Amino acid dipepetide frequency for Rhodobacter sp. SW2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
21.616AlaAla: 21.616 ± 0.278
1.29AlaCys: 1.29 ± 0.036
7.821AlaAsp: 7.821 ± 0.098
8.733AlaGlu: 8.733 ± 0.112
4.552AlaPhe: 4.552 ± 0.077
12.037AlaGly: 12.037 ± 0.152
2.431AlaHis: 2.431 ± 0.046
5.711AlaIle: 5.711 ± 0.084
3.944AlaLys: 3.944 ± 0.076
16.004AlaLeu: 16.004 ± 0.199
4.136AlaMet: 4.136 ± 0.062
2.896AlaAsn: 2.896 ± 0.062
6.454AlaPro: 6.454 ± 0.114
5.023AlaGln: 5.023 ± 0.083
9.913AlaArg: 9.913 ± 0.121
5.855AlaSer: 5.855 ± 0.07
6.769AlaThr: 6.769 ± 0.098
9.93AlaVal: 9.93 ± 0.102
1.493AlaTrp: 1.493 ± 0.038
2.481AlaTyr: 2.481 ± 0.054
0.0AlaXaa: 0.0 ± 0.0
Cys
1.085CysAla: 1.085 ± 0.035
0.127CysCys: 0.127 ± 0.012
0.636CysAsp: 0.636 ± 0.025
0.414CysGlu: 0.414 ± 0.023
0.315CysPhe: 0.315 ± 0.018
1.022CysGly: 1.022 ± 0.033
0.264CysHis: 0.264 ± 0.016
0.419CysIle: 0.419 ± 0.021
0.188CysLys: 0.188 ± 0.015
0.921CysLeu: 0.921 ± 0.026
0.171CysMet: 0.171 ± 0.013
0.22CysAsn: 0.22 ± 0.013
0.554CysPro: 0.554 ± 0.023
0.222CysGln: 0.222 ± 0.013
0.589CysArg: 0.589 ± 0.027
0.426CysSer: 0.426 ± 0.02
0.49CysThr: 0.49 ± 0.023
0.576CysVal: 0.576 ± 0.024
0.127CysTrp: 0.127 ± 0.011
0.205CysTyr: 0.205 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
7.568AspAla: 7.568 ± 0.089
0.518AspCys: 0.518 ± 0.023
2.982AspAsp: 2.982 ± 0.069
2.665AspGlu: 2.665 ± 0.053
2.18AspPhe: 2.18 ± 0.052
5.235AspGly: 5.235 ± 0.097
1.181AspHis: 1.181 ± 0.032
2.58AspIle: 2.58 ± 0.052
1.446AspLys: 1.446 ± 0.044
6.838AspLeu: 6.838 ± 0.083
1.446AspMet: 1.446 ± 0.038
1.119AspAsn: 1.119 ± 0.037
3.666AspPro: 3.666 ± 0.055
1.885AspGln: 1.885 ± 0.052
4.193AspArg: 4.193 ± 0.063
2.109AspSer: 2.109 ± 0.06
2.773AspThr: 2.773 ± 0.088
3.749AspVal: 3.749 ± 0.061
1.169AspTrp: 1.169 ± 0.034
1.424AspTyr: 1.424 ± 0.041
0.0AspXaa: 0.0 ± 0.0
Glu
8.124GluAla: 8.124 ± 0.102
0.327GluCys: 0.327 ± 0.018
2.542GluAsp: 2.542 ± 0.055
2.259GluGlu: 2.259 ± 0.058
1.662GluPhe: 1.662 ± 0.042
4.285GluGly: 4.285 ± 0.071
0.933GluHis: 0.933 ± 0.03
2.951GluIle: 2.951 ± 0.053
1.728GluLys: 1.728 ± 0.044
4.412GluLeu: 4.412 ± 0.068
1.623GluMet: 1.623 ± 0.038
1.364GluAsn: 1.364 ± 0.04
2.475GluPro: 2.475 ± 0.053
1.568GluGln: 1.568 ± 0.038
3.527GluArg: 3.527 ± 0.069
1.942GluSer: 1.942 ± 0.044
3.241GluThr: 3.241 ± 0.057
4.454GluVal: 4.454 ± 0.071
0.652GluTrp: 0.652 ± 0.025
0.858GluTyr: 0.858 ± 0.031
0.0GluXaa: 0.0 ± 0.0
Phe
4.84PheAla: 4.84 ± 0.076
0.437PheCys: 0.437 ± 0.018
2.652PheAsp: 2.652 ± 0.047
1.754PheGlu: 1.754 ± 0.042
1.294PhePhe: 1.294 ± 0.043
3.818PheGly: 3.818 ± 0.065
0.717PheHis: 0.717 ± 0.027
1.469PheIle: 1.469 ± 0.041
0.893PheLys: 0.893 ± 0.028
3.45PheLeu: 3.45 ± 0.063
0.744PheMet: 0.744 ± 0.025
0.984PheAsn: 0.984 ± 0.034
1.553PhePro: 1.553 ± 0.038
1.024PheGln: 1.024 ± 0.029
2.2PheArg: 2.2 ± 0.052
1.977PheSer: 1.977 ± 0.048
2.035PheThr: 2.035 ± 0.045
2.52PheVal: 2.52 ± 0.056
0.538PheTrp: 0.538 ± 0.025
0.861PheTyr: 0.861 ± 0.034
0.0PheXaa: 0.0 ± 0.0
Gly
10.713GlyAla: 10.713 ± 0.153
0.945GlyCys: 0.945 ± 0.034
4.696GlyAsp: 4.696 ± 0.098
4.127GlyGlu: 4.127 ± 0.064
3.971GlyPhe: 3.971 ± 0.064
7.941GlyGly: 7.941 ± 0.153
1.951GlyHis: 1.951 ± 0.048
4.42GlyIle: 4.42 ± 0.057
3.207GlyLys: 3.207 ± 0.06
10.191GlyLeu: 10.191 ± 0.132
2.662GlyMet: 2.662 ± 0.057
2.412GlyAsn: 2.412 ± 0.113
3.938GlyPro: 3.938 ± 0.068
3.318GlyGln: 3.318 ± 0.059
6.091GlyArg: 6.091 ± 0.094
4.388GlySer: 4.388 ± 0.083
4.518GlyThr: 4.518 ± 0.087
6.828GlyVal: 6.828 ± 0.093
1.634GlyTrp: 1.634 ± 0.04
2.141GlyTyr: 2.141 ± 0.05
0.0GlyXaa: 0.0 ± 0.0
His
2.441HisAla: 2.441 ± 0.055
0.231HisCys: 0.231 ± 0.015
1.243HisAsp: 1.243 ± 0.032
0.898HisGlu: 0.898 ± 0.03
0.814HisPhe: 0.814 ± 0.028
1.912HisGly: 1.912 ± 0.044
0.526HisHis: 0.526 ± 0.027
0.862HisIle: 0.862 ± 0.03
0.443HisLys: 0.443 ± 0.021
2.321HisLeu: 2.321 ± 0.054
0.49HisMet: 0.49 ± 0.022
0.421HisAsn: 0.421 ± 0.021
1.42HisPro: 1.42 ± 0.037
0.551HisGln: 0.551 ± 0.022
1.391HisArg: 1.391 ± 0.039
0.911HisSer: 0.911 ± 0.031
0.757HisThr: 0.757 ± 0.028
1.4HisVal: 1.4 ± 0.041
0.383HisTrp: 0.383 ± 0.02
0.524HisTyr: 0.524 ± 0.021
0.0HisXaa: 0.0 ± 0.0
Ile
6.808IleAla: 6.808 ± 0.085
0.581IleCys: 0.581 ± 0.026
3.369IleAsp: 3.369 ± 0.064
2.946IleGlu: 2.946 ± 0.066
1.524IlePhe: 1.524 ± 0.038
4.77IleGly: 4.77 ± 0.064
0.873IleHis: 0.873 ± 0.029
1.916IleIle: 1.916 ± 0.049
1.235IleLys: 1.235 ± 0.037
4.36IleLeu: 4.36 ± 0.076
0.885IleMet: 0.885 ± 0.03
1.26IleAsn: 1.26 ± 0.036
2.16IlePro: 2.16 ± 0.043
0.945IleGln: 0.945 ± 0.03
3.091IleArg: 3.091 ± 0.053
2.826IleSer: 2.826 ± 0.054
2.841IleThr: 2.841 ± 0.054
3.326IleVal: 3.326 ± 0.071
0.662IleTrp: 0.662 ± 0.026
1.023IleTyr: 1.023 ± 0.031
0.0IleXaa: 0.0 ± 0.0
Lys
4.074LysAla: 4.074 ± 0.078
0.176LysCys: 0.176 ± 0.012
1.418LysAsp: 1.418 ± 0.038
1.122LysGlu: 1.122 ± 0.034
0.83LysPhe: 0.83 ± 0.023
2.552LysGly: 2.552 ± 0.051
0.502LysHis: 0.502 ± 0.026
1.447LysIle: 1.447 ± 0.039
0.999LysLys: 0.999 ± 0.035
2.948LysLeu: 2.948 ± 0.056
0.747LysMet: 0.747 ± 0.03
0.617LysAsn: 0.617 ± 0.028
1.972LysPro: 1.972 ± 0.051
0.775LysGln: 0.775 ± 0.029
1.984LysArg: 1.984 ± 0.047
1.557LysSer: 1.557 ± 0.035
1.748LysThr: 1.748 ± 0.044
2.291LysVal: 2.291 ± 0.05
0.349LysTrp: 0.349 ± 0.017
0.578LysTyr: 0.578 ± 0.024
0.0LysXaa: 0.0 ± 0.0
Leu
16.719LeuAla: 16.719 ± 0.203
0.953LeuCys: 0.953 ± 0.03
5.742LeuAsp: 5.742 ± 0.08
4.995LeuGlu: 4.995 ± 0.077
3.38LeuPhe: 3.38 ± 0.068
9.281LeuGly: 9.281 ± 0.121
2.168LeuHis: 2.168 ± 0.048
5.108LeuIle: 5.108 ± 0.067
2.921LeuLys: 2.921 ± 0.054
10.198LeuLeu: 10.198 ± 0.147
2.609LeuMet: 2.609 ± 0.053
2.568LeuAsn: 2.568 ± 0.051
6.275LeuPro: 6.275 ± 0.097
3.129LeuGln: 3.129 ± 0.06
7.806LeuArg: 7.806 ± 0.101
5.812LeuSer: 5.812 ± 0.077
6.581LeuThr: 6.581 ± 0.085
7.581LeuVal: 7.581 ± 0.114
1.489LeuTrp: 1.489 ± 0.041
1.881LeuTyr: 1.881 ± 0.047
0.0LeuXaa: 0.0 ± 0.0
Met
3.965MetAla: 3.965 ± 0.061
0.155MetCys: 0.155 ± 0.012
1.26MetAsp: 1.26 ± 0.035
1.117MetGlu: 1.117 ± 0.033
0.746MetPhe: 0.746 ± 0.025
2.155MetGly: 2.155 ± 0.056
0.417MetHis: 0.417 ± 0.02
1.346MetIle: 1.346 ± 0.035
0.922MetLys: 0.922 ± 0.031
2.713MetLeu: 2.713 ± 0.049
0.706MetMet: 0.706 ± 0.025
0.75MetAsn: 0.75 ± 0.025
1.544MetPro: 1.544 ± 0.042
1.137MetGln: 1.137 ± 0.034
1.764MetArg: 1.764 ± 0.044
1.412MetSer: 1.412 ± 0.037
2.0MetThr: 2.0 ± 0.041
1.886MetVal: 1.886 ± 0.046
0.205MetTrp: 0.205 ± 0.015
0.32MetTyr: 0.32 ± 0.017
0.0MetXaa: 0.0 ± 0.0
Asn
3.042AsnAla: 3.042 ± 0.063
0.222AsnCys: 0.222 ± 0.015
1.487AsnAsp: 1.487 ± 0.086
0.928AsnGlu: 0.928 ± 0.032
0.968AsnPhe: 0.968 ± 0.033
2.334AsnGly: 2.334 ± 0.085
0.468AsnHis: 0.468 ± 0.024
1.17AsnIle: 1.17 ± 0.038
0.545AsnLys: 0.545 ± 0.023
2.596AsnLeu: 2.596 ± 0.057
0.617AsnMet: 0.617 ± 0.025
0.558AsnAsn: 0.558 ± 0.023
1.928AsnPro: 1.928 ± 0.049
0.611AsnGln: 0.611 ± 0.026
1.678AsnArg: 1.678 ± 0.038
1.09AsnSer: 1.09 ± 0.036
1.2AsnThr: 1.2 ± 0.039
1.614AsnVal: 1.614 ± 0.046
0.408AsnTrp: 0.408 ± 0.021
0.532AsnTyr: 0.532 ± 0.023
0.0AsnXaa: 0.0 ± 0.0
Pro
7.042ProAla: 7.042 ± 0.12
0.411ProCys: 0.411 ± 0.021
3.73ProAsp: 3.73 ± 0.062
3.927ProGlu: 3.927 ± 0.064
1.916ProPhe: 1.916 ± 0.047
5.249ProGly: 5.249 ± 0.081
1.026ProHis: 1.026 ± 0.036
2.106ProIle: 2.106 ± 0.05
1.59ProLys: 1.59 ± 0.039
5.181ProLeu: 5.181 ± 0.087
1.395ProMet: 1.395 ± 0.044
1.196ProAsn: 1.196 ± 0.034
2.493ProPro: 2.493 ± 0.067
1.948ProGln: 1.948 ± 0.047
2.993ProArg: 2.993 ± 0.052
2.246ProSer: 2.246 ± 0.051
2.498ProThr: 2.498 ± 0.046
4.661ProVal: 4.661 ± 0.077
0.751ProTrp: 0.751 ± 0.033
1.1ProTyr: 1.1 ± 0.033
0.0ProXaa: 0.0 ± 0.0
Gln
4.975GlnAla: 4.975 ± 0.08
0.201GlnCys: 0.201 ± 0.015
1.552GlnAsp: 1.552 ± 0.043
1.225GlnGlu: 1.225 ± 0.035
0.984GlnPhe: 0.984 ± 0.029
3.1GlnGly: 3.1 ± 0.06
0.626GlnHis: 0.626 ± 0.026
1.978GlnIle: 1.978 ± 0.045
0.913GlnLys: 0.913 ± 0.032
2.7GlnLeu: 2.7 ± 0.048
1.089GlnMet: 1.089 ± 0.034
0.795GlnAsn: 0.795 ± 0.028
1.908GlnPro: 1.908 ± 0.049
1.041GlnGln: 1.041 ± 0.039
2.36GlnArg: 2.36 ± 0.048
1.643GlnSer: 1.643 ± 0.043
1.881GlnThr: 1.881 ± 0.05
2.751GlnVal: 2.751 ± 0.054
0.406GlnTrp: 0.406 ± 0.018
0.495GlnTyr: 0.495 ± 0.023
0.0GlnXaa: 0.0 ± 0.0
Arg
9.035ArgAla: 9.035 ± 0.118
0.511ArgCys: 0.511 ± 0.02
3.984ArgAsp: 3.984 ± 0.059
3.272ArgGlu: 3.272 ± 0.062
2.684ArgPhe: 2.684 ± 0.051
4.911ArgGly: 4.911 ± 0.064
1.624ArgHis: 1.624 ± 0.036
3.786ArgIle: 3.786 ± 0.062
2.063ArgLys: 2.063 ± 0.05
8.339ArgLeu: 8.339 ± 0.094
1.946ArgMet: 1.946 ± 0.042
1.629ArgAsn: 1.629 ± 0.033
3.524ArgPro: 3.524 ± 0.061
2.412ArgGln: 2.412 ± 0.049
5.199ArgArg: 5.199 ± 0.075
3.121ArgSer: 3.121 ± 0.052
2.68ArgThr: 2.68 ± 0.049
4.882ArgVal: 4.882 ± 0.063
0.966ArgTrp: 0.966 ± 0.029
1.46ArgTyr: 1.46 ± 0.041
0.0ArgXaa: 0.0 ± 0.0
Ser
5.608SerAla: 5.608 ± 0.078
0.405SerCys: 0.405 ± 0.017
2.802SerAsp: 2.802 ± 0.061
2.241SerGlu: 2.241 ± 0.05
2.055SerPhe: 2.055 ± 0.046
5.294SerGly: 5.294 ± 0.095
1.084SerHis: 1.084 ± 0.027
2.211SerIle: 2.211 ± 0.056
1.237SerLys: 1.237 ± 0.041
5.119SerLeu: 5.119 ± 0.077
1.224SerMet: 1.224 ± 0.037
1.222SerAsn: 1.222 ± 0.037
2.56SerPro: 2.56 ± 0.055
1.428SerGln: 1.428 ± 0.039
3.164SerArg: 3.164 ± 0.058
2.201SerSer: 2.201 ± 0.056
2.35SerThr: 2.35 ± 0.049
3.677SerVal: 3.677 ± 0.064
0.666SerTrp: 0.666 ± 0.024
1.136SerTyr: 1.136 ± 0.031
0.0SerXaa: 0.0 ± 0.0
Thr
6.886ThrAla: 6.886 ± 0.086
0.489ThrCys: 0.489 ± 0.022
3.056ThrAsp: 3.056 ± 0.056
2.81ThrGlu: 2.81 ± 0.054
1.811ThrPhe: 1.811 ± 0.038
5.523ThrGly: 5.523 ± 0.105
1.072ThrHis: 1.072 ± 0.03
2.36ThrIle: 2.36 ± 0.06
1.284ThrLys: 1.284 ± 0.035
6.367ThrLeu: 6.367 ± 0.085
1.16ThrMet: 1.16 ± 0.036
1.214ThrAsn: 1.214 ± 0.038
3.422ThrPro: 3.422 ± 0.064
1.507ThrGln: 1.507 ± 0.041
3.34ThrArg: 3.34 ± 0.057
2.519ThrSer: 2.519 ± 0.049
2.804ThrThr: 2.804 ± 0.063
4.143ThrVal: 4.143 ± 0.061
0.659ThrTrp: 0.659 ± 0.028
1.156ThrTyr: 1.156 ± 0.032
0.0ThrXaa: 0.0 ± 0.0
Val
10.334ValAla: 10.334 ± 0.115
0.638ValCys: 0.638 ± 0.024
3.682ValAsp: 3.682 ± 0.062
3.989ValGlu: 3.989 ± 0.063
2.76ValPhe: 2.76 ± 0.058
5.503ValGly: 5.503 ± 0.078
1.246ValHis: 1.246 ± 0.036
4.096ValIle: 4.096 ± 0.063
2.167ValLys: 2.167 ± 0.053
8.472ValLeu: 8.472 ± 0.099
2.123ValMet: 2.123 ± 0.045
1.881ValAsn: 1.881 ± 0.047
3.837ValPro: 3.837 ± 0.065
2.623ValGln: 2.623 ± 0.053
4.186ValArg: 4.186 ± 0.065
3.906ValSer: 3.906 ± 0.065
4.712ValThr: 4.712 ± 0.075
6.126ValVal: 6.126 ± 0.09
1.072ValTrp: 1.072 ± 0.033
1.444ValTyr: 1.444 ± 0.036
0.0ValXaa: 0.0 ± 0.0
Trp
1.586TrpAla: 1.586 ± 0.042
0.134TrpCys: 0.134 ± 0.011
0.673TrpAsp: 0.673 ± 0.028
0.555TrpGlu: 0.555 ± 0.022
0.526TrpPhe: 0.526 ± 0.022
1.09TrpGly: 1.09 ± 0.035
0.358TrpHis: 0.358 ± 0.02
0.627TrpIle: 0.627 ± 0.027
0.459TrpLys: 0.459 ± 0.02
1.856TrpLeu: 1.856 ± 0.048
0.341TrpMet: 0.341 ± 0.018
0.373TrpAsn: 0.373 ± 0.019
0.744TrpPro: 0.744 ± 0.025
0.811TrpGln: 0.811 ± 0.031
1.114TrpArg: 1.114 ± 0.036
0.722TrpSer: 0.722 ± 0.027
0.699TrpThr: 0.699 ± 0.025
0.988TrpVal: 0.988 ± 0.036
0.215TrpTrp: 0.215 ± 0.015
0.266TrpTyr: 0.266 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.624TyrAla: 2.624 ± 0.052
0.218TyrCys: 0.218 ± 0.013
1.401TyrAsp: 1.401 ± 0.034
0.952TyrGlu: 0.952 ± 0.036
0.787TyrPhe: 0.787 ± 0.028
2.082TyrGly: 2.082 ± 0.051
0.47TyrHis: 0.47 ± 0.022
0.837TyrIle: 0.837 ± 0.028
0.502TyrLys: 0.502 ± 0.023
2.212TyrLeu: 2.212 ± 0.043
0.405TyrMet: 0.405 ± 0.02
0.522TyrAsn: 0.522 ± 0.023
1.033TyrPro: 1.033 ± 0.033
0.662TyrGln: 0.662 ± 0.024
1.445TyrArg: 1.445 ± 0.04
1.02TyrSer: 1.02 ± 0.031
1.006TyrThr: 1.006 ± 0.029
1.415TyrVal: 1.415 ± 0.039
0.29TyrTrp: 0.29 ± 0.016
0.494TyrTyr: 0.494 ± 0.026
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3405 proteins (1062988 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski