Amino acid dipepetide frequency for Blautia sp. OF03-15BH

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.69AlaAla: 7.69 ± 0.122
1.075AlaCys: 1.075 ± 0.039
4.439AlaAsp: 4.439 ± 0.077
6.025AlaGlu: 6.025 ± 0.084
3.27AlaPhe: 3.27 ± 0.06
6.041AlaGly: 6.041 ± 0.079
1.064AlaHis: 1.064 ± 0.035
4.454AlaIle: 4.454 ± 0.079
4.431AlaLys: 4.431 ± 0.078
7.042AlaLeu: 7.042 ± 0.089
2.364AlaMet: 2.364 ± 0.041
2.257AlaAsn: 2.257 ± 0.055
2.225AlaPro: 2.225 ± 0.053
1.921AlaGln: 1.921 ± 0.046
3.096AlaArg: 3.096 ± 0.062
4.055AlaSer: 4.055 ± 0.069
3.071AlaThr: 3.071 ± 0.066
6.396AlaVal: 6.396 ± 0.084
0.701AlaTrp: 0.701 ± 0.023
2.802AlaTyr: 2.802 ± 0.058
0.0AlaXaa: 0.0 ± 0.0
Cys
0.933CysAla: 0.933 ± 0.031
0.299CysCys: 0.299 ± 0.02
0.756CysAsp: 0.756 ± 0.031
0.919CysGlu: 0.919 ± 0.029
0.735CysPhe: 0.735 ± 0.027
1.462CysGly: 1.462 ± 0.044
0.334CysHis: 0.334 ± 0.017
1.017CysIle: 1.017 ± 0.033
0.732CysLys: 0.732 ± 0.026
1.277CysLeu: 1.277 ± 0.036
0.482CysMet: 0.482 ± 0.023
0.525CysAsn: 0.525 ± 0.023
0.656CysPro: 0.656 ± 0.027
0.451CysGln: 0.451 ± 0.02
0.767CysArg: 0.767 ± 0.029
0.883CysSer: 0.883 ± 0.029
0.802CysThr: 0.802 ± 0.032
0.927CysVal: 0.927 ± 0.029
0.161CysTrp: 0.161 ± 0.013
0.596CysTyr: 0.596 ± 0.024
0.0CysXaa: 0.0 ± 0.0
Asp
3.85AspAla: 3.85 ± 0.068
0.791AspCys: 0.791 ± 0.025
2.618AspAsp: 2.618 ± 0.055
4.548AspGlu: 4.548 ± 0.074
2.692AspPhe: 2.692 ± 0.048
4.68AspGly: 4.68 ± 0.071
1.0AspHis: 1.0 ± 0.034
3.803AspIle: 3.803 ± 0.071
3.028AspLys: 3.028 ± 0.056
4.847AspLeu: 4.847 ± 0.078
1.63AspMet: 1.63 ± 0.04
1.781AspAsn: 1.781 ± 0.04
2.241AspPro: 2.241 ± 0.056
1.602AspGln: 1.602 ± 0.036
2.488AspArg: 2.488 ± 0.051
2.996AspSer: 2.996 ± 0.059
2.977AspThr: 2.977 ± 0.051
3.561AspVal: 3.561 ± 0.06
0.672AspTrp: 0.672 ± 0.027
2.688AspTyr: 2.688 ± 0.056
0.0AspXaa: 0.0 ± 0.0
Glu
6.346GluAla: 6.346 ± 0.099
0.771GluCys: 0.771 ± 0.026
4.253GluAsp: 4.253 ± 0.063
8.185GluGlu: 8.185 ± 0.129
2.531GluPhe: 2.531 ± 0.049
4.752GluGly: 4.752 ± 0.07
1.387GluHis: 1.387 ± 0.041
5.573GluIle: 5.573 ± 0.076
7.904GluLys: 7.904 ± 0.105
7.377GluLeu: 7.377 ± 0.087
2.366GluMet: 2.366 ± 0.057
4.364GluAsn: 4.364 ± 0.067
2.106GluPro: 2.106 ± 0.062
2.787GluGln: 2.787 ± 0.056
3.67GluArg: 3.67 ± 0.072
3.519GluSer: 3.519 ± 0.061
4.56GluThr: 4.56 ± 0.102
4.491GluVal: 4.491 ± 0.068
0.712GluTrp: 0.712 ± 0.027
3.109GluTyr: 3.109 ± 0.061
0.0GluXaa: 0.0 ± 0.0
Phe
2.864PheAla: 2.864 ± 0.06
0.84PheCys: 0.84 ± 0.027
2.532PheAsp: 2.532 ± 0.054
2.667PheGlu: 2.667 ± 0.051
2.067PhePhe: 2.067 ± 0.049
3.086PheGly: 3.086 ± 0.057
0.979PheHis: 0.979 ± 0.034
2.479PheIle: 2.479 ± 0.053
1.801PheLys: 1.801 ± 0.038
4.572PheLeu: 4.572 ± 0.083
1.1PheMet: 1.1 ± 0.03
1.433PheAsn: 1.433 ± 0.046
1.577PhePro: 1.577 ± 0.044
1.624PheGln: 1.624 ± 0.037
2.022PheArg: 2.022 ± 0.037
3.112PheSer: 3.112 ± 0.065
2.382PheThr: 2.382 ± 0.051
2.742PheVal: 2.742 ± 0.047
0.492PheTrp: 0.492 ± 0.024
1.845PheTyr: 1.845 ± 0.048
0.0PheXaa: 0.0 ± 0.0
Gly
4.793GlyAla: 4.793 ± 0.086
1.294GlyCys: 1.294 ± 0.037
3.411GlyAsp: 3.411 ± 0.061
5.25GlyGlu: 5.25 ± 0.08
3.201GlyPhe: 3.201 ± 0.051
4.754GlyGly: 4.754 ± 0.082
1.22GlyHis: 1.22 ± 0.032
5.876GlyIle: 5.876 ± 0.086
5.914GlyLys: 5.914 ± 0.085
5.984GlyLeu: 5.984 ± 0.082
2.501GlyMet: 2.501 ± 0.053
3.068GlyAsn: 3.068 ± 0.064
1.33GlyPro: 1.33 ± 0.042
1.996GlyGln: 1.996 ± 0.046
3.264GlyArg: 3.264 ± 0.059
4.426GlySer: 4.426 ± 0.075
4.384GlyThr: 4.384 ± 0.076
4.792GlyVal: 4.792 ± 0.07
0.794GlyTrp: 0.794 ± 0.036
3.268GlyTyr: 3.268 ± 0.057
0.0GlyXaa: 0.0 ± 0.0
His
1.176HisAla: 1.176 ± 0.035
0.31HisCys: 0.31 ± 0.017
0.884HisAsp: 0.884 ± 0.035
1.194HisGlu: 1.194 ± 0.038
0.96HisPhe: 0.96 ± 0.029
1.277HisGly: 1.277 ± 0.033
0.412HisHis: 0.412 ± 0.023
1.176HisIle: 1.176 ± 0.037
0.864HisLys: 0.864 ± 0.026
1.645HisLeu: 1.645 ± 0.041
0.569HisMet: 0.569 ± 0.022
0.637HisAsn: 0.637 ± 0.027
0.928HisPro: 0.928 ± 0.03
0.603HisGln: 0.603 ± 0.023
0.841HisArg: 0.841 ± 0.028
0.997HisSer: 0.997 ± 0.031
1.025HisThr: 1.025 ± 0.038
1.188HisVal: 1.188 ± 0.033
0.192HisTrp: 0.192 ± 0.014
0.845HisTyr: 0.845 ± 0.029
0.0HisXaa: 0.0 ± 0.0
Ile
4.97IleAla: 4.97 ± 0.079
1.217IleCys: 1.217 ± 0.036
3.501IleAsp: 3.501 ± 0.069
4.035IleGlu: 4.035 ± 0.07
2.949IlePhe: 2.949 ± 0.057
4.476IleGly: 4.476 ± 0.069
1.445IleHis: 1.445 ± 0.04
4.053IleIle: 4.053 ± 0.068
3.4IleLys: 3.4 ± 0.059
7.155IleLeu: 7.155 ± 0.107
1.743IleMet: 1.743 ± 0.048
2.45IleAsn: 2.45 ± 0.053
3.129IlePro: 3.129 ± 0.057
2.341IleGln: 2.341 ± 0.055
4.197IleArg: 4.197 ± 0.071
4.604IleSer: 4.604 ± 0.068
3.647IleThr: 3.647 ± 0.069
4.127IleVal: 4.127 ± 0.07
0.69IleTrp: 0.69 ± 0.023
2.701IleTyr: 2.701 ± 0.053
0.0IleXaa: 0.0 ± 0.0
Lys
5.344LysAla: 5.344 ± 0.071
0.686LysCys: 0.686 ± 0.03
3.874LysAsp: 3.874 ± 0.062
7.067LysGlu: 7.067 ± 0.08
1.815LysPhe: 1.815 ± 0.043
4.368LysGly: 4.368 ± 0.077
0.947LysHis: 0.947 ± 0.031
4.622LysIle: 4.622 ± 0.065
6.6LysLys: 6.6 ± 0.091
5.474LysLeu: 5.474 ± 0.073
2.066LysMet: 2.066 ± 0.045
3.673LysAsn: 3.673 ± 0.058
1.95LysPro: 1.95 ± 0.043
2.236LysGln: 2.236 ± 0.051
3.067LysArg: 3.067 ± 0.059
3.115LysSer: 3.115 ± 0.059
4.014LysThr: 4.014 ± 0.067
4.029LysVal: 4.029 ± 0.069
0.672LysTrp: 0.672 ± 0.025
2.644LysTyr: 2.644 ± 0.05
0.0LysXaa: 0.0 ± 0.0
Leu
7.02LeuAla: 7.02 ± 0.1
1.539LeuCys: 1.539 ± 0.04
5.187LeuAsp: 5.187 ± 0.075
6.647LeuGlu: 6.647 ± 0.103
4.098LeuPhe: 4.098 ± 0.077
6.033LeuGly: 6.033 ± 0.087
1.682LeuHis: 1.682 ± 0.041
5.943LeuIle: 5.943 ± 0.096
6.738LeuLys: 6.738 ± 0.083
9.733LeuLeu: 9.733 ± 0.169
2.592LeuMet: 2.592 ± 0.053
3.827LeuAsn: 3.827 ± 0.055
3.936LeuPro: 3.936 ± 0.071
2.885LeuGln: 2.885 ± 0.053
3.949LeuArg: 3.949 ± 0.061
6.592LeuSer: 6.592 ± 0.088
5.509LeuThr: 5.509 ± 0.092
5.789LeuVal: 5.789 ± 0.088
0.825LeuTrp: 0.825 ± 0.026
3.472LeuTyr: 3.472 ± 0.053
0.0LeuXaa: 0.0 ± 0.0
Met
2.346MetAla: 2.346 ± 0.054
0.31MetCys: 0.31 ± 0.015
1.826MetAsp: 1.826 ± 0.035
2.773MetGlu: 2.773 ± 0.06
0.882MetPhe: 0.882 ± 0.03
1.968MetGly: 1.968 ± 0.046
0.4MetHis: 0.4 ± 0.021
1.976MetIle: 1.976 ± 0.053
2.592MetLys: 2.592 ± 0.049
2.558MetLeu: 2.558 ± 0.05
0.862MetMet: 0.862 ± 0.036
1.51MetAsn: 1.51 ± 0.038
1.073MetPro: 1.073 ± 0.032
1.036MetGln: 1.036 ± 0.03
1.217MetArg: 1.217 ± 0.034
1.577MetSer: 1.577 ± 0.041
1.759MetThr: 1.759 ± 0.045
1.867MetVal: 1.867 ± 0.045
0.234MetTrp: 0.234 ± 0.015
0.853MetTyr: 0.853 ± 0.028
0.0MetXaa: 0.0 ± 0.0
Asn
2.927AsnAla: 2.927 ± 0.057
0.583AsnCys: 0.583 ± 0.024
1.94AsnAsp: 1.94 ± 0.048
2.639AsnGlu: 2.639 ± 0.05
1.589AsnPhe: 1.589 ± 0.041
3.741AsnGly: 3.741 ± 0.063
0.802AsnHis: 0.802 ± 0.032
2.861AsnIle: 2.861 ± 0.056
2.174AsnLys: 2.174 ± 0.049
3.754AsnLeu: 3.754 ± 0.065
1.224AsnMet: 1.224 ± 0.031
1.562AsnAsn: 1.562 ± 0.045
1.923AsnPro: 1.923 ± 0.041
1.45AsnGln: 1.45 ± 0.034
2.123AsnArg: 2.123 ± 0.048
2.226AsnSer: 2.226 ± 0.049
2.28AsnThr: 2.28 ± 0.058
2.592AsnVal: 2.592 ± 0.055
0.464AsnTrp: 0.464 ± 0.024
1.882AsnTyr: 1.882 ± 0.048
0.0AsnXaa: 0.0 ± 0.0
Pro
2.582ProAla: 2.582 ± 0.058
0.449ProCys: 0.449 ± 0.024
2.413ProAsp: 2.413 ± 0.044
4.054ProGlu: 4.054 ± 0.074
1.614ProPhe: 1.614 ± 0.039
2.612ProGly: 2.612 ± 0.053
0.601ProHis: 0.601 ± 0.024
1.822ProIle: 1.822 ± 0.044
1.961ProLys: 1.961 ± 0.046
3.067ProLeu: 3.067 ± 0.062
0.907ProMet: 0.907 ± 0.029
1.139ProAsn: 1.139 ± 0.034
0.754ProPro: 0.754 ± 0.028
0.972ProGln: 0.972 ± 0.034
1.09ProArg: 1.09 ± 0.031
1.947ProSer: 1.947 ± 0.053
1.54ProThr: 1.54 ± 0.039
3.27ProVal: 3.27 ± 0.054
0.351ProTrp: 0.351 ± 0.02
1.504ProTyr: 1.504 ± 0.038
0.0ProXaa: 0.0 ± 0.0
Gln
2.469GlnAla: 2.469 ± 0.05
0.341GlnCys: 0.341 ± 0.018
1.609GlnAsp: 1.609 ± 0.036
3.016GlnGlu: 3.016 ± 0.057
1.109GlnPhe: 1.109 ± 0.029
1.94GlnGly: 1.94 ± 0.045
0.467GlnHis: 0.467 ± 0.022
2.241GlnIle: 2.241 ± 0.044
2.854GlnLys: 2.854 ± 0.053
2.857GlnLeu: 2.857 ± 0.057
1.097GlnMet: 1.097 ± 0.033
1.525GlnAsn: 1.525 ± 0.038
0.954GlnPro: 0.954 ± 0.029
1.115GlnGln: 1.115 ± 0.04
1.441GlnArg: 1.441 ± 0.038
1.545GlnSer: 1.545 ± 0.035
1.6GlnThr: 1.6 ± 0.04
2.046GlnVal: 2.046 ± 0.043
0.32GlnTrp: 0.32 ± 0.017
1.309GlnTyr: 1.309 ± 0.038
0.0GlnXaa: 0.0 ± 0.0
Arg
2.652ArgAla: 2.652 ± 0.055
0.658ArgCys: 0.658 ± 0.027
2.166ArgAsp: 2.166 ± 0.047
4.285ArgGlu: 4.285 ± 0.079
2.051ArgPhe: 2.051 ± 0.044
2.525ArgGly: 2.525 ± 0.047
0.842ArgHis: 0.842 ± 0.03
3.547ArgIle: 3.547 ± 0.058
4.1ArgLys: 4.1 ± 0.059
4.272ArgLeu: 4.272 ± 0.07
1.626ArgMet: 1.626 ± 0.04
2.125ArgAsn: 2.125 ± 0.051
1.458ArgPro: 1.458 ± 0.042
1.775ArgGln: 1.775 ± 0.042
2.394ArgArg: 2.394 ± 0.064
2.413ArgSer: 2.413 ± 0.048
2.453ArgThr: 2.453 ± 0.051
2.821ArgVal: 2.821 ± 0.056
0.465ArgTrp: 0.465 ± 0.024
1.945ArgTyr: 1.945 ± 0.046
0.0ArgXaa: 0.0 ± 0.0
Ser
4.059SerAla: 4.059 ± 0.076
0.934SerCys: 0.934 ± 0.029
3.324SerAsp: 3.324 ± 0.061
4.091SerGlu: 4.091 ± 0.066
2.821SerPhe: 2.821 ± 0.058
5.013SerGly: 5.013 ± 0.08
1.047SerHis: 1.047 ± 0.033
3.788SerIle: 3.788 ± 0.063
2.906SerLys: 2.906 ± 0.053
5.463SerLeu: 5.463 ± 0.073
1.799SerMet: 1.799 ± 0.039
2.038SerAsn: 2.038 ± 0.049
1.778SerPro: 1.778 ± 0.044
1.709SerGln: 1.709 ± 0.041
3.099SerArg: 3.099 ± 0.051
3.674SerSer: 3.674 ± 0.081
2.839SerThr: 2.839 ± 0.062
4.36SerVal: 4.36 ± 0.068
0.697SerTrp: 0.697 ± 0.024
2.569SerTyr: 2.569 ± 0.058
0.0SerXaa: 0.0 ± 0.0
Thr
4.631ThrAla: 4.631 ± 0.076
0.704ThrCys: 0.704 ± 0.035
3.132ThrAsp: 3.132 ± 0.06
4.758ThrGlu: 4.758 ± 0.119
2.276ThrPhe: 2.276 ± 0.047
4.893ThrGly: 4.893 ± 0.082
0.871ThrHis: 0.871 ± 0.03
3.583ThrIle: 3.583 ± 0.064
2.813ThrLys: 2.813 ± 0.057
5.069ThrLeu: 5.069 ± 0.08
1.418ThrMet: 1.418 ± 0.033
1.778ThrAsn: 1.778 ± 0.047
2.195ThrPro: 2.195 ± 0.051
1.3ThrGln: 1.3 ± 0.039
2.139ThrArg: 2.139 ± 0.042
2.921ThrSer: 2.921 ± 0.064
2.771ThrThr: 2.771 ± 0.069
4.662ThrVal: 4.662 ± 0.083
0.568ThrTrp: 0.568 ± 0.022
2.242ThrTyr: 2.242 ± 0.048
0.0ThrXaa: 0.0 ± 0.0
Val
4.387ValAla: 4.387 ± 0.074
1.135ValCys: 1.135 ± 0.031
3.63ValAsp: 3.63 ± 0.056
4.648ValGlu: 4.648 ± 0.071
3.171ValPhe: 3.171 ± 0.065
4.115ValGly: 4.115 ± 0.074
1.096ValHis: 1.096 ± 0.031
4.822ValIle: 4.822 ± 0.067
4.453ValLys: 4.453 ± 0.07
6.85ValLeu: 6.85 ± 0.084
1.907ValMet: 1.907 ± 0.042
2.734ValAsn: 2.734 ± 0.049
2.603ValPro: 2.603 ± 0.053
1.947ValGln: 1.947 ± 0.039
3.096ValArg: 3.096 ± 0.061
4.496ValSer: 4.496 ± 0.062
4.328ValThr: 4.328 ± 0.074
4.522ValVal: 4.522 ± 0.075
0.662ValTrp: 0.662 ± 0.027
2.669ValTyr: 2.669 ± 0.056
0.0ValXaa: 0.0 ± 0.0
Trp
0.571TrpAla: 0.571 ± 0.025
0.158TrpCys: 0.158 ± 0.012
0.555TrpAsp: 0.555 ± 0.023
0.748TrpGlu: 0.748 ± 0.026
0.458TrpPhe: 0.458 ± 0.019
0.691TrpGly: 0.691 ± 0.024
0.2TrpHis: 0.2 ± 0.014
0.718TrpIle: 0.718 ± 0.028
0.93TrpLys: 0.93 ± 0.032
0.989TrpLeu: 0.989 ± 0.03
0.341TrpMet: 0.341 ± 0.019
0.598TrpAsn: 0.598 ± 0.024
0.253TrpPro: 0.253 ± 0.015
0.417TrpGln: 0.417 ± 0.019
0.391TrpArg: 0.391 ± 0.019
0.563TrpSer: 0.563 ± 0.024
0.468TrpThr: 0.468 ± 0.02
0.579TrpVal: 0.579 ± 0.024
0.117TrpTrp: 0.117 ± 0.011
0.469TrpTyr: 0.469 ± 0.022
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.805TyrAla: 2.805 ± 0.05
0.621TyrCys: 0.621 ± 0.028
2.445TyrAsp: 2.445 ± 0.058
3.215TyrGlu: 3.215 ± 0.06
1.93TyrPhe: 1.93 ± 0.047
3.091TyrGly: 3.091 ± 0.055
0.925TyrHis: 0.925 ± 0.032
2.474TyrIle: 2.474 ± 0.05
2.071TyrLys: 2.071 ± 0.048
4.012TyrLeu: 4.012 ± 0.073
1.023TyrMet: 1.023 ± 0.03
1.713TyrAsn: 1.713 ± 0.039
1.58TyrPro: 1.58 ± 0.044
1.69TyrGln: 1.69 ± 0.049
2.223TyrArg: 2.223 ± 0.043
2.347TyrSer: 2.347 ± 0.048
2.312TyrThr: 2.312 ± 0.055
2.512TyrVal: 2.512 ± 0.051
0.426TyrTrp: 0.426 ± 0.022
1.997TyrTyr: 1.997 ± 0.054
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3234 proteins (1085421 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski