Amino acid dipepetide frequency for Apis mellifera associated microvirus 38

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.151AlaAla: 5.151 ± 1.251
1.472AlaCys: 1.472 ± 1.276
5.151AlaAsp: 5.151 ± 1.087
3.679AlaGlu: 3.679 ± 1.957
1.472AlaPhe: 1.472 ± 0.656
9.566AlaGly: 9.566 ± 2.973
0.736AlaHis: 0.736 ± 0.641
3.679AlaIle: 3.679 ± 1.269
8.094AlaLys: 8.094 ± 2.679
8.83AlaLeu: 8.83 ± 3.217
4.415AlaMet: 4.415 ± 1.746
2.943AlaAsn: 2.943 ± 1.01
8.83AlaPro: 8.83 ± 2.697
2.943AlaGln: 2.943 ± 1.455
5.887AlaArg: 5.887 ± 2.798
9.566AlaSer: 9.566 ± 4.156
5.887AlaThr: 5.887 ± 2.706
5.151AlaVal: 5.151 ± 1.344
0.0AlaTrp: 0.0 ± 0.0
0.736AlaTyr: 0.736 ± 0.533
0.0AlaXaa: 0.0 ± 0.0
Cys
2.208CysAla: 2.208 ± 1.365
0.736CysCys: 0.736 ± 0.641
0.736CysAsp: 0.736 ± 0.641
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
2.208CysGly: 2.208 ± 1.062
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
0.736CysLys: 0.736 ± 0.641
0.736CysLeu: 0.736 ± 0.641
0.736CysMet: 0.736 ± 1.227
0.736CysAsn: 0.736 ± 0.641
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
0.736CysArg: 0.736 ± 0.641
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
1.472CysVal: 1.472 ± 0.66
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
3.679AspAla: 3.679 ± 1.622
0.0AspCys: 0.0 ± 0.0
3.679AspAsp: 3.679 ± 1.931
1.472AspGlu: 1.472 ± 0.785
2.943AspPhe: 2.943 ± 0.762
2.943AspGly: 2.943 ± 1.555
0.0AspHis: 0.0 ± 0.0
1.472AspIle: 1.472 ± 0.868
1.472AspLys: 1.472 ± 1.028
3.679AspLeu: 3.679 ± 1.312
2.208AspMet: 2.208 ± 0.977
2.208AspAsn: 2.208 ± 0.977
5.151AspPro: 5.151 ± 2.111
0.736AspGln: 0.736 ± 0.533
3.679AspArg: 3.679 ± 2.615
0.736AspSer: 0.736 ± 0.641
2.943AspThr: 2.943 ± 1.791
2.943AspVal: 2.943 ± 1.455
0.0AspTrp: 0.0 ± 0.0
1.472AspTyr: 1.472 ± 1.066
0.0AspXaa: 0.0 ± 0.0
Glu
6.623GluAla: 6.623 ± 2.082
0.0GluCys: 0.0 ± 0.0
3.679GluAsp: 3.679 ± 1.546
5.151GluGlu: 5.151 ± 2.242
2.208GluPhe: 2.208 ± 1.014
2.208GluGly: 2.208 ± 0.929
1.472GluHis: 1.472 ± 0.66
2.208GluIle: 2.208 ± 1.076
2.208GluLys: 2.208 ± 1.329
3.679GluLeu: 3.679 ± 1.418
0.0GluMet: 0.0 ± 0.0
1.472GluAsn: 1.472 ± 0.656
2.943GluPro: 2.943 ± 2.171
1.472GluGln: 1.472 ± 0.868
1.472GluArg: 1.472 ± 0.656
2.208GluSer: 2.208 ± 1.325
2.943GluThr: 2.943 ± 1.802
5.151GluVal: 5.151 ± 2.33
0.0GluTrp: 0.0 ± 0.0
3.679GluTyr: 3.679 ± 1.189
0.0GluXaa: 0.0 ± 0.0
Phe
3.679PheAla: 3.679 ± 1.161
0.0PheCys: 0.0 ± 0.0
0.0PheAsp: 0.0 ± 0.0
2.943PheGlu: 2.943 ± 1.736
1.472PhePhe: 1.472 ± 0.656
5.887PheGly: 5.887 ± 1.085
0.736PheHis: 0.736 ± 0.641
1.472PheIle: 1.472 ± 1.066
0.0PheLys: 0.0 ± 0.0
2.208PheLeu: 2.208 ± 1.626
0.0PheMet: 0.0 ± 0.0
1.472PheAsn: 1.472 ± 0.785
0.736PhePro: 0.736 ± 0.533
1.472PheGln: 1.472 ± 1.028
2.208PheArg: 2.208 ± 0.977
5.887PheSer: 5.887 ± 2.099
1.472PheThr: 1.472 ± 1.066
0.736PheVal: 0.736 ± 0.641
1.472PheTrp: 1.472 ± 1.066
0.736PheTyr: 0.736 ± 0.533
0.0PheXaa: 0.0 ± 0.0
Gly
5.887GlyAla: 5.887 ± 2.539
1.472GlyCys: 1.472 ± 1.49
3.679GlyAsp: 3.679 ± 1.354
5.151GlyGlu: 5.151 ± 1.978
3.679GlyPhe: 3.679 ± 0.718
8.83GlyGly: 8.83 ± 2.559
1.472GlyHis: 1.472 ± 0.66
5.151GlyIle: 5.151 ± 1.631
2.208GlyLys: 2.208 ± 1.611
5.151GlyLeu: 5.151 ± 2.49
0.736GlyMet: 0.736 ± 0.641
3.679GlyAsn: 3.679 ± 1.351
3.679GlyPro: 3.679 ± 1.577
5.151GlyGln: 5.151 ± 1.701
4.415GlyArg: 4.415 ± 1.991
6.623GlySer: 6.623 ± 1.422
5.887GlyThr: 5.887 ± 2.075
5.887GlyVal: 5.887 ± 2.827
0.736GlyTrp: 0.736 ± 0.687
4.415GlyTyr: 4.415 ± 0.959
0.0GlyXaa: 0.0 ± 0.0
His
1.472HisAla: 1.472 ± 1.276
0.0HisCys: 0.0 ± 0.0
0.736HisAsp: 0.736 ± 0.879
2.208HisGlu: 2.208 ± 0.561
0.0HisPhe: 0.0 ± 0.0
2.208HisGly: 2.208 ± 1.014
2.208HisHis: 2.208 ± 1.319
0.0HisIle: 0.0 ± 0.0
1.472HisLys: 1.472 ± 1.282
2.208HisLeu: 2.208 ± 1.528
0.0HisMet: 0.0 ± 0.0
0.736HisAsn: 0.736 ± 1.411
3.679HisPro: 3.679 ± 1.532
1.472HisGln: 1.472 ± 1.276
2.943HisArg: 2.943 ± 1.63
3.679HisSer: 3.679 ± 2.317
2.208HisThr: 2.208 ± 1.188
1.472HisVal: 1.472 ± 1.276
2.208HisTrp: 2.208 ± 0.977
0.736HisTyr: 0.736 ± 0.641
0.0HisXaa: 0.0 ± 0.0
Ile
2.943IleAla: 2.943 ± 0.762
0.736IleCys: 0.736 ± 1.411
1.472IleAsp: 1.472 ± 0.785
2.208IleGlu: 2.208 ± 1.506
1.472IlePhe: 1.472 ± 1.066
2.943IleGly: 2.943 ± 1.321
1.472IleHis: 1.472 ± 0.656
1.472IleIle: 1.472 ± 1.028
2.208IleLys: 2.208 ± 1.626
2.208IleLeu: 2.208 ± 1.257
1.472IleMet: 1.472 ± 0.66
2.208IleAsn: 2.208 ± 0.977
4.415IlePro: 4.415 ± 1.74
2.208IleGln: 2.208 ± 0.977
4.415IleArg: 4.415 ± 2.127
4.415IleSer: 4.415 ± 1.404
4.415IleThr: 4.415 ± 1.794
0.736IleVal: 0.736 ± 0.687
0.736IleTrp: 0.736 ± 0.533
1.472IleTyr: 1.472 ± 1.066
0.0IleXaa: 0.0 ± 0.0
Lys
4.415LysAla: 4.415 ± 2.843
0.736LysCys: 0.736 ± 0.533
0.736LysAsp: 0.736 ± 0.641
4.415LysGlu: 4.415 ± 1.266
1.472LysPhe: 1.472 ± 0.868
2.208LysGly: 2.208 ± 0.977
2.943LysHis: 2.943 ± 1.373
3.679LysIle: 3.679 ± 2.064
4.415LysLys: 4.415 ± 3.596
2.943LysLeu: 2.943 ± 1.067
1.472LysMet: 1.472 ± 0.785
1.472LysAsn: 1.472 ± 0.785
2.943LysPro: 2.943 ± 2.968
2.208LysGln: 2.208 ± 1.466
1.472LysArg: 1.472 ± 1.282
1.472LysSer: 1.472 ± 1.066
1.472LysThr: 1.472 ± 1.375
2.208LysVal: 2.208 ± 1.141
0.0LysTrp: 0.0 ± 0.0
0.0LysTyr: 0.0 ± 0.0
0.0LysXaa: 0.0 ± 0.0
Leu
13.245LeuAla: 13.245 ± 1.369
0.0LeuCys: 0.0 ± 0.0
1.472LeuAsp: 1.472 ± 1.028
5.151LeuGlu: 5.151 ± 1.013
2.943LeuPhe: 2.943 ± 1.21
7.358LeuGly: 7.358 ± 1.749
1.472LeuHis: 1.472 ± 1.276
4.415LeuIle: 4.415 ± 2.634
2.208LeuLys: 2.208 ± 1.809
4.415LeuLeu: 4.415 ± 1.43
1.472LeuMet: 1.472 ± 0.657
4.415LeuAsn: 4.415 ± 1.266
4.415LeuPro: 4.415 ± 1.413
4.415LeuGln: 4.415 ± 1.121
5.887LeuArg: 5.887 ± 2.703
5.887LeuSer: 5.887 ± 1.88
2.943LeuThr: 2.943 ± 1.321
4.415LeuVal: 4.415 ± 2.492
0.736LeuTrp: 0.736 ± 0.687
1.472LeuTyr: 1.472 ± 0.656
0.0LeuXaa: 0.0 ± 0.0
Met
1.472MetAla: 1.472 ± 0.868
0.0MetCys: 0.0 ± 0.0
0.736MetAsp: 0.736 ± 0.687
0.0MetGlu: 0.0 ± 0.0
1.472MetPhe: 1.472 ± 1.49
2.208MetGly: 2.208 ± 0.561
0.736MetHis: 0.736 ± 0.533
0.0MetIle: 0.0 ± 0.0
2.208MetLys: 2.208 ± 0.929
0.0MetLeu: 0.0 ± 0.0
0.0MetMet: 0.0 ± 0.0
0.736MetAsn: 0.736 ± 0.687
2.208MetPro: 2.208 ± 1.466
2.208MetGln: 2.208 ± 1.233
2.943MetArg: 2.943 ± 1.479
2.208MetSer: 2.208 ± 1.014
1.472MetThr: 1.472 ± 1.276
2.208MetVal: 2.208 ± 1.785
0.0MetTrp: 0.0 ± 0.0
0.736MetTyr: 0.736 ± 0.533
0.0MetXaa: 0.0 ± 0.0
Asn
5.887AsnAla: 5.887 ± 1.534
0.736AsnCys: 0.736 ± 0.641
0.0AsnAsp: 0.0 ± 0.0
0.736AsnGlu: 0.736 ± 0.533
1.472AsnPhe: 1.472 ± 1.375
2.208AsnGly: 2.208 ± 1.233
1.472AsnHis: 1.472 ± 1.375
3.679AsnIle: 3.679 ± 1.957
2.943AsnLys: 2.943 ± 1.321
1.472AsnLeu: 1.472 ± 1.478
1.472AsnMet: 1.472 ± 1.634
0.736AsnAsn: 0.736 ± 0.533
3.679AsnPro: 3.679 ± 1.622
1.472AsnGln: 1.472 ± 0.656
5.151AsnArg: 5.151 ± 1.227
0.736AsnSer: 0.736 ± 0.687
2.943AsnThr: 2.943 ± 0.762
1.472AsnVal: 1.472 ± 0.66
1.472AsnTrp: 1.472 ± 0.66
2.208AsnTyr: 2.208 ± 0.561
0.0AsnXaa: 0.0 ± 0.0
Pro
8.83ProAla: 8.83 ± 2.165
1.472ProCys: 1.472 ± 0.66
2.943ProAsp: 2.943 ± 1.593
4.415ProGlu: 4.415 ± 2.333
1.472ProPhe: 1.472 ± 0.656
4.415ProGly: 4.415 ± 1.023
4.415ProHis: 4.415 ± 2.47
3.679ProIle: 3.679 ± 1.852
2.943ProLys: 2.943 ± 1.532
8.094ProLeu: 8.094 ± 2.683
2.208ProMet: 2.208 ± 1.511
2.208ProAsn: 2.208 ± 1.797
6.623ProPro: 6.623 ± 5.905
1.472ProGln: 1.472 ± 1.375
1.472ProArg: 1.472 ± 1.49
5.151ProSer: 5.151 ± 2.079
5.151ProThr: 5.151 ± 1.733
3.679ProVal: 3.679 ± 1.604
1.472ProTrp: 1.472 ± 0.868
2.943ProTyr: 2.943 ± 2.968
0.0ProXaa: 0.0 ± 0.0
Gln
5.151GlnAla: 5.151 ± 1.779
0.736GlnCys: 0.736 ± 0.641
2.943GlnAsp: 2.943 ± 1.067
3.679GlnGlu: 3.679 ± 1.86
0.736GlnPhe: 0.736 ± 0.533
0.736GlnGly: 0.736 ± 0.879
2.208GlnHis: 2.208 ± 1.528
2.943GlnIle: 2.943 ± 1.442
2.943GlnLys: 2.943 ± 0.762
4.415GlnLeu: 4.415 ± 3.299
0.0GlnMet: 0.0 ± 0.0
1.472GlnAsn: 1.472 ± 0.868
1.472GlnPro: 1.472 ± 1.759
4.415GlnGln: 4.415 ± 1.587
4.415GlnArg: 4.415 ± 1.587
2.943GlnSer: 2.943 ± 1.693
1.472GlnThr: 1.472 ± 0.785
2.208GlnVal: 2.208 ± 1.327
0.736GlnTrp: 0.736 ± 0.687
0.0GlnTyr: 0.0 ± 0.0
0.0GlnXaa: 0.0 ± 0.0
Arg
2.208ArgAla: 2.208 ± 1.536
2.208ArgCys: 2.208 ± 1.188
3.679ArgAsp: 3.679 ± 1.354
0.736ArgGlu: 0.736 ± 0.533
2.943ArgPhe: 2.943 ± 0.762
5.151ArgGly: 5.151 ± 2.499
2.943ArgHis: 2.943 ± 1.791
4.415ArgIle: 4.415 ± 2.028
1.472ArgLys: 1.472 ± 1.49
7.358ArgLeu: 7.358 ± 2.612
1.472ArgMet: 1.472 ± 0.66
4.415ArgAsn: 4.415 ± 2.035
5.151ArgPro: 5.151 ± 2.482
2.943ArgGln: 2.943 ± 2.055
10.302ArgArg: 10.302 ± 6.288
3.679ArgSer: 3.679 ± 1.351
5.887ArgThr: 5.887 ± 1.973
0.736ArgVal: 0.736 ± 0.687
0.0ArgTrp: 0.0 ± 0.0
6.623ArgTyr: 6.623 ± 2.224
0.0ArgXaa: 0.0 ± 0.0
Ser
6.623SerAla: 6.623 ± 1.702
0.0SerCys: 0.0 ± 0.0
6.623SerAsp: 6.623 ± 2.317
2.208SerGlu: 2.208 ± 2.231
1.472SerPhe: 1.472 ± 0.656
6.623SerGly: 6.623 ± 2.183
1.472SerHis: 1.472 ± 1.276
1.472SerIle: 1.472 ± 1.066
0.736SerLys: 0.736 ± 0.533
6.623SerLeu: 6.623 ± 2.096
2.943SerMet: 2.943 ± 1.661
2.208SerAsn: 2.208 ± 0.977
7.358SerPro: 7.358 ± 5.212
4.415SerGln: 4.415 ± 2.381
4.415SerArg: 4.415 ± 1.516
5.151SerSer: 5.151 ± 1.105
2.943SerThr: 2.943 ± 1.798
2.208SerVal: 2.208 ± 1.611
0.736SerTrp: 0.736 ± 0.533
0.736SerTyr: 0.736 ± 0.641
0.0SerXaa: 0.0 ± 0.0
Thr
5.887ThrAla: 5.887 ± 2.706
0.0ThrCys: 0.0 ± 0.0
1.472ThrAsp: 1.472 ± 0.656
0.736ThrGlu: 0.736 ± 0.687
2.208ThrPhe: 2.208 ± 0.929
7.358ThrGly: 7.358 ± 2.316
2.943ThrHis: 2.943 ± 2.147
2.943ThrIle: 2.943 ± 0.762
2.208ThrLys: 2.208 ± 1.598
5.887ThrLeu: 5.887 ± 2.703
0.0ThrMet: 0.0 ± 0.0
3.679ThrAsn: 3.679 ± 1.626
2.943ThrPro: 2.943 ± 2.171
1.472ThrGln: 1.472 ± 1.282
4.415ThrArg: 4.415 ± 2.24
3.679ThrSer: 3.679 ± 1.848
5.887ThrThr: 5.887 ± 1.325
2.208ThrVal: 2.208 ± 1.598
2.208ThrTrp: 2.208 ± 1.809
1.472ThrTyr: 1.472 ± 0.785
0.0ThrXaa: 0.0 ± 0.0
Val
5.887ValAla: 5.887 ± 1.053
0.736ValCys: 0.736 ± 0.641
2.208ValAsp: 2.208 ± 1.141
1.472ValGlu: 1.472 ± 0.656
2.943ValPhe: 2.943 ± 1.074
5.887ValGly: 5.887 ± 1.021
0.736ValHis: 0.736 ± 0.641
2.208ValIle: 2.208 ± 1.327
0.736ValLys: 0.736 ± 0.533
3.679ValLeu: 3.679 ± 2.236
1.472ValMet: 1.472 ± 0.66
2.943ValAsn: 2.943 ± 1.379
7.358ValPro: 7.358 ± 2.097
2.943ValGln: 2.943 ± 1.886
4.415ValArg: 4.415 ± 1.715
0.736ValSer: 0.736 ± 0.533
2.208ValThr: 2.208 ± 1.062
0.736ValVal: 0.736 ± 0.533
0.736ValTrp: 0.736 ± 0.533
1.472ValTyr: 1.472 ± 0.868
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.0TrpCys: 0.0 ± 0.0
0.736TrpAsp: 0.736 ± 0.687
2.208TrpGlu: 2.208 ± 1.141
0.0TrpPhe: 0.0 ± 0.0
0.736TrpGly: 0.736 ± 0.641
1.472TrpHis: 1.472 ± 1.375
0.0TrpIle: 0.0 ± 0.0
0.0TrpLys: 0.0 ± 0.0
1.472TrpLeu: 1.472 ± 0.785
0.0TrpMet: 0.0 ± 0.0
2.208TrpAsn: 2.208 ± 0.977
0.736TrpPro: 0.736 ± 0.533
1.472TrpGln: 1.472 ± 0.66
0.736TrpArg: 0.736 ± 0.687
0.736TrpSer: 0.736 ± 0.533
0.0TrpThr: 0.0 ± 0.0
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
0.736TrpTyr: 0.736 ± 0.533
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.943TyrAla: 2.943 ± 0.762
0.0TyrCys: 0.0 ± 0.0
0.736TyrAsp: 0.736 ± 0.641
2.208TyrGlu: 2.208 ± 0.929
2.208TyrPhe: 2.208 ± 1.062
2.208TyrGly: 2.208 ± 1.365
0.736TyrHis: 0.736 ± 0.641
0.736TyrIle: 0.736 ± 0.533
1.472TyrLys: 1.472 ± 0.656
3.679TyrLeu: 3.679 ± 1.979
0.736TyrMet: 0.736 ± 0.691
0.0TyrAsn: 0.0 ± 0.0
0.736TyrPro: 0.736 ± 0.641
0.736TyrGln: 0.736 ± 0.687
2.943TyrArg: 2.943 ± 1.843
1.472TyrSer: 1.472 ± 0.656
1.472TyrThr: 1.472 ± 0.66
5.887TyrVal: 5.887 ± 1.425
0.0TyrTrp: 0.0 ± 0.0
0.736TyrTyr: 0.736 ± 0.687
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6 proteins (1360 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski