Amino acid dipepetide frequency for Vibrio mangrovi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.405AlaAla: 7.405 ± 0.108	0.965AlaCys: 0.965 ± 0.033	4.414AlaAsp: 4.414 ± 0.064	5.406AlaGlu: 5.406 ± 0.085	3.206AlaPhe: 3.206 ± 0.051	6.149AlaGly: 6.149 ± 0.088	1.724AlaHis: 1.724 ± 0.035	5.578AlaIle: 5.578 ± 0.077	3.843AlaLys: 3.843 ± 0.062	9.164AlaLeu: 9.164 ± 0.1	2.425AlaMet: 2.425 ± 0.045	2.819AlaAsn: 2.819 ± 0.046	2.744AlaPro: 2.744 ± 0.054	3.951AlaGln: 3.951 ± 0.059	4.063AlaArg: 4.063 ± 0.058	5.146AlaSer: 5.146 ± 0.068	4.357AlaThr: 4.357 ± 0.069	5.865AlaVal: 5.865 ± 0.064	0.89AlaTrp: 0.89 ± 0.025	2.395AlaTyr: 2.395 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.832CysAla: 0.832 ± 0.026	0.186CysCys: 0.186 ± 0.012	0.635CysAsp: 0.635 ± 0.021	0.638CysGlu: 0.638 ± 0.022	0.529CysPhe: 0.529 ± 0.017	0.969CysGly: 0.969 ± 0.027	0.417CysHis: 0.417 ± 0.019	0.695CysIle: 0.695 ± 0.02	0.363CysLys: 0.363 ± 0.016	1.112CysLeu: 1.112 ± 0.028	0.267CysMet: 0.267 ± 0.015	0.353CysAsn: 0.353 ± 0.016	0.507CysPro: 0.507 ± 0.021	0.608CysGln: 0.608 ± 0.023	0.639CysArg: 0.639 ± 0.025	0.773CysSer: 0.773 ± 0.021	0.529CysThr: 0.529 ± 0.021	0.679CysVal: 0.679 ± 0.024	0.151CysTrp: 0.151 ± 0.01	0.376CysTyr: 0.376 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	4.246AspAla: 4.246 ± 0.082	0.568AspCys: 0.568 ± 0.02	2.962AspAsp: 2.962 ± 0.057	3.868AspGlu: 3.868 ± 0.071	2.456AspPhe: 2.456 ± 0.041	3.659AspGly: 3.659 ± 0.072	1.277AspHis: 1.277 ± 0.027	4.145AspIle: 4.145 ± 0.05	2.653AspLys: 2.653 ± 0.045	4.977AspLeu: 4.977 ± 0.067	1.433AspMet: 1.433 ± 0.032	2.107AspAsn: 2.107 ± 0.043	2.193AspPro: 2.193 ± 0.041	2.244AspGln: 2.244 ± 0.048	2.4AspArg: 2.4 ± 0.042	3.26AspSer: 3.26 ± 0.049	2.658AspThr: 2.658 ± 0.046	3.839AspVal: 3.839 ± 0.055	0.824AspTrp: 0.824 ± 0.022	2.093AspTyr: 2.093 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	4.952GluAla: 4.952 ± 0.074	0.527GluCys: 0.527 ± 0.019	2.73GluAsp: 2.73 ± 0.048	3.687GluGlu: 3.687 ± 0.06	2.222GluPhe: 2.222 ± 0.036	3.294GluGly: 3.294 ± 0.068	1.771GluHis: 1.771 ± 0.04	4.146GluIle: 4.146 ± 0.059	3.807GluLys: 3.807 ± 0.064	6.671GluLeu: 6.671 ± 0.084	1.832GluMet: 1.832 ± 0.04	2.859GluAsn: 2.859 ± 0.044	2.162GluPro: 2.162 ± 0.052	4.124GluGln: 4.124 ± 0.066	3.417GluArg: 3.417 ± 0.057	4.124GluSer: 4.124 ± 0.052	3.422GluThr: 3.422 ± 0.052	4.043GluVal: 4.043 ± 0.055	0.733GluTrp: 0.733 ± 0.026	1.844GluTyr: 1.844 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	3.246PheAla: 3.246 ± 0.059	0.556PheCys: 0.556 ± 0.022	2.544PheAsp: 2.544 ± 0.04	2.266PheGlu: 2.266 ± 0.05	1.71PhePhe: 1.71 ± 0.047	3.123PheGly: 3.123 ± 0.056	1.036PheHis: 1.036 ± 0.026	2.84PheIle: 2.84 ± 0.054	1.568PheLys: 1.568 ± 0.038	3.54PheLeu: 3.54 ± 0.063	0.98PheMet: 0.98 ± 0.027	1.626PheAsn: 1.626 ± 0.036	1.591PhePro: 1.591 ± 0.032	1.488PheGln: 1.488 ± 0.033	1.864PheArg: 1.864 ± 0.033	3.447PheSer: 3.447 ± 0.052	2.245PheThr: 2.245 ± 0.039	2.616PheVal: 2.616 ± 0.055	0.587PheTrp: 0.587 ± 0.022	1.374PheTyr: 1.374 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	5.104GlyAla: 5.104 ± 0.082	0.986GlyCys: 0.986 ± 0.03	3.508GlyAsp: 3.508 ± 0.05	4.442GlyGlu: 4.442 ± 0.066	3.154GlyPhe: 3.154 ± 0.05	4.727GlyGly: 4.727 ± 0.079	1.73GlyHis: 1.73 ± 0.038	5.044GlyIle: 5.044 ± 0.067	3.83GlyLys: 3.83 ± 0.058	6.851GlyLeu: 6.851 ± 0.075	2.107GlyMet: 2.107 ± 0.044	2.488GlyAsn: 2.488 ± 0.051	1.767GlyPro: 1.767 ± 0.04	3.144GlyGln: 3.144 ± 0.049	3.183GlyArg: 3.183 ± 0.045	4.144GlySer: 4.144 ± 0.069	3.524GlyThr: 3.524 ± 0.067	4.88GlyVal: 4.88 ± 0.06	0.986GlyTrp: 0.986 ± 0.028	2.707GlyTyr: 2.707 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	1.815HisAla: 1.815 ± 0.038	0.348HisCys: 0.348 ± 0.017	1.269HisAsp: 1.269 ± 0.03	1.346HisGlu: 1.346 ± 0.029	1.168HisPhe: 1.168 ± 0.029	1.668HisGly: 1.668 ± 0.034	1.002HisHis: 1.002 ± 0.034	1.668HisIle: 1.668 ± 0.038	0.933HisLys: 0.933 ± 0.027	2.768HisLeu: 2.768 ± 0.045	0.573HisMet: 0.573 ± 0.021	0.865HisAsn: 0.865 ± 0.024	1.381HisPro: 1.381 ± 0.034	1.691HisGln: 1.691 ± 0.038	1.34HisArg: 1.34 ± 0.032	1.55HisSer: 1.55 ± 0.032	1.266HisThr: 1.266 ± 0.03	1.467HisVal: 1.467 ± 0.029	0.439HisTrp: 0.439 ± 0.018	1.02HisTyr: 1.02 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	6.198IleAla: 6.198 ± 0.075	0.837IleCys: 0.837 ± 0.024	4.167IleAsp: 4.167 ± 0.052	4.582IleGlu: 4.582 ± 0.061	2.42IlePhe: 2.42 ± 0.053	4.723IleGly: 4.723 ± 0.065	1.773IleHis: 1.773 ± 0.037	3.727IleIle: 3.727 ± 0.067	2.651IleLys: 2.651 ± 0.051	5.737IleLeu: 5.737 ± 0.075	1.283IleMet: 1.283 ± 0.032	2.596IleAsn: 2.596 ± 0.043	2.978IlePro: 2.978 ± 0.052	3.057IleGln: 3.057 ± 0.045	3.666IleArg: 3.666 ± 0.056	4.846IleSer: 4.846 ± 0.067	3.644IleThr: 3.644 ± 0.066	4.21IleVal: 4.21 ± 0.052	0.709IleTrp: 0.709 ± 0.025	1.931IleTyr: 1.931 ± 0.04	0.0IleXaa: 0.0 ± 0.0
Lys	4.068LysAla: 4.068 ± 0.059	0.337LysCys: 0.337 ± 0.015	2.413LysAsp: 2.413 ± 0.046	2.893LysGlu: 2.893 ± 0.049	1.393LysPhe: 1.393 ± 0.031	2.808LysGly: 2.808 ± 0.049	1.127LysHis: 1.127 ± 0.031	3.036LysIle: 3.036 ± 0.055	2.66LysLys: 2.66 ± 0.059	4.659LysLeu: 4.659 ± 0.066	1.327LysMet: 1.327 ± 0.029	2.089LysAsn: 2.089 ± 0.044	2.035LysPro: 2.035 ± 0.036	2.52LysGln: 2.52 ± 0.042	2.476LysArg: 2.476 ± 0.046	3.059LysSer: 3.059 ± 0.049	2.681LysThr: 2.681 ± 0.044	3.229LysVal: 3.229 ± 0.058	0.463LysTrp: 0.463 ± 0.019	1.444LysTyr: 1.444 ± 0.034	0.0LysXaa: 0.0 ± 0.0
Leu	9.342LeuAla: 9.342 ± 0.106	1.278LeuCys: 1.278 ± 0.03	5.442LeuAsp: 5.442 ± 0.071	5.824LeuGlu: 5.824 ± 0.068	4.229LeuPhe: 4.229 ± 0.068	6.733LeuGly: 6.733 ± 0.07	2.252LeuHis: 2.252 ± 0.043	6.535LeuIle: 6.535 ± 0.099	5.088LeuLys: 5.088 ± 0.073	10.483LeuLeu: 10.483 ± 0.122	2.693LeuMet: 2.693 ± 0.043	4.578LeuAsn: 4.578 ± 0.054	4.869LeuPro: 4.869 ± 0.069	4.08LeuGln: 4.08 ± 0.069	4.685LeuArg: 4.685 ± 0.063	8.328LeuSer: 8.328 ± 0.09	6.058LeuThr: 6.058 ± 0.071	6.694LeuVal: 6.694 ± 0.073	1.143LeuTrp: 1.143 ± 0.03	2.812LeuTyr: 2.812 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	2.385MetAla: 2.385 ± 0.041	0.221MetCys: 0.221 ± 0.013	1.229MetAsp: 1.229 ± 0.03	1.316MetGlu: 1.316 ± 0.03	0.929MetPhe: 0.929 ± 0.032	1.73MetGly: 1.73 ± 0.039	0.561MetHis: 0.561 ± 0.021	1.708MetIle: 1.708 ± 0.041	1.612MetLys: 1.612 ± 0.035	2.712MetLeu: 2.712 ± 0.045	0.902MetMet: 0.902 ± 0.028	1.312MetAsn: 1.312 ± 0.03	1.136MetPro: 1.136 ± 0.03	1.145MetGln: 1.145 ± 0.029	1.193MetArg: 1.193 ± 0.029	2.035MetSer: 2.035 ± 0.036	1.794MetThr: 1.794 ± 0.037	1.816MetVal: 1.816 ± 0.036	0.222MetTrp: 0.222 ± 0.013	0.585MetTyr: 0.585 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	2.994AsnAla: 2.994 ± 0.052	0.384AsnCys: 0.384 ± 0.017	2.077AsnAsp: 2.077 ± 0.043	2.19AsnGlu: 2.19 ± 0.041	1.456AsnPhe: 1.456 ± 0.032	2.797AsnGly: 2.797 ± 0.055	1.157AsnHis: 1.157 ± 0.027	2.737AsnIle: 2.737 ± 0.045	1.682AsnLys: 1.682 ± 0.033	3.732AsnLeu: 3.732 ± 0.054	1.0AsnMet: 1.0 ± 0.025	1.607AsnAsn: 1.607 ± 0.037	2.093AsnPro: 2.093 ± 0.039	2.208AsnGln: 2.208 ± 0.041	2.087AsnArg: 2.087 ± 0.036	2.276AsnSer: 2.276 ± 0.048	2.067AsnThr: 2.067 ± 0.037	2.372AsnVal: 2.372 ± 0.048	0.525AsnTrp: 0.525 ± 0.021	1.37AsnTyr: 1.37 ± 0.034	0.0AsnXaa: 0.0 ± 0.0
Pro	3.225ProAla: 3.225 ± 0.063	0.342ProCys: 0.342 ± 0.015	2.803ProAsp: 2.803 ± 0.046	3.829ProGlu: 3.829 ± 0.062	1.675ProPhe: 1.675 ± 0.035	2.724ProGly: 2.724 ± 0.051	0.952ProHis: 0.952 ± 0.025	2.271ProIle: 2.271 ± 0.042	1.761ProLys: 1.761 ± 0.036	4.178ProLeu: 4.178 ± 0.064	1.035ProMet: 1.035 ± 0.026	1.458ProAsn: 1.458 ± 0.032	1.301ProPro: 1.301 ± 0.034	2.002ProGln: 2.002 ± 0.043	1.542ProArg: 1.542 ± 0.033	2.287ProSer: 2.287 ± 0.04	2.019ProThr: 2.019 ± 0.038	3.586ProVal: 3.586 ± 0.053	0.524ProTrp: 0.524 ± 0.02	1.448ProTyr: 1.448 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	4.43GlnAla: 4.43 ± 0.06	0.49GlnCys: 0.49 ± 0.02	2.338GlnAsp: 2.338 ± 0.044	2.992GlnGlu: 2.992 ± 0.047	1.775GlnPhe: 1.775 ± 0.035	3.239GlnGly: 3.239 ± 0.053	1.319GlnHis: 1.319 ± 0.027	3.103GlnIle: 3.103 ± 0.047	2.345GlnLys: 2.345 ± 0.043	5.436GlnLeu: 5.436 ± 0.072	1.317GlnMet: 1.317 ± 0.031	1.783GlnAsn: 1.783 ± 0.043	2.127GlnPro: 2.127 ± 0.045	3.424GlnGln: 3.424 ± 0.059	2.536GlnArg: 2.536 ± 0.047	3.253GlnSer: 3.253 ± 0.056	2.608GlnThr: 2.608 ± 0.043	3.331GlnVal: 3.331 ± 0.058	0.776GlnTrp: 0.776 ± 0.025	1.602GlnTyr: 1.602 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	3.323ArgAla: 3.323 ± 0.048	0.569ArgCys: 0.569 ± 0.021	2.545ArgAsp: 2.545 ± 0.046	3.325ArgGlu: 3.325 ± 0.051	2.347ArgPhe: 2.347 ± 0.042	2.697ArgGly: 2.697 ± 0.047	1.445ArgHis: 1.445 ± 0.033	3.42ArgIle: 3.42 ± 0.052	2.396ArgLys: 2.396 ± 0.044	5.632ArgLeu: 5.632 ± 0.065	1.361ArgMet: 1.361 ± 0.029	1.925ArgAsn: 1.925 ± 0.037	1.775ArgPro: 1.775 ± 0.038	2.959ArgGln: 2.959 ± 0.045	2.62ArgArg: 2.62 ± 0.05	2.792ArgSer: 2.792 ± 0.043	2.317ArgThr: 2.317 ± 0.036	3.184ArgVal: 3.184 ± 0.054	0.688ArgTrp: 0.688 ± 0.025	2.031ArgTyr: 2.031 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	5.377SerAla: 5.377 ± 0.082	0.715SerCys: 0.715 ± 0.022	3.685SerAsp: 3.685 ± 0.057	4.117SerGlu: 4.117 ± 0.063	2.771SerPhe: 2.771 ± 0.047	5.644SerGly: 5.644 ± 0.072	1.893SerHis: 1.893 ± 0.032	3.998SerIle: 3.998 ± 0.067	2.557SerLys: 2.557 ± 0.046	7.173SerLeu: 7.173 ± 0.085	1.734SerMet: 1.734 ± 0.036	2.217SerAsn: 2.217 ± 0.043	2.768SerPro: 2.768 ± 0.053	3.407SerGln: 3.407 ± 0.051	3.291SerArg: 3.291 ± 0.061	4.515SerSer: 4.515 ± 0.07	3.153SerThr: 3.153 ± 0.067	4.977SerVal: 4.977 ± 0.063	0.919SerTrp: 0.919 ± 0.028	2.221SerTyr: 2.221 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	4.364ThrAla: 4.364 ± 0.056	0.526ThrCys: 0.526 ± 0.021	2.977ThrAsp: 2.977 ± 0.07	3.34ThrGlu: 3.34 ± 0.056	2.117ThrPhe: 2.117 ± 0.041	4.049ThrGly: 4.049 ± 0.071	1.351ThrHis: 1.351 ± 0.026	3.432ThrIle: 3.432 ± 0.068	1.964ThrLys: 1.964 ± 0.042	6.332ThrLeu: 6.332 ± 0.079	1.162ThrMet: 1.162 ± 0.03	1.869ThrAsn: 1.869 ± 0.046	2.808ThrPro: 2.808 ± 0.043	2.583ThrGln: 2.583 ± 0.051	2.399ThrArg: 2.399 ± 0.045	3.423ThrSer: 3.423 ± 0.048	3.022ThrThr: 3.022 ± 0.054	3.841ThrVal: 3.841 ± 0.065	0.557ThrTrp: 0.557 ± 0.021	1.626ThrTyr: 1.626 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	6.066ValAla: 6.066 ± 0.081	0.826ValCys: 0.826 ± 0.023	3.767ValAsp: 3.767 ± 0.055	4.053ValGlu: 4.053 ± 0.061	2.724ValPhe: 2.724 ± 0.048	4.519ValGly: 4.519 ± 0.061	1.406ValHis: 1.406 ± 0.034	4.992ValIle: 4.992 ± 0.066	3.241ValLys: 3.241 ± 0.047	6.704ValLeu: 6.704 ± 0.089	1.997ValMet: 1.997 ± 0.038	2.679ValAsn: 2.679 ± 0.044	2.723ValPro: 2.723 ± 0.049	2.498ValGln: 2.498 ± 0.044	3.284ValArg: 3.284 ± 0.046	5.086ValSer: 5.086 ± 0.064	4.182ValThr: 4.182 ± 0.071	5.104ValVal: 5.104 ± 0.066	0.766ValTrp: 0.766 ± 0.024	1.923ValTyr: 1.923 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	0.779TrpAla: 0.779 ± 0.023	0.167TrpCys: 0.167 ± 0.01	0.645TrpAsp: 0.645 ± 0.021	0.613TrpGlu: 0.613 ± 0.02	0.569TrpPhe: 0.569 ± 0.024	0.836TrpGly: 0.836 ± 0.028	0.374TrpHis: 0.374 ± 0.018	0.789TrpIle: 0.789 ± 0.026	0.552TrpLys: 0.552 ± 0.02	1.71TrpLeu: 1.71 ± 0.038	0.387TrpMet: 0.387 ± 0.019	0.487TrpAsn: 0.487 ± 0.022	0.466TrpPro: 0.466 ± 0.019	0.9TrpGln: 0.9 ± 0.032	0.641TrpArg: 0.641 ± 0.023	0.723TrpSer: 0.723 ± 0.024	0.525TrpThr: 0.525 ± 0.018	0.841TrpVal: 0.841 ± 0.029	0.195TrpTrp: 0.195 ± 0.013	0.419TrpTyr: 0.419 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.361TyrAla: 2.361 ± 0.04	0.428TyrCys: 0.428 ± 0.016	1.712TyrAsp: 1.712 ± 0.048	1.644TyrGlu: 1.644 ± 0.035	1.395TyrPhe: 1.395 ± 0.038	2.219TyrGly: 2.219 ± 0.041	1.01TyrHis: 1.01 ± 0.029	1.871TyrIle: 1.871 ± 0.037	1.213TyrLys: 1.213 ± 0.035	3.575TyrLeu: 3.575 ± 0.061	0.723TyrMet: 0.723 ± 0.026	1.094TyrAsn: 1.094 ± 0.032	1.538TyrPro: 1.538 ± 0.031	2.189TyrGln: 2.189 ± 0.041	2.025TyrArg: 2.025 ± 0.037	2.065TyrSer: 2.065 ± 0.039	1.671TyrThr: 1.671 ± 0.036	1.965TyrVal: 1.965 ± 0.037	0.521TyrTrp: 0.521 ± 0.022	1.132TyrTyr: 1.132 ± 0.034	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4312 proteins (1428354 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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