Amino acid dipepetide frequency for Ideonella dechloratans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
19.103AlaAla: 19.103 ± 0.175
1.415AlaCys: 1.415 ± 0.037
6.672AlaAsp: 6.672 ± 0.073
7.489AlaGlu: 7.489 ± 0.104
3.76AlaPhe: 3.76 ± 0.058
11.243AlaGly: 11.243 ± 0.109
2.912AlaHis: 2.912 ± 0.05
4.281AlaIle: 4.281 ± 0.063
3.392AlaLys: 3.392 ± 0.07
17.166AlaLeu: 17.166 ± 0.165
3.345AlaMet: 3.345 ± 0.054
2.465AlaAsn: 2.465 ± 0.047
7.147AlaPro: 7.147 ± 0.088
6.865AlaGln: 6.865 ± 0.091
9.987AlaArg: 9.987 ± 0.121
6.624AlaSer: 6.624 ± 0.076
6.165AlaThr: 6.165 ± 0.081
9.136AlaVal: 9.136 ± 0.094
2.494AlaTrp: 2.494 ± 0.05
2.363AlaTyr: 2.363 ± 0.042
0.0AlaXaa: 0.0 ± 0.0
Cys
1.162CysAla: 1.162 ± 0.033
0.123CysCys: 0.123 ± 0.011
0.522CysAsp: 0.522 ± 0.018
0.518CysGlu: 0.518 ± 0.019
0.294CysPhe: 0.294 ± 0.015
1.015CysGly: 1.015 ± 0.028
0.299CysHis: 0.299 ± 0.014
0.346CysIle: 0.346 ± 0.016
0.202CysLys: 0.202 ± 0.012
0.932CysLeu: 0.932 ± 0.029
0.189CysMet: 0.189 ± 0.014
0.206CysAsn: 0.206 ± 0.013
0.551CysPro: 0.551 ± 0.021
0.349CysGln: 0.349 ± 0.017
0.661CysArg: 0.661 ± 0.023
0.49CysSer: 0.49 ± 0.021
0.493CysThr: 0.493 ± 0.022
0.65CysVal: 0.65 ± 0.023
0.144CysTrp: 0.144 ± 0.012
0.157CysTyr: 0.157 ± 0.01
0.0CysXaa: 0.0 ± 0.0
Asp
7.086AspAla: 7.086 ± 0.075
0.452AspCys: 0.452 ± 0.019
2.702AspAsp: 2.702 ± 0.052
3.487AspGlu: 3.487 ± 0.056
1.92AspPhe: 1.92 ± 0.037
4.682AspGly: 4.682 ± 0.065
1.268AspHis: 1.268 ± 0.03
2.098AspIle: 2.098 ± 0.048
1.509AspLys: 1.509 ± 0.038
5.748AspLeu: 5.748 ± 0.071
1.081AspMet: 1.081 ± 0.033
1.078AspAsn: 1.078 ± 0.035
3.256AspPro: 3.256 ± 0.054
1.828AspGln: 1.828 ± 0.033
3.522AspArg: 3.522 ± 0.057
2.261AspSer: 2.261 ± 0.036
2.687AspThr: 2.687 ± 0.041
3.569AspVal: 3.569 ± 0.059
1.179AspTrp: 1.179 ± 0.029
1.275AspTyr: 1.275 ± 0.035
0.0AspXaa: 0.0 ± 0.0
Glu
7.978GluAla: 7.978 ± 0.092
0.35GluCys: 0.35 ± 0.017
2.574GluAsp: 2.574 ± 0.045
2.574GluGlu: 2.574 ± 0.05
1.561GluPhe: 1.561 ± 0.037
4.16GluGly: 4.16 ± 0.05
1.401GluHis: 1.401 ± 0.036
2.237GluIle: 2.237 ± 0.047
1.58GluLys: 1.58 ± 0.042
5.959GluLeu: 5.959 ± 0.067
1.188GluMet: 1.188 ± 0.034
1.012GluAsn: 1.012 ± 0.029
2.677GluPro: 2.677 ± 0.048
2.649GluGln: 2.649 ± 0.05
4.758GluArg: 4.758 ± 0.062
2.151GluSer: 2.151 ± 0.038
2.383GluThr: 2.383 ± 0.044
4.325GluVal: 4.325 ± 0.066
0.73GluTrp: 0.73 ± 0.023
0.915GluTyr: 0.915 ± 0.027
0.0GluXaa: 0.0 ± 0.0
Phe
3.66PheAla: 3.66 ± 0.051
0.378PheCys: 0.378 ± 0.018
2.233PheAsp: 2.233 ± 0.039
2.04PheGlu: 2.04 ± 0.04
1.222PhePhe: 1.222 ± 0.036
2.986PheGly: 2.986 ± 0.044
0.722PheHis: 0.722 ± 0.024
1.252PheIle: 1.252 ± 0.035
1.004PheLys: 1.004 ± 0.031
2.861PheLeu: 2.861 ± 0.049
0.643PheMet: 0.643 ± 0.024
0.978PheAsn: 0.978 ± 0.03
1.364PhePro: 1.364 ± 0.033
1.134PheGln: 1.134 ± 0.028
1.821PheArg: 1.821 ± 0.037
1.875PheSer: 1.875 ± 0.039
1.779PheThr: 1.779 ± 0.038
2.444PheVal: 2.444 ± 0.05
0.542PheTrp: 0.542 ± 0.021
0.768PheTyr: 0.768 ± 0.027
0.0PheXaa: 0.0 ± 0.0
Gly
9.28GlyAla: 9.28 ± 0.091
0.957GlyCys: 0.957 ± 0.03
4.076GlyAsp: 4.076 ± 0.046
4.718GlyGlu: 4.718 ± 0.069
3.073GlyPhe: 3.073 ± 0.053
6.931GlyGly: 6.931 ± 0.1
2.16GlyHis: 2.16 ± 0.043
3.202GlyIle: 3.202 ± 0.056
2.688GlyLys: 2.688 ± 0.053
10.202GlyLeu: 10.202 ± 0.108
2.161GlyMet: 2.161 ± 0.048
1.757GlyAsn: 1.757 ± 0.045
3.692GlyPro: 3.692 ± 0.05
4.202GlyGln: 4.202 ± 0.064
6.092GlyArg: 6.092 ± 0.074
4.386GlySer: 4.386 ± 0.061
4.289GlyThr: 4.289 ± 0.057
6.454GlyVal: 6.454 ± 0.07
1.835GlyTrp: 1.835 ± 0.04
2.058GlyTyr: 2.058 ± 0.045
0.0GlyXaa: 0.0 ± 0.0
His
2.938HisAla: 2.938 ± 0.044
0.307HisCys: 0.307 ± 0.018
1.236HisAsp: 1.236 ± 0.032
1.15HisGlu: 1.15 ± 0.031
0.907HisPhe: 0.907 ± 0.024
2.303HisGly: 2.303 ± 0.044
0.737HisHis: 0.737 ± 0.028
0.806HisIle: 0.806 ± 0.023
0.501HisLys: 0.501 ± 0.019
2.641HisLeu: 2.641 ± 0.044
0.459HisMet: 0.459 ± 0.02
0.438HisAsn: 0.438 ± 0.02
1.768HisPro: 1.768 ± 0.043
0.882HisGln: 0.882 ± 0.028
1.771HisArg: 1.771 ± 0.04
0.987HisSer: 0.987 ± 0.027
1.109HisThr: 1.109 ± 0.028
1.545HisVal: 1.545 ± 0.034
0.545HisTrp: 0.545 ± 0.02
0.628HisTyr: 0.628 ± 0.021
0.0HisXaa: 0.0 ± 0.0
Ile
4.824IleAla: 4.824 ± 0.065
0.312IleCys: 0.312 ± 0.013
2.591IleAsp: 2.591 ± 0.047
2.575IleGlu: 2.575 ± 0.046
0.983IlePhe: 0.983 ± 0.028
3.542IleGly: 3.542 ± 0.062
0.828IleHis: 0.828 ± 0.025
1.186IleIle: 1.186 ± 0.032
1.145IleLys: 1.145 ± 0.029
2.818IleLeu: 2.818 ± 0.046
0.554IleMet: 0.554 ± 0.02
1.072IleAsn: 1.072 ± 0.034
1.788IlePro: 1.788 ± 0.038
1.274IleGln: 1.274 ± 0.028
2.325IleArg: 2.325 ± 0.04
1.934IleSer: 1.934 ± 0.043
2.156IleThr: 2.156 ± 0.044
2.848IleVal: 2.848 ± 0.051
0.433IleTrp: 0.433 ± 0.019
0.784IleTyr: 0.784 ± 0.026
0.0IleXaa: 0.0 ± 0.0
Lys
3.744LysAla: 3.744 ± 0.079
0.139LysCys: 0.139 ± 0.01
1.455LysAsp: 1.455 ± 0.038
1.266LysGlu: 1.266 ± 0.042
0.757LysPhe: 0.757 ± 0.022
2.185LysGly: 2.185 ± 0.05
0.529LysHis: 0.529 ± 0.021
1.175LysIle: 1.175 ± 0.035
1.159LysLys: 1.159 ± 0.045
3.049LysLeu: 3.049 ± 0.061
0.609LysMet: 0.609 ± 0.024
0.736LysAsn: 0.736 ± 0.029
1.789LysPro: 1.789 ± 0.042
0.997LysGln: 0.997 ± 0.028
1.788LysArg: 1.788 ± 0.038
1.503LysSer: 1.503 ± 0.041
1.602LysThr: 1.602 ± 0.042
2.387LysVal: 2.387 ± 0.052
0.269LysTrp: 0.269 ± 0.014
0.574LysTyr: 0.574 ± 0.023
0.0LysXaa: 0.0 ± 0.0
Leu
16.857LeuAla: 16.857 ± 0.181
1.046LeuCys: 1.046 ± 0.029
6.456LeuAsp: 6.456 ± 0.078
5.104LeuGlu: 5.104 ± 0.064
3.179LeuPhe: 3.179 ± 0.054
9.761LeuGly: 9.761 ± 0.1
2.561LeuHis: 2.561 ± 0.044
3.786LeuIle: 3.786 ± 0.061
3.444LeuLys: 3.444 ± 0.062
12.423LeuLeu: 12.423 ± 0.16
2.533LeuMet: 2.533 ± 0.046
2.608LeuAsn: 2.608 ± 0.049
7.079LeuPro: 7.079 ± 0.093
5.056LeuGln: 5.056 ± 0.073
8.935LeuArg: 8.935 ± 0.102
6.824LeuSer: 6.824 ± 0.08
5.636LeuThr: 5.636 ± 0.079
7.901LeuVal: 7.901 ± 0.083
1.666LeuTrp: 1.666 ± 0.04
1.991LeuTyr: 1.991 ± 0.04
0.0LeuXaa: 0.0 ± 0.0
Met
3.049MetAla: 3.049 ± 0.044
0.131MetCys: 0.131 ± 0.011
1.211MetAsp: 1.211 ± 0.03
0.925MetGlu: 0.925 ± 0.027
0.567MetPhe: 0.567 ± 0.021
1.813MetGly: 1.813 ± 0.041
0.498MetHis: 0.498 ± 0.018
0.767MetIle: 0.767 ± 0.025
0.807MetLys: 0.807 ± 0.025
2.342MetLeu: 2.342 ± 0.047
0.473MetMet: 0.473 ± 0.02
0.752MetAsn: 0.752 ± 0.025
1.409MetPro: 1.409 ± 0.032
0.959MetGln: 0.959 ± 0.03
1.562MetArg: 1.562 ± 0.034
1.579MetSer: 1.579 ± 0.036
1.429MetThr: 1.429 ± 0.031
1.651MetVal: 1.651 ± 0.036
0.164MetTrp: 0.164 ± 0.011
0.319MetTyr: 0.319 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
2.837AsnAla: 2.837 ± 0.05
0.236AsnCys: 0.236 ± 0.015
1.089AsnAsp: 1.089 ± 0.032
1.076AsnGlu: 1.076 ± 0.031
0.78AsnPhe: 0.78 ± 0.027
1.923AsnGly: 1.923 ± 0.048
0.493AsnHis: 0.493 ± 0.019
0.932AsnIle: 0.932 ± 0.03
0.618AsnLys: 0.618 ± 0.024
2.38AsnLeu: 2.38 ± 0.043
0.439AsnMet: 0.439 ± 0.019
0.56AsnAsn: 0.56 ± 0.025
1.643AsnPro: 1.643 ± 0.036
0.83AsnGln: 0.83 ± 0.027
1.516AsnArg: 1.516 ± 0.035
0.974AsnSer: 0.974 ± 0.03
1.249AsnThr: 1.249 ± 0.038
1.608AsnVal: 1.608 ± 0.04
0.369AsnTrp: 0.369 ± 0.017
0.53AsnTyr: 0.53 ± 0.024
0.0AsnXaa: 0.0 ± 0.0
Pro
8.682ProAla: 8.682 ± 0.095
0.432ProCys: 0.432 ± 0.021
3.422ProAsp: 3.422 ± 0.057
3.69ProGlu: 3.69 ± 0.055
1.694ProPhe: 1.694 ± 0.036
5.134ProGly: 5.134 ± 0.067
1.195ProHis: 1.195 ± 0.027
1.666ProIle: 1.666 ± 0.032
1.373ProLys: 1.373 ± 0.039
6.133ProLeu: 6.133 ± 0.074
1.334ProMet: 1.334 ± 0.032
1.084ProAsn: 1.084 ± 0.031
3.317ProPro: 3.317 ± 0.059
2.29ProGln: 2.29 ± 0.04
3.395ProArg: 3.395 ± 0.056
2.945ProSer: 2.945 ± 0.053
2.723ProThr: 2.723 ± 0.049
4.75ProVal: 4.75 ± 0.065
1.015ProTrp: 1.015 ± 0.031
1.026ProTyr: 1.026 ± 0.028
0.0ProXaa: 0.0 ± 0.0
Gln
7.781GlnAla: 7.781 ± 0.105
0.299GlnCys: 0.299 ± 0.014
1.936GlnAsp: 1.936 ± 0.043
1.666GlnGlu: 1.666 ± 0.037
1.175GlnPhe: 1.175 ± 0.03
3.725GlnGly: 3.725 ± 0.065
1.006GlnHis: 1.006 ± 0.027
1.626GlnIle: 1.626 ± 0.036
0.984GlnLys: 0.984 ± 0.031
4.641GlnLeu: 4.641 ± 0.074
0.954GlnMet: 0.954 ± 0.028
0.728GlnAsn: 0.728 ± 0.027
2.811GlnPro: 2.811 ± 0.051
2.178GlnGln: 2.178 ± 0.054
4.031GlnArg: 4.031 ± 0.057
1.896GlnSer: 1.896 ± 0.041
2.079GlnThr: 2.079 ± 0.044
3.464GlnVal: 3.464 ± 0.056
0.783GlnTrp: 0.783 ± 0.026
0.704GlnTyr: 0.704 ± 0.024
0.0GlnXaa: 0.0 ± 0.0
Arg
8.399ArgAla: 8.399 ± 0.086
0.709ArgCys: 0.709 ± 0.023
3.56ArgAsp: 3.56 ± 0.059
4.377ArgGlu: 4.377 ± 0.065
2.793ArgPhe: 2.793 ± 0.05
4.811ArgGly: 4.811 ± 0.059
2.202ArgHis: 2.202 ± 0.048
2.911ArgIle: 2.911 ± 0.041
1.782ArgLys: 1.782 ± 0.041
9.353ArgLeu: 9.353 ± 0.111
1.8ArgMet: 1.8 ± 0.04
1.458ArgAsn: 1.458 ± 0.039
4.03ArgPro: 4.03 ± 0.064
3.872ArgGln: 3.872 ± 0.058
5.919ArgArg: 5.919 ± 0.086
3.551ArgSer: 3.551 ± 0.062
3.081ArgThr: 3.081 ± 0.047
5.146ArgVal: 5.146 ± 0.065
1.597ArgTrp: 1.597 ± 0.039
1.738ArgTyr: 1.738 ± 0.036
0.0ArgXaa: 0.0 ± 0.0
Ser
6.606SerAla: 6.606 ± 0.076
0.477SerCys: 0.477 ± 0.019
2.495SerAsp: 2.495 ± 0.047
2.396SerGlu: 2.396 ± 0.037
1.847SerPhe: 1.847 ± 0.041
4.876SerGly: 4.876 ± 0.068
1.157SerHis: 1.157 ± 0.03
1.839SerIle: 1.839 ± 0.043
1.311SerLys: 1.311 ± 0.038
5.838SerLeu: 5.838 ± 0.075
1.076SerMet: 1.076 ± 0.03
1.18SerAsn: 1.18 ± 0.035
3.158SerPro: 3.158 ± 0.048
1.977SerGln: 1.977 ± 0.036
3.419SerArg: 3.419 ± 0.051
2.91SerSer: 2.91 ± 0.058
2.927SerThr: 2.927 ± 0.06
3.77SerVal: 3.77 ± 0.05
0.761SerTrp: 0.761 ± 0.026
1.136SerTyr: 1.136 ± 0.035
0.0SerXaa: 0.0 ± 0.0
Thr
6.078ThrAla: 6.078 ± 0.071
0.4ThrCys: 0.4 ± 0.018
2.484ThrAsp: 2.484 ± 0.05
2.494ThrGlu: 2.494 ± 0.043
1.448ThrPhe: 1.448 ± 0.034
4.582ThrGly: 4.582 ± 0.068
1.133ThrHis: 1.133 ± 0.029
1.666ThrIle: 1.666 ± 0.044
1.074ThrLys: 1.074 ± 0.035
6.931ThrLeu: 6.931 ± 0.069
0.985ThrMet: 0.985 ± 0.028
1.07ThrAsn: 1.07 ± 0.037
3.765ThrPro: 3.765 ± 0.061
1.975ThrGln: 1.975 ± 0.043
3.221ThrArg: 3.221 ± 0.052
2.365ThrSer: 2.365 ± 0.052
2.626ThrThr: 2.626 ± 0.051
4.28ThrVal: 4.28 ± 0.064
0.724ThrTrp: 0.724 ± 0.027
0.934ThrTyr: 0.934 ± 0.03
0.0ThrXaa: 0.0 ± 0.0
Val
9.714ValAla: 9.714 ± 0.105
0.726ValCys: 0.726 ± 0.027
4.089ValAsp: 4.089 ± 0.055
3.958ValGlu: 3.958 ± 0.066
2.497ValPhe: 2.497 ± 0.044
5.602ValGly: 5.602 ± 0.064
1.672ValHis: 1.672 ± 0.033
2.947ValIle: 2.947 ± 0.053
2.171ValLys: 2.171 ± 0.05
8.607ValLeu: 8.607 ± 0.095
1.781ValMet: 1.781 ± 0.037
1.959ValAsn: 1.959 ± 0.04
4.082ValPro: 4.082 ± 0.056
3.262ValGln: 3.262 ± 0.048
5.081ValArg: 5.081 ± 0.062
4.063ValSer: 4.063 ± 0.055
3.926ValThr: 3.926 ± 0.056
6.098ValVal: 6.098 ± 0.086
1.136ValTrp: 1.136 ± 0.03
1.4ValTyr: 1.4 ± 0.035
0.0ValXaa: 0.0 ± 0.0
Trp
1.851TrpAla: 1.851 ± 0.042
0.196TrpCys: 0.196 ± 0.014
0.741TrpAsp: 0.741 ± 0.027
0.578TrpGlu: 0.578 ± 0.02
0.525TrpPhe: 0.525 ± 0.023
1.153TrpGly: 1.153 ± 0.028
0.432TrpHis: 0.432 ± 0.018
0.571TrpIle: 0.571 ± 0.022
0.422TrpLys: 0.422 ± 0.018
2.518TrpLeu: 2.518 ± 0.052
0.447TrpMet: 0.447 ± 0.019
0.429TrpAsn: 0.429 ± 0.018
0.96TrpPro: 0.96 ± 0.028
1.028TrpGln: 1.028 ± 0.03
1.606TrpArg: 1.606 ± 0.036
0.826TrpSer: 0.826 ± 0.025
0.827TrpThr: 0.827 ± 0.027
1.311TrpVal: 1.311 ± 0.032
0.362TrpTrp: 0.362 ± 0.017
0.306TrpTyr: 0.306 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.394TyrAla: 2.394 ± 0.053
0.215TyrCys: 0.215 ± 0.014
1.144TyrAsp: 1.144 ± 0.033
1.082TyrGlu: 1.082 ± 0.03
0.724TyrPhe: 0.724 ± 0.026
1.788TyrGly: 1.788 ± 0.039
0.449TyrHis: 0.449 ± 0.015
0.677TyrIle: 0.677 ± 0.022
0.545TyrLys: 0.545 ± 0.023
2.304TyrLeu: 2.304 ± 0.038
0.359TyrMet: 0.359 ± 0.017
0.512TyrAsn: 0.512 ± 0.023
1.016TyrPro: 1.016 ± 0.029
0.857TyrGln: 0.857 ± 0.025
1.677TyrArg: 1.677 ± 0.035
1.012TyrSer: 1.012 ± 0.029
1.074TyrThr: 1.074 ± 0.032
1.434TyrVal: 1.434 ± 0.032
0.341TyrTrp: 0.341 ± 0.016
0.506TyrTyr: 0.506 ± 0.023
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4151 proteins (1362198 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski