Amino acid dipepetide frequency for Edwardsiella phage eiAU

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.806AlaAla: 14.806 ± 1.568
1.163AlaCys: 1.163 ± 0.276
9.302AlaAsp: 9.302 ± 0.999
9.922AlaGlu: 9.922 ± 0.888
4.109AlaPhe: 4.109 ± 0.575
10.853AlaGly: 10.853 ± 0.948
1.24AlaHis: 1.24 ± 0.289
6.047AlaIle: 6.047 ± 0.742
6.434AlaLys: 6.434 ± 0.767
11.318AlaLeu: 11.318 ± 1.103
3.721AlaMet: 3.721 ± 0.472
2.713AlaAsn: 2.713 ± 0.613
4.419AlaPro: 4.419 ± 0.534
4.264AlaGln: 4.264 ± 0.49
5.581AlaArg: 5.581 ± 0.681
6.667AlaSer: 6.667 ± 0.838
6.899AlaThr: 6.899 ± 0.79
7.364AlaVal: 7.364 ± 1.005
1.783AlaTrp: 1.783 ± 0.384
2.713AlaTyr: 2.713 ± 0.384
0.0AlaXaa: 0.0 ± 0.0
Cys
1.395CysAla: 1.395 ± 0.376
0.31CysCys: 0.31 ± 0.179
1.318CysAsp: 1.318 ± 0.374
0.93CysGlu: 0.93 ± 0.246
0.388CysPhe: 0.388 ± 0.156
0.93CysGly: 0.93 ± 0.303
0.233CysHis: 0.233 ± 0.113
0.62CysIle: 0.62 ± 0.28
0.543CysLys: 0.543 ± 0.186
1.008CysLeu: 1.008 ± 0.27
0.233CysMet: 0.233 ± 0.117
0.543CysAsn: 0.543 ± 0.193
0.465CysPro: 0.465 ± 0.18
0.388CysGln: 0.388 ± 0.159
0.698CysArg: 0.698 ± 0.228
0.543CysSer: 0.543 ± 0.178
0.31CysThr: 0.31 ± 0.174
0.853CysVal: 0.853 ± 0.233
0.233CysTrp: 0.233 ± 0.124
0.465CysTyr: 0.465 ± 0.166
0.0CysXaa: 0.0 ± 0.0
Asp
6.899AspAla: 6.899 ± 0.682
1.008AspCys: 1.008 ± 0.321
5.504AspAsp: 5.504 ± 1.103
5.039AspGlu: 5.039 ± 0.908
2.713AspPhe: 2.713 ± 0.42
5.349AspGly: 5.349 ± 0.686
0.62AspHis: 0.62 ± 0.277
3.488AspIle: 3.488 ± 0.555
3.566AspLys: 3.566 ± 0.584
5.194AspLeu: 5.194 ± 0.896
1.628AspMet: 1.628 ± 0.314
1.705AspAsn: 1.705 ± 0.332
2.636AspPro: 2.636 ± 0.538
1.938AspGln: 1.938 ± 0.369
3.643AspArg: 3.643 ± 0.437
2.791AspSer: 2.791 ± 0.462
4.264AspThr: 4.264 ± 0.534
3.333AspVal: 3.333 ± 0.488
0.93AspTrp: 0.93 ± 0.246
1.705AspTyr: 1.705 ± 0.322
0.0AspXaa: 0.0 ± 0.0
Glu
6.512GluAla: 6.512 ± 0.819
0.698GluCys: 0.698 ± 0.227
3.643GluAsp: 3.643 ± 0.644
3.798GluGlu: 3.798 ± 0.661
2.481GluPhe: 2.481 ± 0.462
3.566GluGly: 3.566 ± 0.516
1.008GluHis: 1.008 ± 0.317
4.496GluIle: 4.496 ± 0.426
4.341GluLys: 4.341 ± 0.695
6.279GluLeu: 6.279 ± 0.746
1.783GluMet: 1.783 ± 0.342
2.791GluAsn: 2.791 ± 0.477
1.783GluPro: 1.783 ± 0.449
2.403GluGln: 2.403 ± 0.472
4.186GluArg: 4.186 ± 0.642
2.636GluSer: 2.636 ± 0.436
1.938GluThr: 1.938 ± 0.298
3.566GluVal: 3.566 ± 0.537
0.853GluTrp: 0.853 ± 0.273
1.938GluTyr: 1.938 ± 0.3
0.0GluXaa: 0.0 ± 0.0
Phe
3.411PheAla: 3.411 ± 0.425
0.543PheCys: 0.543 ± 0.201
2.093PheAsp: 2.093 ± 0.374
1.938PheGlu: 1.938 ± 0.419
0.62PhePhe: 0.62 ± 0.214
3.178PheGly: 3.178 ± 0.476
0.465PheHis: 0.465 ± 0.211
1.628PheIle: 1.628 ± 0.344
1.783PheLys: 1.783 ± 0.394
1.938PheLeu: 1.938 ± 0.366
0.388PheMet: 0.388 ± 0.181
1.705PheAsn: 1.705 ± 0.431
1.55PhePro: 1.55 ± 0.388
1.318PheGln: 1.318 ± 0.276
2.248PheArg: 2.248 ± 0.362
1.938PheSer: 1.938 ± 0.276
1.938PheThr: 1.938 ± 0.378
1.55PheVal: 1.55 ± 0.293
0.543PheTrp: 0.543 ± 0.237
1.008PheTyr: 1.008 ± 0.255
0.0PheXaa: 0.0 ± 0.0
Gly
9.767GlyAla: 9.767 ± 0.873
1.085GlyCys: 1.085 ± 0.289
3.876GlyAsp: 3.876 ± 0.666
4.496GlyGlu: 4.496 ± 0.491
2.713GlyPhe: 2.713 ± 0.447
9.38GlyGly: 9.38 ± 1.627
0.93GlyHis: 0.93 ± 0.314
3.876GlyIle: 3.876 ± 0.452
4.961GlyLys: 4.961 ± 0.722
6.977GlyLeu: 6.977 ± 0.789
2.403GlyMet: 2.403 ± 0.494
3.023GlyAsn: 3.023 ± 0.433
1.86GlyPro: 1.86 ± 0.391
2.481GlyGln: 2.481 ± 0.729
4.186GlyArg: 4.186 ± 0.504
4.574GlySer: 4.574 ± 0.852
4.186GlyThr: 4.186 ± 0.675
6.822GlyVal: 6.822 ± 0.769
1.085GlyTrp: 1.085 ± 0.341
3.101GlyTyr: 3.101 ± 0.515
0.0GlyXaa: 0.0 ± 0.0
His
2.093HisAla: 2.093 ± 0.375
0.31HisCys: 0.31 ± 0.178
1.008HisAsp: 1.008 ± 0.254
0.62HisGlu: 0.62 ± 0.327
0.62HisPhe: 0.62 ± 0.183
0.93HisGly: 0.93 ± 0.303
0.698HisHis: 0.698 ± 0.359
1.24HisIle: 1.24 ± 0.281
0.543HisLys: 0.543 ± 0.232
1.008HisLeu: 1.008 ± 0.306
0.233HisMet: 0.233 ± 0.133
0.62HisAsn: 0.62 ± 0.254
1.628HisPro: 1.628 ± 0.447
0.853HisGln: 0.853 ± 0.303
0.543HisArg: 0.543 ± 0.195
0.853HisSer: 0.853 ± 0.221
0.853HisThr: 0.853 ± 0.313
0.775HisVal: 0.775 ± 0.285
0.155HisTrp: 0.155 ± 0.114
1.085HisTyr: 1.085 ± 0.282
0.0HisXaa: 0.0 ± 0.0
Ile
5.891IleAla: 5.891 ± 0.716
0.543IleCys: 0.543 ± 0.206
3.876IleAsp: 3.876 ± 0.451
3.411IleGlu: 3.411 ± 0.459
1.24IlePhe: 1.24 ± 0.32
4.419IleGly: 4.419 ± 0.681
0.698IleHis: 0.698 ± 0.204
2.713IleIle: 2.713 ± 0.443
2.558IleLys: 2.558 ± 0.512
2.636IleLeu: 2.636 ± 0.471
1.473IleMet: 1.473 ± 0.311
2.016IleAsn: 2.016 ± 0.301
1.705IlePro: 1.705 ± 0.427
1.163IleGln: 1.163 ± 0.309
3.721IleArg: 3.721 ± 0.616
2.946IleSer: 2.946 ± 0.576
5.039IleThr: 5.039 ± 0.497
2.481IleVal: 2.481 ± 0.366
0.31IleTrp: 0.31 ± 0.148
1.628IleTyr: 1.628 ± 0.498
0.0IleXaa: 0.0 ± 0.0
Lys
6.822LysAla: 6.822 ± 0.803
0.543LysCys: 0.543 ± 0.19
2.326LysAsp: 2.326 ± 0.386
2.326LysGlu: 2.326 ± 0.368
1.705LysPhe: 1.705 ± 0.421
2.946LysGly: 2.946 ± 0.404
0.853LysHis: 0.853 ± 0.239
2.171LysIle: 2.171 ± 0.39
4.264LysLys: 4.264 ± 0.727
4.496LysLeu: 4.496 ± 0.671
1.705LysMet: 1.705 ± 0.353
2.171LysAsn: 2.171 ± 0.452
2.636LysPro: 2.636 ± 0.418
2.326LysGln: 2.326 ± 0.484
3.721LysArg: 3.721 ± 0.578
2.946LysSer: 2.946 ± 0.452
3.333LysThr: 3.333 ± 0.545
3.643LysVal: 3.643 ± 0.566
1.008LysTrp: 1.008 ± 0.263
1.318LysTyr: 1.318 ± 0.253
0.0LysXaa: 0.0 ± 0.0
Leu
9.612LeuAla: 9.612 ± 0.939
1.783LeuCys: 1.783 ± 0.417
5.581LeuAsp: 5.581 ± 0.692
3.798LeuGlu: 3.798 ± 0.487
1.705LeuPhe: 1.705 ± 0.308
5.039LeuGly: 5.039 ± 0.578
1.085LeuHis: 1.085 ± 0.357
4.031LeuIle: 4.031 ± 0.533
3.643LeuLys: 3.643 ± 0.554
5.814LeuLeu: 5.814 ± 0.611
2.481LeuMet: 2.481 ± 0.401
3.178LeuAsn: 3.178 ± 0.542
3.411LeuPro: 3.411 ± 0.696
3.566LeuGln: 3.566 ± 0.564
6.047LeuArg: 6.047 ± 0.796
4.729LeuSer: 4.729 ± 0.654
4.961LeuThr: 4.961 ± 0.608
4.729LeuVal: 4.729 ± 0.613
0.698LeuTrp: 0.698 ± 0.214
2.093LeuTyr: 2.093 ± 0.408
0.0LeuXaa: 0.0 ± 0.0
Met
4.264MetAla: 4.264 ± 0.593
0.31MetCys: 0.31 ± 0.148
0.62MetAsp: 0.62 ± 0.232
1.24MetGlu: 1.24 ± 0.343
1.395MetPhe: 1.395 ± 0.365
1.473MetGly: 1.473 ± 0.28
1.085MetHis: 1.085 ± 0.269
1.008MetIle: 1.008 ± 0.288
1.163MetLys: 1.163 ± 0.285
1.86MetLeu: 1.86 ± 0.356
0.775MetMet: 0.775 ± 0.264
0.93MetAsn: 0.93 ± 0.273
1.395MetPro: 1.395 ± 0.321
0.698MetGln: 0.698 ± 0.296
2.171MetArg: 2.171 ± 0.405
1.55MetSer: 1.55 ± 0.391
2.248MetThr: 2.248 ± 0.386
1.24MetVal: 1.24 ± 0.271
0.388MetTrp: 0.388 ± 0.167
0.698MetTyr: 0.698 ± 0.296
0.0MetXaa: 0.0 ± 0.0
Asn
5.891AsnAla: 5.891 ± 0.648
0.233AsnCys: 0.233 ± 0.116
2.093AsnAsp: 2.093 ± 0.366
1.705AsnGlu: 1.705 ± 0.323
0.93AsnPhe: 0.93 ± 0.276
4.031AsnGly: 4.031 ± 0.549
0.698AsnHis: 0.698 ± 0.202
1.318AsnIle: 1.318 ± 0.339
1.473AsnLys: 1.473 ± 0.328
2.868AsnLeu: 2.868 ± 0.384
0.853AsnMet: 0.853 ± 0.293
1.395AsnAsn: 1.395 ± 0.335
1.783AsnPro: 1.783 ± 0.396
1.24AsnGln: 1.24 ± 0.295
1.938AsnArg: 1.938 ± 0.394
1.473AsnSer: 1.473 ± 0.313
1.86AsnThr: 1.86 ± 0.312
2.558AsnVal: 2.558 ± 0.566
0.543AsnTrp: 0.543 ± 0.165
1.085AsnTyr: 1.085 ± 0.297
0.0AsnXaa: 0.0 ± 0.0
Pro
5.581ProAla: 5.581 ± 0.763
0.388ProCys: 0.388 ± 0.183
3.643ProAsp: 3.643 ± 0.646
2.713ProGlu: 2.713 ± 0.479
1.24ProPhe: 1.24 ± 0.308
3.411ProGly: 3.411 ± 0.486
1.163ProHis: 1.163 ± 0.246
2.016ProIle: 2.016 ± 0.468
2.093ProLys: 2.093 ± 0.372
2.636ProLeu: 2.636 ± 0.403
0.465ProMet: 0.465 ± 0.235
1.24ProAsn: 1.24 ± 0.347
1.473ProPro: 1.473 ± 0.401
1.318ProGln: 1.318 ± 0.355
2.171ProArg: 2.171 ± 0.417
3.411ProSer: 3.411 ± 0.554
2.093ProThr: 2.093 ± 0.385
3.411ProVal: 3.411 ± 0.465
0.62ProTrp: 0.62 ± 0.246
0.93ProTyr: 0.93 ± 0.263
0.0ProXaa: 0.0 ± 0.0
Gln
3.876GlnAla: 3.876 ± 0.562
0.31GlnCys: 0.31 ± 0.209
1.705GlnAsp: 1.705 ± 0.367
1.783GlnGlu: 1.783 ± 0.286
1.008GlnPhe: 1.008 ± 0.364
2.248GlnGly: 2.248 ± 0.415
1.008GlnHis: 1.008 ± 0.324
1.783GlnIle: 1.783 ± 0.594
2.171GlnLys: 2.171 ± 0.492
3.178GlnLeu: 3.178 ± 0.628
1.473GlnMet: 1.473 ± 0.391
1.55GlnAsn: 1.55 ± 0.382
2.016GlnPro: 2.016 ± 0.323
1.473GlnGln: 1.473 ± 0.496
3.721GlnArg: 3.721 ± 0.516
1.783GlnSer: 1.783 ± 0.476
2.093GlnThr: 2.093 ± 0.37
2.403GlnVal: 2.403 ± 0.407
0.62GlnTrp: 0.62 ± 0.189
1.628GlnTyr: 1.628 ± 0.29
0.0GlnXaa: 0.0 ± 0.0
Arg
8.062ArgAla: 8.062 ± 0.897
0.853ArgCys: 0.853 ± 0.217
3.798ArgAsp: 3.798 ± 0.782
3.876ArgGlu: 3.876 ± 0.672
2.171ArgPhe: 2.171 ± 0.38
5.271ArgGly: 5.271 ± 0.619
1.783ArgHis: 1.783 ± 0.451
3.256ArgIle: 3.256 ± 0.607
3.101ArgLys: 3.101 ± 0.529
5.039ArgLeu: 5.039 ± 0.618
1.705ArgMet: 1.705 ± 0.355
2.093ArgAsn: 2.093 ± 0.367
2.558ArgPro: 2.558 ± 0.426
3.178ArgGln: 3.178 ± 0.431
5.426ArgArg: 5.426 ± 1.145
2.481ArgSer: 2.481 ± 0.51
3.488ArgThr: 3.488 ± 0.522
4.264ArgVal: 4.264 ± 0.75
1.318ArgTrp: 1.318 ± 0.263
1.395ArgTyr: 1.395 ± 0.271
0.0ArgXaa: 0.0 ± 0.0
Ser
7.132SerAla: 7.132 ± 0.774
0.543SerCys: 0.543 ± 0.204
3.333SerAsp: 3.333 ± 0.353
2.326SerGlu: 2.326 ± 0.414
1.705SerPhe: 1.705 ± 0.328
6.512SerGly: 6.512 ± 0.784
0.698SerHis: 0.698 ± 0.268
2.481SerIle: 2.481 ± 0.583
2.481SerLys: 2.481 ± 0.428
3.411SerLeu: 3.411 ± 0.597
1.008SerMet: 1.008 ± 0.253
1.55SerAsn: 1.55 ± 0.379
2.093SerPro: 2.093 ± 0.363
1.783SerGln: 1.783 ± 0.287
4.031SerArg: 4.031 ± 0.679
3.178SerSer: 3.178 ± 0.763
2.946SerThr: 2.946 ± 0.491
4.961SerVal: 4.961 ± 0.76
0.62SerTrp: 0.62 ± 0.18
1.473SerTyr: 1.473 ± 0.293
0.0SerXaa: 0.0 ± 0.0
Thr
7.209ThrAla: 7.209 ± 0.857
0.31ThrCys: 0.31 ± 0.181
3.178ThrAsp: 3.178 ± 0.509
4.109ThrGlu: 4.109 ± 0.526
1.783ThrPhe: 1.783 ± 0.412
5.194ThrGly: 5.194 ± 0.749
0.465ThrHis: 0.465 ± 0.165
3.023ThrIle: 3.023 ± 0.55
2.248ThrLys: 2.248 ± 0.402
4.729ThrLeu: 4.729 ± 0.524
1.318ThrMet: 1.318 ± 0.26
2.248ThrAsn: 2.248 ± 0.391
3.333ThrPro: 3.333 ± 0.545
2.093ThrGln: 2.093 ± 0.493
3.333ThrArg: 3.333 ± 0.544
2.791ThrSer: 2.791 ± 0.439
3.721ThrThr: 3.721 ± 0.627
4.109ThrVal: 4.109 ± 0.491
1.395ThrTrp: 1.395 ± 0.324
2.403ThrTyr: 2.403 ± 0.421
0.0ThrXaa: 0.0 ± 0.0
Val
6.744ValAla: 6.744 ± 0.594
0.543ValCys: 0.543 ± 0.209
4.574ValAsp: 4.574 ± 0.61
3.953ValGlu: 3.953 ± 0.615
1.86ValPhe: 1.86 ± 0.434
3.876ValGly: 3.876 ± 0.776
1.163ValHis: 1.163 ± 0.336
3.178ValIle: 3.178 ± 0.464
3.876ValLys: 3.876 ± 0.697
4.496ValLeu: 4.496 ± 0.535
2.171ValMet: 2.171 ± 0.434
2.868ValAsn: 2.868 ± 0.679
2.791ValPro: 2.791 ± 0.437
2.713ValGln: 2.713 ± 0.489
4.031ValArg: 4.031 ± 0.624
4.574ValSer: 4.574 ± 0.657
4.496ValThr: 4.496 ± 0.684
4.419ValVal: 4.419 ± 0.79
1.163ValTrp: 1.163 ± 0.317
1.395ValTyr: 1.395 ± 0.273
0.0ValXaa: 0.0 ± 0.0
Trp
1.938TrpAla: 1.938 ± 0.383
0.465TrpCys: 0.465 ± 0.162
0.698TrpAsp: 0.698 ± 0.207
1.085TrpGlu: 1.085 ± 0.282
0.465TrpPhe: 0.465 ± 0.191
1.24TrpGly: 1.24 ± 0.284
0.233TrpHis: 0.233 ± 0.131
0.233TrpIle: 0.233 ± 0.114
0.465TrpLys: 0.465 ± 0.193
1.24TrpLeu: 1.24 ± 0.34
0.155TrpMet: 0.155 ± 0.112
0.465TrpAsn: 0.465 ± 0.251
0.93TrpPro: 0.93 ± 0.303
0.698TrpGln: 0.698 ± 0.204
1.473TrpArg: 1.473 ± 0.256
0.62TrpSer: 0.62 ± 0.192
0.698TrpThr: 0.698 ± 0.212
1.008TrpVal: 1.008 ± 0.328
0.155TrpTrp: 0.155 ± 0.118
0.543TrpTyr: 0.543 ± 0.178
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.411TyrAla: 3.411 ± 0.579
0.465TyrCys: 0.465 ± 0.221
1.783TyrAsp: 1.783 ± 0.443
1.628TyrGlu: 1.628 ± 0.33
0.93TyrPhe: 0.93 ± 0.248
1.938TyrGly: 1.938 ± 0.568
0.543TyrHis: 0.543 ± 0.219
1.86TyrIle: 1.86 ± 0.398
1.55TyrLys: 1.55 ± 0.354
1.86TyrLeu: 1.86 ± 0.38
0.465TyrMet: 0.465 ± 0.165
1.24TyrAsn: 1.24 ± 0.306
1.55TyrPro: 1.55 ± 0.366
1.938TyrGln: 1.938 ± 0.376
2.248TyrArg: 2.248 ± 0.402
1.783TyrSer: 1.783 ± 0.402
1.628TyrThr: 1.628 ± 0.269
1.395TyrVal: 1.395 ± 0.286
0.388TyrTrp: 0.388 ± 0.144
0.698TyrTyr: 0.698 ± 0.198
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 54 proteins (12901 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski