Amino acid dipepetide frequency for Xanthomonas phage Xp12

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.26AlaAla: 13.26 ± 1.231
1.178AlaCys: 1.178 ± 0.251
6.553AlaAsp: 6.553 ± 0.631
7.577AlaGlu: 7.577 ± 0.871
4.249AlaPhe: 4.249 ± 0.466
8.345AlaGly: 8.345 ± 0.831
2.202AlaHis: 2.202 ± 0.35
3.891AlaIle: 3.891 ± 0.451
5.888AlaLys: 5.888 ± 0.91
9.574AlaLeu: 9.574 ± 0.647
3.021AlaMet: 3.021 ± 0.397
2.969AlaAsn: 2.969 ± 0.344
4.352AlaPro: 4.352 ± 0.484
3.584AlaGln: 3.584 ± 0.572
6.297AlaArg: 6.297 ± 0.71
6.605AlaSer: 6.605 ± 0.661
5.581AlaThr: 5.581 ± 0.656
6.605AlaVal: 6.605 ± 0.529
2.355AlaTrp: 2.355 ± 0.433
3.174AlaTyr: 3.174 ± 0.387
0.0AlaXaa: 0.0 ± 0.0
Cys
0.717CysAla: 0.717 ± 0.196
0.256CysCys: 0.256 ± 0.102
0.717CysAsp: 0.717 ± 0.207
0.205CysGlu: 0.205 ± 0.106
0.461CysPhe: 0.461 ± 0.118
0.87CysGly: 0.87 ± 0.234
0.307CysHis: 0.307 ± 0.114
0.512CysIle: 0.512 ± 0.167
0.205CysLys: 0.205 ± 0.107
0.768CysLeu: 0.768 ± 0.216
0.358CysMet: 0.358 ± 0.135
0.358CysAsn: 0.358 ± 0.143
0.614CysPro: 0.614 ± 0.181
0.358CysGln: 0.358 ± 0.144
1.024CysArg: 1.024 ± 0.209
0.41CysSer: 0.41 ± 0.153
0.358CysThr: 0.358 ± 0.158
0.666CysVal: 0.666 ± 0.204
0.205CysTrp: 0.205 ± 0.122
0.256CysTyr: 0.256 ± 0.107
0.0CysXaa: 0.0 ± 0.0
Asp
7.065AspAla: 7.065 ± 0.581
0.512AspCys: 0.512 ± 0.145
4.249AspAsp: 4.249 ± 0.445
4.505AspGlu: 4.505 ± 0.356
2.56AspPhe: 2.56 ± 0.406
8.396AspGly: 8.396 ± 0.762
0.717AspHis: 0.717 ± 0.209
1.382AspIle: 1.382 ± 0.245
2.662AspLys: 2.662 ± 0.392
6.144AspLeu: 6.144 ± 0.527
1.638AspMet: 1.638 ± 0.245
1.126AspAsn: 1.126 ± 0.201
4.249AspPro: 4.249 ± 0.489
2.253AspGln: 2.253 ± 0.299
4.352AspArg: 4.352 ± 0.498
3.123AspSer: 3.123 ± 0.391
2.662AspThr: 2.662 ± 0.412
4.864AspVal: 4.864 ± 0.444
0.768AspTrp: 0.768 ± 0.241
1.587AspTyr: 1.587 ± 0.238
0.0AspXaa: 0.0 ± 0.0
Glu
8.345GluAla: 8.345 ± 0.847
0.614GluCys: 0.614 ± 0.163
3.584GluAsp: 3.584 ± 0.474
3.891GluGlu: 3.891 ± 0.547
2.56GluPhe: 2.56 ± 0.41
4.915GluGly: 4.915 ± 0.549
1.28GluHis: 1.28 ± 0.282
2.458GluIle: 2.458 ± 0.321
2.765GluLys: 2.765 ± 0.626
7.065GluLeu: 7.065 ± 0.736
1.69GluMet: 1.69 ± 0.357
1.894GluAsn: 1.894 ± 0.269
2.867GluPro: 2.867 ± 0.493
3.277GluGln: 3.277 ± 0.405
4.249GluArg: 4.249 ± 0.598
3.328GluSer: 3.328 ± 0.55
2.816GluThr: 2.816 ± 0.337
4.505GluVal: 4.505 ± 0.469
1.229GluTrp: 1.229 ± 0.216
1.843GluTyr: 1.843 ± 0.33
0.0GluXaa: 0.0 ± 0.0
Phe
3.277PheAla: 3.277 ± 0.411
0.41PheCys: 0.41 ± 0.153
2.867PheAsp: 2.867 ± 0.409
2.509PheGlu: 2.509 ± 0.406
1.024PhePhe: 1.024 ± 0.251
3.021PheGly: 3.021 ± 0.402
0.512PheHis: 0.512 ± 0.195
1.126PheIle: 1.126 ± 0.257
1.382PheLys: 1.382 ± 0.282
2.56PheLeu: 2.56 ± 0.385
0.87PheMet: 0.87 ± 0.268
1.024PheAsn: 1.024 ± 0.216
1.946PhePro: 1.946 ± 0.341
1.638PheGln: 1.638 ± 0.304
2.918PheArg: 2.918 ± 0.384
2.15PheSer: 2.15 ± 0.338
2.253PheThr: 2.253 ± 0.339
1.792PheVal: 1.792 ± 0.282
0.717PheTrp: 0.717 ± 0.167
0.666PheTyr: 0.666 ± 0.185
0.0PheXaa: 0.0 ± 0.0
Gly
6.605GlyAla: 6.605 ± 0.51
1.024GlyCys: 1.024 ± 0.322
5.171GlyAsp: 5.171 ± 0.629
5.478GlyGlu: 5.478 ± 0.587
3.123GlyPhe: 3.123 ± 0.511
6.809GlyGly: 6.809 ± 0.71
1.382GlyHis: 1.382 ± 0.28
3.277GlyIle: 3.277 ± 0.413
4.761GlyLys: 4.761 ± 0.622
6.963GlyLeu: 6.963 ± 0.558
2.765GlyMet: 2.765 ± 0.371
2.867GlyAsn: 2.867 ± 0.357
2.918GlyPro: 2.918 ± 0.428
3.021GlyGln: 3.021 ± 0.364
6.144GlyArg: 6.144 ± 0.862
4.659GlySer: 4.659 ± 0.713
5.427GlyThr: 5.427 ± 0.636
5.837GlyVal: 5.837 ± 0.405
1.792GlyTrp: 1.792 ± 0.359
2.713GlyTyr: 2.713 ± 0.51
0.0GlyXaa: 0.0 ± 0.0
His
1.792HisAla: 1.792 ± 0.321
0.154HisCys: 0.154 ± 0.086
1.178HisAsp: 1.178 ± 0.256
1.075HisGlu: 1.075 ± 0.258
0.512HisPhe: 0.512 ± 0.159
1.382HisGly: 1.382 ± 0.201
0.41HisHis: 0.41 ± 0.134
0.87HisIle: 0.87 ± 0.189
0.768HisLys: 0.768 ± 0.184
1.946HisLeu: 1.946 ± 0.366
0.768HisMet: 0.768 ± 0.172
0.563HisAsn: 0.563 ± 0.169
1.28HisPro: 1.28 ± 0.243
0.87HisGln: 0.87 ± 0.191
1.075HisArg: 1.075 ± 0.234
1.229HisSer: 1.229 ± 0.253
0.717HisThr: 0.717 ± 0.157
1.434HisVal: 1.434 ± 0.242
0.563HisTrp: 0.563 ± 0.187
0.461HisTyr: 0.461 ± 0.158
0.0HisXaa: 0.0 ± 0.0
Ile
3.635IleAla: 3.635 ± 0.382
0.205IleCys: 0.205 ± 0.115
3.174IleAsp: 3.174 ± 0.399
2.713IleGlu: 2.713 ± 0.339
1.382IlePhe: 1.382 ± 0.233
2.56IleGly: 2.56 ± 0.486
0.461IleHis: 0.461 ± 0.177
0.922IleIle: 0.922 ± 0.245
1.638IleLys: 1.638 ± 0.374
1.638IleLeu: 1.638 ± 0.256
0.768IleMet: 0.768 ± 0.17
1.075IleAsn: 1.075 ± 0.216
1.638IlePro: 1.638 ± 0.231
1.434IleGln: 1.434 ± 0.324
2.765IleArg: 2.765 ± 0.392
1.69IleSer: 1.69 ± 0.314
2.56IleThr: 2.56 ± 0.401
2.765IleVal: 2.765 ± 0.51
0.358IleTrp: 0.358 ± 0.145
0.768IleTyr: 0.768 ± 0.228
0.0IleXaa: 0.0 ± 0.0
Lys
5.734LysAla: 5.734 ± 1.167
0.41LysCys: 0.41 ± 0.152
2.458LysAsp: 2.458 ± 0.321
2.56LysGlu: 2.56 ± 0.483
1.485LysPhe: 1.485 ± 0.342
3.737LysGly: 3.737 ± 0.542
0.614LysHis: 0.614 ± 0.181
0.922LysIle: 0.922 ± 0.236
2.816LysLys: 2.816 ± 0.603
3.635LysLeu: 3.635 ± 0.539
1.382LysMet: 1.382 ± 0.287
1.178LysAsn: 1.178 ± 0.232
3.379LysPro: 3.379 ± 0.491
2.816LysGln: 2.816 ± 0.482
3.072LysArg: 3.072 ± 0.56
2.662LysSer: 2.662 ± 0.473
2.458LysThr: 2.458 ± 0.363
3.072LysVal: 3.072 ± 0.358
0.358LysTrp: 0.358 ± 0.13
1.178LysTyr: 1.178 ± 0.263
0.0LysXaa: 0.0 ± 0.0
Leu
9.369LeuAla: 9.369 ± 0.906
0.717LeuCys: 0.717 ± 0.193
6.093LeuAsp: 6.093 ± 0.503
5.171LeuGlu: 5.171 ± 0.573
2.867LeuPhe: 2.867 ± 0.476
6.656LeuGly: 6.656 ± 0.606
1.741LeuHis: 1.741 ± 0.289
2.56LeuIle: 2.56 ± 0.415
4.505LeuLys: 4.505 ± 0.584
6.605LeuLeu: 6.605 ± 0.443
1.997LeuMet: 1.997 ± 0.312
2.969LeuAsn: 2.969 ± 0.355
5.12LeuPro: 5.12 ± 0.536
3.174LeuGln: 3.174 ± 0.406
6.297LeuArg: 6.297 ± 0.605
5.069LeuSer: 5.069 ± 0.525
5.273LeuThr: 5.273 ± 0.508
5.939LeuVal: 5.939 ± 0.517
1.894LeuTrp: 1.894 ± 0.271
2.406LeuTyr: 2.406 ± 0.42
0.0LeuXaa: 0.0 ± 0.0
Met
3.789MetAla: 3.789 ± 0.345
0.102MetCys: 0.102 ± 0.07
1.843MetAsp: 1.843 ± 0.287
1.434MetGlu: 1.434 ± 0.364
0.614MetPhe: 0.614 ± 0.207
1.946MetGly: 1.946 ± 0.363
0.666MetHis: 0.666 ± 0.186
0.973MetIle: 0.973 ± 0.219
0.922MetLys: 0.922 ± 0.186
2.099MetLeu: 2.099 ± 0.274
1.126MetMet: 1.126 ± 0.252
0.87MetAsn: 0.87 ± 0.219
1.382MetPro: 1.382 ± 0.277
0.717MetGln: 0.717 ± 0.196
2.15MetArg: 2.15 ± 0.316
1.946MetSer: 1.946 ± 0.342
1.638MetThr: 1.638 ± 0.304
1.485MetVal: 1.485 ± 0.233
0.256MetTrp: 0.256 ± 0.111
0.41MetTyr: 0.41 ± 0.146
0.0MetXaa: 0.0 ± 0.0
Asn
2.56AsnAla: 2.56 ± 0.406
0.358AsnCys: 0.358 ± 0.121
1.434AsnAsp: 1.434 ± 0.255
1.946AsnGlu: 1.946 ± 0.291
0.819AsnPhe: 0.819 ± 0.17
3.123AsnGly: 3.123 ± 0.37
0.461AsnHis: 0.461 ± 0.158
0.87AsnIle: 0.87 ± 0.257
1.075AsnLys: 1.075 ± 0.259
2.713AsnLeu: 2.713 ± 0.322
0.819AsnMet: 0.819 ± 0.189
1.382AsnAsn: 1.382 ± 0.23
1.331AsnPro: 1.331 ± 0.252
1.382AsnGln: 1.382 ± 0.268
1.638AsnArg: 1.638 ± 0.259
1.587AsnSer: 1.587 ± 0.247
1.997AsnThr: 1.997 ± 0.369
2.509AsnVal: 2.509 ± 0.309
1.024AsnTrp: 1.024 ± 0.216
0.717AsnTyr: 0.717 ± 0.186
0.0AsnXaa: 0.0 ± 0.0
Pro
5.581ProAla: 5.581 ± 0.652
0.512ProCys: 0.512 ± 0.181
3.84ProAsp: 3.84 ± 0.465
3.737ProGlu: 3.737 ± 0.452
1.536ProPhe: 1.536 ± 0.301
4.761ProGly: 4.761 ± 0.696
1.69ProHis: 1.69 ± 0.277
2.099ProIle: 2.099 ± 0.367
2.048ProLys: 2.048 ± 0.365
2.867ProLeu: 2.867 ± 0.349
1.178ProMet: 1.178 ± 0.288
1.741ProAsn: 1.741 ± 0.275
3.328ProPro: 3.328 ± 0.613
1.741ProGln: 1.741 ± 0.358
2.867ProArg: 2.867 ± 0.468
3.481ProSer: 3.481 ± 0.41
3.891ProThr: 3.891 ± 0.484
3.021ProVal: 3.021 ± 0.385
0.717ProTrp: 0.717 ± 0.219
1.434ProTyr: 1.434 ± 0.287
0.0ProXaa: 0.0 ± 0.0
Gln
5.325GlnAla: 5.325 ± 0.557
0.154GlnCys: 0.154 ± 0.1
1.894GlnAsp: 1.894 ± 0.297
2.048GlnGlu: 2.048 ± 0.381
1.382GlnPhe: 1.382 ± 0.274
3.225GlnGly: 3.225 ± 0.435
0.87GlnHis: 0.87 ± 0.282
1.331GlnIle: 1.331 ± 0.295
1.69GlnLys: 1.69 ± 0.272
3.686GlnLeu: 3.686 ± 0.449
1.485GlnMet: 1.485 ± 0.273
1.075GlnAsn: 1.075 ± 0.253
2.56GlnPro: 2.56 ± 0.339
1.946GlnGln: 1.946 ± 0.302
2.816GlnArg: 2.816 ± 0.394
1.997GlnSer: 1.997 ± 0.428
2.15GlnThr: 2.15 ± 0.352
3.174GlnVal: 3.174 ± 0.309
1.178GlnTrp: 1.178 ± 0.224
1.229GlnTyr: 1.229 ± 0.251
0.0GlnXaa: 0.0 ± 0.0
Arg
8.192ArgAla: 8.192 ± 0.647
0.614ArgCys: 0.614 ± 0.162
4.301ArgAsp: 4.301 ± 0.446
5.017ArgGlu: 5.017 ± 0.59
2.202ArgPhe: 2.202 ± 0.364
5.273ArgGly: 5.273 ± 0.676
1.69ArgHis: 1.69 ± 0.322
1.946ArgIle: 1.946 ± 0.361
2.355ArgLys: 2.355 ± 0.375
6.963ArgLeu: 6.963 ± 0.661
2.048ArgMet: 2.048 ± 0.323
1.536ArgAsn: 1.536 ± 0.215
3.021ArgPro: 3.021 ± 0.369
3.533ArgGln: 3.533 ± 0.407
5.581ArgArg: 5.581 ± 0.519
3.686ArgSer: 3.686 ± 0.467
3.686ArgThr: 3.686 ± 0.418
4.249ArgVal: 4.249 ± 0.6
1.536ArgTrp: 1.536 ± 0.304
1.536ArgTyr: 1.536 ± 0.258
0.0ArgXaa: 0.0 ± 0.0
Ser
5.017SerAla: 5.017 ± 0.519
0.614SerCys: 0.614 ± 0.218
2.713SerAsp: 2.713 ± 0.346
3.686SerGlu: 3.686 ± 0.432
1.843SerPhe: 1.843 ± 0.335
5.478SerGly: 5.478 ± 0.612
1.075SerHis: 1.075 ± 0.232
2.662SerIle: 2.662 ± 0.414
2.969SerLys: 2.969 ± 0.439
5.222SerLeu: 5.222 ± 0.54
0.973SerMet: 0.973 ± 0.237
1.894SerAsn: 1.894 ± 0.333
3.123SerPro: 3.123 ± 0.427
2.509SerGln: 2.509 ± 0.371
3.686SerArg: 3.686 ± 0.421
4.505SerSer: 4.505 ± 0.826
3.481SerThr: 3.481 ± 0.604
4.403SerVal: 4.403 ± 0.434
1.126SerTrp: 1.126 ± 0.229
2.099SerTyr: 2.099 ± 0.445
0.0SerXaa: 0.0 ± 0.0
Thr
5.837ThrAla: 5.837 ± 0.496
0.256ThrCys: 0.256 ± 0.111
3.43ThrAsp: 3.43 ± 0.532
3.123ThrGlu: 3.123 ± 0.333
1.946ThrPhe: 1.946 ± 0.319
4.966ThrGly: 4.966 ± 0.67
0.614ThrHis: 0.614 ± 0.186
2.406ThrIle: 2.406 ± 0.365
2.15ThrLys: 2.15 ± 0.308
4.71ThrLeu: 4.71 ± 0.468
1.331ThrMet: 1.331 ± 0.247
2.15ThrAsn: 2.15 ± 0.334
3.686ThrPro: 3.686 ± 0.439
2.509ThrGln: 2.509 ± 0.376
2.713ThrArg: 2.713 ± 0.367
3.635ThrSer: 3.635 ± 0.422
2.662ThrThr: 2.662 ± 0.445
4.966ThrVal: 4.966 ± 0.644
1.229ThrTrp: 1.229 ± 0.235
1.434ThrTyr: 1.434 ± 0.222
0.0ThrXaa: 0.0 ± 0.0
Val
6.605ValAla: 6.605 ± 0.576
0.717ValCys: 0.717 ± 0.234
5.888ValAsp: 5.888 ± 0.539
4.915ValGlu: 4.915 ± 0.628
2.56ValPhe: 2.56 ± 0.375
3.891ValGly: 3.891 ± 0.446
1.485ValHis: 1.485 ± 0.257
2.304ValIle: 2.304 ± 0.402
3.072ValLys: 3.072 ± 0.457
6.963ValLeu: 6.963 ± 0.722
1.485ValMet: 1.485 ± 0.335
1.638ValAsn: 1.638 ± 0.296
3.481ValPro: 3.481 ± 0.47
2.611ValGln: 2.611 ± 0.329
5.478ValArg: 5.478 ± 0.532
4.249ValSer: 4.249 ± 0.582
4.045ValThr: 4.045 ± 0.551
5.529ValVal: 5.529 ± 0.511
1.178ValTrp: 1.178 ± 0.264
1.894ValTyr: 1.894 ± 0.275
0.0ValXaa: 0.0 ± 0.0
Trp
2.048TrpAla: 2.048 ± 0.317
0.205TrpCys: 0.205 ± 0.092
1.331TrpAsp: 1.331 ± 0.292
1.485TrpGlu: 1.485 ± 0.273
0.973TrpPhe: 0.973 ± 0.244
0.819TrpGly: 0.819 ± 0.201
0.307TrpHis: 0.307 ± 0.115
0.768TrpIle: 0.768 ± 0.207
0.87TrpLys: 0.87 ± 0.242
1.792TrpLeu: 1.792 ± 0.292
0.102TrpMet: 0.102 ± 0.073
0.512TrpAsn: 0.512 ± 0.198
0.512TrpPro: 0.512 ± 0.145
0.87TrpGln: 0.87 ± 0.183
2.099TrpArg: 2.099 ± 0.38
1.28TrpSer: 1.28 ± 0.223
0.87TrpThr: 0.87 ± 0.23
1.075TrpVal: 1.075 ± 0.203
0.358TrpTrp: 0.358 ± 0.116
1.024TrpTyr: 1.024 ± 0.226
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.56TyrAla: 2.56 ± 0.422
0.614TyrCys: 0.614 ± 0.178
2.099TyrAsp: 2.099 ± 0.397
2.099TyrGlu: 2.099 ± 0.365
0.563TyrPhe: 0.563 ± 0.171
2.56TyrGly: 2.56 ± 0.358
0.563TyrHis: 0.563 ± 0.177
0.87TyrIle: 0.87 ± 0.221
1.382TyrLys: 1.382 ± 0.321
2.509TyrLeu: 2.509 ± 0.442
0.512TyrMet: 0.512 ± 0.15
0.922TyrAsn: 0.922 ± 0.2
1.28TyrPro: 1.28 ± 0.309
0.973TyrGln: 0.973 ± 0.239
1.741TyrArg: 1.741 ± 0.299
1.792TyrSer: 1.792 ± 0.352
1.229TyrThr: 1.229 ± 0.309
2.099TyrVal: 2.099 ± 0.384
0.461TyrTrp: 0.461 ± 0.142
0.87TyrTyr: 0.87 ± 0.239
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 82 proteins (19533 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski