Amino acid dipepetide frequency for Papaya lethal yellowing virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.988AlaAla: 2.988 ± 1.908
2.49AlaCys: 2.49 ± 1.008
3.486AlaAsp: 3.486 ± 1.092
8.466AlaGlu: 8.466 ± 1.297
0.498AlaPhe: 0.498 ± 0.323
1.992AlaGly: 1.992 ± 1.159
0.498AlaHis: 0.498 ± 0.73
3.486AlaIle: 3.486 ± 0.845
5.478AlaLys: 5.478 ± 1.443
7.968AlaLeu: 7.968 ± 1.389
2.988AlaMet: 2.988 ± 0.404
3.486AlaAsn: 3.486 ± 0.51
3.486AlaPro: 3.486 ± 0.845
1.494AlaGln: 1.494 ± 0.731
1.992AlaArg: 1.992 ± 0.935
4.98AlaSer: 4.98 ± 1.332
4.98AlaThr: 4.98 ± 2.986
6.972AlaVal: 6.972 ± 0.789
0.498AlaTrp: 0.498 ± 0.695
0.498AlaTyr: 0.498 ± 0.323
0.0AlaXaa: 0.0 ± 0.0
Cys
1.992CysAla: 1.992 ± 0.397
1.494CysCys: 1.494 ± 0.907
1.494CysAsp: 1.494 ± 0.758
4.482CysGlu: 4.482 ± 0.974
0.996CysPhe: 0.996 ± 0.646
0.0CysGly: 0.0 ± 0.0
0.0CysHis: 0.0 ± 0.0
2.49CysIle: 2.49 ± 0.676
1.494CysLys: 1.494 ± 0.969
2.988CysLeu: 2.988 ± 0.404
1.494CysMet: 1.494 ± 0.502
1.494CysAsn: 1.494 ± 0.907
1.494CysPro: 1.494 ± 0.502
0.0CysGln: 0.0 ± 0.0
2.988CysArg: 2.988 ± 1.213
3.486CysSer: 3.486 ± 1.14
1.494CysThr: 1.494 ± 0.758
2.49CysVal: 2.49 ± 2.073
0.0CysTrp: 0.0 ± 0.0
0.498CysTyr: 0.498 ± 0.323
0.0CysXaa: 0.0 ± 0.0
Asp
2.49AspAla: 2.49 ± 0.787
1.992AspCys: 1.992 ± 1.357
0.498AspAsp: 0.498 ± 0.323
3.984AspGlu: 3.984 ± 1.108
2.49AspPhe: 2.49 ± 0.76
1.992AspGly: 1.992 ± 0.712
0.498AspHis: 0.498 ± 0.73
1.494AspIle: 1.494 ± 0.463
0.996AspLys: 0.996 ± 0.356
3.984AspLeu: 3.984 ± 1.429
1.494AspMet: 1.494 ± 0.498
0.498AspAsn: 0.498 ± 0.695
2.988AspPro: 2.988 ± 1.213
2.49AspGln: 2.49 ± 0.521
3.486AspArg: 3.486 ± 1.223
4.482AspSer: 4.482 ± 1.301
1.992AspThr: 1.992 ± 0.397
0.498AspVal: 0.498 ± 0.695
1.992AspTrp: 1.992 ± 0.953
1.992AspTyr: 1.992 ± 0.714
0.0AspXaa: 0.0 ± 0.0
Glu
3.486GluAla: 3.486 ± 0.653
3.486GluCys: 3.486 ± 1.16
3.984GluAsp: 3.984 ± 1.182
3.984GluGlu: 3.984 ± 1.429
1.992GluPhe: 1.992 ± 0.591
6.474GluGly: 6.474 ± 0.897
0.0GluHis: 0.0 ± 0.0
6.972GluIle: 6.972 ± 1.54
4.98GluLys: 4.98 ± 1.256
7.968GluLeu: 7.968 ± 3.244
0.498GluMet: 0.498 ± 0.695
0.996GluAsn: 0.996 ± 0.671
3.984GluPro: 3.984 ± 0.65
0.996GluGln: 0.996 ± 0.671
2.988GluArg: 2.988 ± 1.315
4.482GluSer: 4.482 ± 1.301
2.988GluThr: 2.988 ± 0.926
5.478GluVal: 5.478 ± 0.717
2.49GluTrp: 2.49 ± 0.676
1.494GluTyr: 1.494 ± 0.502
0.0GluXaa: 0.0 ± 0.0
Phe
2.49PheAla: 2.49 ± 0.76
1.992PheCys: 1.992 ± 0.591
0.996PheAsp: 0.996 ± 0.671
0.498PheGlu: 0.498 ± 0.73
0.0PhePhe: 0.0 ± 0.0
3.984PheGly: 3.984 ± 1.426
0.498PheHis: 0.498 ± 0.73
1.992PheIle: 1.992 ± 0.712
1.494PheLys: 1.494 ± 0.758
0.996PheLeu: 0.996 ± 0.356
0.498PheMet: 0.498 ± 0.323
0.996PheAsn: 0.996 ± 0.356
0.0PhePro: 0.0 ± 0.0
0.498PheGln: 0.498 ± 0.323
2.49PheArg: 2.49 ± 1.204
1.494PheSer: 1.494 ± 0.463
1.494PheThr: 1.494 ± 1.292
2.49PheVal: 2.49 ± 1.246
0.498PheTrp: 0.498 ± 0.323
0.498PheTyr: 0.498 ± 0.695
0.0PheXaa: 0.0 ± 0.0
Gly
6.474GlyAla: 6.474 ± 1.665
1.992GlyCys: 1.992 ± 0.973
2.49GlyAsp: 2.49 ± 0.676
4.98GlyGlu: 4.98 ± 1.252
3.486GlyPhe: 3.486 ± 1.223
5.478GlyGly: 5.478 ± 1.87
0.996GlyHis: 0.996 ± 0.646
0.996GlyIle: 0.996 ± 0.745
5.976GlyLys: 5.976 ± 0.624
4.482GlyLeu: 4.482 ± 0.434
3.984GlyMet: 3.984 ± 0.681
1.992GlyAsn: 1.992 ± 0.935
1.992GlyPro: 1.992 ± 1.159
0.498GlyGln: 0.498 ± 0.323
4.98GlyArg: 4.98 ± 1.343
9.462GlySer: 9.462 ± 2.226
2.988GlyThr: 2.988 ± 0.942
6.972GlyVal: 6.972 ± 1.562
2.49GlyTrp: 2.49 ± 0.676
2.988GlyTyr: 2.988 ± 1.476
0.0GlyXaa: 0.0 ± 0.0
His
0.0HisAla: 0.0 ± 0.0
0.498HisCys: 0.498 ± 0.73
0.996HisAsp: 0.996 ± 0.356
0.498HisGlu: 0.498 ± 0.323
0.0HisPhe: 0.0 ± 0.0
1.992HisGly: 1.992 ± 0.591
0.0HisHis: 0.0 ± 0.0
0.0HisIle: 0.0 ± 0.0
0.498HisLys: 0.498 ± 0.73
1.992HisLeu: 1.992 ± 0.714
1.494HisMet: 1.494 ± 1.338
0.0HisAsn: 0.0 ± 0.0
1.494HisPro: 1.494 ± 0.671
2.988HisGln: 2.988 ± 1.177
0.996HisArg: 0.996 ± 0.646
0.996HisSer: 0.996 ± 0.671
0.996HisThr: 0.996 ± 0.356
2.49HisVal: 2.49 ± 0.76
0.498HisTrp: 0.498 ± 0.323
0.996HisTyr: 0.996 ± 0.356
0.0HisXaa: 0.0 ± 0.0
Ile
1.494IleAla: 1.494 ± 0.969
2.988IleCys: 2.988 ± 0.404
3.984IleAsp: 3.984 ± 1.182
4.482IleGlu: 4.482 ± 1.388
0.498IlePhe: 0.498 ± 0.323
3.486IleGly: 3.486 ± 0.51
1.992IleHis: 1.992 ± 0.973
2.988IleIle: 2.988 ± 0.709
2.49IleLys: 2.49 ± 0.524
3.486IleLeu: 3.486 ± 1.31
0.0IleMet: 0.0 ± 0.0
1.494IleAsn: 1.494 ± 0.463
1.494IlePro: 1.494 ± 0.463
1.992IleGln: 1.992 ± 0.591
1.494IleArg: 1.494 ± 0.731
4.482IleSer: 4.482 ± 0.434
3.984IleThr: 3.984 ± 1.501
1.992IleVal: 1.992 ± 0.712
1.494IleTrp: 1.494 ± 0.463
0.996IleTyr: 0.996 ± 0.646
0.0IleXaa: 0.0 ± 0.0
Lys
4.98LysAla: 4.98 ± 0.967
1.494LysCys: 1.494 ± 0.671
1.494LysAsp: 1.494 ± 0.463
3.486LysGlu: 3.486 ± 1.482
2.988LysPhe: 2.988 ± 0.926
5.976LysGly: 5.976 ± 1.191
2.49LysHis: 2.49 ± 1.204
4.482LysIle: 4.482 ± 1.677
1.992LysLys: 1.992 ± 1.357
7.47LysLeu: 7.47 ± 2.257
0.996LysMet: 0.996 ± 0.636
0.498LysAsn: 0.498 ± 0.695
2.988LysPro: 2.988 ± 1.177
1.992LysGln: 1.992 ± 0.771
2.49LysArg: 2.49 ± 0.787
2.49LysSer: 2.49 ± 0.521
0.996LysThr: 0.996 ± 0.356
3.486LysVal: 3.486 ± 0.403
0.996LysTrp: 0.996 ± 1.044
3.486LysTyr: 3.486 ± 0.771
0.0LysXaa: 0.0 ± 0.0
Leu
5.478LeuAla: 5.478 ± 2.182
1.494LeuCys: 1.494 ± 1.365
2.988LeuAsp: 2.988 ± 1.067
4.482LeuGlu: 4.482 ± 1.184
0.996LeuPhe: 0.996 ± 0.671
4.98LeuGly: 4.98 ± 1.252
0.0LeuHis: 0.0 ± 0.0
5.478LeuIle: 5.478 ± 1.008
7.47LeuLys: 7.47 ± 2.411
8.964LeuLeu: 8.964 ± 3.056
0.996LeuMet: 0.996 ± 0.659
4.482LeuAsn: 4.482 ± 0.46
3.984LeuPro: 3.984 ± 1.197
1.494LeuGln: 1.494 ± 2.084
5.976LeuArg: 5.976 ± 2.008
6.972LeuSer: 6.972 ± 2.118
5.478LeuThr: 5.478 ± 0.878
10.956LeuVal: 10.956 ± 2.268
2.49LeuTrp: 2.49 ± 0.676
2.988LeuTyr: 2.988 ± 1.067
0.0LeuXaa: 0.0 ± 0.0
Met
1.494MetAla: 1.494 ± 0.463
1.494MetCys: 1.494 ± 1.292
0.996MetAsp: 0.996 ± 0.356
0.996MetGlu: 0.996 ± 0.636
0.0MetPhe: 0.0 ± 0.0
2.49MetGly: 2.49 ± 0.521
0.996MetHis: 0.996 ± 0.356
0.996MetIle: 0.996 ± 0.636
0.498MetLys: 0.498 ± 0.323
2.49MetLeu: 2.49 ± 0.524
0.0MetMet: 0.0 ± 0.0
1.494MetAsn: 1.494 ± 0.502
2.49MetPro: 2.49 ± 1.032
0.0MetGln: 0.0 ± 0.0
0.498MetArg: 0.498 ± 0.323
1.494MetSer: 1.494 ± 0.671
0.996MetThr: 0.996 ± 0.356
0.996MetVal: 0.996 ± 0.356
0.0MetTrp: 0.0 ± 0.0
1.494MetTyr: 1.494 ± 0.502
0.0MetXaa: 0.0 ± 0.0
Asn
3.984AsnAla: 3.984 ± 3.095
1.494AsnCys: 1.494 ± 0.731
0.498AsnAsp: 0.498 ± 0.323
0.498AsnGlu: 0.498 ± 0.323
0.498AsnPhe: 0.498 ± 0.323
4.482AsnGly: 4.482 ± 1.436
0.996AsnHis: 0.996 ± 0.356
0.498AsnIle: 0.498 ± 0.323
3.486AsnLys: 3.486 ± 1.223
4.482AsnLeu: 4.482 ± 0.785
0.996AsnMet: 0.996 ± 0.636
0.0AsnAsn: 0.0 ± 0.0
1.494AsnPro: 1.494 ± 0.463
0.996AsnGln: 0.996 ± 0.636
1.992AsnArg: 1.992 ± 0.712
2.988AsnSer: 2.988 ± 0.77
1.494AsnThr: 1.494 ± 0.803
4.482AsnVal: 4.482 ± 1.279
1.992AsnTrp: 1.992 ± 0.806
2.988AsnTyr: 2.988 ± 0.404
0.0AsnXaa: 0.0 ± 0.0
Pro
1.992ProAla: 1.992 ± 0.935
0.996ProCys: 0.996 ± 0.671
2.49ProAsp: 2.49 ± 1.522
5.478ProGlu: 5.478 ± 1.662
0.0ProPhe: 0.0 ± 0.0
3.984ProGly: 3.984 ± 1.021
1.494ProHis: 1.494 ± 0.969
2.988ProIle: 2.988 ± 0.709
2.988ProLys: 2.988 ± 1.337
3.486ProLeu: 3.486 ± 1.092
0.0ProMet: 0.0 ± 0.0
1.494ProAsn: 1.494 ± 0.463
1.992ProPro: 1.992 ± 0.771
0.498ProGln: 0.498 ± 0.323
0.498ProArg: 0.498 ± 0.323
3.984ProSer: 3.984 ± 1.897
4.482ProThr: 4.482 ± 2.337
6.474ProVal: 6.474 ± 2.159
0.498ProTrp: 0.498 ± 0.323
0.498ProTyr: 0.498 ± 0.695
0.0ProXaa: 0.0 ± 0.0
Gln
1.992GlnAla: 1.992 ± 1.272
0.498GlnCys: 0.498 ± 0.73
0.498GlnAsp: 0.498 ± 0.323
2.49GlnGlu: 2.49 ± 0.676
0.498GlnPhe: 0.498 ± 0.323
1.992GlnGly: 1.992 ± 0.397
0.0GlnHis: 0.0 ± 0.0
0.996GlnIle: 0.996 ± 0.356
0.0GlnLys: 0.0 ± 0.0
2.988GlnLeu: 2.988 ± 0.88
0.498GlnMet: 0.498 ± 0.498
2.49GlnAsn: 2.49 ± 0.524
1.494GlnPro: 1.494 ± 0.502
0.996GlnGln: 0.996 ± 1.389
2.49GlnArg: 2.49 ± 1.032
1.494GlnSer: 1.494 ± 1.068
3.984GlnThr: 3.984 ± 1.219
1.494GlnVal: 1.494 ± 2.084
0.0GlnTrp: 0.0 ± 0.0
0.996GlnTyr: 0.996 ± 1.389
0.0GlnXaa: 0.0 ± 0.0
Arg
2.49ArgAla: 2.49 ± 1.915
1.992ArgCys: 1.992 ± 1.292
1.992ArgAsp: 1.992 ± 0.591
0.996ArgGlu: 0.996 ± 0.646
2.988ArgPhe: 2.988 ± 1.375
4.482ArgGly: 4.482 ± 0.434
0.0ArgHis: 0.0 ± 0.0
1.992ArgIle: 1.992 ± 0.953
2.988ArgLys: 2.988 ± 1.474
5.478ArgLeu: 5.478 ± 1.136
0.498ArgMet: 0.498 ± 0.323
1.992ArgAsn: 1.992 ± 0.397
0.498ArgPro: 0.498 ± 0.323
1.992ArgGln: 1.992 ± 1.471
4.482ArgArg: 4.482 ± 1.542
5.478ArgSer: 5.478 ± 0.717
1.494ArgThr: 1.494 ± 0.463
3.984ArgVal: 3.984 ± 0.963
1.992ArgTrp: 1.992 ± 0.397
2.988ArgTyr: 2.988 ± 0.88
0.0ArgXaa: 0.0 ± 0.0
Ser
6.474SerAla: 6.474 ± 0.988
0.996SerCys: 0.996 ± 0.636
2.988SerAsp: 2.988 ± 1.213
7.968SerGlu: 7.968 ± 2.297
1.992SerPhe: 1.992 ± 1.52
4.98SerGly: 4.98 ± 0.89
2.988SerHis: 2.988 ± 1.067
2.49SerIle: 2.49 ± 1.137
4.98SerLys: 4.98 ± 0.92
6.972SerLeu: 6.972 ± 1.541
0.996SerMet: 0.996 ± 0.356
5.976SerAsn: 5.976 ± 1.812
3.984SerPro: 3.984 ± 0.727
1.992SerGln: 1.992 ± 1.287
3.984SerArg: 3.984 ± 0.267
5.976SerSer: 5.976 ± 1.376
3.984SerThr: 3.984 ± 0.793
9.96SerVal: 9.96 ± 2.772
0.498SerTrp: 0.498 ± 0.323
1.992SerTyr: 1.992 ± 1.292
0.0SerXaa: 0.0 ± 0.0
Thr
7.47ThrAla: 7.47 ± 2.439
0.498ThrCys: 0.498 ± 0.323
0.996ThrAsp: 0.996 ± 0.636
3.984ThrGlu: 3.984 ± 0.752
0.996ThrPhe: 0.996 ± 0.356
6.474ThrGly: 6.474 ± 1.208
0.498ThrHis: 0.498 ± 0.695
2.49ThrIle: 2.49 ± 0.521
2.49ThrLys: 2.49 ± 1.137
2.49ThrLeu: 2.49 ± 0.985
0.996ThrMet: 0.996 ± 0.356
2.49ThrAsn: 2.49 ± 0.521
3.486ThrPro: 3.486 ± 1.203
1.992ThrGln: 1.992 ± 0.397
1.494ThrArg: 1.494 ± 1.292
5.478ThrSer: 5.478 ± 1.704
3.486ThrThr: 3.486 ± 2.404
5.478ThrVal: 5.478 ± 2.801
1.494ThrTrp: 1.494 ± 0.502
4.482ThrTyr: 4.482 ± 0.709
0.0ThrXaa: 0.0 ± 0.0
Val
5.976ValAla: 5.976 ± 1.853
2.49ValCys: 2.49 ± 0.605
6.474ValAsp: 6.474 ± 1.086
3.984ValGlu: 3.984 ± 0.953
3.486ValPhe: 3.486 ± 1.265
4.98ValGly: 4.98 ± 0.967
1.992ValHis: 1.992 ± 0.771
3.486ValIle: 3.486 ± 1.31
6.474ValLys: 6.474 ± 1.034
4.98ValLeu: 4.98 ± 2.374
2.49ValMet: 2.49 ± 0.524
3.984ValAsn: 3.984 ± 0.793
4.482ValPro: 4.482 ± 0.709
4.482ValGln: 4.482 ± 3.176
2.988ValArg: 2.988 ± 1.004
5.478ValSer: 5.478 ± 0.97
5.478ValThr: 5.478 ± 2.744
3.486ValVal: 3.486 ± 0.771
3.486ValTrp: 3.486 ± 0.742
1.494ValTyr: 1.494 ± 0.671
0.0ValXaa: 0.0 ± 0.0
Trp
1.494TrpAla: 1.494 ± 0.463
0.996TrpCys: 0.996 ± 0.671
0.498TrpAsp: 0.498 ± 0.323
0.996TrpGlu: 0.996 ± 0.671
0.0TrpPhe: 0.0 ± 0.0
1.494TrpGly: 1.494 ± 0.969
0.996TrpHis: 0.996 ± 0.356
0.498TrpIle: 0.498 ± 0.73
0.0TrpLys: 0.0 ± 0.0
2.988TrpLeu: 2.988 ± 0.404
0.0TrpMet: 0.0 ± 0.0
1.992TrpAsn: 1.992 ± 0.712
1.494TrpPro: 1.494 ± 0.758
0.0TrpGln: 0.0 ± 0.0
2.49TrpArg: 2.49 ± 1.032
3.486TrpSer: 3.486 ± 1.045
2.49TrpThr: 2.49 ± 0.76
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
2.49TrpTyr: 2.49 ± 0.605
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.486TyrAla: 3.486 ± 1.092
1.494TyrCys: 1.494 ± 0.969
2.49TyrAsp: 2.49 ± 1.929
2.988TyrGlu: 2.988 ± 1.13
1.494TyrPhe: 1.494 ± 0.463
3.984TyrGly: 3.984 ± 1.207
2.49TyrHis: 2.49 ± 0.787
0.498TyrIle: 0.498 ± 0.695
0.498TyrLys: 0.498 ± 0.323
1.992TyrLeu: 1.992 ± 0.397
0.498TyrMet: 0.498 ± 0.323
2.49TyrAsn: 2.49 ± 1.032
0.996TyrPro: 0.996 ± 0.646
0.498TyrGln: 0.498 ± 0.323
0.0TyrArg: 0.0 ± 0.0
2.988TyrSer: 2.988 ± 0.77
3.984TyrThr: 3.984 ± 0.963
1.992TyrVal: 1.992 ± 0.714
0.996TyrTrp: 0.996 ± 0.356
1.494TyrTyr: 1.494 ± 0.502
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (2009 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski