Amino acid dipepetide frequency for Vibrio ponticus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.923AlaAla: 7.923 ± 0.107	1.012AlaCys: 1.012 ± 0.029	4.689AlaAsp: 4.689 ± 0.071	5.859AlaGlu: 5.859 ± 0.071	3.478AlaPhe: 3.478 ± 0.059	5.934AlaGly: 5.934 ± 0.071	1.733AlaHis: 1.733 ± 0.04	6.293AlaIle: 6.293 ± 0.07	5.018AlaLys: 5.018 ± 0.077	10.262AlaLeu: 10.262 ± 0.109	3.012AlaMet: 3.012 ± 0.052	3.82AlaAsn: 3.82 ± 0.061	2.87AlaPro: 2.87 ± 0.056	4.286AlaGln: 4.286 ± 0.063	3.771AlaArg: 3.771 ± 0.048	5.515AlaSer: 5.515 ± 0.066	4.759AlaThr: 4.759 ± 0.062	5.932AlaVal: 5.932 ± 0.078	1.055AlaTrp: 1.055 ± 0.03	2.35AlaTyr: 2.35 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	0.834CysAla: 0.834 ± 0.024	0.19CysCys: 0.19 ± 0.012	0.6CysAsp: 0.6 ± 0.025	0.627CysGlu: 0.627 ± 0.022	0.461CysPhe: 0.461 ± 0.02	0.898CysGly: 0.898 ± 0.03	0.344CysHis: 0.344 ± 0.02	0.551CysIle: 0.551 ± 0.022	0.452CysLys: 0.452 ± 0.021	1.119CysLeu: 1.119 ± 0.03	0.312CysMet: 0.312 ± 0.015	0.376CysAsn: 0.376 ± 0.017	0.445CysPro: 0.445 ± 0.023	0.563CysGln: 0.563 ± 0.021	0.512CysArg: 0.512 ± 0.02	0.731CysSer: 0.731 ± 0.024	0.504CysThr: 0.504 ± 0.021	0.731CysVal: 0.731 ± 0.022	0.159CysTrp: 0.159 ± 0.011	0.363CysTyr: 0.363 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	4.524AspAla: 4.524 ± 0.066	0.541AspCys: 0.541 ± 0.023	2.998AspAsp: 2.998 ± 0.06	3.853AspGlu: 3.853 ± 0.066	2.427AspPhe: 2.427 ± 0.048	3.813AspGly: 3.813 ± 0.097	1.117AspHis: 1.117 ± 0.034	3.855AspIle: 3.855 ± 0.056	3.238AspLys: 3.238 ± 0.048	5.243AspLeu: 5.243 ± 0.062	1.362AspMet: 1.362 ± 0.034	2.48AspAsn: 2.48 ± 0.052	1.937AspPro: 1.937 ± 0.048	2.084AspGln: 2.084 ± 0.043	2.11AspArg: 2.11 ± 0.041	3.34AspSer: 3.34 ± 0.06	2.519AspThr: 2.519 ± 0.055	3.977AspVal: 3.977 ± 0.064	0.826AspTrp: 0.826 ± 0.029	1.998AspTyr: 1.998 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	5.282GluAla: 5.282 ± 0.07	0.556GluCys: 0.556 ± 0.02	2.741GluAsp: 2.741 ± 0.051	3.841GluGlu: 3.841 ± 0.068	2.54GluPhe: 2.54 ± 0.043	3.347GluGly: 3.347 ± 0.06	1.58GluHis: 1.58 ± 0.032	3.83GluIle: 3.83 ± 0.053	3.659GluLys: 3.659 ± 0.068	7.499GluLeu: 7.499 ± 0.085	1.835GluMet: 1.835 ± 0.04	2.517GluAsn: 2.517 ± 0.051	2.072GluPro: 2.072 ± 0.043	4.665GluGln: 4.665 ± 0.081	3.515GluArg: 3.515 ± 0.054	3.64GluSer: 3.64 ± 0.052	3.027GluThr: 3.027 ± 0.053	4.489GluVal: 4.489 ± 0.068	0.781GluTrp: 0.781 ± 0.024	1.784GluTyr: 1.784 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	4.148PheAla: 4.148 ± 0.063	0.53PheCys: 0.53 ± 0.023	2.745PheAsp: 2.745 ± 0.05	2.52PheGlu: 2.52 ± 0.042	1.585PhePhe: 1.585 ± 0.049	3.242PheGly: 3.242 ± 0.053	0.831PheHis: 0.831 ± 0.022	2.689PheIle: 2.689 ± 0.05	1.928PheLys: 1.928 ± 0.033	3.34PheLeu: 3.34 ± 0.064	0.993PheMet: 0.993 ± 0.024	1.933PheAsn: 1.933 ± 0.038	1.336PhePro: 1.336 ± 0.032	1.196PheGln: 1.196 ± 0.03	1.427PheArg: 1.427 ± 0.036	3.228PheSer: 3.228 ± 0.053	2.357PheThr: 2.357 ± 0.045	3.045PheVal: 3.045 ± 0.06	0.529PheTrp: 0.529 ± 0.024	1.289PheTyr: 1.289 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	5.35GlyAla: 5.35 ± 0.084	0.896GlyCys: 0.896 ± 0.028	3.627GlyAsp: 3.627 ± 0.074	4.541GlyGlu: 4.541 ± 0.066	3.249GlyPhe: 3.249 ± 0.061	4.693GlyGly: 4.693 ± 0.08	1.455GlyHis: 1.455 ± 0.04	4.742GlyIle: 4.742 ± 0.068	3.927GlyLys: 3.927 ± 0.066	6.753GlyLeu: 6.753 ± 0.075	2.117GlyMet: 2.117 ± 0.044	2.583GlyAsn: 2.583 ± 0.051	1.436GlyPro: 1.436 ± 0.029	2.734GlyGln: 2.734 ± 0.048	2.911GlyArg: 2.911 ± 0.052	4.055GlySer: 4.055 ± 0.053	3.205GlyThr: 3.205 ± 0.055	5.166GlyVal: 5.166 ± 0.067	0.947GlyTrp: 0.947 ± 0.029	2.497GlyTyr: 2.497 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	1.711HisAla: 1.711 ± 0.037	0.343HisCys: 0.343 ± 0.019	1.097HisAsp: 1.097 ± 0.032	1.076HisGlu: 1.076 ± 0.027	1.036HisPhe: 1.036 ± 0.03	1.541HisGly: 1.541 ± 0.037	0.721HisHis: 0.721 ± 0.027	1.354HisIle: 1.354 ± 0.036	1.058HisLys: 1.058 ± 0.03	2.246HisLeu: 2.246 ± 0.041	0.578HisMet: 0.578 ± 0.021	0.913HisAsn: 0.913 ± 0.026	1.08HisPro: 1.08 ± 0.031	1.352HisGln: 1.352 ± 0.035	1.022HisArg: 1.022 ± 0.029	1.413HisSer: 1.413 ± 0.035	1.108HisThr: 1.108 ± 0.027	1.291HisVal: 1.291 ± 0.035	0.375HisTrp: 0.375 ± 0.017	0.882HisTyr: 0.882 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	6.697IleAla: 6.697 ± 0.08	0.721IleCys: 0.721 ± 0.024	4.273IleAsp: 4.273 ± 0.063	4.981IleGlu: 4.981 ± 0.063	2.177IlePhe: 2.177 ± 0.048	4.645IleGly: 4.645 ± 0.057	1.23IleHis: 1.23 ± 0.033	3.448IleIle: 3.448 ± 0.055	3.215IleLys: 3.215 ± 0.045	5.192IleLeu: 5.192 ± 0.07	1.402IleMet: 1.402 ± 0.032	2.867IleAsn: 2.867 ± 0.044	2.563IlePro: 2.563 ± 0.044	2.24IleGln: 2.24 ± 0.043	2.684IleArg: 2.684 ± 0.043	4.468IleSer: 4.468 ± 0.058	3.7IleThr: 3.7 ± 0.057	4.255IleVal: 4.255 ± 0.059	0.63IleTrp: 0.63 ± 0.022	1.749IleTyr: 1.749 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	4.782LysAla: 4.782 ± 0.074	0.353LysCys: 0.353 ± 0.017	2.532LysAsp: 2.532 ± 0.047	3.083LysGlu: 3.083 ± 0.055	1.621LysPhe: 1.621 ± 0.041	3.138LysGly: 3.138 ± 0.05	1.254LysHis: 1.254 ± 0.034	2.766LysIle: 2.766 ± 0.042	2.623LysLys: 2.623 ± 0.047	5.541LysLeu: 5.541 ± 0.063	1.443LysMet: 1.443 ± 0.028	1.878LysAsn: 1.878 ± 0.039	2.514LysPro: 2.514 ± 0.045	3.361LysGln: 3.361 ± 0.064	2.708LysArg: 2.708 ± 0.053	2.916LysSer: 2.916 ± 0.048	2.611LysThr: 2.611 ± 0.044	3.822LysVal: 3.822 ± 0.056	0.606LysTrp: 0.606 ± 0.023	1.343LysTyr: 1.343 ± 0.034	0.0LysXaa: 0.0 ± 0.0
Leu	10.631LeuAla: 10.631 ± 0.109	1.142LeuCys: 1.142 ± 0.033	5.814LeuAsp: 5.814 ± 0.073	6.519LeuGlu: 6.519 ± 0.084	4.285LeuPhe: 4.285 ± 0.068	7.0LeuGly: 7.0 ± 0.087	2.086LeuHis: 2.086 ± 0.046	6.189LeuIle: 6.189 ± 0.075	5.196LeuLys: 5.196 ± 0.074	10.464LeuLeu: 10.464 ± 0.121	2.873LeuMet: 2.873 ± 0.051	4.602LeuAsn: 4.602 ± 0.074	4.819LeuPro: 4.819 ± 0.061	3.748LeuGln: 3.748 ± 0.061	4.404LeuArg: 4.404 ± 0.067	7.857LeuSer: 7.857 ± 0.088	6.1LeuThr: 6.1 ± 0.067	7.457LeuVal: 7.457 ± 0.077	0.958LeuTrp: 0.958 ± 0.027	2.582LeuTyr: 2.582 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	2.836MetAla: 2.836 ± 0.047	0.248MetCys: 0.248 ± 0.015	1.363MetAsp: 1.363 ± 0.033	1.343MetGlu: 1.343 ± 0.034	1.075MetPhe: 1.075 ± 0.029	1.86MetGly: 1.86 ± 0.045	0.541MetHis: 0.541 ± 0.02	1.679MetIle: 1.679 ± 0.034	1.494MetLys: 1.494 ± 0.033	3.042MetLeu: 3.042 ± 0.047	0.933MetMet: 0.933 ± 0.03	1.12MetAsn: 1.12 ± 0.029	1.326MetPro: 1.326 ± 0.03	1.282MetGln: 1.282 ± 0.03	1.315MetArg: 1.315 ± 0.035	2.117MetSer: 2.117 ± 0.037	1.654MetThr: 1.654 ± 0.038	2.054MetVal: 2.054 ± 0.039	0.252MetTrp: 0.252 ± 0.016	0.566MetTyr: 0.566 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	3.46AsnAla: 3.46 ± 0.049	0.438AsnCys: 0.438 ± 0.019	2.271AsnAsp: 2.271 ± 0.049	2.267AsnGlu: 2.267 ± 0.039	1.553AsnPhe: 1.553 ± 0.027	2.99AsnGly: 2.99 ± 0.054	1.066AsnHis: 1.066 ± 0.028	2.664AsnIle: 2.664 ± 0.051	2.126AsnLys: 2.126 ± 0.039	4.072AsnLeu: 4.072 ± 0.059	1.068AsnMet: 1.068 ± 0.029	1.872AsnAsn: 1.872 ± 0.044	2.061AsnPro: 2.061 ± 0.041	2.476AsnGln: 2.476 ± 0.05	1.975AsnArg: 1.975 ± 0.035	2.523AsnSer: 2.523 ± 0.053	2.154AsnThr: 2.154 ± 0.048	2.721AsnVal: 2.721 ± 0.052	0.612AsnTrp: 0.612 ± 0.023	1.333AsnTyr: 1.333 ± 0.034	0.0AsnXaa: 0.0 ± 0.0
Pro	3.09ProAla: 3.09 ± 0.055	0.343ProCys: 0.343 ± 0.019	2.11ProAsp: 2.11 ± 0.046	3.036ProGlu: 3.036 ± 0.05	1.689ProPhe: 1.689 ± 0.032	1.989ProGly: 1.989 ± 0.043	0.84ProHis: 0.84 ± 0.027	2.546ProIle: 2.546 ± 0.047	1.774ProLys: 1.774 ± 0.039	4.106ProLeu: 4.106 ± 0.054	1.147ProMet: 1.147 ± 0.032	1.734ProAsn: 1.734 ± 0.037	1.07ProPro: 1.07 ± 0.032	1.81ProGln: 1.81 ± 0.036	1.313ProArg: 1.313 ± 0.034	2.449ProSer: 2.449 ± 0.046	2.158ProThr: 2.158 ± 0.044	2.975ProVal: 2.975 ± 0.059	0.451ProTrp: 0.451 ± 0.018	1.237ProTyr: 1.237 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	4.914GlnAla: 4.914 ± 0.071	0.422GlnCys: 0.422 ± 0.022	2.258GlnAsp: 2.258 ± 0.043	2.707GlnGlu: 2.707 ± 0.045	1.868GlnPhe: 1.868 ± 0.038	3.202GlnGly: 3.202 ± 0.047	1.248GlnHis: 1.248 ± 0.03	2.757GlnIle: 2.757 ± 0.048	2.032GlnLys: 2.032 ± 0.043	5.64GlnLeu: 5.64 ± 0.086	1.25GlnMet: 1.25 ± 0.036	1.61GlnAsn: 1.61 ± 0.038	1.85GlnPro: 1.85 ± 0.04	3.401GlnGln: 3.401 ± 0.07	2.39GlnArg: 2.39 ± 0.043	2.921GlnSer: 2.921 ± 0.051	2.497GlnThr: 2.497 ± 0.043	3.578GlnVal: 3.578 ± 0.053	0.678GlnTrp: 0.678 ± 0.023	1.488GlnTyr: 1.488 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	3.491ArgAla: 3.491 ± 0.056	0.545ArgCys: 0.545 ± 0.024	2.479ArgAsp: 2.479 ± 0.05	3.033ArgGlu: 3.033 ± 0.052	2.219ArgPhe: 2.219 ± 0.043	2.507ArgGly: 2.507 ± 0.049	1.072ArgHis: 1.072 ± 0.03	2.928ArgIle: 2.928 ± 0.05	2.29ArgLys: 2.29 ± 0.048	4.884ArgLeu: 4.884 ± 0.073	1.327ArgMet: 1.327 ± 0.031	1.946ArgAsn: 1.946 ± 0.039	1.415ArgPro: 1.415 ± 0.034	2.134ArgGln: 2.134 ± 0.038	2.34ArgArg: 2.34 ± 0.048	2.748ArgSer: 2.748 ± 0.044	2.079ArgThr: 2.079 ± 0.041	3.202ArgVal: 3.202 ± 0.05	0.605ArgTrp: 0.605 ± 0.022	1.724ArgTyr: 1.724 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	5.502SerAla: 5.502 ± 0.068	0.636SerCys: 0.636 ± 0.021	3.592SerAsp: 3.592 ± 0.068	4.012SerGlu: 4.012 ± 0.059	2.752SerPhe: 2.752 ± 0.052	4.755SerGly: 4.755 ± 0.07	1.488SerHis: 1.488 ± 0.035	4.183SerIle: 4.183 ± 0.057	3.203SerLys: 3.203 ± 0.052	7.028SerLeu: 7.028 ± 0.093	1.88SerMet: 1.88 ± 0.035	2.737SerAsn: 2.737 ± 0.053	2.346SerPro: 2.346 ± 0.046	3.231SerGln: 3.231 ± 0.049	2.864SerArg: 2.864 ± 0.049	4.315SerSer: 4.315 ± 0.072	3.332SerThr: 3.332 ± 0.056	4.656SerVal: 4.656 ± 0.062	0.819SerTrp: 0.819 ± 0.027	2.063SerTyr: 2.063 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	4.529ThrAla: 4.529 ± 0.06	0.488ThrCys: 0.488 ± 0.019	2.711ThrAsp: 2.711 ± 0.057	3.001ThrGlu: 3.001 ± 0.042	2.083ThrPhe: 2.083 ± 0.037	3.852ThrGly: 3.852 ± 0.063	1.171ThrHis: 1.171 ± 0.03	3.555ThrIle: 3.555 ± 0.057	2.315ThrLys: 2.315 ± 0.046	6.157ThrLeu: 6.157 ± 0.076	1.285ThrMet: 1.285 ± 0.033	2.154ThrAsn: 2.154 ± 0.044	2.591ThrPro: 2.591 ± 0.043	2.566ThrGln: 2.566 ± 0.051	2.262ThrArg: 2.262 ± 0.04	3.382ThrSer: 3.382 ± 0.047	3.029ThrThr: 3.029 ± 0.054	3.807ThrVal: 3.807 ± 0.06	0.624ThrTrp: 0.624 ± 0.021	1.43ThrTyr: 1.43 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	6.759ValAla: 6.759 ± 0.078	0.816ValCys: 0.816 ± 0.026	4.181ValAsp: 4.181 ± 0.06	5.051ValGlu: 5.051 ± 0.075	2.811ValPhe: 2.811 ± 0.046	4.727ValGly: 4.727 ± 0.07	1.267ValHis: 1.267 ± 0.03	4.81ValIle: 4.81 ± 0.066	3.627ValLys: 3.627 ± 0.051	6.972ValLeu: 6.972 ± 0.076	2.19ValMet: 2.19 ± 0.045	2.998ValAsn: 2.998 ± 0.054	2.522ValPro: 2.522 ± 0.045	2.309ValGln: 2.309 ± 0.04	3.015ValArg: 3.015 ± 0.054	4.998ValSer: 4.998 ± 0.056	4.219ValThr: 4.219 ± 0.063	5.728ValVal: 5.728 ± 0.075	0.758ValTrp: 0.758 ± 0.025	1.812ValTyr: 1.812 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	0.824TrpAla: 0.824 ± 0.023	0.165TrpCys: 0.165 ± 0.012	0.556TrpAsp: 0.556 ± 0.021	0.476TrpGlu: 0.476 ± 0.019	0.607TrpPhe: 0.607 ± 0.024	0.728TrpGly: 0.728 ± 0.026	0.36TrpHis: 0.36 ± 0.018	0.666TrpIle: 0.666 ± 0.021	0.496TrpLys: 0.496 ± 0.021	1.814TrpLeu: 1.814 ± 0.045	0.401TrpMet: 0.401 ± 0.018	0.448TrpAsn: 0.448 ± 0.02	0.354TrpPro: 0.354 ± 0.017	1.063TrpGln: 1.063 ± 0.028	0.704TrpArg: 0.704 ± 0.024	0.753TrpSer: 0.753 ± 0.023	0.477TrpThr: 0.477 ± 0.02	0.856TrpVal: 0.856 ± 0.028	0.202TrpTrp: 0.202 ± 0.013	0.379TrpTyr: 0.379 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.286TyrAla: 2.286 ± 0.037	0.387TyrCys: 0.387 ± 0.016	1.606TyrAsp: 1.606 ± 0.037	1.373TyrGlu: 1.373 ± 0.03	1.375TyrPhe: 1.375 ± 0.04	2.021TyrGly: 2.021 ± 0.048	0.793TyrHis: 0.793 ± 0.026	1.634TyrIle: 1.634 ± 0.034	1.221TyrLys: 1.221 ± 0.035	3.356TyrLeu: 3.356 ± 0.055	0.69TyrMet: 0.69 ± 0.023	1.113TyrAsn: 1.113 ± 0.029	1.26TyrPro: 1.26 ± 0.028	2.209TyrGln: 2.209 ± 0.046	1.728TyrArg: 1.728 ± 0.034	2.025TyrSer: 2.025 ± 0.038	1.503TyrThr: 1.503 ± 0.034	1.826TyrVal: 1.826 ± 0.04	0.463TyrTrp: 0.463 ± 0.021	0.987TyrTyr: 0.987 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5653 proteins (1295991 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---