.815 ± 0.186
1.542GluTrp: 1.542 ± 0.109
2.519GluTyr: 2.519 ± 0.131
0.0GluXaa: 0.0 ± 0.0
Phe
1.98PheAla: 1.98 ± 0.115
0.798PheCys: 0.798 ± 0.069
2.483PheAsp: 2.483 ± 0.134
4.139PheGlu: 4.139 ± 0.164
4.241PhePhe: 4.241 ± 0.218
2.969PheGly: 2.969 ± 0.148
0.84PheHis: 0.84 ± 0.078
4.145PheIle: 4.145 ± 0.181
5.909PheLys: 5.909 ± 0.202
6.958PheLeu: 6.958 ± 0.281
0.876PheMet: 0.876 ± 0.072
3.575PheAsn: 3.575 ± 0.151
1.92PhePro: 1.92 ± 0.102
2.064PheGln: 2.064 ± 0.135
1.812PheArg: 1.812 ± 0.095
6.394PheSer: 6.394 ± 0.22
2.171PheThr: 2.171 ± 0.121
2.273PheVal: 2.273 ± 0.131
1.05PheTrp: 1.05 ± 0.083
2.375PheTyr: 2.375 ± 0.137
0.0PheXaa: 0.0 ± 0.0
Gly
2.615GlyAla: 2.615 ± 0.131
0.78GlyCys: 0.78 ± 0.067
2.627GlyAsp: 2.627 ± 0.144
4.289GlyGlu: 4.289 ± 0.162
2.585GlyPhe: 2.585 ± 0.142
4.541GlyGly: 4.541 ± 0.232
0.69GlyHis: 0.69 ± 0.077
4.847GlyIle: 4.847 ± 0.196
5.423GlyLys: 5.423 ± 0.171
4.247GlyLeu: 4.247 ± 0.173
0.768GlyMet: 0.768 ± 0.074
3.227GlyAsn: 3.227 ± 0.153
0.852GlyPro: 0.852 ± 0.07
1.71GlyGln: 1.71 ± 0.107
2.135GlyArg: 2.135 ± 0.133
3.407GlySer: 3.407 ± 0.154
2.04GlyThr: 2.04 ± 0.139
3.077GlyVal: 3.077 ± 0.143
0.942GlyTrp: 0.942 ± 0.083
1.656GlyTyr: 1.656 ± 0.106
0.0GlyXaa: 0.0 ± 0.0
His
0.498HisAla: 0.498 ± 0.059
0.132HisCys: 0.132 ± 0.027
0.51HisAsp: 0.51 ± 0.056
0.756HisGlu: 0.756 ± 0.069
0.954HisPhe: 0.954 ± 0.082
0.684HisGly: 0.684 ± 0.068
0.288HisHis: 0.288 ± 0.07
1.05HisIle: 1.05 ± 0.084
1.254HisLys: 1.254 ± 0.089
1.872HisLeu: 1.872 ± 0.103
0.156HisMet: 0.156 ± 0.035
0.822HisAsn: 0.822 ± 0.072
0.456HisPro: 0.456 ± 0.049
0.396HisGln: 0.396 ± 0.045
0.42HisArg: 0.42 ± 0.047
1.296HisSer: 1.296 ± 0.087
0.546HisThr: 0.546 ± 0.061
0.504HisVal: 0.504 ± 0.056
0.228HisTrp: 0.228 ± 0.036
0.612HisTyr: 0.612 ± 0.062
0.0HisXaa: 0.0 ± 0.0
Ile
3.437IleAla: 3.437 ± 0.167
1.062IleCys: 1.062 ± 0.076
3.959IleAsp: 3.959 ± 0.192
6.61IleGlu: 6.61 ± 0.193
5.777IlePhe: 5.777 ± 0.233
4.391IleGly: 4.391 ± 0.174
1.068IleHis: 1.068 ± 0.073
6.52IleIle: 6.52 ± 0.25
9.19IleLys: 9.19 ± 0.265
7.906IleLeu: 7.906 ± 0.24
1.2IleMet: 1.2 ± 0.093
5.921IleAsn: 5.921 ± 0.179
3.191IlePro: 3.191 ± 0.159
2.723IleGln: 2.723 ± 0.12
2.663IleArg: 2.663 ± 0.133
8.512IleSer: 8.512 ± 0.259
3.461IleThr: 3.461 ± 0.155
4.169IleVal: 4.169 ± 0.146
1.296IleTrp: 1.296 ± 0.081
3.317IleTyr: 3.317 ± 0.156
0.0IleXaa: 0.0 ± 0.0
Lys
3.737LysAla: 3.737 ± 0.159
1.092LysCys: 1.092 ± 0.078
5.375LysAsp: 5.375 ± 0.2
12.399LysGlu: 12.399 ± 0.303
4.877LysPhe: 4.877 ± 0.214
5.051LysGly: 5.051 ± 0.193
1.182LysHis: 1.182 ± 0.092
10.006LysIle: 10.006 ± 0.293
13.329LysLys: 13.329 ± 0.398
11.043LysLeu: 11.043 ± 0.255
2.189LysMet: 2.189 ± 0.104
9.814LysAsn: 9.814 ± 0.323
1.728LysPro: 1.728 ± 0.101
3.167LysGln: 3.167 ± 0.146
3.989LysArg: 3.989 ± 0.158
6.394LysSer: 6.394 ± 0.204
4.877LysThr: 4.877 ± 0.219
5.795LysVal: 5.795 ± 0.2
1.782LysTrp: 1.782 ± 0.111
4.637LysTyr: 4.637 ± 0.171
0.0LysXaa: 0.0 ± 0.0
Leu
3.959LeuAla: 3.959 ± 0.184
1.002LeuCys: 1.002 ± 0.078
4.859LeuAsp: 4.859 ± 0.198
8.302LeuGlu: 8.302 ± 0.287
6.454LeuPhe: 6.454 ± 0.273
4.889LeuGly: 4.889 ± 0.169
1.374LeuHis: 1.374 ± 0.092
9.082LeuIle: 9.082 ± 0.278
12.423LeuLys: 12.423 ± 0.306
10.108LeuLeu: 10.108 ± 0.309
1.638LeuMet: 1.638 ± 0.093
7.99LeuAsn: 7.99 ± 0.238
3.317LeuPro: 3.317 ± 0.124
2.981LeuGln: 2.981 ± 0.15
3.287LeuArg: 3.287 ± 0.123
9.946LeuSer: 9.946 ± 0.304
4.139LeuThr: 4.139 ± 0.171
4.487LeuVal: 4.487 ± 0.187
1.398LeuTrp: 1.398 ± 0.112
2.795LeuTyr: 2.795 ± 0.144
0.0LeuXaa: 0.0 ± 0.0
Met
0.636MetAla: 0.636 ± 0.067
0.138MetCys: 0.138 ± 0.028
0.6MetAsp: 0.6 ± 0.057
1.17MetGlu: 1.17 ± 0.077
0.87MetPhe: 0.87 ± 0.075
1.134MetGly: 1.134 ± 0.083
0.252MetHis: 0.252 ± 0.035
1.32MetIle: 1.32 ± 0.088
1.788MetLys: 1.788 ± 0.112
1.296MetLeu: 1.296 ± 0.076
0.204MetMet: 0.204 ± 0.033
1.23MetAsn: 1.23 ± 0.088
0.534MetPro: 0.534 ± 0.056
0.45MetGln: 0.45 ± 0.048
0.678MetArg: 0.678 ± 0.068
1.386MetSer: 1.386 ± 0.075
0.708MetThr: 0.708 ± 0.058
0.768MetVal: 0.768 ± 0.065
0.258MetTrp: 0.258 ± 0.042
0.384MetTyr: 0.384 ± 0.045
0.0MetXaa: 0.0 ± 0.0
Asn
1.746AsnAla: 1.746 ± 0.102
0.768AsnCys: 0.768 ± 0.075
2.303AsnAsp: 2.303 ± 0.109
4.829AsnGlu: 4.829 ± 0.181
4.733AsnPhe: 4.733 ± 0.181
3.383AsnGly: 3.383 ± 0.172
0.942AsnHis: 0.942 ± 0.076
5.837AsnIle: 5.837 ± 0.176
7.978AsnLys: 7.978 ± 0.269
8.092AsnLeu: 8.092 ± 0.236
1.05AsnMet: 1.05 ± 0.086
5.705AsnAsn: 5.705 ± 0.253
1.794AsnPro: 1.794 ± 0.095
2.717AsnGln: 2.717 ± 0.134
2.225AsnArg: 2.225 ± 0.127
6.341AsnSer: 6.341 ± 0.239
2.399AsnThr: 2.399 ± 0.126
2.483AsnVal: 2.483 ± 0.117
1.548AsnTrp: 1.548 ± 0.12
3.167AsnTyr: 3.167 ± 0.146
0.0AsnXaa: 0.0 ± 0.0
Pro
1.032ProAla: 1.032 ± 0.081
0.252ProCys: 0.252 ± 0.035
0.99ProAsp: 0.99 ± 0.074
2.237ProGlu: 2.237 ± 0.114
1.608ProPhe: 1.608 ± 0.094
0.87ProGly: 0.87 ± 0.073
0.51ProHis: 0.51 ± 0.05
2.423ProIle: 2.423 ± 0.129
2.813ProLys: 2.813 ± 0.112
2.663ProLeu: 2.663 ± 0.144
0.372ProMet: 0.372 ± 0.048
1.338ProAsn: 1.338 ± 0.098
0.678ProPro: 0.678 ± 0.063
0.864ProGln: 0.864 ± 0.082
0.72ProArg: 0.72 ± 0.065
2.028ProSer: 2.028 ± 0.116
1.374ProThr: 1.374 ± 0.092
1.236ProVal: 1.236 ± 0.088
0.342ProTrp: 0.342 ± 0.047
1.014ProTyr: 1.014 ± 0.065
0.0ProXaa: 0.0 ± 0.0
Gln
1.23GlnAla: 1.23 ± 0.09
0.18GlnCys: 0.18 ± 0.034
1.296GlnAsp: 1.296 ± 0.074
3.293GlnGlu: 3.293 ± 0.144
1.434GlnPhe: 1.434 ± 0.107
1.476GlnGly: 1.476 ± 0.09
0.51GlnHis: 0.51 ± 0.058
2.957GlnIle: 2.957 ± 0.141
4.337GlnLys: 4.337 ± 0.178
3.743GlnLeu: 3.743 ± 0.144
0.498GlnMet: 0.498 ± 0.054
2.447GlnAsn: 2.447 ± 0.135
0.63GlnPro: 0.63 ± 0.067
1.47GlnGln: 1.47 ± 0.123
1.056GlnArg: 1.056 ± 0.073
1.944GlnSer: 1.944 ± 0.116
1.41GlnThr: 1.41 ± 0.105
1.194GlnVal: 1.194 ± 0.085
0.48GlnTrp: 0.48 ± 0.052
1.062GlnTyr: 1.062 ± 0.081
0.0GlnXaa: 0.0 ± 0.0
Arg
1.488ArgAla: 1.488 ± 0.086
0.246ArgCys: 0.246 ± 0.036
1.644ArgAsp: 1.644 ± 0.11
3.941ArgGlu: 3.941 ± 0.155
1.428ArgPhe: 1.428 ± 0.097
2.004ArgGly: 2.004 ± 0.116
0.348ArgHis: 0.348 ± 0.048
3.047ArgIle: 3.047 ± 0.146
3.971ArgLys: 3.971 ± 0.189
2.837ArgLeu: 2.837 ± 0.124
0.678ArgMet: 0.678 ± 0.068
2.519ArgAsn: 2.519 ± 0.107
0.72ArgPro: 0.72 ± 0.073
0.948ArgGln: 0.948 ± 0.078
1.494ArgArg: 1.494 ± 0.111
2.207ArgSer: 2.207 ± 0.103
1.578ArgThr: 1.578 ± 0.086
1.77ArgVal: 1.77 ± 0.127
0.6ArgTrp: 0.6 ± 0.057
1.116ArgTyr: 1.116 ± 0.095
0.0ArgXaa: 0.0 ± 0.0
Ser
2.927SerAla: 2.927 ± 0.128
1.098SerCys: 1.098 ± 0.085
3.155SerAsp: 3.155 ± 0.128
6.065SerGlu: 6.065 ± 0.166
5.351SerPhe: 5.351 ± 0.175
4.193SerGly: 4.193 ± 0.178
1.032SerHis: 1.032 ± 0.084
6.718SerIle: 6.718 ± 0.215
8.512SerLys: 8.512 ± 0.224
9.352SerLeu: 9.352 ± 0.25
1.062SerMet: 1.062 ± 0.081
5.399SerAsn: 5.399 ± 0.219
2.447SerPro: 2.447 ± 0.122
3.017SerGln: 3.017 ± 0.12
2.675SerArg: 2.675 ± 0.139
8.956SerSer: 8.956 ± 0.314
3.461SerThr: 3.461 ± 0.157
2.795SerVal: 2.795 ± 0.154
1.266SerTrp: 1.266 ± 0.085
2.891SerTyr: 2.891 ± 0.142
0.0SerXaa: 0.0 ± 0.0
Thr
1.692ThrAla: 1.692 ± 0.104
0.426ThrCys: 0.426 ± 0.048
1.302ThrAsp: 1.302 ± 0.1
2.597ThrGlu: 2.597 ± 0.114
2.417ThrPhe: 2.417 ± 0.116
2.345ThrGly: 2.345 ± 0.119
0.684ThrHis: 0.684 ± 0.061
3.491ThrIle: 3.491 ± 0.15
4.331ThrLys: 4.331 ± 0.181
4.145ThrLeu: 4.145 ± 0.171
0.57ThrMet: 0.57 ± 0.055
2.639ThrAsn: 2.639 ± 0.149
1.326ThrPro: 1.326 ± 0.097
1.368ThrGln: 1.368 ± 0.083
1.278ThrArg: 1.278 ± 0.081
3.317ThrSer: 3.317 ± 0.152
2.04ThrThr: 2.04 ± 0.133
1.806ThrVal: 1.806 ± 0.118
0.642ThrTrp: 0.642 ± 0.054
1.194ThrTyr: 1.194 ± 0.086
0.0ThrXaa: 0.0 ± 0.0
Val
1.968ValAla: 1.968 ± 0.121
0.486ValCys: 0.486 ± 0.048
2.088ValAsp: 2.088 ± 0.122
3.323ValGlu: 3.323 ± 0.144
2.789ValPhe: 2.789 ± 0.13
3.035ValGly: 3.035 ± 0.155
0.648ValHis: 0.648 ± 0.061
3.911ValIle: 3.911 ± 0.146
4.301ValLys: 4.301 ± 0.169
4.733ValLeu: 4.733 ± 0.16
0.666ValMet: 0.666 ± 0.058
2.741ValAsn: 2.741 ± 0.128
1.242ValPro: 1.242 ± 0.095
1.17ValGln: 1.17 ± 0.09
1.662ValArg: 1.662 ± 0.119
3.215ValSer: 3.215 ± 0.128
1.8ValThr: 1.8 ± 0.114
2.429ValVal: 2.429 ± 0.125
0.762ValTrp: 0.762 ± 0.069
1.2ValTyr: 1.2 ± 0.07
0.0ValXaa: 0.0 ± 0.0
Trp
0.708TrpAla: 0.708 ± 0.069
0.252TrpCys: 0.252 ± 0.036
0.876TrpAsp: 0.876 ± 0.072
1.632TrpGlu: 1.632 ± 0.092
1.026TrpPhe: 1.026 ± 0.08
0.924TrpGly: 0.924 ± 0.075
0.198TrpHis: 0.198 ± 0.036
1.434TrpIle: 1.434 ± 0.104
2.129TrpLys: 2.129 ± 0.138
1.302TrpLeu: 1.302 ± 0.103
0.402TrpMet: 0.402 ± 0.05
1.494TrpAsn: 1.494 ± 0.106
0.27TrpPro: 0.27 ± 0.037
0.48TrpGln: 0.48 ± 0.051
0.648TrpArg: 0.648 ± 0.059
0.948TrpSer: 0.948 ± 0.078
0.792TrpThr: 0.792 ± 0.071
0.858TrpVal: 0.858 ± 0.079
0.462TrpTrp: 0.462 ± 0.057
0.456TrpTyr: 0.456 ± 0.055
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.194TyrAla: 1.194 ± 0.081
0.51TyrCys: 0.51 ± 0.054
1.476TyrAsp: 1.476 ± 0.088
2.447TyrGlu: 2.447 ± 0.098
2.747TyrPhe: 2.747 ± 0.138
1.542TyrGly: 1.542 ± 0.083
0.522TyrHis: 0.522 ± 0.05
2.507TyrIle: 2.507 ± 0.139
3.659TyrLys: 3.659 ± 0.13
5.153TyrLeu: 5.153 ± 0.161
0.552TyrMet: 0.552 ± 0.055
1.284TyrAsn: 1.284 ± 0.096
0.972TyrPro: 0.972 ± 0.072
1.26TyrGln: 1.26 ± 0.08
1.524TyrArg: 1.524 ± 0.094
3.617TyrSer: 3.617 ± 0.155
1.122TyrThr: 1.122 ± 0.093
1.128TyrVal: 1.128 ± 0.079
0.822TyrTrp: 0.822 ± 0.085
1.764TyrTyr: 1.764 ± 0.124
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 580 proteins (166707 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski