Amino acid dipepetide frequency for Streptococcus phage D4276

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.588AlaAla: 2.588 ± 0.936
0.162AlaCys: 0.162 ± 0.11
4.61AlaAsp: 4.61 ± 0.751
4.044AlaGlu: 4.044 ± 0.531
2.265AlaPhe: 2.265 ± 0.502
3.559AlaGly: 3.559 ± 0.741
0.485AlaHis: 0.485 ± 0.181
3.559AlaIle: 3.559 ± 0.596
5.419AlaLys: 5.419 ± 0.896
5.581AlaLeu: 5.581 ± 0.57
1.698AlaMet: 1.698 ± 0.346
5.338AlaAsn: 5.338 ± 0.834
1.051AlaPro: 1.051 ± 0.253
2.831AlaGln: 2.831 ± 0.552
2.993AlaArg: 2.993 ± 0.46
4.448AlaSer: 4.448 ± 0.584
3.559AlaThr: 3.559 ± 0.806
4.044AlaVal: 4.044 ± 0.639
0.971AlaTrp: 0.971 ± 0.32
2.588AlaTyr: 2.588 ± 0.476
0.0AlaXaa: 0.0 ± 0.0
Cys
0.243CysAla: 0.243 ± 0.155
0.081CysCys: 0.081 ± 0.072
0.485CysAsp: 0.485 ± 0.232
0.243CysGlu: 0.243 ± 0.171
0.404CysPhe: 0.404 ± 0.184
0.243CysGly: 0.243 ± 0.125
0.162CysHis: 0.162 ± 0.121
0.324CysIle: 0.324 ± 0.19
0.485CysLys: 0.485 ± 0.2
0.404CysLeu: 0.404 ± 0.246
0.081CysMet: 0.081 ± 0.078
0.324CysAsn: 0.324 ± 0.153
0.243CysPro: 0.243 ± 0.124
0.162CysGln: 0.162 ± 0.134
0.404CysArg: 0.404 ± 0.216
0.809CysSer: 0.809 ± 0.287
0.485CysThr: 0.485 ± 0.191
0.566CysVal: 0.566 ± 0.175
0.162CysTrp: 0.162 ± 0.12
0.324CysTyr: 0.324 ± 0.166
0.0CysXaa: 0.0 ± 0.0
Asp
3.397AspAla: 3.397 ± 0.647
0.243AspCys: 0.243 ± 0.136
4.448AspAsp: 4.448 ± 0.611
4.61AspGlu: 4.61 ± 0.614
3.478AspPhe: 3.478 ± 0.529
5.257AspGly: 5.257 ± 1.005
0.971AspHis: 0.971 ± 0.318
5.257AspIle: 5.257 ± 0.58
5.5AspLys: 5.5 ± 0.649
4.61AspLeu: 4.61 ± 0.644
1.941AspMet: 1.941 ± 0.379
3.882AspAsn: 3.882 ± 0.542
1.941AspPro: 1.941 ± 0.454
1.537AspGln: 1.537 ± 0.286
2.507AspArg: 2.507 ± 0.354
4.125AspSer: 4.125 ± 0.584
3.882AspThr: 3.882 ± 0.481
2.346AspVal: 2.346 ± 0.48
0.89AspTrp: 0.89 ± 0.26
2.831AspTyr: 2.831 ± 0.486
0.0AspXaa: 0.0 ± 0.0
Glu
4.206GluAla: 4.206 ± 0.54
0.566GluCys: 0.566 ± 0.204
3.397GluAsp: 3.397 ± 0.588
4.044GluGlu: 4.044 ± 0.652
2.588GluPhe: 2.588 ± 0.466
3.154GluGly: 3.154 ± 0.461
1.213GluHis: 1.213 ± 0.361
5.742GluIle: 5.742 ± 0.765
5.015GluLys: 5.015 ± 0.954
6.066GluLeu: 6.066 ± 0.719
2.993GluMet: 2.993 ± 0.574
4.125GluAsn: 4.125 ± 0.681
1.86GluPro: 1.86 ± 0.45
3.073GluGln: 3.073 ± 0.526
3.235GluArg: 3.235 ± 0.537
2.993GluSer: 2.993 ± 0.438
4.044GluThr: 4.044 ± 0.442
5.015GluVal: 5.015 ± 0.809
0.971GluTrp: 0.971 ± 0.269
2.912GluTyr: 2.912 ± 0.444
0.0GluXaa: 0.0 ± 0.0
Phe
2.507PheAla: 2.507 ± 0.444
0.485PheCys: 0.485 ± 0.291
3.235PheAsp: 3.235 ± 0.438
2.831PheGlu: 2.831 ± 0.532
1.294PhePhe: 1.294 ± 0.318
3.478PheGly: 3.478 ± 0.676
0.485PheHis: 0.485 ± 0.161
2.75PheIle: 2.75 ± 0.533
4.206PheLys: 4.206 ± 0.703
2.993PheLeu: 2.993 ± 0.458
0.566PheMet: 0.566 ± 0.24
3.478PheAsn: 3.478 ± 0.662
0.485PhePro: 0.485 ± 0.214
1.456PheGln: 1.456 ± 0.285
1.213PheArg: 1.213 ± 0.301
2.912PheSer: 2.912 ± 0.465
2.669PheThr: 2.669 ± 0.677
2.669PheVal: 2.669 ± 0.362
0.809PheTrp: 0.809 ± 0.218
1.618PheTyr: 1.618 ± 0.365
0.0PheXaa: 0.0 ± 0.0
Gly
3.073GlyAla: 3.073 ± 0.678
0.324GlyCys: 0.324 ± 0.14
4.206GlyAsp: 4.206 ± 0.566
2.993GlyGlu: 2.993 ± 0.525
3.154GlyPhe: 3.154 ± 0.385
4.287GlyGly: 4.287 ± 0.675
1.051GlyHis: 1.051 ± 0.248
5.5GlyIle: 5.5 ± 0.649
6.309GlyLys: 6.309 ± 0.696
5.742GlyLeu: 5.742 ± 0.783
1.537GlyMet: 1.537 ± 0.352
3.72GlyAsn: 3.72 ± 0.614
1.375GlyPro: 1.375 ± 0.709
3.316GlyGln: 3.316 ± 0.565
2.507GlyArg: 2.507 ± 0.393
3.64GlySer: 3.64 ± 0.719
3.963GlyThr: 3.963 ± 0.513
4.125GlyVal: 4.125 ± 0.64
1.294GlyTrp: 1.294 ± 0.284
3.316GlyTyr: 3.316 ± 0.511
0.0GlyXaa: 0.0 ± 0.0
His
0.647HisAla: 0.647 ± 0.235
0.081HisCys: 0.081 ± 0.078
0.971HisAsp: 0.971 ± 0.237
0.647HisGlu: 0.647 ± 0.219
0.647HisPhe: 0.647 ± 0.198
0.89HisGly: 0.89 ± 0.269
0.324HisHis: 0.324 ± 0.157
0.971HisIle: 0.971 ± 0.274
1.132HisLys: 1.132 ± 0.289
1.375HisLeu: 1.375 ± 0.285
0.081HisMet: 0.081 ± 0.079
0.89HisAsn: 0.89 ± 0.389
0.728HisPro: 0.728 ± 0.208
0.485HisGln: 0.485 ± 0.213
0.971HisArg: 0.971 ± 0.243
1.051HisSer: 1.051 ± 0.279
0.971HisThr: 0.971 ± 0.335
1.456HisVal: 1.456 ± 0.285
0.081HisTrp: 0.081 ± 0.075
0.809HisTyr: 0.809 ± 0.301
0.0HisXaa: 0.0 ± 0.0
Ile
4.448IleAla: 4.448 ± 0.805
0.485IleCys: 0.485 ± 0.178
5.662IleAsp: 5.662 ± 0.741
4.934IleGlu: 4.934 ± 0.761
1.456IlePhe: 1.456 ± 0.332
4.287IleGly: 4.287 ± 0.546
0.728IleHis: 0.728 ± 0.255
3.72IleIle: 3.72 ± 0.591
7.279IleLys: 7.279 ± 0.596
4.529IleLeu: 4.529 ± 0.714
2.184IleMet: 2.184 ± 0.468
4.368IleAsn: 4.368 ± 0.6
2.426IlePro: 2.426 ± 0.417
2.831IleGln: 2.831 ± 0.382
2.346IleArg: 2.346 ± 0.418
4.772IleSer: 4.772 ± 0.635
3.72IleThr: 3.72 ± 0.51
3.478IleVal: 3.478 ± 0.537
1.051IleTrp: 1.051 ± 0.28
2.103IleTyr: 2.103 ± 0.417
0.0IleXaa: 0.0 ± 0.0
Lys
5.176LysAla: 5.176 ± 0.507
0.485LysCys: 0.485 ± 0.245
4.772LysAsp: 4.772 ± 0.678
8.331LysGlu: 8.331 ± 0.938
3.397LysPhe: 3.397 ± 0.665
5.662LysGly: 5.662 ± 0.704
1.618LysHis: 1.618 ± 0.408
6.066LysIle: 6.066 ± 0.819
6.875LysLys: 6.875 ± 1.008
7.603LysLeu: 7.603 ± 0.89
2.426LysMet: 2.426 ± 0.484
4.772LysAsn: 4.772 ± 0.683
2.75LysPro: 2.75 ± 0.414
3.801LysGln: 3.801 ± 0.504
3.64LysArg: 3.64 ± 0.614
5.176LysSer: 5.176 ± 0.499
5.095LysThr: 5.095 ± 0.752
4.125LysVal: 4.125 ± 0.637
1.051LysTrp: 1.051 ± 0.223
5.176LysTyr: 5.176 ± 0.853
0.0LysXaa: 0.0 ± 0.0
Leu
6.066LeuAla: 6.066 ± 0.589
0.485LeuCys: 0.485 ± 0.216
5.5LeuAsp: 5.5 ± 0.729
6.47LeuGlu: 6.47 ± 0.716
2.426LeuPhe: 2.426 ± 0.36
5.742LeuGly: 5.742 ± 0.838
1.132LeuHis: 1.132 ± 0.304
3.882LeuIle: 3.882 ± 0.54
7.36LeuLys: 7.36 ± 0.617
5.662LeuLeu: 5.662 ± 0.649
2.507LeuMet: 2.507 ± 0.398
4.529LeuAsn: 4.529 ± 0.805
2.588LeuPro: 2.588 ± 0.471
2.426LeuGln: 2.426 ± 0.441
3.963LeuArg: 3.963 ± 0.574
5.419LeuSer: 5.419 ± 0.694
6.147LeuThr: 6.147 ± 0.836
4.125LeuVal: 4.125 ± 0.46
0.647LeuTrp: 0.647 ± 0.186
2.588LeuTyr: 2.588 ± 0.507
0.0LeuXaa: 0.0 ± 0.0
Met
1.86MetAla: 1.86 ± 0.391
0.162MetCys: 0.162 ± 0.116
1.375MetAsp: 1.375 ± 0.277
1.375MetGlu: 1.375 ± 0.454
1.375MetPhe: 1.375 ± 0.262
0.728MetGly: 0.728 ± 0.238
0.485MetHis: 0.485 ± 0.225
2.022MetIle: 2.022 ± 0.423
3.397MetLys: 3.397 ± 0.721
1.779MetLeu: 1.779 ± 0.279
0.89MetMet: 0.89 ± 0.249
1.537MetAsn: 1.537 ± 0.365
0.809MetPro: 0.809 ± 0.216
0.728MetGln: 0.728 ± 0.18
0.728MetArg: 0.728 ± 0.213
1.86MetSer: 1.86 ± 0.335
2.184MetThr: 2.184 ± 0.339
1.294MetVal: 1.294 ± 0.313
0.243MetTrp: 0.243 ± 0.118
0.809MetTyr: 0.809 ± 0.267
0.0MetXaa: 0.0 ± 0.0
Asn
4.529AsnAla: 4.529 ± 1.042
0.485AsnCys: 0.485 ± 0.182
2.912AsnAsp: 2.912 ± 0.381
3.801AsnGlu: 3.801 ± 0.652
3.397AsnPhe: 3.397 ± 0.424
6.066AsnGly: 6.066 ± 0.914
0.728AsnHis: 0.728 ± 0.236
3.963AsnIle: 3.963 ± 0.632
5.176AsnLys: 5.176 ± 0.615
5.5AsnLeu: 5.5 ± 0.584
1.051AsnMet: 1.051 ± 0.261
4.448AsnAsn: 4.448 ± 0.602
2.426AsnPro: 2.426 ± 0.481
3.559AsnGln: 3.559 ± 0.567
2.588AsnArg: 2.588 ± 0.471
3.559AsnSer: 3.559 ± 0.503
3.72AsnThr: 3.72 ± 0.455
2.912AsnVal: 2.912 ± 0.392
1.294AsnTrp: 1.294 ± 0.352
2.184AsnTyr: 2.184 ± 0.362
0.0AsnXaa: 0.0 ± 0.0
Pro
1.86ProAla: 1.86 ± 0.365
0.162ProCys: 0.162 ± 0.144
1.456ProAsp: 1.456 ± 0.428
2.184ProGlu: 2.184 ± 0.37
1.375ProPhe: 1.375 ± 0.324
0.89ProGly: 0.89 ± 0.36
0.404ProHis: 0.404 ± 0.14
1.537ProIle: 1.537 ± 0.373
3.397ProLys: 3.397 ± 0.473
2.022ProLeu: 2.022 ± 0.338
0.081ProMet: 0.081 ± 0.067
2.669ProAsn: 2.669 ± 0.424
0.485ProPro: 0.485 ± 0.254
1.779ProGln: 1.779 ± 0.449
0.728ProArg: 0.728 ± 0.369
2.265ProSer: 2.265 ± 0.372
1.941ProThr: 1.941 ± 0.386
1.132ProVal: 1.132 ± 0.36
0.728ProTrp: 0.728 ± 0.217
1.132ProTyr: 1.132 ± 0.301
0.0ProXaa: 0.0 ± 0.0
Gln
4.125GlnAla: 4.125 ± 0.53
0.081GlnCys: 0.081 ± 0.074
2.831GlnAsp: 2.831 ± 0.461
3.235GlnGlu: 3.235 ± 0.601
1.86GlnPhe: 1.86 ± 0.519
3.559GlnGly: 3.559 ± 0.864
0.243GlnHis: 0.243 ± 0.149
2.265GlnIle: 2.265 ± 0.448
3.073GlnLys: 3.073 ± 0.607
3.154GlnLeu: 3.154 ± 0.466
1.375GlnMet: 1.375 ± 0.283
2.346GlnAsn: 2.346 ± 0.434
0.566GlnPro: 0.566 ± 0.206
3.154GlnGln: 3.154 ± 0.629
1.86GlnArg: 1.86 ± 0.343
2.184GlnSer: 2.184 ± 0.387
2.831GlnThr: 2.831 ± 0.366
2.265GlnVal: 2.265 ± 0.543
0.566GlnTrp: 0.566 ± 0.272
1.941GlnTyr: 1.941 ± 0.316
0.0GlnXaa: 0.0 ± 0.0
Arg
2.184ArgAla: 2.184 ± 0.3
0.081ArgCys: 0.081 ± 0.072
2.507ArgAsp: 2.507 ± 0.468
2.507ArgGlu: 2.507 ± 0.519
2.184ArgPhe: 2.184 ± 0.426
2.669ArgGly: 2.669 ± 0.461
0.89ArgHis: 0.89 ± 0.232
3.073ArgIle: 3.073 ± 0.489
3.559ArgLys: 3.559 ± 0.547
3.801ArgLeu: 3.801 ± 0.646
0.728ArgMet: 0.728 ± 0.237
2.507ArgAsn: 2.507 ± 0.397
1.051ArgPro: 1.051 ± 0.226
2.265ArgGln: 2.265 ± 0.414
1.213ArgArg: 1.213 ± 0.319
1.618ArgSer: 1.618 ± 0.348
2.426ArgThr: 2.426 ± 0.631
2.75ArgVal: 2.75 ± 0.341
0.89ArgTrp: 0.89 ± 0.222
2.184ArgTyr: 2.184 ± 0.471
0.0ArgXaa: 0.0 ± 0.0
Ser
2.831SerAla: 2.831 ± 0.39
0.647SerCys: 0.647 ± 0.26
4.448SerAsp: 4.448 ± 0.469
3.72SerGlu: 3.72 ± 0.429
2.669SerPhe: 2.669 ± 0.382
4.125SerGly: 4.125 ± 0.603
1.051SerHis: 1.051 ± 0.271
5.095SerIle: 5.095 ± 0.565
5.581SerLys: 5.581 ± 0.686
4.61SerLeu: 4.61 ± 0.488
1.779SerMet: 1.779 ± 0.333
4.125SerAsn: 4.125 ± 0.492
1.941SerPro: 1.941 ± 0.311
2.669SerGln: 2.669 ± 0.533
3.073SerArg: 3.073 ± 0.572
2.831SerSer: 2.831 ± 0.619
3.397SerThr: 3.397 ± 0.462
4.529SerVal: 4.529 ± 0.636
0.647SerTrp: 0.647 ± 0.208
2.588SerTyr: 2.588 ± 0.434
0.0SerXaa: 0.0 ± 0.0
Thr
4.368ThrAla: 4.368 ± 0.621
0.404ThrCys: 0.404 ± 0.221
3.559ThrAsp: 3.559 ± 0.603
3.72ThrGlu: 3.72 ± 0.563
2.426ThrPhe: 2.426 ± 0.525
4.206ThrGly: 4.206 ± 0.476
0.809ThrHis: 0.809 ± 0.233
4.368ThrIle: 4.368 ± 0.598
5.176ThrLys: 5.176 ± 0.559
5.904ThrLeu: 5.904 ± 0.598
1.132ThrMet: 1.132 ± 0.299
4.368ThrAsn: 4.368 ± 0.659
1.618ThrPro: 1.618 ± 0.415
2.912ThrGln: 2.912 ± 0.515
1.941ThrArg: 1.941 ± 0.312
3.559ThrSer: 3.559 ± 0.422
3.882ThrThr: 3.882 ± 0.583
3.235ThrVal: 3.235 ± 0.474
1.051ThrTrp: 1.051 ± 0.333
3.64ThrTyr: 3.64 ± 0.544
0.0ThrXaa: 0.0 ± 0.0
Val
4.287ValAla: 4.287 ± 0.69
0.485ValCys: 0.485 ± 0.189
3.72ValAsp: 3.72 ± 0.564
3.963ValGlu: 3.963 ± 0.686
3.154ValPhe: 3.154 ± 0.566
3.559ValGly: 3.559 ± 0.415
0.728ValHis: 0.728 ± 0.2
3.154ValIle: 3.154 ± 0.409
4.529ValLys: 4.529 ± 0.48
3.316ValLeu: 3.316 ± 0.598
0.809ValMet: 0.809 ± 0.247
3.478ValAsn: 3.478 ± 0.563
2.265ValPro: 2.265 ± 0.375
1.86ValGln: 1.86 ± 0.4
2.022ValArg: 2.022 ± 0.422
5.095ValSer: 5.095 ± 0.611
4.529ValThr: 4.529 ± 0.551
3.073ValVal: 3.073 ± 0.514
0.809ValTrp: 0.809 ± 0.207
2.346ValTyr: 2.346 ± 0.42
0.0ValXaa: 0.0 ± 0.0
Trp
0.566TrpAla: 0.566 ± 0.193
0.081TrpCys: 0.081 ± 0.092
1.051TrpAsp: 1.051 ± 0.395
0.971TrpGlu: 0.971 ± 0.244
0.485TrpPhe: 0.485 ± 0.17
0.485TrpGly: 0.485 ± 0.167
0.324TrpHis: 0.324 ± 0.138
0.647TrpIle: 0.647 ± 0.172
1.213TrpLys: 1.213 ± 0.334
1.213TrpLeu: 1.213 ± 0.329
0.162TrpMet: 0.162 ± 0.115
1.051TrpAsn: 1.051 ± 0.322
0.162TrpPro: 0.162 ± 0.116
0.485TrpGln: 0.485 ± 0.253
0.971TrpArg: 0.971 ± 0.295
1.537TrpSer: 1.537 ± 0.386
1.051TrpThr: 1.051 ± 0.447
1.213TrpVal: 1.213 ± 0.26
0.162TrpTrp: 0.162 ± 0.093
0.728TrpTyr: 0.728 ± 0.253
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.831TyrAla: 2.831 ± 0.5
0.647TyrCys: 0.647 ± 0.228
2.588TyrAsp: 2.588 ± 0.455
2.588TyrGlu: 2.588 ± 0.523
2.103TyrPhe: 2.103 ± 0.413
2.588TyrGly: 2.588 ± 0.588
1.375TyrHis: 1.375 ± 0.318
2.912TyrIle: 2.912 ± 0.541
3.316TyrLys: 3.316 ± 0.506
3.801TyrLeu: 3.801 ± 0.465
1.537TyrMet: 1.537 ± 0.385
2.346TyrAsn: 2.346 ± 0.425
1.456TyrPro: 1.456 ± 0.339
2.184TyrGln: 2.184 ± 0.348
2.184TyrArg: 2.184 ± 0.357
2.507TyrSer: 2.507 ± 0.522
1.779TyrThr: 1.779 ± 0.404
2.831TyrVal: 2.831 ± 0.438
0.243TyrTrp: 0.243 ± 0.121
2.507TyrTyr: 2.507 ± 0.612
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 54 proteins (12365 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski