Amino acid dipepetide frequency for Kytococcus aerolatus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
19.277AlaAla: 19.277 ± 0.249
0.942AlaCys: 0.942 ± 0.037
7.57AlaAsp: 7.57 ± 0.117
9.748AlaGlu: 9.748 ± 0.137
3.042AlaPhe: 3.042 ± 0.076
13.43AlaGly: 13.43 ± 0.174
2.885AlaHis: 2.885 ± 0.07
3.591AlaIle: 3.591 ± 0.083
2.181AlaLys: 2.181 ± 0.077
14.156AlaLeu: 14.156 ± 0.179
3.124AlaMet: 3.124 ± 0.067
1.648AlaAsn: 1.648 ± 0.048
6.904AlaPro: 6.904 ± 0.117
3.972AlaGln: 3.972 ± 0.071
10.058AlaArg: 10.058 ± 0.15
5.817AlaSer: 5.817 ± 0.101
7.226AlaThr: 7.226 ± 0.105
11.346AlaVal: 11.346 ± 0.143
2.1AlaTrp: 2.1 ± 0.054
1.933AlaTyr: 1.933 ± 0.056
0.0AlaXaa: 0.0 ± 0.0
Cys
0.783CysAla: 0.783 ± 0.031
0.07CysCys: 0.07 ± 0.01
0.414CysAsp: 0.414 ± 0.023
0.449CysGlu: 0.449 ± 0.024
0.189CysPhe: 0.189 ± 0.016
0.876CysGly: 0.876 ± 0.039
0.173CysHis: 0.173 ± 0.017
0.207CysIle: 0.207 ± 0.019
0.078CysLys: 0.078 ± 0.011
0.664CysLeu: 0.664 ± 0.035
0.106CysMet: 0.106 ± 0.011
0.117CysAsn: 0.117 ± 0.011
0.438CysPro: 0.438 ± 0.024
0.185CysGln: 0.185 ± 0.017
0.518CysArg: 0.518 ± 0.028
0.39CysSer: 0.39 ± 0.026
0.467CysThr: 0.467 ± 0.023
0.556CysVal: 0.556 ± 0.027
0.11CysTrp: 0.11 ± 0.012
0.127CysTyr: 0.127 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
7.697AspAla: 7.697 ± 0.119
0.359AspCys: 0.359 ± 0.024
3.562AspAsp: 3.562 ± 0.083
4.735AspGlu: 4.735 ± 0.102
1.502AspPhe: 1.502 ± 0.045
5.615AspGly: 5.615 ± 0.11
1.528AspHis: 1.528 ± 0.048
1.59AspIle: 1.59 ± 0.057
0.819AspLys: 0.819 ± 0.043
6.661AspLeu: 6.661 ± 0.099
0.945AspMet: 0.945 ± 0.035
0.702AspAsn: 0.702 ± 0.036
4.746AspPro: 4.746 ± 0.091
1.688AspGln: 1.688 ± 0.046
4.569AspArg: 4.569 ± 0.097
2.418AspSer: 2.418 ± 0.063
2.71AspThr: 2.71 ± 0.07
4.644AspVal: 4.644 ± 0.089
0.83AspTrp: 0.83 ± 0.032
0.949AspTyr: 0.949 ± 0.04
0.0AspXaa: 0.0 ± 0.0
Glu
9.041GluAla: 9.041 ± 0.127
0.395GluCys: 0.395 ± 0.022
3.641GluAsp: 3.641 ± 0.086
5.055GluGlu: 5.055 ± 0.099
1.471GluPhe: 1.471 ± 0.046
6.063GluGly: 6.063 ± 0.104
2.108GluHis: 2.108 ± 0.054
2.624GluIle: 2.624 ± 0.068
1.615GluLys: 1.615 ± 0.07
7.693GluLeu: 7.693 ± 0.136
1.221GluMet: 1.221 ± 0.043
1.209GluAsn: 1.209 ± 0.045
3.726GluPro: 3.726 ± 0.082
2.926GluGln: 2.926 ± 0.07
6.012GluArg: 6.012 ± 0.117
2.905GluSer: 2.905 ± 0.077
3.075GluThr: 3.075 ± 0.077
6.443GluVal: 6.443 ± 0.109
0.887GluTrp: 0.887 ± 0.038
1.035GluTyr: 1.035 ± 0.04
0.0GluXaa: 0.0 ± 0.0
Phe
3.163PheAla: 3.163 ± 0.069
0.207PheCys: 0.207 ± 0.019
1.756PheAsp: 1.756 ± 0.048
1.52PheGlu: 1.52 ± 0.049
0.742PhePhe: 0.742 ± 0.039
2.792PheGly: 2.792 ± 0.07
0.611PheHis: 0.611 ± 0.032
0.724PheIle: 0.724 ± 0.036
0.368PheLys: 0.368 ± 0.023
2.438PheLeu: 2.438 ± 0.073
0.452PheMet: 0.452 ± 0.029
0.509PheAsn: 0.509 ± 0.029
1.205PhePro: 1.205 ± 0.04
0.584PheGln: 0.584 ± 0.032
1.46PheArg: 1.46 ± 0.045
1.377PheSer: 1.377 ± 0.044
1.848PheThr: 1.848 ± 0.06
2.341PheVal: 2.341 ± 0.061
0.443PheTrp: 0.443 ± 0.031
0.456PheTyr: 0.456 ± 0.025
0.0PheXaa: 0.0 ± 0.0
Gly
11.23GlyAla: 11.23 ± 0.162
0.786GlyCys: 0.786 ± 0.034
5.133GlyAsp: 5.133 ± 0.096
6.436GlyGlu: 6.436 ± 0.106
2.595GlyPhe: 2.595 ± 0.058
8.847GlyGly: 8.847 ± 0.147
2.339GlyHis: 2.339 ± 0.06
3.616GlyIle: 3.616 ± 0.072
2.058GlyLys: 2.058 ± 0.066
9.923GlyLeu: 9.923 ± 0.136
2.335GlyMet: 2.335 ± 0.058
1.484GlyAsn: 1.484 ± 0.043
4.843GlyPro: 4.843 ± 0.098
3.299GlyGln: 3.299 ± 0.08
7.585GlyArg: 7.585 ± 0.139
5.305GlySer: 5.305 ± 0.105
5.63GlyThr: 5.63 ± 0.107
8.381GlyVal: 8.381 ± 0.104
1.913GlyTrp: 1.913 ± 0.057
1.919GlyTyr: 1.919 ± 0.058
0.0GlyXaa: 0.0 ± 0.0
His
2.759HisAla: 2.759 ± 0.075
0.197HisCys: 0.197 ± 0.017
1.454HisAsp: 1.454 ± 0.046
1.593HisGlu: 1.593 ± 0.051
0.516HisPhe: 0.516 ± 0.027
2.378HisGly: 2.378 ± 0.062
0.783HisHis: 0.783 ± 0.037
0.523HisIle: 0.523 ± 0.026
0.292HisLys: 0.292 ± 0.018
2.711HisLeu: 2.711 ± 0.07
0.324HisMet: 0.324 ± 0.021
0.351HisAsn: 0.351 ± 0.019
1.91HisPro: 1.91 ± 0.059
0.688HisGln: 0.688 ± 0.032
2.141HisArg: 2.141 ± 0.066
0.993HisSer: 0.993 ± 0.037
1.26HisThr: 1.26 ± 0.044
1.977HisVal: 1.977 ± 0.051
0.358HisTrp: 0.358 ± 0.021
0.408HisTyr: 0.408 ± 0.024
0.0HisXaa: 0.0 ± 0.0
Ile
4.394IleAla: 4.394 ± 0.093
0.252IleCys: 0.252 ± 0.018
2.316IleAsp: 2.316 ± 0.059
2.151IleGlu: 2.151 ± 0.06
0.779IlePhe: 0.779 ± 0.037
3.457IleGly: 3.457 ± 0.086
0.668IleHis: 0.668 ± 0.031
1.114IleIle: 1.114 ± 0.045
0.587IleLys: 0.587 ± 0.03
2.547IleLeu: 2.547 ± 0.07
0.523IleMet: 0.523 ± 0.026
0.606IleAsn: 0.606 ± 0.031
1.762IlePro: 1.762 ± 0.049
0.651IleGln: 0.651 ± 0.028
2.001IleArg: 2.001 ± 0.057
1.588IleSer: 1.588 ± 0.054
2.262IleThr: 2.262 ± 0.058
2.813IleVal: 2.813 ± 0.064
0.347IleTrp: 0.347 ± 0.02
0.475IleTyr: 0.475 ± 0.026
0.0IleXaa: 0.0 ± 0.0
Lys
2.345LysAla: 2.345 ± 0.077
0.077LysCys: 0.077 ± 0.009
1.135LysAsp: 1.135 ± 0.045
1.104LysGlu: 1.104 ± 0.049
0.362LysPhe: 0.362 ± 0.024
1.616LysGly: 1.616 ± 0.061
0.402LysHis: 0.402 ± 0.026
0.713LysIle: 0.713 ± 0.034
0.768LysLys: 0.768 ± 0.048
1.314LysLeu: 1.314 ± 0.045
0.399LysMet: 0.399 ± 0.027
0.436LysAsn: 0.436 ± 0.028
0.983LysPro: 0.983 ± 0.05
0.638LysGln: 0.638 ± 0.031
1.275LysArg: 1.275 ± 0.049
0.964LysSer: 0.964 ± 0.044
0.993LysThr: 0.993 ± 0.043
1.805LysVal: 1.805 ± 0.064
0.176LysTrp: 0.176 ± 0.017
0.336LysTyr: 0.336 ± 0.021
0.0LysXaa: 0.0 ± 0.0
Leu
14.999LeuAla: 14.999 ± 0.198
0.697LeuCys: 0.697 ± 0.032
6.236LeuAsp: 6.236 ± 0.102
6.288LeuGlu: 6.288 ± 0.111
2.36LeuPhe: 2.36 ± 0.077
10.151LeuGly: 10.151 ± 0.154
2.22LeuHis: 2.22 ± 0.068
2.458LeuIle: 2.458 ± 0.071
1.534LeuLys: 1.534 ± 0.05
11.127LeuLeu: 11.127 ± 0.18
1.793LeuMet: 1.793 ± 0.053
1.526LeuAsn: 1.526 ± 0.041
6.359LeuPro: 6.359 ± 0.106
2.69LeuGln: 2.69 ± 0.067
7.861LeuArg: 7.861 ± 0.124
4.972LeuSer: 4.972 ± 0.077
6.693LeuThr: 6.693 ± 0.094
10.635LeuVal: 10.635 ± 0.162
1.462LeuTrp: 1.462 ± 0.051
1.355LeuTyr: 1.355 ± 0.05
0.0LeuXaa: 0.0 ± 0.0
Met
2.511MetAla: 2.511 ± 0.057
0.12MetCys: 0.12 ± 0.013
1.029MetAsp: 1.029 ± 0.037
0.984MetGlu: 0.984 ± 0.034
0.463MetPhe: 0.463 ± 0.024
1.772MetGly: 1.772 ± 0.047
0.366MetHis: 0.366 ± 0.023
0.664MetIle: 0.664 ± 0.031
0.452MetLys: 0.452 ± 0.027
2.016MetLeu: 2.016 ± 0.064
0.39MetMet: 0.39 ± 0.022
0.483MetAsn: 0.483 ± 0.029
1.174MetPro: 1.174 ± 0.048
0.632MetGln: 0.632 ± 0.032
1.443MetArg: 1.443 ± 0.045
1.539MetSer: 1.539 ± 0.048
1.798MetThr: 1.798 ± 0.052
1.782MetVal: 1.782 ± 0.043
0.215MetTrp: 0.215 ± 0.019
0.267MetTyr: 0.267 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
2.067AsnAla: 2.067 ± 0.052
0.117AsnCys: 0.117 ± 0.015
0.898AsnAsp: 0.898 ± 0.037
0.807AsnGlu: 0.807 ± 0.032
0.438AsnPhe: 0.438 ± 0.026
1.393AsnGly: 1.393 ± 0.045
0.373AsnHis: 0.373 ± 0.023
0.609AsnIle: 0.609 ± 0.03
0.332AsnLys: 0.332 ± 0.025
1.575AsnLeu: 1.575 ± 0.049
0.28AsnMet: 0.28 ± 0.021
0.315AsnAsn: 0.315 ± 0.025
1.426AsnPro: 1.426 ± 0.042
0.478AsnGln: 0.478 ± 0.028
1.113AsnArg: 1.113 ± 0.038
0.709AsnSer: 0.709 ± 0.034
0.99AsnThr: 0.99 ± 0.039
1.344AsnVal: 1.344 ± 0.052
0.222AsnTrp: 0.222 ± 0.019
0.339AsnTyr: 0.339 ± 0.023
0.0AsnXaa: 0.0 ± 0.0
Pro
7.954ProAla: 7.954 ± 0.132
0.277ProCys: 0.277 ± 0.019
3.726ProAsp: 3.726 ± 0.075
5.198ProGlu: 5.198 ± 0.095
1.38ProPhe: 1.38 ± 0.044
6.291ProGly: 6.291 ± 0.111
1.378ProHis: 1.378 ± 0.05
1.314ProIle: 1.314 ± 0.05
0.935ProLys: 0.935 ± 0.052
5.015ProLeu: 5.015 ± 0.081
1.074ProMet: 1.074 ± 0.042
0.863ProAsn: 0.863 ± 0.037
2.682ProPro: 2.682 ± 0.067
1.939ProGln: 1.939 ± 0.054
4.026ProArg: 4.026 ± 0.082
3.099ProSer: 3.099 ± 0.066
3.976ProThr: 3.976 ± 0.087
5.676ProVal: 5.676 ± 0.086
1.146ProTrp: 1.146 ± 0.044
0.927ProTyr: 0.927 ± 0.036
0.0ProXaa: 0.0 ± 0.0
Gln
3.92GlnAla: 3.92 ± 0.078
0.156GlnCys: 0.156 ± 0.015
1.629GlnAsp: 1.629 ± 0.051
2.12GlnGlu: 2.12 ± 0.052
0.731GlnPhe: 0.731 ± 0.034
2.587GlnGly: 2.587 ± 0.057
0.755GlnHis: 0.755 ± 0.032
1.089GlnIle: 1.089 ± 0.044
0.547GlnLys: 0.547 ± 0.031
3.076GlnLeu: 3.076 ± 0.073
0.613GlnMet: 0.613 ± 0.035
0.538GlnAsn: 0.538 ± 0.03
1.855GlnPro: 1.855 ± 0.048
1.355GlnGln: 1.355 ± 0.045
2.912GlnArg: 2.912 ± 0.071
1.25GlnSer: 1.25 ± 0.037
1.402GlnThr: 1.402 ± 0.041
3.146GlnVal: 3.146 ± 0.066
0.523GlnTrp: 0.523 ± 0.029
0.563GlnTyr: 0.563 ± 0.032
0.0GlnXaa: 0.0 ± 0.0
Arg
9.538ArgAla: 9.538 ± 0.158
0.543ArgCys: 0.543 ± 0.028
4.007ArgAsp: 4.007 ± 0.085
5.678ArgGlu: 5.678 ± 0.106
2.01ArgPhe: 2.01 ± 0.05
6.068ArgGly: 6.068 ± 0.104
1.86ArgHis: 1.86 ± 0.051
2.941ArgIle: 2.941 ± 0.069
1.348ArgLys: 1.348 ± 0.052
7.707ArgLeu: 7.707 ± 0.123
1.932ArgMet: 1.932 ± 0.047
1.183ArgAsn: 1.183 ± 0.037
4.493ArgPro: 4.493 ± 0.085
2.509ArgGln: 2.509 ± 0.063
7.433ArgArg: 7.433 ± 0.13
4.069ArgSer: 4.069 ± 0.081
4.727ArgThr: 4.727 ± 0.081
6.27ArgVal: 6.27 ± 0.111
1.6ArgTrp: 1.6 ± 0.055
1.404ArgTyr: 1.404 ± 0.046
0.0ArgXaa: 0.0 ± 0.0
Ser
6.259SerAla: 6.259 ± 0.093
0.361SerCys: 0.361 ± 0.023
2.36SerAsp: 2.36 ± 0.065
2.857SerGlu: 2.857 ± 0.067
1.473SerPhe: 1.473 ± 0.051
5.392SerGly: 5.392 ± 0.098
0.979SerHis: 0.979 ± 0.04
1.614SerIle: 1.614 ± 0.044
0.843SerLys: 0.843 ± 0.039
4.87SerLeu: 4.87 ± 0.082
1.144SerMet: 1.144 ± 0.036
0.742SerAsn: 0.742 ± 0.037
3.214SerPro: 3.214 ± 0.088
1.403SerGln: 1.403 ± 0.048
3.689SerArg: 3.689 ± 0.073
3.152SerSer: 3.152 ± 0.107
3.7SerThr: 3.7 ± 0.071
4.085SerVal: 4.085 ± 0.085
0.848SerTrp: 0.848 ± 0.036
0.896SerTyr: 0.896 ± 0.032
0.0SerXaa: 0.0 ± 0.0
Thr
7.395ThrAla: 7.395 ± 0.111
0.421ThrCys: 0.421 ± 0.025
3.605ThrAsp: 3.605 ± 0.082
3.769ThrGlu: 3.769 ± 0.07
1.612ThrPhe: 1.612 ± 0.047
6.416ThrGly: 6.416 ± 0.095
1.382ThrHis: 1.382 ± 0.04
1.965ThrIle: 1.965 ± 0.056
0.994ThrLys: 0.994 ± 0.044
5.963ThrLeu: 5.963 ± 0.097
1.062ThrMet: 1.062 ± 0.042
0.949ThrAsn: 0.949 ± 0.037
4.424ThrPro: 4.424 ± 0.085
1.665ThrGln: 1.665 ± 0.047
3.928ThrArg: 3.928 ± 0.075
3.116ThrSer: 3.116 ± 0.069
4.117ThrThr: 4.117 ± 0.081
5.842ThrVal: 5.842 ± 0.095
0.962ThrTrp: 0.962 ± 0.036
1.059ThrTyr: 1.059 ± 0.042
0.0ThrXaa: 0.0 ± 0.0
Val
11.768ValAla: 11.768 ± 0.158
0.624ValCys: 0.624 ± 0.026
5.987ValAsp: 5.987 ± 0.093
6.707ValGlu: 6.707 ± 0.109
2.235ValPhe: 2.235 ± 0.062
7.594ValGly: 7.594 ± 0.113
2.177ValHis: 2.177 ± 0.058
2.999ValIle: 2.999 ± 0.069
1.524ValLys: 1.524 ± 0.059
10.316ValLeu: 10.316 ± 0.162
1.8ValMet: 1.8 ± 0.055
1.566ValAsn: 1.566 ± 0.047
5.052ValPro: 5.052 ± 0.086
2.43ValGln: 2.43 ± 0.055
6.663ValArg: 6.663 ± 0.113
4.37ValSer: 4.37 ± 0.086
5.809ValThr: 5.809 ± 0.086
9.958ValVal: 9.958 ± 0.137
1.217ValTrp: 1.217 ± 0.041
1.238ValTyr: 1.238 ± 0.043
0.0ValXaa: 0.0 ± 0.0
Trp
1.957TrpAla: 1.957 ± 0.059
0.189TrpCys: 0.189 ± 0.016
0.763TrpAsp: 0.763 ± 0.033
0.888TrpGlu: 0.888 ± 0.042
0.565TrpPhe: 0.565 ± 0.029
1.309TrpGly: 1.309 ± 0.043
0.324TrpHis: 0.324 ± 0.02
0.525TrpIle: 0.525 ± 0.026
0.271TrpLys: 0.271 ± 0.021
1.797TrpLeu: 1.797 ± 0.063
0.372TrpMet: 0.372 ± 0.022
0.306TrpAsn: 0.306 ± 0.022
0.803TrpPro: 0.803 ± 0.036
0.549TrpGln: 0.549 ± 0.029
1.307TrpArg: 1.307 ± 0.044
0.983TrpSer: 0.983 ± 0.042
0.929TrpThr: 0.929 ± 0.038
1.482TrpVal: 1.482 ± 0.047
0.548TrpTrp: 0.548 ± 0.029
0.28TrpTyr: 0.28 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.893TyrAla: 1.893 ± 0.062
0.128TyrCys: 0.128 ± 0.012
1.052TyrAsp: 1.052 ± 0.052
1.055TyrGlu: 1.055 ± 0.04
0.53TyrPhe: 0.53 ± 0.029
1.611TyrGly: 1.611 ± 0.051
0.304TyrHis: 0.304 ± 0.02
0.414TyrIle: 0.414 ± 0.026
0.296TyrLys: 0.296 ± 0.024
1.845TyrLeu: 1.845 ± 0.05
0.212TyrMet: 0.212 ± 0.018
0.289TyrAsn: 0.289 ± 0.021
0.877TyrPro: 0.877 ± 0.038
0.486TyrGln: 0.486 ± 0.029
1.327TyrArg: 1.327 ± 0.045
0.866TyrSer: 0.866 ± 0.032
1.035TyrThr: 1.035 ± 0.042
1.506TyrVal: 1.506 ± 0.046
0.237TyrTrp: 0.237 ± 0.016
0.347TyrTyr: 0.347 ± 0.023
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2173 proteins (726268 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski