Amino acid dipepetide frequency for Berryella intestinalis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.162AlaAla: 15.162 ± 0.272	2.012AlaCys: 2.012 ± 0.084	7.119AlaAsp: 7.119 ± 0.144	7.165AlaGlu: 7.165 ± 0.16	4.654AlaPhe: 4.654 ± 0.119	9.702AlaGly: 9.702 ± 0.17	1.932AlaHis: 1.932 ± 0.063	5.557AlaIle: 5.557 ± 0.115	4.066AlaLys: 4.066 ± 0.093	12.392AlaLeu: 12.392 ± 0.213	2.724AlaMet: 2.724 ± 0.087	2.728AlaAsn: 2.728 ± 0.09	4.374AlaPro: 4.374 ± 0.115	3.616AlaGln: 3.616 ± 0.086	7.839AlaArg: 7.839 ± 0.182	7.552AlaSer: 7.552 ± 0.154	5.002AlaThr: 5.002 ± 0.106	9.219AlaVal: 9.219 ± 0.165	1.212AlaTrp: 1.212 ± 0.052	2.892AlaTyr: 2.892 ± 0.083	0.0AlaXaa: 0.0 ± 0.0
Cys	1.749CysAla: 1.749 ± 0.061	0.239CysCys: 0.239 ± 0.025	1.027CysAsp: 1.027 ± 0.046	0.903CysGlu: 0.903 ± 0.042	0.521CysPhe: 0.521 ± 0.035	1.77CysGly: 1.77 ± 0.063	0.279CysHis: 0.279 ± 0.028	0.811CysIle: 0.811 ± 0.042	0.395CysLys: 0.395 ± 0.028	1.138CysLeu: 1.138 ± 0.051	0.437CysMet: 0.437 ± 0.031	0.361CysAsn: 0.361 ± 0.036	0.893CysPro: 0.893 ± 0.052	0.349CysGln: 0.349 ± 0.031	0.802CysArg: 0.802 ± 0.049	0.926CysSer: 0.926 ± 0.045	0.756CysThr: 0.756 ± 0.039	1.121CysVal: 1.121 ± 0.053	0.147CysTrp: 0.147 ± 0.018	0.389CysTyr: 0.389 ± 0.033	0.0CysXaa: 0.0 ± 0.0
Asp	7.619AspAla: 7.619 ± 0.141	0.668AspCys: 0.668 ± 0.034	3.419AspAsp: 3.419 ± 0.084	5.214AspGlu: 5.214 ± 0.116	2.337AspPhe: 2.337 ± 0.073	5.168AspGly: 5.168 ± 0.125	1.006AspHis: 1.006 ± 0.045	3.322AspIle: 3.322 ± 0.088	2.106AspLys: 2.106 ± 0.075	5.737AspLeu: 5.737 ± 0.112	1.56AspMet: 1.56 ± 0.06	1.489AspAsn: 1.489 ± 0.059	3.448AspPro: 3.448 ± 0.097	1.617AspGln: 1.617 ± 0.057	3.885AspArg: 3.885 ± 0.098	2.93AspSer: 2.93 ± 0.082	2.61AspThr: 2.61 ± 0.078	4.704AspVal: 4.704 ± 0.106	0.649AspTrp: 0.649 ± 0.04	1.905AspTyr: 1.905 ± 0.072	0.0AspXaa: 0.0 ± 0.0
Glu	7.961GluAla: 7.961 ± 0.172	0.737GluCys: 0.737 ± 0.043	3.467GluAsp: 3.467 ± 0.101	3.986GluGlu: 3.986 ± 0.115	2.279GluPhe: 2.279 ± 0.063	5.924GluGly: 5.924 ± 0.102	1.205GluHis: 1.205 ± 0.048	3.192GluIle: 3.192 ± 0.089	2.965GluLys: 2.965 ± 0.088	6.004GluLeu: 6.004 ± 0.12	1.623GluMet: 1.623 ± 0.063	2.083GluAsn: 2.083 ± 0.071	2.297GluPro: 2.297 ± 0.073	2.165GluGln: 2.165 ± 0.071	5.565GluArg: 5.565 ± 0.131	3.707GluSer: 3.707 ± 0.089	3.152GluThr: 3.152 ± 0.085	4.935GluVal: 4.935 ± 0.12	0.569GluTrp: 0.569 ± 0.034	1.634GluTyr: 1.634 ± 0.069	0.0GluXaa: 0.0 ± 0.0
Phe	4.4PheAla: 4.4 ± 0.103	0.651PheCys: 0.651 ± 0.036	3.049PheAsp: 3.049 ± 0.092	2.692PheGlu: 2.692 ± 0.082	1.571PhePhe: 1.571 ± 0.075	3.667PheGly: 3.667 ± 0.094	0.548PheHis: 0.548 ± 0.033	1.768PheIle: 1.768 ± 0.077	1.376PheLys: 1.376 ± 0.053	3.207PheLeu: 3.207 ± 0.108	0.935PheMet: 0.935 ± 0.047	1.117PheAsn: 1.117 ± 0.054	1.481PhePro: 1.481 ± 0.051	0.983PheGln: 0.983 ± 0.046	1.63PheArg: 1.63 ± 0.054	3.123PheSer: 3.123 ± 0.074	1.888PheThr: 1.888 ± 0.071	3.284PheVal: 3.284 ± 0.097	0.447PheTrp: 0.447 ± 0.033	1.075PheTyr: 1.075 ± 0.05	0.0PheXaa: 0.0 ± 0.0
Gly	9.238GlyAla: 9.238 ± 0.175	1.619GlyCys: 1.619 ± 0.071	4.706GlyAsp: 4.706 ± 0.106	4.975GlyGlu: 4.975 ± 0.098	3.719GlyPhe: 3.719 ± 0.096	6.665GlyGly: 6.665 ± 0.153	1.401GlyHis: 1.401 ± 0.053	5.061GlyIle: 5.061 ± 0.121	4.005GlyLys: 4.005 ± 0.11	7.505GlyLeu: 7.505 ± 0.137	2.331GlyMet: 2.331 ± 0.074	2.381GlyAsn: 2.381 ± 0.08	2.381GlyPro: 2.381 ± 0.068	2.18GlyGln: 2.18 ± 0.067	5.063GlyArg: 5.063 ± 0.111	5.935GlySer: 5.935 ± 0.142	4.586GlyThr: 4.586 ± 0.113	6.985GlyVal: 6.985 ± 0.115	0.893GlyTrp: 0.893 ± 0.046	2.717GlyTyr: 2.717 ± 0.083	0.0GlyXaa: 0.0 ± 0.0
His	1.901HisAla: 1.901 ± 0.058	0.29HisCys: 0.29 ± 0.026	1.029HisAsp: 1.029 ± 0.048	0.966HisGlu: 0.966 ± 0.047	0.609HisPhe: 0.609 ± 0.04	1.548HisGly: 1.548 ± 0.053	0.393HisHis: 0.393 ± 0.026	0.92HisIle: 0.92 ± 0.047	0.456HisLys: 0.456 ± 0.035	1.481HisLeu: 1.481 ± 0.052	0.426HisMet: 0.426 ± 0.034	0.456HisAsn: 0.456 ± 0.037	1.008HisPro: 1.008 ± 0.043	0.391HisGln: 0.391 ± 0.031	1.113HisArg: 1.113 ± 0.051	0.924HisSer: 0.924 ± 0.048	0.8HisThr: 0.8 ± 0.038	1.384HisVal: 1.384 ± 0.056	0.141HisTrp: 0.141 ± 0.022	0.515HisTyr: 0.515 ± 0.037	0.0HisXaa: 0.0 ± 0.0
Ile	6.842IleAla: 6.842 ± 0.138	0.794IleCys: 0.794 ± 0.043	4.271IleAsp: 4.271 ± 0.1	4.423IleGlu: 4.423 ± 0.104	1.338IlePhe: 1.338 ± 0.06	4.486IleGly: 4.486 ± 0.109	0.758IleHis: 0.758 ± 0.039	2.432IleIle: 2.432 ± 0.093	1.693IleLys: 1.693 ± 0.065	3.816IleLeu: 3.816 ± 0.094	1.313IleMet: 1.313 ± 0.059	1.31IleAsn: 1.31 ± 0.052	2.423IlePro: 2.423 ± 0.074	1.184IleGln: 1.184 ± 0.054	2.583IleArg: 2.583 ± 0.073	2.976IleSer: 2.976 ± 0.089	2.594IleThr: 2.594 ± 0.077	4.696IleVal: 4.696 ± 0.111	0.386IleTrp: 0.386 ± 0.033	1.079IleTyr: 1.079 ± 0.055	0.0IleXaa: 0.0 ± 0.0
Lys	4.162LysAla: 4.162 ± 0.112	0.416LysCys: 0.416 ± 0.034	2.111LysAsp: 2.111 ± 0.078	2.297LysGlu: 2.297 ± 0.075	0.97LysPhe: 0.97 ± 0.045	3.116LysGly: 3.116 ± 0.086	0.563LysHis: 0.563 ± 0.032	1.743LysIle: 1.743 ± 0.062	2.085LysLys: 2.085 ± 0.076	3.434LysLeu: 3.434 ± 0.085	0.96LysMet: 0.96 ± 0.045	1.26LysAsn: 1.26 ± 0.048	1.768LysPro: 1.768 ± 0.067	1.17LysGln: 1.17 ± 0.051	2.942LysArg: 2.942 ± 0.077	2.346LysSer: 2.346 ± 0.074	2.417LysThr: 2.417 ± 0.078	3.051LysVal: 3.051 ± 0.097	0.378LysTrp: 0.378 ± 0.03	0.947LysTyr: 0.947 ± 0.051	0.0LysXaa: 0.0 ± 0.0
Leu	11.197LeuAla: 11.197 ± 0.167	1.426LeuCys: 1.426 ± 0.055	6.052LeuAsp: 6.052 ± 0.117	5.666LeuGlu: 5.666 ± 0.135	3.822LeuPhe: 3.822 ± 0.093	7.508LeuGly: 7.508 ± 0.131	1.403LeuHis: 1.403 ± 0.049	4.299LeuIle: 4.299 ± 0.117	3.434LeuLys: 3.434 ± 0.091	7.776LeuLeu: 7.776 ± 0.165	2.411LeuMet: 2.411 ± 0.079	2.373LeuAsn: 2.373 ± 0.068	4.007LeuPro: 4.007 ± 0.098	2.012LeuGln: 2.012 ± 0.072	5.389LeuArg: 5.389 ± 0.12	6.957LeuSer: 6.957 ± 0.139	4.158LeuThr: 4.158 ± 0.101	8.32LeuVal: 8.32 ± 0.162	0.788LeuTrp: 0.788 ± 0.043	2.186LeuTyr: 2.186 ± 0.077	0.0LeuXaa: 0.0 ± 0.0
Met	2.911MetAla: 2.911 ± 0.073	0.37MetCys: 0.37 ± 0.03	1.382MetAsp: 1.382 ± 0.053	1.39MetGlu: 1.39 ± 0.054	0.842MetPhe: 0.842 ± 0.045	2.314MetGly: 2.314 ± 0.075	0.458MetHis: 0.458 ± 0.03	1.157MetIle: 1.157 ± 0.047	1.224MetLys: 1.224 ± 0.047	2.449MetLeu: 2.449 ± 0.075	0.689MetMet: 0.689 ± 0.04	0.932MetAsn: 0.932 ± 0.042	1.216MetPro: 1.216 ± 0.053	0.773MetGln: 0.773 ± 0.039	1.901MetArg: 1.901 ± 0.067	1.764MetSer: 1.764 ± 0.067	1.464MetThr: 1.464 ± 0.053	1.917MetVal: 1.917 ± 0.066	0.2MetTrp: 0.2 ± 0.02	0.55MetTyr: 0.55 ± 0.034	0.0MetXaa: 0.0 ± 0.0
Asn	3.144AsnAla: 3.144 ± 0.081	0.347AsnCys: 0.347 ± 0.032	1.712AsnAsp: 1.712 ± 0.067	1.63AsnGlu: 1.63 ± 0.066	0.861AsnPhe: 0.861 ± 0.044	2.434AsnGly: 2.434 ± 0.081	0.489AsnHis: 0.489 ± 0.036	1.51AsnIle: 1.51 ± 0.057	0.947AsnLys: 0.947 ± 0.048	2.524AsnLeu: 2.524 ± 0.076	0.777AsnMet: 0.777 ± 0.046	0.832AsnAsn: 0.832 ± 0.054	1.821AsnPro: 1.821 ± 0.059	0.8AsnGln: 0.8 ± 0.042	1.76AsnArg: 1.76 ± 0.062	1.392AsnSer: 1.392 ± 0.055	1.35AsnThr: 1.35 ± 0.058	2.402AsnVal: 2.402 ± 0.081	0.292AsnTrp: 0.292 ± 0.026	0.815AsnTyr: 0.815 ± 0.039	0.0AsnXaa: 0.0 ± 0.0
Pro	4.649ProAla: 4.649 ± 0.115	0.561ProCys: 0.561 ± 0.033	2.967ProAsp: 2.967 ± 0.081	3.236ProGlu: 3.236 ± 0.077	1.823ProPhe: 1.823 ± 0.063	3.303ProGly: 3.303 ± 0.092	0.865ProHis: 0.865 ± 0.043	1.97ProIle: 1.97 ± 0.069	1.514ProLys: 1.514 ± 0.059	3.782ProLeu: 3.782 ± 0.085	0.83ProMet: 0.83 ± 0.039	1.174ProAsn: 1.174 ± 0.049	1.119ProPro: 1.119 ± 0.06	1.279ProGln: 1.279 ± 0.053	2.26ProArg: 2.26 ± 0.07	2.94ProSer: 2.94 ± 0.083	2.253ProThr: 2.253 ± 0.062	3.694ProVal: 3.694 ± 0.093	0.416ProTrp: 0.416 ± 0.028	1.279ProTyr: 1.279 ± 0.058	0.0ProXaa: 0.0 ± 0.0
Gln	3.182GlnAla: 3.182 ± 0.082	0.311GlnCys: 0.311 ± 0.026	1.184GlnAsp: 1.184 ± 0.048	1.453GlnGlu: 1.453 ± 0.057	0.89GlnPhe: 0.89 ± 0.052	2.228GlnGly: 2.228 ± 0.07	0.481GlnHis: 0.481 ± 0.036	1.701GlnIle: 1.701 ± 0.05	1.151GlnLys: 1.151 ± 0.047	2.541GlnLeu: 2.541 ± 0.077	0.817GlnMet: 0.817 ± 0.044	0.779GlnAsn: 0.779 ± 0.042	1.14GlnPro: 1.14 ± 0.055	0.974GlnGln: 0.974 ± 0.049	2.188GlnArg: 2.188 ± 0.076	1.527GlnSer: 1.527 ± 0.065	1.399GlnThr: 1.399 ± 0.06	2.22GlnVal: 2.22 ± 0.073	0.323GlnTrp: 0.323 ± 0.029	0.645GlnTyr: 0.645 ± 0.043	0.0GlnXaa: 0.0 ± 0.0
Arg	7.153ArgAla: 7.153 ± 0.159	0.922ArgCys: 0.922 ± 0.049	3.591ArgAsp: 3.591 ± 0.082	4.547ArgGlu: 4.547 ± 0.124	3.022ArgPhe: 3.022 ± 0.08	4.448ArgGly: 4.448 ± 0.1	1.086ArgHis: 1.086 ± 0.052	4.045ArgIle: 4.045 ± 0.101	2.436ArgLys: 2.436 ± 0.07	5.517ArgLeu: 5.517 ± 0.118	2.106ArgMet: 2.106 ± 0.058	1.869ArgAsn: 1.869 ± 0.067	2.365ArgPro: 2.365 ± 0.075	1.581ArgGln: 1.581 ± 0.061	4.429ArgArg: 4.429 ± 0.133	3.912ArgSer: 3.912 ± 0.09	3.326ArgThr: 3.326 ± 0.08	4.786ArgVal: 4.786 ± 0.118	0.603ArgTrp: 0.603 ± 0.038	1.903ArgTyr: 1.903 ± 0.054	0.0ArgXaa: 0.0 ± 0.0
Ser	7.138SerAla: 7.138 ± 0.15	0.853SerCys: 0.853 ± 0.043	4.101SerAsp: 4.101 ± 0.125	4.017SerGlu: 4.017 ± 0.104	2.795SerPhe: 2.795 ± 0.076	5.563SerGly: 5.563 ± 0.115	1.046SerHis: 1.046 ± 0.046	3.551SerIle: 3.551 ± 0.095	2.337SerLys: 2.337 ± 0.071	5.979SerLeu: 5.979 ± 0.11	1.842SerMet: 1.842 ± 0.06	1.741SerAsn: 1.741 ± 0.062	2.554SerPro: 2.554 ± 0.08	1.852SerGln: 1.852 ± 0.069	3.547SerArg: 3.547 ± 0.083	4.353SerSer: 4.353 ± 0.141	3.142SerThr: 3.142 ± 0.091	5.422SerVal: 5.422 ± 0.124	0.689SerTrp: 0.689 ± 0.041	1.915SerTyr: 1.915 ± 0.066	0.0SerXaa: 0.0 ± 0.0
Thr	5.069ThrAla: 5.069 ± 0.113	0.783ThrCys: 0.783 ± 0.041	2.902ThrAsp: 2.902 ± 0.079	2.778ThrGlu: 2.778 ± 0.081	1.968ThrPhe: 1.968 ± 0.064	4.824ThrGly: 4.824 ± 0.114	0.93ThrHis: 0.93 ± 0.039	2.652ThrIle: 2.652 ± 0.074	1.634ThrLys: 1.634 ± 0.067	4.486ThrLeu: 4.486 ± 0.119	1.208ThrMet: 1.208 ± 0.058	1.3ThrAsn: 1.3 ± 0.056	2.411ThrPro: 2.411 ± 0.074	1.325ThrGln: 1.325 ± 0.058	2.562ThrArg: 2.562 ± 0.079	2.902ThrSer: 2.902 ± 0.091	2.386ThrThr: 2.386 ± 0.084	4.824ThrVal: 4.824 ± 0.116	0.603ThrTrp: 0.603 ± 0.038	1.527ThrTyr: 1.527 ± 0.057	0.0ThrXaa: 0.0 ± 0.0
Val	9.452ValAla: 9.452 ± 0.173	1.436ValCys: 1.436 ± 0.062	4.79ValAsp: 4.79 ± 0.13	5.689ValGlu: 5.689 ± 0.131	3.375ValPhe: 3.375 ± 0.113	6.363ValGly: 6.363 ± 0.136	1.313ValHis: 1.313 ± 0.056	3.982ValIle: 3.982 ± 0.094	3.104ValLys: 3.104 ± 0.091	7.604ValLeu: 7.604 ± 0.147	2.056ValMet: 2.056 ± 0.071	2.491ValAsn: 2.491 ± 0.075	3.744ValPro: 3.744 ± 0.085	1.896ValGln: 1.896 ± 0.069	5.464ValArg: 5.464 ± 0.121	6.172ValSer: 6.172 ± 0.13	3.986ValThr: 3.986 ± 0.103	7.715ValVal: 7.715 ± 0.132	0.762ValTrp: 0.762 ± 0.039	2.117ValTyr: 2.117 ± 0.063	0.0ValXaa: 0.0 ± 0.0
Trp	1.037TrpAla: 1.037 ± 0.051	0.17TrpCys: 0.17 ± 0.022	0.701TrpAsp: 0.701 ± 0.043	0.674TrpGlu: 0.674 ± 0.038	0.454TrpPhe: 0.454 ± 0.027	0.832TrpGly: 0.832 ± 0.045	0.206TrpHis: 0.206 ± 0.02	0.533TrpIle: 0.533 ± 0.033	0.397TrpLys: 0.397 ± 0.029	0.951TrpLeu: 0.951 ± 0.054	0.29TrpMet: 0.29 ± 0.025	0.397TrpAsn: 0.397 ± 0.029	0.326TrpPro: 0.326 ± 0.024	0.29TrpGln: 0.29 ± 0.024	0.586TrpArg: 0.586 ± 0.04	0.561TrpSer: 0.561 ± 0.041	0.42TrpThr: 0.42 ± 0.032	0.714TrpVal: 0.714 ± 0.044	0.116TrpTrp: 0.116 ± 0.017	0.239TrpTyr: 0.239 ± 0.026	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.953TyrAla: 2.953 ± 0.083	0.41TyrCys: 0.41 ± 0.027	1.814TyrAsp: 1.814 ± 0.063	1.749TyrGlu: 1.749 ± 0.076	1.042TyrPhe: 1.042 ± 0.049	2.484TyrGly: 2.484 ± 0.079	0.386TyrHis: 0.386 ± 0.028	1.191TyrIle: 1.191 ± 0.052	0.813TyrLys: 0.813 ± 0.043	2.86TyrLeu: 2.86 ± 0.089	0.567TyrMet: 0.567 ± 0.04	0.764TyrAsn: 0.764 ± 0.048	1.138TyrPro: 1.138 ± 0.054	0.697TyrGln: 0.697 ± 0.037	2.138TyrArg: 2.138 ± 0.067	1.539TyrSer: 1.539 ± 0.059	1.384TyrThr: 1.384 ± 0.056	2.117TyrVal: 2.117 ± 0.072	0.281TyrTrp: 0.281 ± 0.026	0.848TyrTyr: 0.848 ± 0.042	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1405 proteins (476188 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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