Amino acid dipepetide frequency for Galactobacter caseinivorans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.055AlaAla: 21.055 ± 0.284	0.713AlaCys: 0.713 ± 0.03	7.021AlaAsp: 7.021 ± 0.106	7.826AlaGlu: 7.826 ± 0.125	3.605AlaPhe: 3.605 ± 0.065	12.504AlaGly: 12.504 ± 0.14	2.488AlaHis: 2.488 ± 0.067	4.589AlaIle: 4.589 ± 0.077	3.753AlaLys: 3.753 ± 0.107	14.471AlaLeu: 14.471 ± 0.2	2.882AlaMet: 2.882 ± 0.055	2.425AlaAsn: 2.425 ± 0.054	7.045AlaPro: 7.045 ± 0.158	5.625AlaGln: 5.625 ± 0.099	8.722AlaArg: 8.722 ± 0.137	7.665AlaSer: 7.665 ± 0.125	7.355AlaThr: 7.355 ± 0.107	11.246AlaVal: 11.246 ± 0.132	2.084AlaTrp: 2.084 ± 0.06	2.116AlaTyr: 2.116 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.741CysAla: 0.741 ± 0.029	0.044CysCys: 0.044 ± 0.008	0.281CysAsp: 0.281 ± 0.018	0.261CysGlu: 0.261 ± 0.019	0.189CysPhe: 0.189 ± 0.016	0.636CysGly: 0.636 ± 0.027	0.089CysHis: 0.089 ± 0.01	0.21CysIle: 0.21 ± 0.015	0.099CysLys: 0.099 ± 0.01	0.504CysLeu: 0.504 ± 0.025	0.076CysMet: 0.076 ± 0.009	0.106CysAsn: 0.106 ± 0.012	0.3CysPro: 0.3 ± 0.021	0.158CysGln: 0.158 ± 0.014	0.292CysArg: 0.292 ± 0.019	0.343CysSer: 0.343 ± 0.019	0.369CysThr: 0.369 ± 0.018	0.459CysVal: 0.459 ± 0.026	0.083CysTrp: 0.083 ± 0.01	0.075CysTyr: 0.075 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	8.184AspAla: 8.184 ± 0.116	0.25AspCys: 0.25 ± 0.019	2.835AspAsp: 2.835 ± 0.066	3.434AspGlu: 3.434 ± 0.079	1.658AspPhe: 1.658 ± 0.051	5.348AspGly: 5.348 ± 0.086	1.249AspHis: 1.249 ± 0.041	1.745AspIle: 1.745 ± 0.049	1.217AspLys: 1.217 ± 0.046	5.614AspLeu: 5.614 ± 0.088	0.93AspMet: 0.93 ± 0.037	0.801AspAsn: 0.801 ± 0.036	4.149AspPro: 4.149 ± 0.073	1.899AspGln: 1.899 ± 0.052	3.623AspArg: 3.623 ± 0.065	2.882AspSer: 2.882 ± 0.067	2.483AspThr: 2.483 ± 0.064	4.852AspVal: 4.852 ± 0.08	0.795AspTrp: 0.795 ± 0.032	1.13AspTyr: 1.13 ± 0.033	0.0AspXaa: 0.0 ± 0.0
Glu	7.776GluAla: 7.776 ± 0.121	0.237GluCys: 0.237 ± 0.018	3.243GluAsp: 3.243 ± 0.066	3.454GluGlu: 3.454 ± 0.083	1.574GluPhe: 1.574 ± 0.045	4.421GluGly: 4.421 ± 0.072	1.479GluHis: 1.479 ± 0.045	2.12GluIle: 2.12 ± 0.055	1.405GluLys: 1.405 ± 0.053	6.843GluLeu: 6.843 ± 0.097	0.971GluMet: 0.971 ± 0.037	1.231GluAsn: 1.231 ± 0.039	3.098GluPro: 3.098 ± 0.077	2.572GluGln: 2.572 ± 0.064	4.957GluArg: 4.957 ± 0.095	3.099GluSer: 3.099 ± 0.064	2.702GluThr: 2.702 ± 0.061	4.333GluVal: 4.333 ± 0.081	0.841GluTrp: 0.841 ± 0.036	1.072GluTyr: 1.072 ± 0.039	0.0GluXaa: 0.0 ± 0.0
Phe	3.723PheAla: 3.723 ± 0.071	0.224PheCys: 0.224 ± 0.016	1.986PheAsp: 1.986 ± 0.048	1.67PheGlu: 1.67 ± 0.054	1.036PhePhe: 1.036 ± 0.037	3.209PheGly: 3.209 ± 0.068	0.529PheHis: 0.529 ± 0.025	1.042PheIle: 1.042 ± 0.038	0.729PheLys: 0.729 ± 0.03	2.69PheLeu: 2.69 ± 0.065	0.56PheMet: 0.56 ± 0.026	0.74PheAsn: 0.74 ± 0.034	1.407PhePro: 1.407 ± 0.038	0.797PheGln: 0.797 ± 0.036	1.505PheArg: 1.505 ± 0.042	1.826PheSer: 1.826 ± 0.045	1.95PheThr: 1.95 ± 0.046	2.532PheVal: 2.532 ± 0.059	0.462PheTrp: 0.462 ± 0.027	0.58PheTyr: 0.58 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	11.611GlyAla: 11.611 ± 0.17	0.568GlyCys: 0.568 ± 0.024	4.25GlyAsp: 4.25 ± 0.07	4.947GlyGlu: 4.947 ± 0.092	3.191GlyPhe: 3.191 ± 0.074	8.022GlyGly: 8.022 ± 0.11	2.052GlyHis: 2.052 ± 0.051	3.738GlyIle: 3.738 ± 0.073	2.914GlyLys: 2.914 ± 0.067	9.598GlyLeu: 9.598 ± 0.129	2.097GlyMet: 2.097 ± 0.049	1.881GlyAsn: 1.881 ± 0.05	4.182GlyPro: 4.182 ± 0.079	3.369GlyGln: 3.369 ± 0.066	5.982GlyArg: 5.982 ± 0.102	5.799GlySer: 5.799 ± 0.095	5.919GlyThr: 5.919 ± 0.087	7.9GlyVal: 7.9 ± 0.094	1.763GlyTrp: 1.763 ± 0.051	2.017GlyTyr: 2.017 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	2.484HisAla: 2.484 ± 0.064	0.106HisCys: 0.106 ± 0.011	1.082HisAsp: 1.082 ± 0.039	1.089HisGlu: 1.089 ± 0.035	0.6HisPhe: 0.6 ± 0.026	2.04HisGly: 2.04 ± 0.049	0.69HisHis: 0.69 ± 0.03	0.62HisIle: 0.62 ± 0.029	0.352HisLys: 0.352 ± 0.021	2.266HisLeu: 2.266 ± 0.058	0.335HisMet: 0.335 ± 0.019	0.359HisAsn: 0.359 ± 0.02	1.635HisPro: 1.635 ± 0.052	0.771HisGln: 0.771 ± 0.032	1.668HisArg: 1.668 ± 0.05	1.184HisSer: 1.184 ± 0.037	1.091HisThr: 1.091 ± 0.038	1.715HisVal: 1.715 ± 0.048	0.277HisTrp: 0.277 ± 0.018	0.415HisTyr: 0.415 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	5.137IleAla: 5.137 ± 0.094	0.243IleCys: 0.243 ± 0.018	2.286IleAsp: 2.286 ± 0.051	2.054IleGlu: 2.054 ± 0.06	1.096IlePhe: 1.096 ± 0.044	3.604IleGly: 3.604 ± 0.084	0.707IleHis: 0.707 ± 0.028	1.567IleIle: 1.567 ± 0.061	1.064IleLys: 1.064 ± 0.043	3.564IleLeu: 3.564 ± 0.082	0.775IleMet: 0.775 ± 0.031	1.077IleAsn: 1.077 ± 0.038	2.119IlePro: 2.119 ± 0.052	1.044IleGln: 1.044 ± 0.037	2.006IleArg: 2.006 ± 0.051	2.269IleSer: 2.269 ± 0.052	2.581IleThr: 2.581 ± 0.057	3.322IleVal: 3.322 ± 0.075	0.403IleTrp: 0.403 ± 0.02	0.643IleTyr: 0.643 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	3.403LysAla: 3.403 ± 0.092	0.085LysCys: 0.085 ± 0.011	1.687LysAsp: 1.687 ± 0.058	1.475LysGlu: 1.475 ± 0.05	0.537LysPhe: 0.537 ± 0.032	2.109LysGly: 2.109 ± 0.064	0.588LysHis: 0.588 ± 0.024	1.093LysIle: 1.093 ± 0.041	1.174LysLys: 1.174 ± 0.057	2.388LysLeu: 2.388 ± 0.069	0.574LysMet: 0.574 ± 0.029	0.812LysAsn: 0.812 ± 0.037	1.568LysPro: 1.568 ± 0.052	0.918LysGln: 0.918 ± 0.039	1.788LysArg: 1.788 ± 0.052	1.525LysSer: 1.525 ± 0.052	1.613LysThr: 1.613 ± 0.049	2.248LysVal: 2.248 ± 0.066	0.281LysTrp: 0.281 ± 0.019	0.56LysTyr: 0.56 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	14.425LeuAla: 14.425 ± 0.182	0.635LeuCys: 0.635 ± 0.027	6.163LeuAsp: 6.163 ± 0.096	5.548LeuGlu: 5.548 ± 0.101	2.788LeuPhe: 2.788 ± 0.068	9.796LeuGly: 9.796 ± 0.128	1.942LeuHis: 1.942 ± 0.05	4.116LeuIle: 4.116 ± 0.08	2.484LeuLys: 2.484 ± 0.067	10.385LeuLeu: 10.385 ± 0.155	2.073LeuMet: 2.073 ± 0.052	2.234LeuAsn: 2.234 ± 0.052	5.767LeuPro: 5.767 ± 0.092	2.763LeuGln: 2.763 ± 0.057	7.612LeuArg: 7.612 ± 0.105	6.593LeuSer: 6.593 ± 0.076	6.12LeuThr: 6.12 ± 0.095	9.038LeuVal: 9.038 ± 0.129	1.353LeuTrp: 1.353 ± 0.049	1.503LeuTyr: 1.503 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	2.455MetAla: 2.455 ± 0.052	0.099MetCys: 0.099 ± 0.011	1.176MetAsp: 1.176 ± 0.043	0.927MetGlu: 0.927 ± 0.035	0.495MetPhe: 0.495 ± 0.024	1.777MetGly: 1.777 ± 0.056	0.362MetHis: 0.362 ± 0.021	0.872MetIle: 0.872 ± 0.036	0.526MetLys: 0.526 ± 0.024	1.891MetLeu: 1.891 ± 0.051	0.399MetMet: 0.399 ± 0.022	0.56MetAsn: 0.56 ± 0.025	1.177MetPro: 1.177 ± 0.037	0.58MetGln: 0.58 ± 0.022	1.364MetArg: 1.364 ± 0.049	1.62MetSer: 1.62 ± 0.045	1.39MetThr: 1.39 ± 0.046	1.6MetVal: 1.6 ± 0.047	0.214MetTrp: 0.214 ± 0.018	0.307MetTyr: 0.307 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	2.65AsnAla: 2.65 ± 0.061	0.106AsnCys: 0.106 ± 0.011	1.079AsnAsp: 1.079 ± 0.034	1.069AsnGlu: 1.069 ± 0.034	0.631AsnPhe: 0.631 ± 0.029	2.034AsnGly: 2.034 ± 0.051	0.466AsnHis: 0.466 ± 0.024	0.822AsnIle: 0.822 ± 0.037	0.641AsnLys: 0.641 ± 0.034	1.938AsnLeu: 1.938 ± 0.049	0.422AsnMet: 0.422 ± 0.021	0.576AsnAsn: 0.576 ± 0.029	1.62AsnPro: 1.62 ± 0.044	0.797AsnGln: 0.797 ± 0.041	1.274AsnArg: 1.274 ± 0.044	1.127AsnSer: 1.127 ± 0.037	1.188AsnThr: 1.188 ± 0.042	1.734AsnVal: 1.734 ± 0.051	0.321AsnTrp: 0.321 ± 0.02	0.484AsnTyr: 0.484 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	7.965ProAla: 7.965 ± 0.149	0.203ProCys: 0.203 ± 0.014	3.459ProAsp: 3.459 ± 0.066	4.265ProGlu: 4.265 ± 0.077	1.572ProPhe: 1.572 ± 0.043	5.777ProGly: 5.777 ± 0.089	1.153ProHis: 1.153 ± 0.039	1.531ProIle: 1.531 ± 0.041	1.371ProLys: 1.371 ± 0.05	5.114ProLeu: 5.114 ± 0.088	0.904ProMet: 0.904 ± 0.033	0.992ProAsn: 0.992 ± 0.039	2.257ProPro: 2.257 ± 0.073	2.245ProGln: 2.245 ± 0.058	3.38ProArg: 3.38 ± 0.07	3.475ProSer: 3.475 ± 0.073	3.534ProThr: 3.534 ± 0.071	4.829ProVal: 4.829 ± 0.084	0.894ProTrp: 0.894 ± 0.037	0.881ProTyr: 0.881 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	4.988GlnAla: 4.988 ± 0.079	0.145GlnCys: 0.145 ± 0.013	2.103GlnAsp: 2.103 ± 0.056	2.09GlnGlu: 2.09 ± 0.05	0.86GlnPhe: 0.86 ± 0.032	3.006GlnGly: 3.006 ± 0.069	0.83GlnHis: 0.83 ± 0.036	1.474GlnIle: 1.474 ± 0.039	0.833GlnLys: 0.833 ± 0.039	3.692GlnLeu: 3.692 ± 0.067	0.635GlnMet: 0.635 ± 0.027	0.801GlnAsn: 0.801 ± 0.032	1.879GlnPro: 1.879 ± 0.063	1.472GlnGln: 1.472 ± 0.051	2.997GlnArg: 2.997 ± 0.07	1.766GlnSer: 1.766 ± 0.046	1.662GlnThr: 1.662 ± 0.047	2.852GlnVal: 2.852 ± 0.058	0.537GlnTrp: 0.537 ± 0.029	0.6GlnTyr: 0.6 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	8.34ArgAla: 8.34 ± 0.127	0.375ArgCys: 0.375 ± 0.022	3.458ArgAsp: 3.458 ± 0.078	4.334ArgGlu: 4.334 ± 0.079	2.178ArgPhe: 2.178 ± 0.059	5.523ArgGly: 5.523 ± 0.093	1.617ArgHis: 1.617 ± 0.04	2.803ArgIle: 2.803 ± 0.059	1.676ArgLys: 1.676 ± 0.047	7.253ArgLeu: 7.253 ± 0.118	1.578ArgMet: 1.578 ± 0.047	1.325ArgAsn: 1.325 ± 0.043	3.628ArgPro: 3.628 ± 0.062	2.355ArgGln: 2.355 ± 0.053	6.303ArgArg: 6.303 ± 0.126	3.951ArgSer: 3.951 ± 0.075	3.974ArgThr: 3.974 ± 0.069	5.651ArgVal: 5.651 ± 0.084	1.269ArgTrp: 1.269 ± 0.042	1.334ArgTyr: 1.334 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	7.848SerAla: 7.848 ± 0.128	0.298SerCys: 0.298 ± 0.02	2.877SerAsp: 2.877 ± 0.061	3.127SerGlu: 3.127 ± 0.06	1.769SerPhe: 1.769 ± 0.047	6.274SerGly: 6.274 ± 0.087	1.162SerHis: 1.162 ± 0.038	2.202SerIle: 2.202 ± 0.061	1.605SerLys: 1.605 ± 0.047	5.924SerLeu: 5.924 ± 0.082	1.318SerMet: 1.318 ± 0.04	1.264SerAsn: 1.264 ± 0.045	3.254SerPro: 3.254 ± 0.076	2.063SerGln: 2.063 ± 0.048	3.676SerArg: 3.676 ± 0.067	3.81SerSer: 3.81 ± 0.092	3.988SerThr: 3.988 ± 0.073	5.0SerVal: 5.0 ± 0.09	0.981SerTrp: 0.981 ± 0.033	1.236SerTyr: 1.236 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	7.392ThrAla: 7.392 ± 0.117	0.252ThrCys: 0.252 ± 0.016	3.078ThrAsp: 3.078 ± 0.058	3.172ThrGlu: 3.172 ± 0.063	1.722ThrPhe: 1.722 ± 0.048	5.54ThrGly: 5.54 ± 0.091	1.183ThrHis: 1.183 ± 0.042	2.066ThrIle: 2.066 ± 0.059	1.517ThrLys: 1.517 ± 0.054	6.073ThrLeu: 6.073 ± 0.08	0.978ThrMet: 0.978 ± 0.03	1.19ThrAsn: 1.19 ± 0.039	4.144ThrPro: 4.144 ± 0.072	2.031ThrGln: 2.031 ± 0.056	3.619ThrArg: 3.619 ± 0.073	3.471ThrSer: 3.471 ± 0.07	3.549ThrThr: 3.549 ± 0.086	5.437ThrVal: 5.437 ± 0.077	0.865ThrTrp: 0.865 ± 0.03	1.063ThrTyr: 1.063 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	11.012ValAla: 11.012 ± 0.121	0.494ValCys: 0.494 ± 0.025	5.143ValAsp: 5.143 ± 0.08	4.937ValGlu: 4.937 ± 0.077	2.508ValPhe: 2.508 ± 0.059	7.199ValGly: 7.199 ± 0.102	1.644ValHis: 1.644 ± 0.051	3.689ValIle: 3.689 ± 0.075	2.266ValLys: 2.266 ± 0.063	9.345ValLeu: 9.345 ± 0.115	1.689ValMet: 1.689 ± 0.046	1.843ValAsn: 1.843 ± 0.047	4.864ValPro: 4.864 ± 0.08	2.592ValGln: 2.592 ± 0.055	5.733ValArg: 5.733 ± 0.09	5.284ValSer: 5.284 ± 0.086	5.054ValThr: 5.054 ± 0.083	8.311ValVal: 8.311 ± 0.122	1.072ValTrp: 1.072 ± 0.04	1.334ValTyr: 1.334 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	1.783TrpAla: 1.783 ± 0.053	0.123TrpCys: 0.123 ± 0.012	0.878TrpAsp: 0.878 ± 0.034	0.773TrpGlu: 0.773 ± 0.03	0.551TrpPhe: 0.551 ± 0.027	1.281TrpGly: 1.281 ± 0.04	0.28TrpHis: 0.28 ± 0.017	0.75TrpIle: 0.75 ± 0.03	0.34TrpLys: 0.34 ± 0.02	1.747TrpLeu: 1.747 ± 0.053	0.34TrpMet: 0.34 ± 0.017	0.377TrpAsn: 0.377 ± 0.02	0.742TrpPro: 0.742 ± 0.034	0.539TrpGln: 0.539 ± 0.028	1.127TrpArg: 1.127 ± 0.039	0.794TrpSer: 0.794 ± 0.032	0.768TrpThr: 0.768 ± 0.029	1.375TrpVal: 1.375 ± 0.045	0.39TrpTrp: 0.39 ± 0.022	0.236TrpTyr: 0.236 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.217TyrAla: 2.217 ± 0.054	0.116TyrCys: 0.116 ± 0.011	0.993TyrAsp: 0.993 ± 0.03	0.977TyrGlu: 0.977 ± 0.037	0.64TyrPhe: 0.64 ± 0.027	1.701TyrGly: 1.701 ± 0.053	0.272TyrHis: 0.272 ± 0.017	0.513TyrIle: 0.513 ± 0.023	0.46TyrLys: 0.46 ± 0.02	2.038TyrLeu: 2.038 ± 0.05	0.254TyrMet: 0.254 ± 0.018	0.387TyrAsn: 0.387 ± 0.022	0.964TyrPro: 0.964 ± 0.031	0.629TyrGln: 0.629 ± 0.029	1.294TyrArg: 1.294 ± 0.038	1.19TyrSer: 1.19 ± 0.035	1.053TyrThr: 1.053 ± 0.039	1.578TyrVal: 1.578 ± 0.043	0.308TyrTrp: 0.308 ± 0.019	0.366TyrTyr: 0.366 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2599 proteins (856916 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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