Amino acid dipepetide frequency for Porphyromonas sp. COT-108 OH1349

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.909AlaAla: 4.909 ± 0.111	0.783AlaCys: 0.783 ± 0.04	3.858AlaAsp: 3.858 ± 0.086	5.059AlaGlu: 5.059 ± 0.109	3.154AlaPhe: 3.154 ± 0.065	4.836AlaGly: 4.836 ± 0.103	1.47AlaHis: 1.47 ± 0.053	5.045AlaIle: 5.045 ± 0.113	4.65AlaLys: 4.65 ± 0.093	7.889AlaLeu: 7.889 ± 0.147	1.975AlaMet: 1.975 ± 0.056	2.743AlaAsn: 2.743 ± 0.084	2.641AlaPro: 2.641 ± 0.074	2.651AlaGln: 2.651 ± 0.076	3.06AlaArg: 3.06 ± 0.077	4.577AlaSer: 4.577 ± 0.088	3.855AlaThr: 3.855 ± 0.074	4.728AlaVal: 4.728 ± 0.079	0.691AlaTrp: 0.691 ± 0.037	2.892AlaTyr: 2.892 ± 0.072	0.005AlaXaa: 0.005 ± 0.003
Cys	0.642CysAla: 0.642 ± 0.043	0.166CysCys: 0.166 ± 0.019	0.49CysAsp: 0.49 ± 0.028	0.584CysGlu: 0.584 ± 0.035	0.491CysPhe: 0.491 ± 0.031	0.922CysGly: 0.922 ± 0.037	0.27CysHis: 0.27 ± 0.026	0.711CysIle: 0.711 ± 0.038	0.595CysLys: 0.595 ± 0.034	0.855CysLeu: 0.855 ± 0.043	0.26CysMet: 0.26 ± 0.021	0.444CysAsn: 0.444 ± 0.03	0.458CysPro: 0.458 ± 0.032	0.215CysGln: 0.215 ± 0.019	0.58CysArg: 0.58 ± 0.026	0.781CysSer: 0.781 ± 0.04	0.53CysThr: 0.53 ± 0.03	0.625CysVal: 0.625 ± 0.038	0.08CysTrp: 0.08 ± 0.011	0.359CysTyr: 0.359 ± 0.025	0.0CysXaa: 0.0 ± 0.0
Asp	3.851AspAla: 3.851 ± 0.082	0.461AspCys: 0.461 ± 0.032	2.074AspAsp: 2.074 ± 0.065	3.499AspGlu: 3.499 ± 0.084	2.539AspPhe: 2.539 ± 0.068	3.63AspGly: 3.63 ± 0.098	0.984AspHis: 0.984 ± 0.039	4.227AspIle: 4.227 ± 0.095	3.811AspLys: 3.811 ± 0.088	5.127AspLeu: 5.127 ± 0.107	1.358AspMet: 1.358 ± 0.048	2.178AspAsn: 2.178 ± 0.063	2.131AspPro: 2.131 ± 0.058	1.07AspGln: 1.07 ± 0.045	2.77AspArg: 2.77 ± 0.078	2.998AspSer: 2.998 ± 0.086	2.842AspThr: 2.842 ± 0.081	3.491AspVal: 3.491 ± 0.092	0.558AspTrp: 0.558 ± 0.031	2.205AspTyr: 2.205 ± 0.067	0.003AspXaa: 0.003 ± 0.002
Glu	5.26GluAla: 5.26 ± 0.104	0.572GluCys: 0.572 ± 0.031	3.644GluAsp: 3.644 ± 0.082	6.38GluGlu: 6.38 ± 0.126	2.436GluPhe: 2.436 ± 0.072	4.266GluGly: 4.266 ± 0.085	1.407GluHis: 1.407 ± 0.043	5.446GluIle: 5.446 ± 0.104	5.639GluLys: 5.639 ± 0.111	6.556GluLeu: 6.556 ± 0.121	2.118GluMet: 2.118 ± 0.06	3.078GluAsn: 3.078 ± 0.075	1.853GluPro: 1.853 ± 0.054	3.028GluGln: 3.028 ± 0.081	4.024GluArg: 4.024 ± 0.081	3.766GluSer: 3.766 ± 0.078	3.394GluThr: 3.394 ± 0.074	4.779GluVal: 4.779 ± 0.091	0.852GluTrp: 0.852 ± 0.038	2.664GluTyr: 2.664 ± 0.067	0.002GluXaa: 0.002 ± 0.002
Phe	3.072PheAla: 3.072 ± 0.071	0.575PheCys: 0.575 ± 0.034	2.634PheAsp: 2.634 ± 0.055	2.472PheGlu: 2.472 ± 0.063	2.426PhePhe: 2.426 ± 0.081	3.328PheGly: 3.328 ± 0.089	0.864PheHis: 0.864 ± 0.034	3.089PheIle: 3.089 ± 0.079	2.285PheLys: 2.285 ± 0.062	4.396PheLeu: 4.396 ± 0.104	1.103PheMet: 1.103 ± 0.047	1.989PheAsn: 1.989 ± 0.063	1.724PhePro: 1.724 ± 0.063	1.169PheGln: 1.169 ± 0.04	2.368PheArg: 2.368 ± 0.058	3.862PheSer: 3.862 ± 0.091	2.505PheThr: 2.505 ± 0.069	2.966PheVal: 2.966 ± 0.084	0.469PheTrp: 0.469 ± 0.026	1.891PheTyr: 1.891 ± 0.061	0.0PheXaa: 0.0 ± 0.0
Gly	4.826GlyAla: 4.826 ± 0.109	0.768GlyCys: 0.768 ± 0.039	3.308GlyAsp: 3.308 ± 0.088	4.787GlyGlu: 4.787 ± 0.096	3.184GlyPhe: 3.184 ± 0.082	4.938GlyGly: 4.938 ± 0.128	1.417GlyHis: 1.417 ± 0.048	5.243GlyIle: 5.243 ± 0.105	5.285GlyLys: 5.285 ± 0.101	6.011GlyLeu: 6.011 ± 0.113	1.922GlyMet: 1.922 ± 0.06	2.939GlyAsn: 2.939 ± 0.076	1.241GlyPro: 1.241 ± 0.049	1.891GlyGln: 1.891 ± 0.064	3.286GlyArg: 3.286 ± 0.085	4.281GlySer: 4.281 ± 0.09	3.652GlyThr: 3.652 ± 0.07	5.154GlyVal: 5.154 ± 0.11	0.771GlyTrp: 0.771 ± 0.039	3.208GlyTyr: 3.208 ± 0.087	0.005GlyXaa: 0.005 ± 0.003
His	1.333HisAla: 1.333 ± 0.05	0.221HisCys: 0.221 ± 0.02	0.837HisAsp: 0.837 ± 0.035	1.117HisGlu: 1.117 ± 0.042	1.1HisPhe: 1.1 ± 0.045	1.256HisGly: 1.256 ± 0.043	0.528HisHis: 0.528 ± 0.028	1.618HisIle: 1.618 ± 0.054	1.167HisLys: 1.167 ± 0.044	2.16HisLeu: 2.16 ± 0.065	0.372HisMet: 0.372 ± 0.023	0.909HisAsn: 0.909 ± 0.037	1.19HisPro: 1.19 ± 0.049	0.572HisGln: 0.572 ± 0.033	1.11HisArg: 1.11 ± 0.037	1.427HisSer: 1.427 ± 0.051	1.34HisThr: 1.34 ± 0.048	1.051HisVal: 1.051 ± 0.043	0.208HisTrp: 0.208 ± 0.018	0.91HisTyr: 0.91 ± 0.04	0.002HisXaa: 0.002 ± 0.002
Ile	5.679IleAla: 5.679 ± 0.101	0.807IleCys: 0.807 ± 0.04	4.111IleAsp: 4.111 ± 0.096	5.248IleGlu: 5.248 ± 0.093	3.226IlePhe: 3.226 ± 0.076	4.732IleGly: 4.732 ± 0.106	1.37IleHis: 1.37 ± 0.045	4.594IleIle: 4.594 ± 0.106	4.237IleLys: 4.237 ± 0.094	6.653IleLeu: 6.653 ± 0.124	1.425IleMet: 1.425 ± 0.053	2.752IleAsn: 2.752 ± 0.072	3.407IlePro: 3.407 ± 0.074	2.014IleGln: 2.014 ± 0.061	3.722IleArg: 3.722 ± 0.087	5.324IleSer: 5.324 ± 0.109	3.714IleThr: 3.714 ± 0.087	4.759IleVal: 4.759 ± 0.104	0.61IleTrp: 0.61 ± 0.036	2.518IleTyr: 2.518 ± 0.071	0.002IleXaa: 0.002 ± 0.002
Lys	4.78LysAla: 4.78 ± 0.089	0.438LysCys: 0.438 ± 0.029	3.878LysAsp: 3.878 ± 0.099	6.417LysGlu: 6.417 ± 0.122	1.985LysPhe: 1.985 ± 0.066	4.858LysGly: 4.858 ± 0.09	1.373LysHis: 1.373 ± 0.05	4.588LysIle: 4.588 ± 0.096	5.314LysLys: 5.314 ± 0.132	5.203LysLeu: 5.203 ± 0.105	1.997LysMet: 1.997 ± 0.058	3.038LysAsn: 3.038 ± 0.093	2.295LysPro: 2.295 ± 0.057	2.535LysGln: 2.535 ± 0.071	3.748LysArg: 3.748 ± 0.098	4.09LysSer: 4.09 ± 0.084	3.39LysThr: 3.39 ± 0.083	4.256LysVal: 4.256 ± 0.09	0.671LysTrp: 0.671 ± 0.038	2.555LysTyr: 2.555 ± 0.073	0.0LysXaa: 0.0 ± 0.0
Leu	6.388LeuAla: 6.388 ± 0.108	1.154LeuCys: 1.154 ± 0.047	4.635LeuAsp: 4.635 ± 0.098	5.902LeuGlu: 5.902 ± 0.107	5.084LeuPhe: 5.084 ± 0.101	6.278LeuGly: 6.278 ± 0.123	2.007LeuHis: 2.007 ± 0.067	5.859LeuIle: 5.859 ± 0.11	6.231LeuLys: 6.231 ± 0.092	10.614LeuLeu: 10.614 ± 0.161	2.384LeuMet: 2.384 ± 0.069	4.029LeuAsn: 4.029 ± 0.091	4.656LeuPro: 4.656 ± 0.095	3.193LeuGln: 3.193 ± 0.067	5.049LeuArg: 5.049 ± 0.098	8.677LeuSer: 8.677 ± 0.149	5.112LeuThr: 5.112 ± 0.099	5.19LeuVal: 5.19 ± 0.104	0.967LeuTrp: 0.967 ± 0.045	3.706LeuTyr: 3.706 ± 0.078	0.002LeuXaa: 0.002 ± 0.002
Met	2.16MetAla: 2.16 ± 0.058	0.23MetCys: 0.23 ± 0.017	1.39MetAsp: 1.39 ± 0.047	1.927MetGlu: 1.927 ± 0.061	0.921MetPhe: 0.921 ± 0.042	2.031MetGly: 2.031 ± 0.064	0.426MetHis: 0.426 ± 0.026	1.465MetIle: 1.465 ± 0.048	2.129MetLys: 2.129 ± 0.057	2.478MetLeu: 2.478 ± 0.073	0.703MetMet: 0.703 ± 0.037	1.276MetAsn: 1.276 ± 0.043	1.197MetPro: 1.197 ± 0.045	0.967MetGln: 0.967 ± 0.036	1.299MetArg: 1.299 ± 0.055	1.588MetSer: 1.588 ± 0.056	1.236MetThr: 1.236 ± 0.046	1.549MetVal: 1.549 ± 0.056	0.189MetTrp: 0.189 ± 0.019	0.719MetTyr: 0.719 ± 0.031	0.0MetXaa: 0.0 ± 0.0
Asn	3.129AsnAla: 3.129 ± 0.069	0.36AsnCys: 0.36 ± 0.031	1.923AsnAsp: 1.923 ± 0.058	2.463AsnGlu: 2.463 ± 0.064	1.86AsnPhe: 1.86 ± 0.063	3.208AsnGly: 3.208 ± 0.095	0.842AsnHis: 0.842 ± 0.039	3.685AsnIle: 3.685 ± 0.083	2.909AsnLys: 2.909 ± 0.077	3.862AsnLeu: 3.862 ± 0.08	1.113AsnMet: 1.113 ± 0.039	2.064AsnAsn: 2.064 ± 0.078	2.232AsnPro: 2.232 ± 0.073	1.105AsnGln: 1.105 ± 0.047	2.366AsnArg: 2.366 ± 0.061	2.616AsnSer: 2.616 ± 0.066	2.349AsnThr: 2.349 ± 0.07	2.594AsnVal: 2.594 ± 0.082	0.414AsnTrp: 0.414 ± 0.033	1.692AsnTyr: 1.692 ± 0.052	0.002AsnXaa: 0.002 ± 0.002
Pro	2.644ProAla: 2.644 ± 0.07	0.29ProCys: 0.29 ± 0.021	2.433ProAsp: 2.433 ± 0.075	3.478ProGlu: 3.478 ± 0.078	2.039ProPhe: 2.039 ± 0.052	2.374ProGly: 2.374 ± 0.067	0.984ProHis: 0.984 ± 0.041	2.656ProIle: 2.656 ± 0.062	2.416ProLys: 2.416 ± 0.065	3.635ProLeu: 3.635 ± 0.076	1.011ProMet: 1.011 ± 0.039	1.808ProAsn: 1.808 ± 0.053	1.105ProPro: 1.105 ± 0.043	1.41ProGln: 1.41 ± 0.045	1.477ProArg: 1.477 ± 0.046	2.736ProSer: 2.736 ± 0.082	2.205ProThr: 2.205 ± 0.06	2.726ProVal: 2.726 ± 0.074	0.359ProTrp: 0.359 ± 0.027	1.707ProTyr: 1.707 ± 0.058	0.0ProXaa: 0.0 ± 0.0
Gln	2.339GlnAla: 2.339 ± 0.067	0.233GlnCys: 0.233 ± 0.021	1.606GlnAsp: 1.606 ± 0.056	2.733GlnGlu: 2.733 ± 0.07	1.125GlnPhe: 1.125 ± 0.049	2.004GlnGly: 2.004 ± 0.058	0.589GlnHis: 0.589 ± 0.032	2.17GlnIle: 2.17 ± 0.063	2.535GlnLys: 2.535 ± 0.072	2.899GlnLeu: 2.899 ± 0.074	0.941GlnMet: 0.941 ± 0.035	1.524GlnAsn: 1.524 ± 0.052	1.11GlnPro: 1.11 ± 0.047	1.237GlnGln: 1.237 ± 0.05	1.699GlnArg: 1.699 ± 0.056	1.873GlnSer: 1.873 ± 0.056	1.818GlnThr: 1.818 ± 0.06	1.821GlnVal: 1.821 ± 0.058	0.362GlnTrp: 0.362 ± 0.025	1.222GlnTyr: 1.222 ± 0.043	0.0GlnXaa: 0.0 ± 0.0
Arg	3.255ArgAla: 3.255 ± 0.078	0.434ArgCys: 0.434 ± 0.03	2.438ArgAsp: 2.438 ± 0.067	3.93ArgGlu: 3.93 ± 0.087	2.408ArgPhe: 2.408 ± 0.063	2.871ArgGly: 2.871 ± 0.078	1.127ArgHis: 1.127 ± 0.042	3.853ArgIle: 3.853 ± 0.084	3.625ArgLys: 3.625 ± 0.082	5.07ArgLeu: 5.07 ± 0.108	1.522ArgMet: 1.522 ± 0.047	2.106ArgAsn: 2.106 ± 0.052	1.682ArgPro: 1.682 ± 0.063	1.796ArgGln: 1.796 ± 0.051	2.71ArgArg: 2.71 ± 0.08	3.146ArgSer: 3.146 ± 0.074	2.783ArgThr: 2.783 ± 0.073	3.09ArgVal: 3.09 ± 0.076	0.562ArgTrp: 0.562 ± 0.033	2.324ArgTyr: 2.324 ± 0.062	0.0ArgXaa: 0.0 ± 0.0
Ser	4.755SerAla: 4.755 ± 0.091	0.758SerCys: 0.758 ± 0.039	3.424SerAsp: 3.424 ± 0.087	4.08SerGlu: 4.08 ± 0.082	3.68SerPhe: 3.68 ± 0.085	4.983SerGly: 4.983 ± 0.11	1.393SerHis: 1.393 ± 0.05	4.869SerIle: 4.869 ± 0.099	4.126SerLys: 4.126 ± 0.085	7.165SerLeu: 7.165 ± 0.133	1.68SerMet: 1.68 ± 0.051	2.733SerAsn: 2.733 ± 0.072	2.98SerPro: 2.98 ± 0.09	2.012SerGln: 2.012 ± 0.067	3.226SerArg: 3.226 ± 0.068	5.034SerSer: 5.034 ± 0.131	3.238SerThr: 3.238 ± 0.075	4.517SerVal: 4.517 ± 0.092	0.677SerTrp: 0.677 ± 0.035	3.015SerTyr: 3.015 ± 0.075	0.0SerXaa: 0.0 ± 0.0
Thr	3.875ThrAla: 3.875 ± 0.091	0.418ThrCys: 0.418 ± 0.029	2.931ThrAsp: 2.931 ± 0.072	3.389ThrGlu: 3.389 ± 0.085	2.492ThrPhe: 2.492 ± 0.072	3.769ThrGly: 3.769 ± 0.078	1.159ThrHis: 1.159 ± 0.046	4.029ThrIle: 4.029 ± 0.087	3.0ThrLys: 3.0 ± 0.068	5.79ThrLeu: 5.79 ± 0.092	1.164ThrMet: 1.164 ± 0.048	2.084ThrAsn: 2.084 ± 0.061	3.018ThrPro: 3.018 ± 0.083	1.59ThrGln: 1.59 ± 0.045	2.116ThrArg: 2.116 ± 0.059	3.462ThrSer: 3.462 ± 0.077	2.988ThrThr: 2.988 ± 0.083	3.102ThrVal: 3.102 ± 0.071	0.451ThrTrp: 0.451 ± 0.03	2.044ThrTyr: 2.044 ± 0.063	0.002ThrXaa: 0.002 ± 0.002
Val	5.154ValAla: 5.154 ± 0.099	0.807ValCys: 0.807 ± 0.038	3.384ValAsp: 3.384 ± 0.073	4.73ValGlu: 4.73 ± 0.101	2.686ValPhe: 2.686 ± 0.068	4.297ValGly: 4.297 ± 0.112	1.105ValHis: 1.105 ± 0.047	4.168ValIle: 4.168 ± 0.089	4.118ValLys: 4.118 ± 0.085	5.848ValLeu: 5.848 ± 0.106	1.585ValMet: 1.585 ± 0.055	2.483ValAsn: 2.483 ± 0.077	2.627ValPro: 2.627 ± 0.07	1.927ValGln: 1.927 ± 0.056	3.387ValArg: 3.387 ± 0.081	4.764ValSer: 4.764 ± 0.088	3.095ValThr: 3.095 ± 0.072	4.879ValVal: 4.879 ± 0.108	0.706ValTrp: 0.706 ± 0.035	2.324ValTyr: 2.324 ± 0.062	0.002ValXaa: 0.002 ± 0.002
Trp	0.602TrpAla: 0.602 ± 0.033	0.134TrpCys: 0.134 ± 0.014	0.584TrpAsp: 0.584 ± 0.031	0.704TrpGlu: 0.704 ± 0.034	0.433TrpPhe: 0.433 ± 0.027	0.726TrpGly: 0.726 ± 0.037	0.241TrpHis: 0.241 ± 0.015	0.756TrpIle: 0.756 ± 0.039	0.741TrpLys: 0.741 ± 0.044	0.946TrpLeu: 0.946 ± 0.043	0.322TrpMet: 0.322 ± 0.028	0.56TrpAsn: 0.56 ± 0.035	0.216TrpPro: 0.216 ± 0.024	0.382TrpGln: 0.382 ± 0.027	0.52TrpArg: 0.52 ± 0.025	0.713TrpSer: 0.713 ± 0.038	0.475TrpThr: 0.475 ± 0.027	0.563TrpVal: 0.563 ± 0.032	0.166TrpTrp: 0.166 ± 0.02	0.401TrpTyr: 0.401 ± 0.026	0.002TrpXaa: 0.002 ± 0.002
Tyr	2.819TyrAla: 2.819 ± 0.067	0.451TyrCys: 0.451 ± 0.032	2.228TyrAsp: 2.228 ± 0.061	2.264TyrGlu: 2.264 ± 0.064	1.906TyrPhe: 1.906 ± 0.059	2.812TyrGly: 2.812 ± 0.085	0.872TyrHis: 0.872 ± 0.037	2.83TyrIle: 2.83 ± 0.066	2.592TyrLys: 2.592 ± 0.063	3.954TyrLeu: 3.954 ± 0.073	0.924TyrMet: 0.924 ± 0.035	2.049TyrAsn: 2.049 ± 0.067	1.73TyrPro: 1.73 ± 0.053	1.076TyrGln: 1.076 ± 0.048	2.215TyrArg: 2.215 ± 0.063	2.629TyrSer: 2.629 ± 0.067	2.349TyrThr: 2.349 ± 0.061	2.235TyrVal: 2.235 ± 0.065	0.421TyrTrp: 0.421 ± 0.031	1.742TyrTyr: 1.742 ± 0.069	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.002XaaGlu: 0.002 ± 0.002	0.012XaaPhe: 0.012 ± 0.005	0.002XaaGly: 0.002 ± 0.002	0.0XaaHis: 0.0 ± 0.0	0.002XaaIle: 0.002 ± 0.002	0.002XaaLys: 0.002 ± 0.002	0.003XaaLeu: 0.003 ± 0.002	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.003XaaSer: 0.003 ± 0.002	0.002XaaThr: 0.002 ± 0.002	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1734 proteins (596397 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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