Amino acid dipepetide frequency for Altererythrobacter sp. B11

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.533AlaAla: 19.533 ± 0.2	1.147AlaCys: 1.147 ± 0.036	7.321AlaAsp: 7.321 ± 0.092	8.901AlaGlu: 8.901 ± 0.115	4.241AlaPhe: 4.241 ± 0.065	11.922AlaGly: 11.922 ± 0.116	2.29AlaHis: 2.29 ± 0.05	6.296AlaIle: 6.296 ± 0.087	3.46AlaLys: 3.46 ± 0.078	14.331AlaLeu: 14.331 ± 0.167	3.79AlaMet: 3.79 ± 0.06	3.009AlaAsn: 3.009 ± 0.052	6.612AlaPro: 6.612 ± 0.093	4.717AlaGln: 4.717 ± 0.074	9.949AlaArg: 9.949 ± 0.136	6.572AlaSer: 6.572 ± 0.094	6.077AlaThr: 6.077 ± 0.106	8.642AlaVal: 8.642 ± 0.094	1.63AlaTrp: 1.63 ± 0.043	2.564AlaTyr: 2.564 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	1.086CysAla: 1.086 ± 0.032	0.096CysCys: 0.096 ± 0.009	0.551CysAsp: 0.551 ± 0.025	0.486CysGlu: 0.486 ± 0.023	0.306CysPhe: 0.306 ± 0.019	0.883CysGly: 0.883 ± 0.031	0.241CysHis: 0.241 ± 0.017	0.314CysIle: 0.314 ± 0.017	0.161CysLys: 0.161 ± 0.013	0.729CysLeu: 0.729 ± 0.027	0.157CysMet: 0.157 ± 0.014	0.207CysAsn: 0.207 ± 0.012	0.425CysPro: 0.425 ± 0.02	0.211CysGln: 0.211 ± 0.016	0.611CysArg: 0.611 ± 0.026	0.508CysSer: 0.508 ± 0.023	0.427CysThr: 0.427 ± 0.022	0.585CysVal: 0.585 ± 0.022	0.12CysTrp: 0.12 ± 0.011	0.182CysTyr: 0.182 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.261AspAla: 7.261 ± 0.096	0.496AspCys: 0.496 ± 0.02	3.024AspAsp: 3.024 ± 0.056	3.585AspGlu: 3.585 ± 0.065	2.192AspPhe: 2.192 ± 0.048	5.546AspGly: 5.546 ± 0.076	1.274AspHis: 1.274 ± 0.035	2.684AspIle: 2.684 ± 0.044	1.493AspLys: 1.493 ± 0.044	5.922AspLeu: 5.922 ± 0.071	1.372AspMet: 1.372 ± 0.035	1.352AspAsn: 1.352 ± 0.04	3.83AspPro: 3.83 ± 0.067	1.672AspGln: 1.672 ± 0.041	4.816AspArg: 4.816 ± 0.072	2.497AspSer: 2.497 ± 0.052	2.504AspThr: 2.504 ± 0.052	3.784AspVal: 3.784 ± 0.06	1.154AspTrp: 1.154 ± 0.034	1.653AspTyr: 1.653 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	8.354GluAla: 8.354 ± 0.122	0.376GluCys: 0.376 ± 0.022	3.266GluAsp: 3.266 ± 0.061	3.915GluGlu: 3.915 ± 0.085	1.73GluPhe: 1.73 ± 0.041	5.23GluGly: 5.23 ± 0.078	1.166GluHis: 1.166 ± 0.031	3.013GluIle: 3.013 ± 0.059	2.02GluLys: 2.02 ± 0.053	5.746GluLeu: 5.746 ± 0.091	1.548GluMet: 1.548 ± 0.038	1.425GluAsn: 1.425 ± 0.034	2.888GluPro: 2.888 ± 0.051	2.481GluGln: 2.481 ± 0.048	5.304GluArg: 5.304 ± 0.085	2.451GluSer: 2.451 ± 0.048	3.066GluThr: 3.066 ± 0.052	3.9GluVal: 3.9 ± 0.06	0.951GluTrp: 0.951 ± 0.029	1.136GluTyr: 1.136 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	5.124PheAla: 5.124 ± 0.072	0.347PheCys: 0.347 ± 0.019	2.61PheAsp: 2.61 ± 0.05	2.04PheGlu: 2.04 ± 0.041	1.274PhePhe: 1.274 ± 0.041	3.563PheGly: 3.563 ± 0.064	0.73PheHis: 0.73 ± 0.028	1.468PheIle: 1.468 ± 0.038	0.73PheLys: 0.73 ± 0.026	3.215PheLeu: 3.215 ± 0.067	0.708PheMet: 0.708 ± 0.026	1.024PheAsn: 1.024 ± 0.04	1.617PhePro: 1.617 ± 0.046	0.919PheGln: 0.919 ± 0.031	2.225PheArg: 2.225 ± 0.044	2.052PheSer: 2.052 ± 0.043	2.13PheThr: 2.13 ± 0.053	2.608PheVal: 2.608 ± 0.046	0.536PheTrp: 0.536 ± 0.022	0.929PheTyr: 0.929 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	10.344GlyAla: 10.344 ± 0.132	0.827GlyCys: 0.827 ± 0.031	4.929GlyAsp: 4.929 ± 0.075	5.528GlyGlu: 5.528 ± 0.074	3.605GlyPhe: 3.605 ± 0.067	8.402GlyGly: 8.402 ± 0.156	1.818GlyHis: 1.818 ± 0.045	4.224GlyIle: 4.224 ± 0.065	3.141GlyLys: 3.141 ± 0.06	8.875GlyLeu: 8.875 ± 0.1	2.432GlyMet: 2.432 ± 0.05	2.268GlyAsn: 2.268 ± 0.072	3.926GlyPro: 3.926 ± 0.065	2.97GlyGln: 2.97 ± 0.058	6.508GlyArg: 6.508 ± 0.083	5.155GlySer: 5.155 ± 0.115	5.142GlyThr: 5.142 ± 0.128	6.097GlyVal: 6.097 ± 0.08	1.646GlyTrp: 1.646 ± 0.036	2.237GlyTyr: 2.237 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	2.336HisAla: 2.336 ± 0.054	0.247HisCys: 0.247 ± 0.013	1.178HisAsp: 1.178 ± 0.036	1.057HisGlu: 1.057 ± 0.031	0.808HisPhe: 0.808 ± 0.029	1.959HisGly: 1.959 ± 0.046	0.507HisHis: 0.507 ± 0.026	0.838HisIle: 0.838 ± 0.03	0.398HisLys: 0.398 ± 0.021	1.905HisLeu: 1.905 ± 0.045	0.446HisMet: 0.446 ± 0.02	0.429HisAsn: 0.429 ± 0.021	1.365HisPro: 1.365 ± 0.038	0.52HisGln: 0.52 ± 0.017	1.513HisArg: 1.513 ± 0.035	0.973HisSer: 0.973 ± 0.029	0.764HisThr: 0.764 ± 0.026	1.442HisVal: 1.442 ± 0.038	0.377HisTrp: 0.377 ± 0.018	0.536HisTyr: 0.536 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	7.184IleAla: 7.184 ± 0.077	0.428IleCys: 0.428 ± 0.021	3.382IleAsp: 3.382 ± 0.06	3.309IleGlu: 3.309 ± 0.064	1.485IlePhe: 1.485 ± 0.043	4.825IleGly: 4.825 ± 0.069	0.854IleHis: 0.854 ± 0.031	1.841IleIle: 1.841 ± 0.043	1.022IleLys: 1.022 ± 0.033	3.736IleLeu: 3.736 ± 0.06	0.834IleMet: 0.834 ± 0.031	1.236IleAsn: 1.236 ± 0.037	2.195IlePro: 2.195 ± 0.046	1.08IleGln: 1.08 ± 0.032	3.175IleArg: 3.175 ± 0.054	2.601IleSer: 2.601 ± 0.056	2.479IleThr: 2.479 ± 0.054	3.728IleVal: 3.728 ± 0.056	0.574IleTrp: 0.574 ± 0.022	1.045IleTyr: 1.045 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	3.493LysAla: 3.493 ± 0.064	0.14LysCys: 0.14 ± 0.012	1.413LysAsp: 1.413 ± 0.038	1.303LysGlu: 1.303 ± 0.042	0.746LysPhe: 0.746 ± 0.024	2.382LysGly: 2.382 ± 0.051	0.502LysHis: 0.502 ± 0.022	1.27LysIle: 1.27 ± 0.038	0.968LysLys: 0.968 ± 0.038	2.839LysLeu: 2.839 ± 0.054	0.659LysMet: 0.659 ± 0.024	0.637LysAsn: 0.637 ± 0.023	1.75LysPro: 1.75 ± 0.043	0.847LysGln: 0.847 ± 0.028	2.109LysArg: 2.109 ± 0.058	1.359LysSer: 1.359 ± 0.043	1.467LysThr: 1.467 ± 0.043	2.012LysVal: 2.012 ± 0.045	0.369LysTrp: 0.369 ± 0.019	0.497LysTyr: 0.497 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	15.26LeuAla: 15.26 ± 0.19	0.862LeuCys: 0.862 ± 0.026	6.108LeuAsp: 6.108 ± 0.083	5.429LeuGlu: 5.429 ± 0.085	3.703LeuPhe: 3.703 ± 0.064	8.53LeuGly: 8.53 ± 0.096	1.847LeuHis: 1.847 ± 0.047	4.398LeuIle: 4.398 ± 0.07	2.688LeuLys: 2.688 ± 0.058	10.193LeuLeu: 10.193 ± 0.164	2.105LeuMet: 2.105 ± 0.047	2.222LeuAsn: 2.222 ± 0.049	5.752LeuPro: 5.752 ± 0.082	2.889LeuGln: 2.889 ± 0.058	7.545LeuArg: 7.545 ± 0.095	6.037LeuSer: 6.037 ± 0.087	5.429LeuThr: 5.429 ± 0.081	7.256LeuVal: 7.256 ± 0.095	1.243LeuTrp: 1.243 ± 0.038	1.911LeuTyr: 1.911 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	3.258MetAla: 3.258 ± 0.055	0.146MetCys: 0.146 ± 0.013	1.218MetAsp: 1.218 ± 0.04	1.214MetGlu: 1.214 ± 0.034	0.686MetPhe: 0.686 ± 0.028	1.885MetGly: 1.885 ± 0.045	0.484MetHis: 0.484 ± 0.022	1.286MetIle: 1.286 ± 0.035	0.859MetLys: 0.859 ± 0.027	2.565MetLeu: 2.565 ± 0.058	0.628MetMet: 0.628 ± 0.027	0.648MetAsn: 0.648 ± 0.023	1.444MetPro: 1.444 ± 0.036	0.793MetGln: 0.793 ± 0.031	1.802MetArg: 1.802 ± 0.042	1.365MetSer: 1.365 ± 0.034	1.47MetThr: 1.47 ± 0.04	1.606MetVal: 1.606 ± 0.038	0.234MetTrp: 0.234 ± 0.015	0.283MetTyr: 0.283 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.948AsnAla: 2.948 ± 0.055	0.248AsnCys: 0.248 ± 0.015	1.273AsnAsp: 1.273 ± 0.033	1.157AsnGlu: 1.157 ± 0.03	0.946AsnPhe: 0.946 ± 0.033	2.41AsnGly: 2.41 ± 0.072	0.478AsnHis: 0.478 ± 0.022	1.192AsnIle: 1.192 ± 0.036	0.552AsnLys: 0.552 ± 0.024	2.398AsnLeu: 2.398 ± 0.051	0.544AsnMet: 0.544 ± 0.021	0.626AsnAsn: 0.626 ± 0.028	1.743AsnPro: 1.743 ± 0.041	0.7AsnGln: 0.7 ± 0.024	1.766AsnArg: 1.766 ± 0.04	1.301AsnSer: 1.301 ± 0.044	1.137AsnThr: 1.137 ± 0.038	1.813AsnVal: 1.813 ± 0.05	0.418AsnTrp: 0.418 ± 0.018	0.683AsnTyr: 0.683 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	7.549ProAla: 7.549 ± 0.093	0.356ProCys: 0.356 ± 0.019	3.803ProAsp: 3.803 ± 0.057	3.927ProGlu: 3.927 ± 0.063	1.944ProPhe: 1.944 ± 0.042	5.04ProGly: 5.04 ± 0.07	1.055ProHis: 1.055 ± 0.033	2.334ProIle: 2.334 ± 0.046	1.234ProLys: 1.234 ± 0.043	5.295ProLeu: 5.295 ± 0.074	1.14ProMet: 1.14 ± 0.033	1.213ProAsn: 1.213 ± 0.038	3.187ProPro: 3.187 ± 0.081	1.972ProGln: 1.972 ± 0.042	3.378ProArg: 3.378 ± 0.064	2.651ProSer: 2.651 ± 0.043	2.406ProThr: 2.406 ± 0.05	4.234ProVal: 4.234 ± 0.066	0.704ProTrp: 0.704 ± 0.026	1.119ProTyr: 1.119 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	4.421GlnAla: 4.421 ± 0.075	0.232GlnCys: 0.232 ± 0.016	1.614GlnAsp: 1.614 ± 0.039	1.587GlnGlu: 1.587 ± 0.038	1.136GlnPhe: 1.136 ± 0.03	2.662GlnGly: 2.662 ± 0.052	0.626GlnHis: 0.626 ± 0.024	1.651GlnIle: 1.651 ± 0.043	0.788GlnLys: 0.788 ± 0.03	3.395GlnLeu: 3.395 ± 0.058	0.853GlnMet: 0.853 ± 0.029	0.741GlnAsn: 0.741 ± 0.025	2.026GlnPro: 2.026 ± 0.039	1.311GlnGln: 1.311 ± 0.039	2.604GlnArg: 2.604 ± 0.05	1.714GlnSer: 1.714 ± 0.042	1.5GlnThr: 1.5 ± 0.032	2.377GlnVal: 2.377 ± 0.045	0.467GlnTrp: 0.467 ± 0.022	0.68GlnTyr: 0.68 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	8.8ArgAla: 8.8 ± 0.111	0.557ArgCys: 0.557 ± 0.025	4.142ArgAsp: 4.142 ± 0.062	4.675ArgGlu: 4.675 ± 0.078	3.101ArgPhe: 3.101 ± 0.066	5.323ArgGly: 5.323 ± 0.076	1.703ArgHis: 1.703 ± 0.042	4.025ArgIle: 4.025 ± 0.065	2.146ArgLys: 2.146 ± 0.049	8.429ArgLeu: 8.429 ± 0.102	2.014ArgMet: 2.014 ± 0.049	1.852ArgAsn: 1.852 ± 0.041	3.679ArgPro: 3.679 ± 0.064	2.795ArgGln: 2.795 ± 0.048	6.242ArgArg: 6.242 ± 0.089	3.933ArgSer: 3.933 ± 0.059	3.28ArgThr: 3.28 ± 0.047	4.748ArgVal: 4.748 ± 0.06	1.255ArgTrp: 1.255 ± 0.032	1.863ArgTyr: 1.863 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	6.701SerAla: 6.701 ± 0.11	0.443SerCys: 0.443 ± 0.021	2.967SerAsp: 2.967 ± 0.055	2.802SerGlu: 2.802 ± 0.054	2.291SerPhe: 2.291 ± 0.05	5.619SerGly: 5.619 ± 0.109	0.988SerHis: 0.988 ± 0.026	2.462SerIle: 2.462 ± 0.059	1.229SerLys: 1.229 ± 0.038	5.269SerLeu: 5.269 ± 0.077	1.132SerMet: 1.132 ± 0.033	1.295SerAsn: 1.295 ± 0.045	2.922SerPro: 2.922 ± 0.054	1.606SerGln: 1.606 ± 0.038	3.647SerArg: 3.647 ± 0.062	2.791SerSer: 2.791 ± 0.074	2.642SerThr: 2.642 ± 0.057	3.657SerVal: 3.657 ± 0.084	0.876SerTrp: 0.876 ± 0.029	1.437SerTyr: 1.437 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	6.21ThrAla: 6.21 ± 0.107	0.399ThrCys: 0.399 ± 0.02	2.803ThrAsp: 2.803 ± 0.057	2.483ThrGlu: 2.483 ± 0.052	1.847ThrPhe: 1.847 ± 0.048	5.356ThrGly: 5.356 ± 0.112	0.927ThrHis: 0.927 ± 0.029	2.692ThrIle: 2.692 ± 0.049	1.092ThrLys: 1.092 ± 0.036	5.461ThrLeu: 5.461 ± 0.108	1.14ThrMet: 1.14 ± 0.034	1.199ThrAsn: 1.199 ± 0.045	3.301ThrPro: 3.301 ± 0.058	1.453ThrGln: 1.453 ± 0.035	3.294ThrArg: 3.294 ± 0.057	2.635ThrSer: 2.635 ± 0.064	2.49ThrThr: 2.49 ± 0.059	3.99ThrVal: 3.99 ± 0.084	0.572ThrTrp: 0.572 ± 0.021	1.235ThrTyr: 1.235 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	8.996ValAla: 8.996 ± 0.105	0.566ValCys: 0.566 ± 0.02	4.27ValAsp: 4.27 ± 0.067	4.703ValGlu: 4.703 ± 0.079	2.305ValPhe: 2.305 ± 0.042	5.418ValGly: 5.418 ± 0.073	1.258ValHis: 1.258 ± 0.035	3.487ValIle: 3.487 ± 0.056	1.843ValLys: 1.843 ± 0.044	7.083ValLeu: 7.083 ± 0.085	1.635ValMet: 1.635 ± 0.041	1.864ValAsn: 1.864 ± 0.048	4.063ValPro: 4.063 ± 0.057	2.07ValGln: 2.07 ± 0.043	4.733ValArg: 4.733 ± 0.071	3.988ValSer: 3.988 ± 0.078	4.344ValThr: 4.344 ± 0.11	5.296ValVal: 5.296 ± 0.089	0.841ValTrp: 0.841 ± 0.027	1.315ValTyr: 1.315 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.482TrpAla: 1.482 ± 0.038	0.124TrpCys: 0.124 ± 0.011	0.729TrpAsp: 0.729 ± 0.029	0.643TrpGlu: 0.643 ± 0.024	0.618TrpPhe: 0.618 ± 0.025	0.999TrpGly: 0.999 ± 0.032	0.365TrpHis: 0.365 ± 0.02	0.679TrpIle: 0.679 ± 0.024	0.421TrpLys: 0.421 ± 0.018	1.848TrpLeu: 1.848 ± 0.045	0.344TrpMet: 0.344 ± 0.019	0.455TrpAsn: 0.455 ± 0.019	0.722TrpPro: 0.722 ± 0.025	0.678TrpGln: 0.678 ± 0.024	1.414TrpArg: 1.414 ± 0.034	0.921TrpSer: 0.921 ± 0.028	0.753TrpThr: 0.753 ± 0.024	0.831TrpVal: 0.831 ± 0.028	0.241TrpTrp: 0.241 ± 0.016	0.289TrpTyr: 0.289 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.664TyrAla: 2.664 ± 0.054	0.249TyrCys: 0.249 ± 0.014	1.508TyrAsp: 1.508 ± 0.041	1.221TyrGlu: 1.221 ± 0.033	0.887TyrPhe: 0.887 ± 0.031	2.12TyrGly: 2.12 ± 0.048	0.487TyrHis: 0.487 ± 0.018	0.857TyrIle: 0.857 ± 0.029	0.519TyrLys: 0.519 ± 0.022	2.172TyrLeu: 2.172 ± 0.046	0.393TyrMet: 0.393 ± 0.019	0.631TyrAsn: 0.631 ± 0.03	1.093TyrPro: 1.093 ± 0.036	0.699TyrGln: 0.699 ± 0.024	1.927TyrArg: 1.927 ± 0.043	1.273TyrSer: 1.273 ± 0.038	1.071TyrThr: 1.071 ± 0.036	1.473TyrVal: 1.473 ± 0.04	0.35TyrTrp: 0.35 ± 0.021	0.647TyrTyr: 0.647 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3568 proteins (1161600 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---