Amino acid dipepetide frequency for Enterobacteria phage GA (Bacteriophage GA)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.386AlaAla: 5.386 ± 0.748
1.795AlaCys: 1.795 ± 1.092
3.591AlaAsp: 3.591 ± 0.934
2.693AlaGlu: 2.693 ± 2.938
1.795AlaPhe: 1.795 ± 0.549
3.591AlaGly: 3.591 ± 0.934
0.898AlaHis: 0.898 ± 0.546
3.591AlaIle: 3.591 ± 3.558
8.079AlaLys: 8.079 ± 3.26
5.386AlaLeu: 5.386 ± 1.736
1.795AlaMet: 1.795 ± 1.259
3.591AlaAsn: 3.591 ± 1.311
3.591AlaPro: 3.591 ± 1.312
0.898AlaGln: 0.898 ± 0.546
3.591AlaArg: 3.591 ± 2.183
8.079AlaSer: 8.079 ± 3.829
4.488AlaThr: 4.488 ± 2.373
3.591AlaVal: 3.591 ± 2.183
1.795AlaTrp: 1.795 ± 1.504
8.977AlaTyr: 8.977 ± 1.834
0.0AlaXaa: 0.0 ± 0.0
Cys
1.795CysAla: 1.795 ± 1.092
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
0.0CysGlu: 0.0 ± 0.0
0.898CysPhe: 0.898 ± 0.696
0.898CysGly: 0.898 ± 0.546
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
3.591CysLys: 3.591 ± 2.183
0.898CysLeu: 0.898 ± 0.546
0.898CysMet: 0.898 ± 0.546
1.795CysAsn: 1.795 ± 1.092
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
0.898CysArg: 0.898 ± 0.546
1.795CysSer: 1.795 ± 1.901
0.0CysThr: 0.0 ± 0.0
0.898CysVal: 0.898 ± 0.546
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
2.693AspAla: 2.693 ± 1.638
1.795AspCys: 1.795 ± 1.092
2.693AspAsp: 2.693 ± 1.126
1.795AspGlu: 1.795 ± 1.092
2.693AspPhe: 2.693 ± 1.66
3.591AspGly: 3.591 ± 1.312
0.0AspHis: 0.0 ± 0.0
2.693AspIle: 2.693 ± 0.845
2.693AspLys: 2.693 ± 1.126
8.079AspLeu: 8.079 ± 1.006
2.693AspMet: 2.693 ± 1.638
1.795AspAsn: 1.795 ± 1.504
2.693AspPro: 2.693 ± 0.845
2.693AspGln: 2.693 ± 0.845
5.386AspArg: 5.386 ± 1.69
4.488AspSer: 4.488 ± 1.844
1.795AspThr: 1.795 ± 0.549
1.795AspVal: 1.795 ± 1.337
0.898AspTrp: 0.898 ± 0.696
1.795AspTyr: 1.795 ± 0.549
0.0AspXaa: 0.0 ± 0.0
Glu
3.591GluAla: 3.591 ± 1.311
1.795GluCys: 1.795 ± 1.092
0.0GluAsp: 0.0 ± 0.0
0.898GluGlu: 0.898 ± 0.546
0.898GluPhe: 0.898 ± 0.546
0.0GluGly: 0.0 ± 0.0
0.898GluHis: 0.898 ± 0.696
1.795GluIle: 1.795 ± 0.549
2.693GluLys: 2.693 ± 0.845
5.386GluLeu: 5.386 ± 1.367
0.0GluMet: 0.0 ± 0.0
2.693GluAsn: 2.693 ± 1.66
0.898GluPro: 0.898 ± 0.546
0.898GluGln: 0.898 ± 0.696
0.898GluArg: 0.898 ± 1.924
5.386GluSer: 5.386 ± 1.69
3.591GluThr: 3.591 ± 2.183
3.591GluVal: 3.591 ± 1.311
1.795GluTrp: 1.795 ± 1.337
0.0GluTyr: 0.0 ± 0.0
0.0GluXaa: 0.0 ± 0.0
Phe
1.795PheAla: 1.795 ± 1.337
0.0PheCys: 0.0 ± 0.0
0.898PheAsp: 0.898 ± 0.546
2.693PheGlu: 2.693 ± 0.845
0.898PhePhe: 0.898 ± 0.546
0.0PheGly: 0.0 ± 0.0
0.898PheHis: 0.898 ± 0.546
1.795PheIle: 1.795 ± 0.549
4.488PheLys: 4.488 ± 1.957
2.693PheLeu: 2.693 ± 0.845
0.898PheMet: 0.898 ± 0.696
1.795PheAsn: 1.795 ± 0.549
4.488PhePro: 4.488 ± 1.316
0.898PheGln: 0.898 ± 0.696
5.386PheArg: 5.386 ± 1.69
4.488PheSer: 4.488 ± 1.844
5.386PheThr: 5.386 ± 1.597
2.693PheVal: 2.693 ± 2.386
1.795PheTrp: 1.795 ± 0.549
2.693PheTyr: 2.693 ± 1.126
0.0PheXaa: 0.0 ± 0.0
Gly
3.591GlyAla: 3.591 ± 1.598
0.898GlyCys: 0.898 ± 0.546
4.488GlyAsp: 4.488 ± 1.316
0.898GlyGlu: 0.898 ± 0.546
4.488GlyPhe: 4.488 ± 1.957
5.386GlyGly: 5.386 ± 1.333
0.898GlyHis: 0.898 ± 0.546
3.591GlyIle: 3.591 ± 1.312
0.898GlyLys: 0.898 ± 0.696
8.079GlyLeu: 8.079 ± 3.086
0.898GlyMet: 0.898 ± 0.546
5.386GlyAsn: 5.386 ± 2.253
0.898GlyPro: 0.898 ± 0.696
0.898GlyGln: 0.898 ± 0.546
3.591GlyArg: 3.591 ± 1.097
6.284GlySer: 6.284 ± 2.859
4.488GlyThr: 4.488 ± 2.821
5.386GlyVal: 5.386 ± 2.241
2.693GlyTrp: 2.693 ± 1.128
3.591GlyTyr: 3.591 ± 1.097
0.0GlyXaa: 0.0 ± 0.0
His
0.898HisAla: 0.898 ± 0.546
0.0HisCys: 0.0 ± 0.0
0.0HisAsp: 0.0 ± 0.0
0.898HisGlu: 0.898 ± 0.546
1.795HisPhe: 1.795 ± 1.092
0.0HisGly: 0.0 ± 0.0
0.0HisHis: 0.0 ± 0.0
0.898HisIle: 0.898 ± 0.546
1.795HisLys: 1.795 ± 1.901
1.795HisLeu: 1.795 ± 1.392
0.898HisMet: 0.898 ± 0.546
0.898HisAsn: 0.898 ± 0.696
0.898HisPro: 0.898 ± 0.546
0.0HisGln: 0.0 ± 0.0
1.795HisArg: 1.795 ± 1.392
0.0HisSer: 0.0 ± 0.0
0.0HisThr: 0.0 ± 0.0
1.795HisVal: 1.795 ± 1.092
1.795HisTrp: 1.795 ± 1.901
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
6.284IleAla: 6.284 ± 1.404
0.0IleCys: 0.0 ± 0.0
7.181IleAsp: 7.181 ± 1.336
2.693IleGlu: 2.693 ± 0.845
2.693IlePhe: 2.693 ± 2.386
0.898IleGly: 0.898 ± 0.696
0.0IleHis: 0.0 ± 0.0
1.795IleIle: 1.795 ± 0.549
0.898IleLys: 0.898 ± 1.516
1.795IleLeu: 1.795 ± 1.901
0.898IleMet: 0.898 ± 0.546
1.795IleAsn: 1.795 ± 1.392
2.693IlePro: 2.693 ± 1.369
0.898IleGln: 0.898 ± 0.546
4.488IleArg: 4.488 ± 1.316
7.181IleSer: 7.181 ± 2.622
0.0IleThr: 0.0 ± 0.0
3.591IleVal: 3.591 ± 2.077
2.693IleTrp: 2.693 ± 1.66
2.693IleTyr: 2.693 ± 1.128
0.0IleXaa: 0.0 ± 0.0
Lys
3.591LysAla: 3.591 ± 2.402
0.0LysCys: 0.0 ± 0.0
1.795LysAsp: 1.795 ± 0.549
3.591LysGlu: 3.591 ± 2.285
1.795LysPhe: 1.795 ± 0.549
2.693LysGly: 2.693 ± 0.845
1.795LysHis: 1.795 ± 1.901
3.591LysIle: 3.591 ± 1.598
1.795LysLys: 1.795 ± 0.549
8.977LysLeu: 8.977 ± 3.9
0.898LysMet: 0.898 ± 0.696
0.898LysAsn: 0.898 ± 0.546
3.591LysPro: 3.591 ± 1.312
0.898LysGln: 0.898 ± 0.696
5.386LysArg: 5.386 ± 1.625
3.591LysSer: 3.591 ± 1.311
5.386LysThr: 5.386 ± 1.69
4.488LysVal: 4.488 ± 0.917
1.795LysTrp: 1.795 ± 1.092
0.898LysTyr: 0.898 ± 1.516
0.0LysXaa: 0.0 ± 0.0
Leu
9.874LeuAla: 9.874 ± 0.81
2.693LeuCys: 2.693 ± 2.029
2.693LeuAsp: 2.693 ± 0.845
6.284LeuGlu: 6.284 ± 1.008
5.386LeuPhe: 5.386 ± 1.367
7.181LeuGly: 7.181 ± 2.195
2.693LeuHis: 2.693 ± 0.845
5.386LeuIle: 5.386 ± 3.394
4.488LeuLys: 4.488 ± 1.553
8.079LeuLeu: 8.079 ± 1.879
2.693LeuMet: 2.693 ± 1.66
5.386LeuAsn: 5.386 ± 2.256
8.977LeuPro: 8.977 ± 1.915
3.591LeuGln: 3.591 ± 1.668
4.488LeuArg: 4.488 ± 1.036
12.567LeuSer: 12.567 ± 1.082
4.488LeuThr: 4.488 ± 0.917
5.386LeuVal: 5.386 ± 1.367
0.0LeuTrp: 0.0 ± 0.0
1.795LeuTyr: 1.795 ± 3.849
0.0LeuXaa: 0.0 ± 0.0
Met
0.898MetAla: 0.898 ± 1.516
0.0MetCys: 0.0 ± 0.0
2.693MetAsp: 2.693 ± 2.029
0.898MetGlu: 0.898 ± 0.546
1.795MetPhe: 1.795 ± 0.549
3.591MetGly: 3.591 ± 2.285
0.0MetHis: 0.0 ± 0.0
2.693MetIle: 2.693 ± 1.638
0.898MetLys: 0.898 ± 0.546
1.795MetLeu: 1.795 ± 1.092
0.0MetMet: 0.0 ± 0.0
1.795MetAsn: 1.795 ± 1.901
0.898MetPro: 0.898 ± 0.696
0.898MetGln: 0.898 ± 0.546
0.0MetArg: 0.0 ± 0.0
2.693MetSer: 2.693 ± 1.128
0.898MetThr: 0.898 ± 0.696
0.898MetVal: 0.898 ± 0.696
0.0MetTrp: 0.0 ± 0.0
0.898MetTyr: 0.898 ± 0.546
0.0MetXaa: 0.0 ± 0.0
Asn
2.693AsnAla: 2.693 ± 1.787
0.0AsnCys: 0.0 ± 0.0
1.795AsnAsp: 1.795 ± 1.092
0.898AsnGlu: 0.898 ± 0.546
1.795AsnPhe: 1.795 ± 0.549
8.079AsnGly: 8.079 ± 3.538
0.898AsnHis: 0.898 ± 0.546
2.693AsnIle: 2.693 ± 2.088
2.693AsnLys: 2.693 ± 1.128
4.488AsnLeu: 4.488 ± 1.553
1.795AsnMet: 1.795 ± 0.549
1.795AsnAsn: 1.795 ± 1.337
3.591AsnPro: 3.591 ± 2.256
2.693AsnGln: 2.693 ± 1.128
1.795AsnArg: 1.795 ± 0.549
4.488AsnSer: 4.488 ± 1.036
0.0AsnThr: 0.0 ± 0.0
2.693AsnVal: 2.693 ± 2.386
0.898AsnTrp: 0.898 ± 0.696
3.591AsnTyr: 3.591 ± 2.784
0.0AsnXaa: 0.0 ± 0.0
Pro
3.591ProAla: 3.591 ± 1.792
0.0ProCys: 0.0 ± 0.0
3.591ProAsp: 3.591 ± 2.183
0.0ProGlu: 0.0 ± 0.0
2.693ProPhe: 2.693 ± 0.845
3.591ProGly: 3.591 ± 1.311
0.898ProHis: 0.898 ± 0.546
2.693ProIle: 2.693 ± 2.806
3.591ProLys: 3.591 ± 0.934
7.181ProLeu: 7.181 ± 3.585
0.898ProMet: 0.898 ± 0.546
2.693ProAsn: 2.693 ± 0.845
1.795ProPro: 1.795 ± 1.092
0.898ProGln: 0.898 ± 0.546
1.795ProArg: 1.795 ± 0.549
0.898ProSer: 0.898 ± 0.546
3.591ProThr: 3.591 ± 1.694
3.591ProVal: 3.591 ± 1.311
1.795ProTrp: 1.795 ± 0.549
1.795ProTyr: 1.795 ± 0.549
0.0ProXaa: 0.0 ± 0.0
Gln
2.693GlnAla: 2.693 ± 1.369
0.0GlnCys: 0.0 ± 0.0
0.0GlnAsp: 0.0 ± 0.0
2.693GlnGlu: 2.693 ± 1.638
0.0GlnPhe: 0.0 ± 0.0
0.898GlnGly: 0.898 ± 0.546
0.898GlnHis: 0.898 ± 0.696
0.898GlnIle: 0.898 ± 0.546
0.898GlnLys: 0.898 ± 0.546
1.795GlnLeu: 1.795 ± 1.392
0.0GlnMet: 0.0 ± 0.0
1.795GlnAsn: 1.795 ± 0.549
0.898GlnPro: 0.898 ± 0.696
0.0GlnGln: 0.0 ± 0.0
2.693GlnArg: 2.693 ± 1.128
3.591GlnSer: 3.591 ± 1.311
3.591GlnThr: 3.591 ± 1.668
2.693GlnVal: 2.693 ± 1.787
0.0GlnTrp: 0.0 ± 0.0
0.898GlnTyr: 0.898 ± 0.696
0.0GlnXaa: 0.0 ± 0.0
Arg
4.488ArgAla: 4.488 ± 1.771
2.693ArgCys: 2.693 ± 0.845
4.488ArgAsp: 4.488 ± 1.824
2.693ArgGlu: 2.693 ± 0.845
2.693ArgPhe: 2.693 ± 0.845
1.795ArgGly: 1.795 ± 0.549
0.898ArgHis: 0.898 ± 0.696
3.591ArgIle: 3.591 ± 1.312
3.591ArgLys: 3.591 ± 0.934
8.079ArgLeu: 8.079 ± 1.943
0.0ArgMet: 0.0 ± 0.627
2.693ArgAsn: 2.693 ± 1.128
2.693ArgPro: 2.693 ± 0.845
0.898ArgGln: 0.898 ± 0.696
3.591ArgArg: 3.591 ± 1.097
6.284ArgSer: 6.284 ± 2.732
3.591ArgThr: 3.591 ± 1.312
2.693ArgVal: 2.693 ± 1.126
0.898ArgTrp: 0.898 ± 0.696
1.795ArgTyr: 1.795 ± 1.092
0.0ArgXaa: 0.0 ± 0.0
Ser
4.488SerAla: 4.488 ± 1.036
0.898SerCys: 0.898 ± 0.546
10.772SerAsp: 10.772 ± 3.195
2.693SerGlu: 2.693 ± 1.66
6.284SerPhe: 6.284 ± 1.008
8.977SerGly: 8.977 ± 1.834
2.693SerHis: 2.693 ± 2.029
6.284SerIle: 6.284 ± 1.404
3.591SerLys: 3.591 ± 2.077
7.181SerLeu: 7.181 ± 1.336
2.693SerMet: 2.693 ± 1.505
7.181SerAsn: 7.181 ± 1.98
2.693SerPro: 2.693 ± 0.845
5.386SerGln: 5.386 ± 2.767
0.898SerArg: 0.898 ± 1.516
4.488SerSer: 4.488 ± 1.036
2.693SerThr: 2.693 ± 1.128
3.591SerVal: 3.591 ± 1.097
0.0SerTrp: 0.0 ± 0.0
3.591SerTyr: 3.591 ± 1.311
0.0SerXaa: 0.0 ± 0.0
Thr
7.181ThrAla: 7.181 ± 2.561
0.898ThrCys: 0.898 ± 0.546
0.898ThrAsp: 0.898 ± 1.516
0.0ThrGlu: 0.0 ± 0.0
4.488ThrPhe: 4.488 ± 1.553
3.591ThrGly: 3.591 ± 1.598
0.898ThrHis: 0.898 ± 0.696
2.693ThrIle: 2.693 ± 1.369
3.591ThrLys: 3.591 ± 1.097
5.386ThrLeu: 5.386 ± 1.828
1.795ThrMet: 1.795 ± 1.092
0.898ThrAsn: 0.898 ± 0.696
1.795ThrPro: 1.795 ± 1.392
2.693ThrGln: 2.693 ± 1.126
3.591ThrArg: 3.591 ± 1.097
1.795ThrSer: 1.795 ± 1.901
1.795ThrThr: 1.795 ± 0.549
4.488ThrVal: 4.488 ± 2.373
1.795ThrTrp: 1.795 ± 1.392
2.693ThrTyr: 2.693 ± 0.845
0.0ThrXaa: 0.0 ± 0.0
Val
4.488ValAla: 4.488 ± 0.917
0.0ValCys: 0.0 ± 0.0
1.795ValAsp: 1.795 ± 1.504
4.488ValGlu: 4.488 ± 1.771
0.0ValPhe: 0.0 ± 0.0
5.386ValGly: 5.386 ± 1.333
0.898ValHis: 0.898 ± 0.546
1.795ValIle: 1.795 ± 1.504
2.693ValLys: 2.693 ± 1.128
7.181ValLeu: 7.181 ± 1.377
2.693ValMet: 2.693 ± 3.355
3.591ValAsn: 3.591 ± 1.311
3.591ValPro: 3.591 ± 2.674
0.0ValGln: 0.0 ± 0.0
3.591ValArg: 3.591 ± 1.312
3.591ValSer: 3.591 ± 0.934
6.284ValThr: 6.284 ± 5.379
2.693ValVal: 2.693 ± 2.938
1.795ValTrp: 1.795 ± 1.901
2.693ValTyr: 2.693 ± 1.638
0.0ValXaa: 0.0 ± 0.0
Trp
1.795TrpAla: 1.795 ± 0.549
0.0TrpCys: 0.0 ± 0.0
0.898TrpAsp: 0.898 ± 0.546
0.898TrpGlu: 0.898 ± 0.696
1.795TrpPhe: 1.795 ± 0.549
1.795TrpGly: 1.795 ± 1.901
0.0TrpHis: 0.0 ± 0.0
1.795TrpIle: 1.795 ± 3.849
1.795TrpLys: 1.795 ± 1.337
3.591TrpLeu: 3.591 ± 1.311
0.0TrpMet: 0.0 ± 0.0
0.898TrpAsn: 0.898 ± 0.696
0.0TrpPro: 0.0 ± 0.0
1.795TrpGln: 1.795 ± 0.549
1.795TrpArg: 1.795 ± 0.549
2.693TrpSer: 2.693 ± 2.088
0.0TrpThr: 0.0 ± 0.0
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
1.795TrpTyr: 1.795 ± 0.549
0.0TrpXaa: 0.0 ± 0.0
Tyr
5.386TyrAla: 5.386 ± 3.871
0.898TyrCys: 0.898 ± 0.546
4.488TyrAsp: 4.488 ± 1.632
0.0TyrGlu: 0.0 ± 0.0
1.795TyrPhe: 1.795 ± 0.549
5.386TyrGly: 5.386 ± 1.69
0.0TyrHis: 0.0 ± 0.0
0.898TyrIle: 0.898 ± 0.696
2.693TyrLys: 2.693 ± 2.088
6.284TyrLeu: 6.284 ± 2.535
0.898TyrMet: 0.898 ± 0.546
0.0TyrAsn: 0.0 ± 0.0
0.898TyrPro: 0.898 ± 0.696
0.0TyrGln: 0.0 ± 0.0
5.386TyrArg: 5.386 ± 2.767
2.693TyrSer: 2.693 ± 0.845
0.898TyrThr: 0.898 ± 0.696
2.693TyrVal: 2.693 ± 1.66
0.898TyrTrp: 0.898 ± 0.696
0.0TyrTyr: 0.0 ± 0.0
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (1115 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski