Amino acid dipepetide frequency for Amylibacter cionae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.413AlaAla: 14.413 ± 0.172	1.085AlaCys: 1.085 ± 0.03	6.566AlaAsp: 6.566 ± 0.083	7.703AlaGlu: 7.703 ± 0.106	4.262AlaPhe: 4.262 ± 0.051	9.764AlaGly: 9.764 ± 0.102	1.992AlaHis: 1.992 ± 0.045	5.774AlaIle: 5.774 ± 0.074	4.55AlaLys: 4.55 ± 0.077	12.262AlaLeu: 12.262 ± 0.174	3.399AlaMet: 3.399 ± 0.052	3.061AlaAsn: 3.061 ± 0.057	4.97AlaPro: 4.97 ± 0.084	4.463AlaGln: 4.463 ± 0.079	6.861AlaArg: 6.861 ± 0.108	5.694AlaSer: 5.694 ± 0.072	5.627AlaThr: 5.627 ± 0.082	8.149AlaVal: 8.149 ± 0.09	1.136AlaTrp: 1.136 ± 0.03	2.548AlaTyr: 2.548 ± 0.048	0.001AlaXaa: 0.001 ± 0.001
Cys	1.056CysAla: 1.056 ± 0.029	0.125CysCys: 0.125 ± 0.008	0.651CysAsp: 0.651 ± 0.022	0.502CysGlu: 0.502 ± 0.021	0.38CysPhe: 0.38 ± 0.019	0.969CysGly: 0.969 ± 0.033	0.265CysHis: 0.265 ± 0.018	0.468CysIle: 0.468 ± 0.022	0.283CysLys: 0.283 ± 0.015	0.862CysLeu: 0.862 ± 0.026	0.186CysMet: 0.186 ± 0.011	0.243CysAsn: 0.243 ± 0.015	0.459CysPro: 0.459 ± 0.026	0.237CysGln: 0.237 ± 0.013	0.479CysArg: 0.479 ± 0.02	0.516CysSer: 0.516 ± 0.021	0.499CysThr: 0.499 ± 0.02	0.673CysVal: 0.673 ± 0.027	0.122CysTrp: 0.122 ± 0.009	0.217CysTyr: 0.217 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	6.646AspAla: 6.646 ± 0.099	0.538AspCys: 0.538 ± 0.022	3.416AspAsp: 3.416 ± 0.084	3.42AspGlu: 3.42 ± 0.057	2.414AspPhe: 2.414 ± 0.055	5.51AspGly: 5.51 ± 0.082	1.378AspHis: 1.378 ± 0.039	3.321AspIle: 3.321 ± 0.054	2.035AspLys: 2.035 ± 0.041	6.22AspLeu: 6.22 ± 0.071	1.767AspMet: 1.767 ± 0.04	1.466AspAsn: 1.466 ± 0.036	3.39AspPro: 3.39 ± 0.052	1.932AspGln: 1.932 ± 0.037	3.763AspArg: 3.763 ± 0.053	2.68AspSer: 2.68 ± 0.052	3.379AspThr: 3.379 ± 0.102	4.507AspVal: 4.507 ± 0.062	1.094AspTrp: 1.094 ± 0.031	1.7AspTyr: 1.7 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	7.009GluAla: 7.009 ± 0.08	0.373GluCys: 0.373 ± 0.016	3.414GluAsp: 3.414 ± 0.057	3.636GluGlu: 3.636 ± 0.071	1.976GluPhe: 1.976 ± 0.043	4.614GluGly: 4.614 ± 0.064	1.173GluHis: 1.173 ± 0.029	3.862GluIle: 3.862 ± 0.058	2.639GluLys: 2.639 ± 0.055	5.477GluLeu: 5.477 ± 0.07	1.868GluMet: 1.868 ± 0.04	2.229GluAsn: 2.229 ± 0.042	2.424GluPro: 2.424 ± 0.047	2.362GluGln: 2.362 ± 0.054	3.843GluArg: 3.843 ± 0.066	2.582GluSer: 2.582 ± 0.053	4.288GluThr: 4.288 ± 0.063	4.285GluVal: 4.285 ± 0.05	0.68GluTrp: 0.68 ± 0.023	1.254GluTyr: 1.254 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	4.556PheAla: 4.556 ± 0.07	0.487PheCys: 0.487 ± 0.021	2.912PheAsp: 2.912 ± 0.054	2.362PheGlu: 2.362 ± 0.045	1.509PhePhe: 1.509 ± 0.039	3.95PheGly: 3.95 ± 0.063	0.766PheHis: 0.766 ± 0.024	1.899PheIle: 1.899 ± 0.04	1.262PheLys: 1.262 ± 0.033	3.584PheLeu: 3.584 ± 0.058	0.963PheMet: 0.963 ± 0.03	1.279PheAsn: 1.279 ± 0.034	1.586PhePro: 1.586 ± 0.039	1.136PheGln: 1.136 ± 0.027	1.931PheArg: 1.931 ± 0.039	2.422PheSer: 2.422 ± 0.042	2.246PheThr: 2.246 ± 0.048	2.841PheVal: 2.841 ± 0.049	0.567PheTrp: 0.567 ± 0.023	0.995PheTyr: 0.995 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	9.374GlyAla: 9.374 ± 0.105	0.843GlyCys: 0.843 ± 0.028	4.675GlyAsp: 4.675 ± 0.083	4.726GlyGlu: 4.726 ± 0.072	3.886GlyPhe: 3.886 ± 0.066	7.548GlyGly: 7.548 ± 0.122	1.768GlyHis: 1.768 ± 0.037	4.732GlyIle: 4.732 ± 0.071	3.63GlyLys: 3.63 ± 0.066	8.948GlyLeu: 8.948 ± 0.089	2.613GlyMet: 2.613 ± 0.046	2.469GlyAsn: 2.469 ± 0.052	3.288GlyPro: 3.288 ± 0.054	3.048GlyGln: 3.048 ± 0.051	4.797GlyArg: 4.797 ± 0.067	4.7GlySer: 4.7 ± 0.081	4.782GlyThr: 4.782 ± 0.077	6.466GlyVal: 6.466 ± 0.077	1.3GlyTrp: 1.3 ± 0.035	2.283GlyTyr: 2.283 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	1.974HisAla: 1.974 ± 0.039	0.24HisCys: 0.24 ± 0.014	1.17HisAsp: 1.17 ± 0.031	0.964HisGlu: 0.964 ± 0.025	0.85HisPhe: 0.85 ± 0.027	1.785HisGly: 1.785 ± 0.041	0.53HisHis: 0.53 ± 0.026	1.046HisIle: 1.046 ± 0.029	0.688HisLys: 0.688 ± 0.023	2.008HisLeu: 2.008 ± 0.048	0.539HisMet: 0.539 ± 0.024	0.522HisAsn: 0.522 ± 0.021	1.312HisPro: 1.312 ± 0.038	0.618HisGln: 0.618 ± 0.024	1.155HisArg: 1.155 ± 0.032	1.087HisSer: 1.087 ± 0.032	0.949HisThr: 0.949 ± 0.028	1.353HisVal: 1.353 ± 0.03	0.302HisTrp: 0.302 ± 0.015	0.576HisTyr: 0.576 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	6.891IleAla: 6.891 ± 0.084	0.69IleCys: 0.69 ± 0.024	3.45IleAsp: 3.45 ± 0.079	3.573IleGlu: 3.573 ± 0.054	1.957IlePhe: 1.957 ± 0.042	5.072IleGly: 5.072 ± 0.075	0.982IleHis: 0.982 ± 0.029	2.568IleIle: 2.568 ± 0.05	1.882IleLys: 1.882 ± 0.043	5.131IleLeu: 5.131 ± 0.061	1.2IleMet: 1.2 ± 0.029	1.634IleAsn: 1.634 ± 0.035	2.47IlePro: 2.47 ± 0.051	1.319IleGln: 1.319 ± 0.032	3.043IleArg: 3.043 ± 0.051	3.382IleSer: 3.382 ± 0.052	3.192IleThr: 3.192 ± 0.052	3.994IleVal: 3.994 ± 0.057	0.697IleTrp: 0.697 ± 0.024	1.287IleTyr: 1.287 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	4.543LysAla: 4.543 ± 0.072	0.208LysCys: 0.208 ± 0.012	2.271LysAsp: 2.271 ± 0.043	2.056LysGlu: 2.056 ± 0.048	1.152LysPhe: 1.152 ± 0.032	3.157LysGly: 3.157 ± 0.054	0.737LysHis: 0.737 ± 0.025	2.138LysIle: 2.138 ± 0.042	1.577LysLys: 1.577 ± 0.048	3.664LysLeu: 3.664 ± 0.054	1.097LysMet: 1.097 ± 0.033	1.15LysAsn: 1.15 ± 0.034	2.068LysPro: 2.068 ± 0.047	1.19LysGln: 1.19 ± 0.032	2.399LysArg: 2.399 ± 0.043	2.298LysSer: 2.298 ± 0.043	2.537LysThr: 2.537 ± 0.046	2.512LysVal: 2.512 ± 0.053	0.428LysTrp: 0.428 ± 0.019	0.774LysTyr: 0.774 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	11.536LeuAla: 11.536 ± 0.133	1.009LeuCys: 1.009 ± 0.026	6.019LeuAsp: 6.019 ± 0.073	5.747LeuGlu: 5.747 ± 0.075	3.792LeuPhe: 3.792 ± 0.067	8.351LeuGly: 8.351 ± 0.092	1.787LeuHis: 1.787 ± 0.036	5.195LeuIle: 5.195 ± 0.067	3.677LeuLys: 3.677 ± 0.057	8.812LeuLeu: 8.812 ± 0.097	2.679LeuMet: 2.679 ± 0.05	3.133LeuAsn: 3.133 ± 0.051	5.144LeuPro: 5.144 ± 0.074	2.989LeuGln: 2.989 ± 0.042	6.34LeuArg: 6.34 ± 0.086	6.986LeuSer: 6.986 ± 0.116	5.75LeuThr: 5.75 ± 0.125	6.923LeuVal: 6.923 ± 0.082	1.196LeuTrp: 1.196 ± 0.032	1.999LeuTyr: 1.999 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	3.318MetAla: 3.318 ± 0.058	0.204MetCys: 0.204 ± 0.012	1.518MetAsp: 1.518 ± 0.034	1.573MetGlu: 1.573 ± 0.037	0.927MetPhe: 0.927 ± 0.027	2.267MetGly: 2.267 ± 0.047	0.439MetHis: 0.439 ± 0.018	1.717MetIle: 1.717 ± 0.037	1.207MetLys: 1.207 ± 0.037	2.633MetLeu: 2.633 ± 0.048	0.814MetMet: 0.814 ± 0.026	0.952MetAsn: 0.952 ± 0.025	1.451MetPro: 1.451 ± 0.034	0.978MetGln: 0.978 ± 0.028	1.745MetArg: 1.745 ± 0.039	1.801MetSer: 1.801 ± 0.038	2.012MetThr: 2.012 ± 0.037	1.918MetVal: 1.918 ± 0.04	0.25MetTrp: 0.25 ± 0.013	0.392MetTyr: 0.392 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.396AsnAla: 3.396 ± 0.057	0.286AsnCys: 0.286 ± 0.015	1.717AsnAsp: 1.717 ± 0.051	1.385AsnGlu: 1.385 ± 0.038	1.153AsnPhe: 1.153 ± 0.029	2.948AsnGly: 2.948 ± 0.06	0.631AsnHis: 0.631 ± 0.024	1.727AsnIle: 1.727 ± 0.044	0.945AsnLys: 0.945 ± 0.029	2.993AsnLeu: 2.993 ± 0.053	0.79AsnMet: 0.79 ± 0.025	0.832AsnAsn: 0.832 ± 0.029	1.959AsnPro: 1.959 ± 0.039	0.807AsnGln: 0.807 ± 0.024	1.921AsnArg: 1.921 ± 0.043	1.52AsnSer: 1.52 ± 0.034	1.667AsnThr: 1.667 ± 0.043	2.066AsnVal: 2.066 ± 0.042	0.532AsnTrp: 0.532 ± 0.02	0.765AsnTyr: 0.765 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	5.17ProAla: 5.17 ± 0.076	0.335ProCys: 0.335 ± 0.018	3.745ProAsp: 3.745 ± 0.062	4.073ProGlu: 4.073 ± 0.062	2.05ProPhe: 2.05 ± 0.038	3.167ProGly: 3.167 ± 0.059	0.97ProHis: 0.97 ± 0.028	2.187ProIle: 2.187 ± 0.046	1.882ProLys: 1.882 ± 0.038	4.455ProLeu: 4.455 ± 0.066	1.311ProMet: 1.311 ± 0.038	1.425ProAsn: 1.425 ± 0.036	2.023ProPro: 2.023 ± 0.052	1.63ProGln: 1.63 ± 0.039	2.27ProArg: 2.27 ± 0.05	2.458ProSer: 2.458 ± 0.047	2.328ProThr: 2.328 ± 0.045	4.302ProVal: 4.302 ± 0.062	0.61ProTrp: 0.61 ± 0.022	1.201ProTyr: 1.201 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	3.893GlnAla: 3.893 ± 0.07	0.226GlnCys: 0.226 ± 0.014	1.884GlnAsp: 1.884 ± 0.041	1.774GlnGlu: 1.774 ± 0.039	1.153GlnPhe: 1.153 ± 0.031	2.643GlnGly: 2.643 ± 0.044	0.621GlnHis: 0.621 ± 0.023	2.13GlnIle: 2.13 ± 0.044	1.356GlnLys: 1.356 ± 0.036	2.864GlnLeu: 2.864 ± 0.054	1.14GlnMet: 1.14 ± 0.034	1.163GlnAsn: 1.163 ± 0.03	1.485GlnPro: 1.485 ± 0.036	1.21GlnGln: 1.21 ± 0.035	2.023GlnArg: 2.023 ± 0.051	2.075GlnSer: 2.075 ± 0.043	1.944GlnThr: 1.944 ± 0.045	2.299GlnVal: 2.299 ± 0.047	0.388GlnTrp: 0.388 ± 0.019	0.656GlnTyr: 0.656 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	6.376ArgAla: 6.376 ± 0.082	0.462ArgCys: 0.462 ± 0.02	3.732ArgAsp: 3.732 ± 0.056	3.459ArgGlu: 3.459 ± 0.061	2.538ArgPhe: 2.538 ± 0.045	3.969ArgGly: 3.969 ± 0.061	1.254ArgHis: 1.254 ± 0.034	3.656ArgIle: 3.656 ± 0.052	2.647ArgLys: 2.647 ± 0.05	6.189ArgLeu: 6.189 ± 0.082	1.83ArgMet: 1.83 ± 0.043	1.905ArgAsn: 1.905 ± 0.036	2.602ArgPro: 2.602 ± 0.048	2.08ArgGln: 2.08 ± 0.041	3.745ArgArg: 3.745 ± 0.063	3.18ArgSer: 3.18 ± 0.056	2.796ArgThr: 2.796 ± 0.047	4.137ArgVal: 4.137 ± 0.056	0.807ArgTrp: 0.807 ± 0.027	1.463ArgTyr: 1.463 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	6.124SerAla: 6.124 ± 0.081	0.481SerCys: 0.481 ± 0.023	3.614SerAsp: 3.614 ± 0.068	3.271SerGlu: 3.271 ± 0.052	2.449SerPhe: 2.449 ± 0.048	6.119SerGly: 6.119 ± 0.072	1.134SerHis: 1.134 ± 0.033	2.906SerIle: 2.906 ± 0.049	1.962SerLys: 1.962 ± 0.046	5.577SerLeu: 5.577 ± 0.096	1.486SerMet: 1.486 ± 0.032	1.623SerAsn: 1.623 ± 0.035	2.472SerPro: 2.472 ± 0.048	1.699SerGln: 1.699 ± 0.038	3.12SerArg: 3.12 ± 0.051	2.883SerSer: 2.883 ± 0.063	2.734SerThr: 2.734 ± 0.052	4.25SerVal: 4.25 ± 0.062	0.672SerTrp: 0.672 ± 0.024	1.51SerTyr: 1.51 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	6.229ThrAla: 6.229 ± 0.092	0.521ThrCys: 0.521 ± 0.021	3.253ThrAsp: 3.253 ± 0.069	3.105ThrGlu: 3.105 ± 0.052	2.082ThrPhe: 2.082 ± 0.041	5.471ThrGly: 5.471 ± 0.082	1.12ThrHis: 1.12 ± 0.029	2.977ThrIle: 2.977 ± 0.061	1.798ThrLys: 1.798 ± 0.04	6.083ThrLeu: 6.083 ± 0.117	1.36ThrMet: 1.36 ± 0.036	1.492ThrAsn: 1.492 ± 0.037	3.449ThrPro: 3.449 ± 0.051	1.731ThrGln: 1.731 ± 0.04	3.173ThrArg: 3.173 ± 0.052	2.959ThrSer: 2.959 ± 0.047	3.002ThrThr: 3.002 ± 0.049	4.57ThrVal: 4.57 ± 0.095	0.589ThrTrp: 0.589 ± 0.022	1.37ThrTyr: 1.37 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	8.135ValAla: 8.135 ± 0.084	0.697ValCys: 0.697 ± 0.025	4.219ValAsp: 4.219 ± 0.065	4.658ValGlu: 4.658 ± 0.055	3.145ValPhe: 3.145 ± 0.052	5.363ValGly: 5.363 ± 0.07	1.281ValHis: 1.281 ± 0.03	4.333ValIle: 4.333 ± 0.062	2.647ValLys: 2.647 ± 0.054	7.489ValLeu: 7.489 ± 0.09	2.151ValMet: 2.151 ± 0.043	2.318ValAsn: 2.318 ± 0.049	3.344ValPro: 3.344 ± 0.053	2.214ValGln: 2.214 ± 0.043	3.833ValArg: 3.833 ± 0.059	4.684ValSer: 4.684 ± 0.069	4.624ValThr: 4.624 ± 0.096	5.769ValVal: 5.769 ± 0.072	0.904ValTrp: 0.904 ± 0.027	1.61ValTyr: 1.61 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.189TrpAla: 1.189 ± 0.032	0.116TrpCys: 0.116 ± 0.01	0.769TrpAsp: 0.769 ± 0.025	0.645TrpGlu: 0.645 ± 0.022	0.582TrpPhe: 0.582 ± 0.024	0.947TrpGly: 0.947 ± 0.027	0.297TrpHis: 0.297 ± 0.016	0.699TrpIle: 0.699 ± 0.025	0.456TrpLys: 0.456 ± 0.019	1.466TrpLeu: 1.466 ± 0.037	0.402TrpMet: 0.402 ± 0.018	0.445TrpAsn: 0.445 ± 0.018	0.582TrpPro: 0.582 ± 0.024	0.555TrpGln: 0.555 ± 0.019	0.875TrpArg: 0.875 ± 0.024	0.819TrpSer: 0.819 ± 0.024	0.676TrpThr: 0.676 ± 0.023	0.841TrpVal: 0.841 ± 0.024	0.212TrpTrp: 0.212 ± 0.013	0.294TrpTyr: 0.294 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.452TyrAla: 2.452 ± 0.048	0.268TyrCys: 0.268 ± 0.014	1.583TyrAsp: 1.583 ± 0.034	1.355TyrGlu: 1.355 ± 0.034	0.996TyrPhe: 0.996 ± 0.027	2.261TyrGly: 2.261 ± 0.048	0.543TyrHis: 0.543 ± 0.024	1.079TyrIle: 1.079 ± 0.033	0.832TyrLys: 0.832 ± 0.027	2.345TyrLeu: 2.345 ± 0.043	0.519TyrMet: 0.519 ± 0.021	0.699TyrAsn: 0.699 ± 0.025	1.115TyrPro: 1.115 ± 0.03	0.727TyrGln: 0.727 ± 0.026	1.511TyrArg: 1.511 ± 0.033	1.361TyrSer: 1.361 ± 0.035	1.3TyrThr: 1.3 ± 0.034	1.565TyrVal: 1.565 ± 0.041	0.384TyrTrp: 0.384 ± 0.016	0.638TyrTyr: 0.638 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3948 proteins (1297894 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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