Amino acid dipepetide frequency for Marinitoga camini virus 1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.631AlaAla: 1.631 ± 0.336
0.125AlaCys: 0.125 ± 0.084
2.384AlaAsp: 2.384 ± 0.486
3.387AlaGlu: 3.387 ± 0.388
2.509AlaPhe: 2.509 ± 0.592
3.136AlaGly: 3.136 ± 0.746
0.69AlaHis: 0.69 ± 0.198
5.018AlaIle: 5.018 ± 0.653
5.395AlaLys: 5.395 ± 0.453
4.767AlaLeu: 4.767 ± 0.82
1.004AlaMet: 1.004 ± 0.303
3.136AlaAsn: 3.136 ± 0.513
0.941AlaPro: 0.941 ± 0.255
0.815AlaGln: 0.815 ± 0.24
2.258AlaArg: 2.258 ± 0.347
2.07AlaSer: 2.07 ± 0.39
3.199AlaThr: 3.199 ± 0.494
2.321AlaVal: 2.321 ± 0.384
0.502AlaTrp: 0.502 ± 0.21
2.258AlaTyr: 2.258 ± 0.388
0.0AlaXaa: 0.0 ± 0.0
Cys
0.251CysAla: 0.251 ± 0.122
0.0CysCys: 0.0 ± 0.0
0.125CysAsp: 0.125 ± 0.08
0.251CysGlu: 0.251 ± 0.144
0.125CysPhe: 0.125 ± 0.09
0.376CysGly: 0.376 ± 0.141
0.125CysHis: 0.125 ± 0.093
0.376CysIle: 0.376 ± 0.144
0.376CysLys: 0.376 ± 0.162
0.188CysLeu: 0.188 ± 0.105
0.125CysMet: 0.125 ± 0.085
0.376CysAsn: 0.376 ± 0.188
0.565CysPro: 0.565 ± 0.203
0.251CysGln: 0.251 ± 0.127
0.063CysArg: 0.063 ± 0.056
0.439CysSer: 0.439 ± 0.176
0.063CysThr: 0.063 ± 0.063
0.376CysVal: 0.376 ± 0.178
0.063CysTrp: 0.063 ± 0.058
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
2.823AspAla: 2.823 ± 0.454
0.188AspCys: 0.188 ± 0.118
3.011AspAsp: 3.011 ± 0.375
4.642AspGlu: 4.642 ± 0.536
3.513AspPhe: 3.513 ± 0.411
3.575AspGly: 3.575 ± 0.555
0.69AspHis: 0.69 ± 0.246
5.332AspIle: 5.332 ± 0.609
4.454AspLys: 4.454 ± 0.516
5.708AspLeu: 5.708 ± 0.603
1.129AspMet: 1.129 ± 0.22
3.575AspAsn: 3.575 ± 0.494
1.568AspPro: 1.568 ± 0.24
0.878AspGln: 0.878 ± 0.228
1.631AspArg: 1.631 ± 0.253
2.321AspSer: 2.321 ± 0.399
2.509AspThr: 2.509 ± 0.404
3.45AspVal: 3.45 ± 0.47
0.815AspTrp: 0.815 ± 0.253
3.638AspTyr: 3.638 ± 0.569
0.0AspXaa: 0.0 ± 0.0
Glu
2.885GluAla: 2.885 ± 0.345
0.565GluCys: 0.565 ± 0.248
4.516GluAsp: 4.516 ± 0.582
6.524GluGlu: 6.524 ± 0.762
3.826GluPhe: 3.826 ± 0.522
3.387GluGly: 3.387 ± 0.411
1.004GluHis: 1.004 ± 0.196
10.35GluIle: 10.35 ± 1.06
11.667GluLys: 11.667 ± 1.284
7.653GluLeu: 7.653 ± 0.711
1.756GluMet: 1.756 ± 0.3
7.339GluAsn: 7.339 ± 0.632
2.07GluPro: 2.07 ± 0.404
2.258GluGln: 2.258 ± 0.457
2.258GluArg: 2.258 ± 0.398
3.826GluSer: 3.826 ± 0.465
3.575GluThr: 3.575 ± 0.564
3.325GluVal: 3.325 ± 0.475
0.941GluTrp: 0.941 ± 0.235
3.701GluTyr: 3.701 ± 0.408
0.0GluXaa: 0.0 ± 0.0
Phe
2.76PheAla: 2.76 ± 0.681
0.125PheCys: 0.125 ± 0.086
4.328PheAsp: 4.328 ± 0.452
4.077PheGlu: 4.077 ± 0.395
2.384PhePhe: 2.384 ± 0.548
2.635PheGly: 2.635 ± 0.636
0.565PheHis: 0.565 ± 0.195
3.387PheIle: 3.387 ± 0.473
5.52PheLys: 5.52 ± 0.678
4.454PheLeu: 4.454 ± 0.487
0.878PheMet: 0.878 ± 0.234
2.948PheAsn: 2.948 ± 0.384
1.192PhePro: 1.192 ± 0.244
1.756PheGln: 1.756 ± 0.424
1.694PheArg: 1.694 ± 0.361
3.011PheSer: 3.011 ± 0.469
1.819PheThr: 1.819 ± 0.531
2.384PheVal: 2.384 ± 0.369
0.753PheTrp: 0.753 ± 0.197
2.133PheTyr: 2.133 ± 0.336
0.0PheXaa: 0.0 ± 0.0
Gly
2.823GlyAla: 2.823 ± 0.714
0.125GlyCys: 0.125 ± 0.087
2.948GlyAsp: 2.948 ± 0.431
3.199GlyGlu: 3.199 ± 0.426
2.07GlyPhe: 2.07 ± 0.383
2.07GlyGly: 2.07 ± 0.435
0.376GlyHis: 0.376 ± 0.161
5.332GlyIle: 5.332 ± 0.463
5.834GlyLys: 5.834 ± 0.572
4.077GlyLeu: 4.077 ± 0.422
1.004GlyMet: 1.004 ± 0.255
3.889GlyAsn: 3.889 ± 0.425
1.066GlyPro: 1.066 ± 0.295
1.129GlyGln: 1.129 ± 0.302
2.195GlyArg: 2.195 ± 0.332
3.011GlySer: 3.011 ± 0.628
3.387GlyThr: 3.387 ± 0.603
3.136GlyVal: 3.136 ± 0.514
0.439GlyTrp: 0.439 ± 0.126
2.572GlyTyr: 2.572 ± 0.408
0.0GlyXaa: 0.0 ± 0.0
His
0.753HisAla: 0.753 ± 0.177
0.125HisCys: 0.125 ± 0.131
0.815HisAsp: 0.815 ± 0.243
0.627HisGlu: 0.627 ± 0.211
0.815HisPhe: 0.815 ± 0.22
0.565HisGly: 0.565 ± 0.187
0.188HisHis: 0.188 ± 0.105
1.317HisIle: 1.317 ± 0.26
1.004HisLys: 1.004 ± 0.25
0.878HisLeu: 0.878 ± 0.27
0.376HisMet: 0.376 ± 0.129
0.815HisAsn: 0.815 ± 0.26
0.69HisPro: 0.69 ± 0.192
0.439HisGln: 0.439 ± 0.199
0.439HisArg: 0.439 ± 0.174
1.066HisSer: 1.066 ± 0.337
0.753HisThr: 0.753 ± 0.282
0.502HisVal: 0.502 ± 0.145
0.188HisTrp: 0.188 ± 0.106
0.69HisTyr: 0.69 ± 0.178
0.0HisXaa: 0.0 ± 0.0
Ile
4.642IleAla: 4.642 ± 0.648
0.565IleCys: 0.565 ± 0.248
6.022IleAsp: 6.022 ± 0.707
9.095IleGlu: 9.095 ± 1.02
4.705IlePhe: 4.705 ± 0.58
4.705IleGly: 4.705 ± 0.524
0.878IleHis: 0.878 ± 0.28
8.594IleIle: 8.594 ± 0.931
11.793IleLys: 11.793 ± 0.993
9.221IleLeu: 9.221 ± 0.836
1.756IleMet: 1.756 ± 0.346
6.586IleAsn: 6.586 ± 0.544
4.265IlePro: 4.265 ± 0.465
3.45IleGln: 3.45 ± 0.491
3.199IleArg: 3.199 ± 0.443
8.28IleSer: 8.28 ± 0.768
5.708IleThr: 5.708 ± 0.675
4.454IleVal: 4.454 ± 0.536
0.502IleTrp: 0.502 ± 0.178
4.454IleTyr: 4.454 ± 0.487
0.0IleXaa: 0.0 ± 0.0
Lys
4.642LysAla: 4.642 ± 0.464
0.376LysCys: 0.376 ± 0.14
5.583LysAsp: 5.583 ± 0.463
10.225LysGlu: 10.225 ± 0.99
4.83LysPhe: 4.83 ± 0.577
4.642LysGly: 4.642 ± 0.546
1.38LysHis: 1.38 ± 0.329
14.239LysIle: 14.239 ± 1.139
12.671LysLys: 12.671 ± 1.298
9.095LysLeu: 9.095 ± 0.795
2.258LysMet: 2.258 ± 0.352
8.092LysAsn: 8.092 ± 0.711
2.321LysPro: 2.321 ± 0.422
3.45LysGln: 3.45 ± 0.61
3.701LysArg: 3.701 ± 0.517
4.705LysSer: 4.705 ± 0.575
5.834LysThr: 5.834 ± 0.591
5.018LysVal: 5.018 ± 0.52
0.878LysTrp: 0.878 ± 0.262
6.147LysTyr: 6.147 ± 0.632
0.0LysXaa: 0.0 ± 0.0
Leu
3.889LeuAla: 3.889 ± 0.449
0.502LeuCys: 0.502 ± 0.174
4.955LeuAsp: 4.955 ± 0.534
7.402LeuGlu: 7.402 ± 0.867
3.638LeuPhe: 3.638 ± 0.508
4.767LeuGly: 4.767 ± 0.695
0.878LeuHis: 0.878 ± 0.274
8.092LeuIle: 8.092 ± 0.644
11.103LeuLys: 11.103 ± 0.949
6.586LeuLeu: 6.586 ± 0.719
1.568LeuMet: 1.568 ± 0.305
7.025LeuAsn: 7.025 ± 0.531
2.572LeuPro: 2.572 ± 0.448
3.387LeuGln: 3.387 ± 0.55
3.45LeuArg: 3.45 ± 0.44
4.705LeuSer: 4.705 ± 0.663
4.955LeuThr: 4.955 ± 0.514
4.642LeuVal: 4.642 ± 0.503
0.878LeuTrp: 0.878 ± 0.365
3.826LeuTyr: 3.826 ± 0.556
0.0LeuXaa: 0.0 ± 0.0
Met
1.505MetAla: 1.505 ± 0.31
0.125MetCys: 0.125 ± 0.088
0.753MetAsp: 0.753 ± 0.201
1.882MetGlu: 1.882 ± 0.329
1.129MetPhe: 1.129 ± 0.245
1.129MetGly: 1.129 ± 0.25
0.376MetHis: 0.376 ± 0.176
1.505MetIle: 1.505 ± 0.359
2.885MetLys: 2.885 ± 0.414
1.317MetLeu: 1.317 ± 0.24
0.188MetMet: 0.188 ± 0.114
1.129MetAsn: 1.129 ± 0.231
0.69MetPro: 0.69 ± 0.227
0.753MetGln: 0.753 ± 0.213
0.815MetArg: 0.815 ± 0.215
1.192MetSer: 1.192 ± 0.208
0.878MetThr: 0.878 ± 0.187
0.753MetVal: 0.753 ± 0.217
0.063MetTrp: 0.063 ± 0.059
1.004MetTyr: 1.004 ± 0.248
0.0MetXaa: 0.0 ± 0.0
Asn
3.575AsnAla: 3.575 ± 0.635
0.439AsnCys: 0.439 ± 0.186
3.575AsnAsp: 3.575 ± 0.571
5.52AsnGlu: 5.52 ± 0.601
3.826AsnPhe: 3.826 ± 0.539
4.265AsnGly: 4.265 ± 0.538
1.38AsnHis: 1.38 ± 0.317
7.151AsnIle: 7.151 ± 0.676
7.59AsnLys: 7.59 ± 0.794
7.402AsnLeu: 7.402 ± 0.658
1.192AsnMet: 1.192 ± 0.238
5.52AsnAsn: 5.52 ± 0.817
1.694AsnPro: 1.694 ± 0.317
1.819AsnGln: 1.819 ± 0.301
2.007AsnArg: 2.007 ± 0.31
4.265AsnSer: 4.265 ± 0.473
3.011AsnThr: 3.011 ± 0.375
2.76AsnVal: 2.76 ± 0.413
1.255AsnTrp: 1.255 ± 0.363
3.136AsnTyr: 3.136 ± 0.375
0.0AsnXaa: 0.0 ± 0.0
Pro
1.505ProAla: 1.505 ± 0.323
0.0ProCys: 0.0 ± 0.0
2.007ProAsp: 2.007 ± 0.449
2.635ProGlu: 2.635 ± 0.377
1.505ProPhe: 1.505 ± 0.323
0.69ProGly: 0.69 ± 0.22
0.314ProHis: 0.314 ± 0.157
3.011ProIle: 3.011 ± 0.464
2.321ProLys: 2.321 ± 0.403
1.945ProLeu: 1.945 ± 0.329
0.188ProMet: 0.188 ± 0.106
2.195ProAsn: 2.195 ± 0.375
0.815ProPro: 0.815 ± 0.212
0.815ProGln: 0.815 ± 0.204
0.439ProArg: 0.439 ± 0.168
1.505ProSer: 1.505 ± 0.313
1.443ProThr: 1.443 ± 0.426
2.007ProVal: 2.007 ± 0.377
0.439ProTrp: 0.439 ± 0.143
1.38ProTyr: 1.38 ± 0.256
0.0ProXaa: 0.0 ± 0.0
Gln
1.505GlnAla: 1.505 ± 0.504
0.188GlnCys: 0.188 ± 0.115
0.941GlnAsp: 0.941 ± 0.207
2.509GlnGlu: 2.509 ± 0.371
1.129GlnPhe: 1.129 ± 0.281
1.129GlnGly: 1.129 ± 0.281
0.314GlnHis: 0.314 ± 0.141
3.387GlnIle: 3.387 ± 0.484
3.575GlnLys: 3.575 ± 0.418
3.638GlnLeu: 3.638 ± 0.523
0.565GlnMet: 0.565 ± 0.144
2.823GlnAsn: 2.823 ± 0.352
0.439GlnPro: 0.439 ± 0.164
1.004GlnGln: 1.004 ± 0.248
1.192GlnArg: 1.192 ± 0.247
0.941GlnSer: 0.941 ± 0.379
2.007GlnThr: 2.007 ± 0.366
1.38GlnVal: 1.38 ± 0.262
0.439GlnTrp: 0.439 ± 0.149
1.129GlnTyr: 1.129 ± 0.297
0.0GlnXaa: 0.0 ± 0.0
Arg
1.505ArgAla: 1.505 ± 0.351
0.188ArgCys: 0.188 ± 0.098
1.255ArgAsp: 1.255 ± 0.312
2.509ArgGlu: 2.509 ± 0.486
1.505ArgPhe: 1.505 ± 0.301
1.756ArgGly: 1.756 ± 0.319
0.565ArgHis: 0.565 ± 0.194
3.764ArgIle: 3.764 ± 0.559
4.203ArgLys: 4.203 ± 0.628
2.446ArgLeu: 2.446 ± 0.383
1.443ArgMet: 1.443 ± 0.278
1.945ArgAsn: 1.945 ± 0.406
0.815ArgPro: 0.815 ± 0.279
1.505ArgGln: 1.505 ± 0.252
1.568ArgArg: 1.568 ± 0.346
1.192ArgSer: 1.192 ± 0.255
1.945ArgThr: 1.945 ± 0.291
1.505ArgVal: 1.505 ± 0.384
0.565ArgTrp: 0.565 ± 0.159
1.004ArgTyr: 1.004 ± 0.252
0.0ArgXaa: 0.0 ± 0.0
Ser
3.074SerAla: 3.074 ± 0.594
0.188SerCys: 0.188 ± 0.109
2.76SerAsp: 2.76 ± 0.474
4.893SerGlu: 4.893 ± 0.578
2.948SerPhe: 2.948 ± 0.491
3.701SerGly: 3.701 ± 0.639
1.004SerHis: 1.004 ± 0.406
6.085SerIle: 6.085 ± 0.64
5.081SerLys: 5.081 ± 0.568
5.018SerLeu: 5.018 ± 0.548
1.192SerMet: 1.192 ± 0.311
3.826SerAsn: 3.826 ± 0.64
0.941SerPro: 0.941 ± 0.29
1.505SerGln: 1.505 ± 0.305
1.129SerArg: 1.129 ± 0.306
3.952SerSer: 3.952 ± 0.751
2.572SerThr: 2.572 ± 0.408
2.635SerVal: 2.635 ± 0.404
0.753SerTrp: 0.753 ± 0.205
1.945SerTyr: 1.945 ± 0.306
0.0SerXaa: 0.0 ± 0.0
Thr
2.446ThrAla: 2.446 ± 0.611
0.188ThrCys: 0.188 ± 0.098
2.446ThrAsp: 2.446 ± 0.448
4.203ThrGlu: 4.203 ± 0.638
2.321ThrPhe: 2.321 ± 0.351
3.575ThrGly: 3.575 ± 0.523
1.066ThrHis: 1.066 ± 0.261
5.457ThrIle: 5.457 ± 0.629
4.265ThrLys: 4.265 ± 0.509
4.83ThrLeu: 4.83 ± 0.608
0.878ThrMet: 0.878 ± 0.252
3.262ThrAsn: 3.262 ± 0.777
1.945ThrPro: 1.945 ± 0.284
2.007ThrGln: 2.007 ± 0.408
1.38ThrArg: 1.38 ± 0.27
2.321ThrSer: 2.321 ± 0.364
4.203ThrThr: 4.203 ± 0.649
3.011ThrVal: 3.011 ± 0.661
0.815ThrTrp: 0.815 ± 0.194
1.694ThrTyr: 1.694 ± 0.295
0.0ThrXaa: 0.0 ± 0.0
Val
3.136ValAla: 3.136 ± 0.739
0.376ValCys: 0.376 ± 0.14
3.199ValAsp: 3.199 ± 0.364
4.83ValGlu: 4.83 ± 0.656
2.635ValPhe: 2.635 ± 0.408
2.572ValGly: 2.572 ± 0.372
0.627ValHis: 0.627 ± 0.189
4.579ValIle: 4.579 ± 0.518
4.705ValLys: 4.705 ± 0.472
4.015ValLeu: 4.015 ± 0.517
1.255ValMet: 1.255 ± 0.255
3.513ValAsn: 3.513 ± 0.472
1.004ValPro: 1.004 ± 0.258
1.882ValGln: 1.882 ± 0.326
1.882ValArg: 1.882 ± 0.296
2.885ValSer: 2.885 ± 0.436
1.756ValThr: 1.756 ± 0.343
2.572ValVal: 2.572 ± 0.466
0.439ValTrp: 0.439 ± 0.167
1.443ValTyr: 1.443 ± 0.212
0.0ValXaa: 0.0 ± 0.0
Trp
0.314TrpAla: 0.314 ± 0.162
0.063TrpCys: 0.063 ± 0.061
0.878TrpAsp: 0.878 ± 0.302
1.255TrpGlu: 1.255 ± 0.263
1.004TrpPhe: 1.004 ± 0.612
0.376TrpGly: 0.376 ± 0.143
0.0TrpHis: 0.0 ± 0.0
1.066TrpIle: 1.066 ± 0.373
1.38TrpLys: 1.38 ± 0.264
0.941TrpLeu: 0.941 ± 0.241
0.251TrpMet: 0.251 ± 0.118
0.878TrpAsn: 0.878 ± 0.193
0.063TrpPro: 0.063 ± 0.058
0.125TrpGln: 0.125 ± 0.07
0.251TrpArg: 0.251 ± 0.13
0.69TrpSer: 0.69 ± 0.201
0.565TrpThr: 0.565 ± 0.211
0.878TrpVal: 0.878 ± 0.218
0.063TrpTrp: 0.063 ± 0.063
0.188TrpTyr: 0.188 ± 0.092
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.882TyrAla: 1.882 ± 0.383
0.063TyrCys: 0.063 ± 0.053
3.011TyrAsp: 3.011 ± 0.391
3.764TyrGlu: 3.764 ± 0.46
2.384TyrPhe: 2.384 ± 0.481
1.631TyrGly: 1.631 ± 0.292
0.627TyrHis: 0.627 ± 0.164
4.83TyrIle: 4.83 ± 0.602
4.265TyrLys: 4.265 ± 0.593
4.642TyrLeu: 4.642 ± 0.678
1.004TyrMet: 1.004 ± 0.24
2.509TyrAsn: 2.509 ± 0.388
1.505TyrPro: 1.505 ± 0.268
1.004TyrGln: 1.004 ± 0.244
1.631TyrArg: 1.631 ± 0.37
2.823TyrSer: 2.823 ± 0.494
2.133TyrThr: 2.133 ± 0.342
2.195TyrVal: 2.195 ± 0.394
0.439TyrTrp: 0.439 ± 0.154
2.321TyrTyr: 2.321 ± 0.426
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 77 proteins (15943 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski