Amino acid dipepetide frequency for Enterococcus dispar ATCC 51266

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.089AlaAla: 7.089 ± 0.137	0.523AlaCys: 0.523 ± 0.029	4.294AlaAsp: 4.294 ± 0.07	5.325AlaGlu: 5.325 ± 0.09	3.303AlaPhe: 3.303 ± 0.068	5.552AlaGly: 5.552 ± 0.093	1.188AlaHis: 1.188 ± 0.043	6.039AlaIle: 6.039 ± 0.104	5.873AlaLys: 5.873 ± 0.097	7.689AlaLeu: 7.689 ± 0.111	2.134AlaMet: 2.134 ± 0.055	3.364AlaAsn: 3.364 ± 0.066	2.308AlaPro: 2.308 ± 0.057	3.455AlaGln: 3.455 ± 0.072	2.535AlaArg: 2.535 ± 0.054	4.074AlaSer: 4.074 ± 0.075	4.678AlaThr: 4.678 ± 0.079	5.392AlaVal: 5.392 ± 0.096	0.651AlaTrp: 0.651 ± 0.028	2.601AlaTyr: 2.601 ± 0.063	0.0AlaXaa: 0.0 ± 0.0
Cys	0.368CysAla: 0.368 ± 0.023	0.092CysCys: 0.092 ± 0.013	0.364CysAsp: 0.364 ± 0.023	0.372CysGlu: 0.372 ± 0.023	0.29CysPhe: 0.29 ± 0.021	0.633CysGly: 0.633 ± 0.032	0.165CysHis: 0.165 ± 0.016	0.383CysIle: 0.383 ± 0.022	0.227CysLys: 0.227 ± 0.018	0.636CysLeu: 0.636 ± 0.031	0.141CysMet: 0.141 ± 0.013	0.251CysAsn: 0.251 ± 0.018	0.256CysPro: 0.256 ± 0.019	0.3CysGln: 0.3 ± 0.022	0.255CysArg: 0.255 ± 0.019	0.369CysSer: 0.369 ± 0.022	0.286CysThr: 0.286 ± 0.021	0.364CysVal: 0.364 ± 0.022	0.062CysTrp: 0.062 ± 0.008	0.284CysTyr: 0.284 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	3.843AspAla: 3.843 ± 0.069	0.353AspCys: 0.353 ± 0.025	2.683AspAsp: 2.683 ± 0.069	4.368AspGlu: 4.368 ± 0.084	3.089AspPhe: 3.089 ± 0.06	3.642AspGly: 3.642 ± 0.072	0.982AspHis: 0.982 ± 0.04	3.676AspIle: 3.676 ± 0.072	3.552AspLys: 3.552 ± 0.077	5.384AspLeu: 5.384 ± 0.092	1.329AspMet: 1.329 ± 0.043	2.359AspAsn: 2.359 ± 0.056	1.854AspPro: 1.854 ± 0.046	2.016AspGln: 2.016 ± 0.056	1.864AspArg: 1.864 ± 0.05	2.784AspSer: 2.784 ± 0.068	2.91AspThr: 2.91 ± 0.07	3.764AspVal: 3.764 ± 0.073	0.67AspTrp: 0.67 ± 0.03	2.562AspTyr: 2.562 ± 0.059	0.0AspXaa: 0.0 ± 0.0
Glu	5.217GluAla: 5.217 ± 0.099	0.275GluCys: 0.275 ± 0.021	3.489GluAsp: 3.489 ± 0.071	5.43GluGlu: 5.43 ± 0.099	2.655GluPhe: 2.655 ± 0.062	3.486GluGly: 3.486 ± 0.076	1.055GluHis: 1.055 ± 0.036	5.75GluIle: 5.75 ± 0.101	6.765GluLys: 6.765 ± 0.1	6.753GluLeu: 6.753 ± 0.102	2.214GluMet: 2.214 ± 0.068	4.313GluAsn: 4.313 ± 0.08	1.646GluPro: 1.646 ± 0.05	2.842GluGln: 2.842 ± 0.068	2.682GluArg: 2.682 ± 0.07	2.999GluSer: 2.999 ± 0.066	3.847GluThr: 3.847 ± 0.083	4.785GluVal: 4.785 ± 0.092	0.595GluTrp: 0.595 ± 0.029	2.143GluTyr: 2.143 ± 0.058	0.0GluXaa: 0.0 ± 0.0
Phe	3.455PheAla: 3.455 ± 0.074	0.379PheCys: 0.379 ± 0.026	2.726PheAsp: 2.726 ± 0.06	2.854PheGlu: 2.854 ± 0.063	2.454PhePhe: 2.454 ± 0.069	3.335PheGly: 3.335 ± 0.071	0.8PheHis: 0.8 ± 0.033	3.465PheIle: 3.465 ± 0.079	2.563PheLys: 2.563 ± 0.051	4.825PheLeu: 4.825 ± 0.101	1.146PheMet: 1.146 ± 0.036	2.052PheAsn: 2.052 ± 0.05	1.547PhePro: 1.547 ± 0.044	1.626PheGln: 1.626 ± 0.043	1.441PheArg: 1.441 ± 0.044	3.194PheSer: 3.194 ± 0.075	2.788PheThr: 2.788 ± 0.066	3.322PheVal: 3.322 ± 0.067	0.471PheTrp: 0.471 ± 0.026	1.97PheTyr: 1.97 ± 0.06	0.0PheXaa: 0.0 ± 0.0
Gly	4.854GlyAla: 4.854 ± 0.104	0.48GlyCys: 0.48 ± 0.029	3.278GlyAsp: 3.278 ± 0.062	4.062GlyGlu: 4.062 ± 0.08	3.261GlyPhe: 3.261 ± 0.075	4.557GlyGly: 4.557 ± 0.095	1.165GlyHis: 1.165 ± 0.038	5.735GlyIle: 5.735 ± 0.09	4.935GlyLys: 4.935 ± 0.092	6.244GlyLeu: 6.244 ± 0.095	1.921GlyMet: 1.921 ± 0.06	3.062GlyAsn: 3.062 ± 0.068	1.464GlyPro: 1.464 ± 0.045	2.521GlyGln: 2.521 ± 0.056	2.417GlyArg: 2.417 ± 0.063	3.648GlySer: 3.648 ± 0.063	4.059GlyThr: 4.059 ± 0.076	4.793GlyVal: 4.793 ± 0.087	0.648GlyTrp: 0.648 ± 0.03	2.759GlyTyr: 2.759 ± 0.061	0.0GlyXaa: 0.0 ± 0.0
His	1.112HisAla: 1.112 ± 0.035	0.132HisCys: 0.132 ± 0.012	1.006HisAsp: 1.006 ± 0.037	1.221HisGlu: 1.221 ± 0.041	1.08HisPhe: 1.08 ± 0.039	1.16HisGly: 1.16 ± 0.043	0.557HisHis: 0.557 ± 0.03	1.113HisIle: 1.113 ± 0.035	0.874HisLys: 0.874 ± 0.031	1.897HisLeu: 1.897 ± 0.052	0.427HisMet: 0.427 ± 0.025	0.715HisAsn: 0.715 ± 0.033	0.861HisPro: 0.861 ± 0.033	0.81HisGln: 0.81 ± 0.03	0.709HisArg: 0.709 ± 0.029	0.922HisSer: 0.922 ± 0.035	0.94HisThr: 0.94 ± 0.038	1.155HisVal: 1.155 ± 0.038	0.187HisTrp: 0.187 ± 0.017	0.942HisTyr: 0.942 ± 0.037	0.0HisXaa: 0.0 ± 0.0
Ile	6.435IleAla: 6.435 ± 0.103	0.604IleCys: 0.604 ± 0.03	4.157IleAsp: 4.157 ± 0.078	4.619IleGlu: 4.619 ± 0.085	3.459IlePhe: 3.459 ± 0.091	5.236IleGly: 5.236 ± 0.091	1.349IleHis: 1.349 ± 0.043	5.261IleIle: 5.261 ± 0.11	4.578IleLys: 4.578 ± 0.083	7.339IleLeu: 7.339 ± 0.124	1.712IleMet: 1.712 ± 0.052	3.339IleAsn: 3.339 ± 0.075	3.107IlePro: 3.107 ± 0.067	2.67IleGln: 2.67 ± 0.055	2.643IleArg: 2.643 ± 0.059	4.575IleSer: 4.575 ± 0.078	4.567IleThr: 4.567 ± 0.08	5.16IleVal: 5.16 ± 0.098	0.618IleTrp: 0.618 ± 0.027	2.548IleTyr: 2.548 ± 0.061	0.0IleXaa: 0.0 ± 0.0
Lys	5.422LysAla: 5.422 ± 0.102	0.221LysCys: 0.221 ± 0.019	4.168LysAsp: 4.168 ± 0.084	6.849LysGlu: 6.849 ± 0.105	2.138LysPhe: 2.138 ± 0.058	4.049LysGly: 4.049 ± 0.08	0.979LysHis: 0.979 ± 0.032	5.545LysIle: 5.545 ± 0.089	6.648LysLys: 6.648 ± 0.108	5.599LysLeu: 5.599 ± 0.089	2.387LysMet: 2.387 ± 0.063	4.192LysAsn: 4.192 ± 0.08	1.986LysPro: 1.986 ± 0.054	3.053LysGln: 3.053 ± 0.066	3.121LysArg: 3.121 ± 0.07	3.418LysSer: 3.418 ± 0.073	4.292LysThr: 4.292 ± 0.074	4.749LysVal: 4.749 ± 0.087	0.66LysTrp: 0.66 ± 0.03	2.374LysTyr: 2.374 ± 0.07	0.0LysXaa: 0.0 ± 0.0
Leu	8.959LeuAla: 8.959 ± 0.122	0.572LeuCys: 0.572 ± 0.029	4.881LeuAsp: 4.881 ± 0.079	5.807LeuGlu: 5.807 ± 0.12	4.657LeuPhe: 4.657 ± 0.1	6.26LeuGly: 6.26 ± 0.109	1.677LeuHis: 1.677 ± 0.048	6.758LeuIle: 6.758 ± 0.128	6.887LeuLys: 6.887 ± 0.105	10.168LeuLeu: 10.168 ± 0.184	2.431LeuMet: 2.431 ± 0.059	4.588LeuAsn: 4.588 ± 0.083	4.298LeuPro: 4.298 ± 0.076	4.047LeuGln: 4.047 ± 0.092	3.562LeuArg: 3.562 ± 0.077	6.122LeuSer: 6.122 ± 0.107	6.479LeuThr: 6.479 ± 0.087	6.636LeuVal: 6.636 ± 0.104	0.814LeuTrp: 0.814 ± 0.035	3.02LeuTyr: 3.02 ± 0.073	0.0LeuXaa: 0.0 ± 0.0
Met	2.269MetAla: 2.269 ± 0.063	0.103MetCys: 0.103 ± 0.01	1.322MetAsp: 1.322 ± 0.042	1.653MetGlu: 1.653 ± 0.047	0.952MetPhe: 0.952 ± 0.033	1.717MetGly: 1.717 ± 0.054	0.411MetHis: 0.411 ± 0.022	2.006MetIle: 2.006 ± 0.056	2.299MetLys: 2.299 ± 0.052	2.22MetLeu: 2.22 ± 0.058	0.877MetMet: 0.877 ± 0.043	1.441MetAsn: 1.441 ± 0.046	0.996MetPro: 0.996 ± 0.037	1.099MetGln: 1.099 ± 0.041	1.048MetArg: 1.048 ± 0.035	1.513MetSer: 1.513 ± 0.044	1.734MetThr: 1.734 ± 0.044	1.783MetVal: 1.783 ± 0.045	0.172MetTrp: 0.172 ± 0.015	0.685MetTyr: 0.685 ± 0.028	0.0MetXaa: 0.0 ± 0.0
Asn	3.162AsnAla: 3.162 ± 0.063	0.34AsnCys: 0.34 ± 0.02	2.538AsnAsp: 2.538 ± 0.057	3.518AsnGlu: 3.518 ± 0.062	2.319AsnPhe: 2.319 ± 0.058	3.53AsnGly: 3.53 ± 0.086	1.099AsnHis: 1.099 ± 0.039	3.304AsnIle: 3.304 ± 0.069	3.118AsnLys: 3.118 ± 0.071	4.569AsnLeu: 4.569 ± 0.089	1.138AsnMet: 1.138 ± 0.045	2.278AsnAsn: 2.278 ± 0.061	2.155AsnPro: 2.155 ± 0.047	2.416AsnGln: 2.416 ± 0.059	1.989AsnArg: 1.989 ± 0.049	2.647AsnSer: 2.647 ± 0.069	2.442AsnThr: 2.442 ± 0.061	3.062AsnVal: 3.062 ± 0.074	0.539AsnTrp: 0.539 ± 0.03	2.111AsnTyr: 2.111 ± 0.052	0.0AsnXaa: 0.0 ± 0.0
Pro	2.653ProAla: 2.653 ± 0.057	0.155ProCys: 0.155 ± 0.015	1.962ProAsp: 1.962 ± 0.05	2.758ProGlu: 2.758 ± 0.062	1.828ProPhe: 1.828 ± 0.05	1.962ProGly: 1.962 ± 0.052	0.658ProHis: 0.658 ± 0.029	2.479ProIle: 2.479 ± 0.053	2.348ProLys: 2.348 ± 0.052	3.396ProLeu: 3.396 ± 0.059	0.785ProMet: 0.785 ± 0.034	1.819ProAsn: 1.819 ± 0.048	0.758ProPro: 0.758 ± 0.034	1.597ProGln: 1.597 ± 0.044	0.996ProArg: 0.996 ± 0.034	1.863ProSer: 1.863 ± 0.049	2.3ProThr: 2.3 ± 0.057	2.607ProVal: 2.607 ± 0.057	0.303ProTrp: 0.303 ± 0.021	1.345ProTyr: 1.345 ± 0.045	0.0ProXaa: 0.0 ± 0.0
Gln	3.333GlnAla: 3.333 ± 0.062	0.166GlnCys: 0.166 ± 0.015	2.016GlnAsp: 2.016 ± 0.043	2.974GlnGlu: 2.974 ± 0.068	1.588GlnPhe: 1.588 ± 0.046	2.168GlnGly: 2.168 ± 0.053	0.702GlnHis: 0.702 ± 0.028	2.944GlnIle: 2.944 ± 0.072	3.905GlnLys: 3.905 ± 0.078	4.657GlnLeu: 4.657 ± 0.091	1.259GlnMet: 1.259 ± 0.039	2.279GlnAsn: 2.279 ± 0.05	1.303GlnPro: 1.303 ± 0.039	2.357GlnGln: 2.357 ± 0.064	1.651GlnArg: 1.651 ± 0.048	2.064GlnSer: 2.064 ± 0.05	2.634GlnThr: 2.634 ± 0.063	2.857GlnVal: 2.857 ± 0.056	0.401GlnTrp: 0.401 ± 0.021	1.382GlnTyr: 1.382 ± 0.046	0.0GlnXaa: 0.0 ± 0.0
Arg	2.168ArgAla: 2.168 ± 0.054	0.251ArgCys: 0.251 ± 0.019	1.756ArgAsp: 1.756 ± 0.056	2.349ArgGlu: 2.349 ± 0.064	1.965ArgPhe: 1.965 ± 0.051	2.106ArgGly: 2.106 ± 0.049	0.768ArgHis: 0.768 ± 0.034	2.745ArgIle: 2.745 ± 0.076	2.838ArgLys: 2.838 ± 0.063	4.044ArgLeu: 4.044 ± 0.078	1.009ArgMet: 1.009 ± 0.036	1.887ArgAsn: 1.887 ± 0.055	1.303ArgPro: 1.303 ± 0.045	1.976ArgGln: 1.976 ± 0.06	1.78ArgArg: 1.78 ± 0.056	1.91ArgSer: 1.91 ± 0.056	1.791ArgThr: 1.791 ± 0.048	2.328ArgVal: 2.328 ± 0.061	0.348ArgTrp: 0.348 ± 0.023	1.613ArgTyr: 1.613 ± 0.048	0.0ArgXaa: 0.0 ± 0.0
Ser	3.854SerAla: 3.854 ± 0.071	0.333SerCys: 0.333 ± 0.022	3.141SerAsp: 3.141 ± 0.071	3.805SerGlu: 3.805 ± 0.075	3.001SerPhe: 3.001 ± 0.074	4.324SerGly: 4.324 ± 0.085	1.04SerHis: 1.04 ± 0.035	3.945SerIle: 3.945 ± 0.089	3.334SerLys: 3.334 ± 0.073	5.66SerLeu: 5.66 ± 0.092	1.305SerMet: 1.305 ± 0.042	2.545SerAsn: 2.545 ± 0.057	1.754SerPro: 1.754 ± 0.045	2.51SerGln: 2.51 ± 0.057	2.041SerArg: 2.041 ± 0.049	3.351SerSer: 3.351 ± 0.091	2.96SerThr: 2.96 ± 0.071	3.732SerVal: 3.732 ± 0.073	0.609SerTrp: 0.609 ± 0.029	2.224SerTyr: 2.224 ± 0.052	0.0SerXaa: 0.0 ± 0.0
Thr	4.775ThrAla: 4.775 ± 0.09	0.315ThrCys: 0.315 ± 0.017	3.278ThrAsp: 3.278 ± 0.056	3.711ThrGlu: 3.711 ± 0.072	2.76ThrPhe: 2.76 ± 0.06	4.317ThrGly: 4.317 ± 0.08	1.043ThrHis: 1.043 ± 0.039	4.94ThrIle: 4.94 ± 0.091	4.156ThrLys: 4.156 ± 0.075	5.823ThrLeu: 5.823 ± 0.08	1.318ThrMet: 1.318 ± 0.047	2.712ThrAsn: 2.712 ± 0.064	2.514ThrPro: 2.514 ± 0.054	2.167ThrGln: 2.167 ± 0.046	1.798ThrArg: 1.798 ± 0.058	3.307ThrSer: 3.307 ± 0.083	3.755ThrThr: 3.755 ± 0.086	4.322ThrVal: 4.322 ± 0.086	0.528ThrTrp: 0.528 ± 0.029	2.003ThrTyr: 2.003 ± 0.062	0.0ThrXaa: 0.0 ± 0.0
Val	6.152ValAla: 6.152 ± 0.093	0.467ValCys: 0.467 ± 0.026	3.824ValAsp: 3.824 ± 0.075	4.187ValGlu: 4.187 ± 0.094	3.097ValPhe: 3.097 ± 0.08	4.672ValGly: 4.672 ± 0.096	1.065ValHis: 1.065 ± 0.04	5.189ValIle: 5.189 ± 0.091	4.764ValLys: 4.764 ± 0.082	6.477ValLeu: 6.477 ± 0.105	1.758ValMet: 1.758 ± 0.052	3.062ValAsn: 3.062 ± 0.074	2.716ValPro: 2.716 ± 0.054	2.16ValGln: 2.16 ± 0.05	2.286ValArg: 2.286 ± 0.055	4.206ValSer: 4.206 ± 0.074	4.724ValThr: 4.724 ± 0.079	5.119ValVal: 5.119 ± 0.088	0.56ValTrp: 0.56 ± 0.026	2.236ValTyr: 2.236 ± 0.055	0.0ValXaa: 0.0 ± 0.0
Trp	0.49TrpAla: 0.49 ± 0.023	0.064TrpCys: 0.064 ± 0.009	0.518TrpAsp: 0.518 ± 0.027	0.611TrpGlu: 0.611 ± 0.028	0.457TrpPhe: 0.457 ± 0.026	0.667TrpGly: 0.667 ± 0.032	0.214TrpHis: 0.214 ± 0.018	0.567TrpIle: 0.567 ± 0.029	0.454TrpLys: 0.454 ± 0.026	1.122TrpLeu: 1.122 ± 0.041	0.24TrpMet: 0.24 ± 0.017	0.447TrpAsn: 0.447 ± 0.026	0.249TrpPro: 0.249 ± 0.017	0.829TrpGln: 0.829 ± 0.034	0.425TrpArg: 0.425 ± 0.028	0.521TrpSer: 0.521 ± 0.026	0.464TrpThr: 0.464 ± 0.03	0.535TrpVal: 0.535 ± 0.026	0.144TrpTrp: 0.144 ± 0.015	0.366TrpTyr: 0.366 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.456TyrAla: 2.456 ± 0.059	0.274TyrCys: 0.274 ± 0.02	2.284TyrAsp: 2.284 ± 0.062	2.467TyrGlu: 2.467 ± 0.053	2.059TyrPhe: 2.059 ± 0.052	2.487TyrGly: 2.487 ± 0.056	0.902TyrHis: 0.902 ± 0.037	2.134TyrIle: 2.134 ± 0.056	1.734TyrLys: 1.734 ± 0.05	4.118TyrLeu: 4.118 ± 0.088	0.768TyrMet: 0.768 ± 0.027	1.568TyrAsn: 1.568 ± 0.051	1.5TyrPro: 1.5 ± 0.05	2.188TyrGln: 2.188 ± 0.056	1.692TyrArg: 1.692 ± 0.051	1.982TyrSer: 1.982 ± 0.056	1.891TyrThr: 1.891 ± 0.056	2.259TyrVal: 2.259 ± 0.063	0.402TyrTrp: 0.402 ± 0.021	1.668TyrTyr: 1.668 ± 0.047	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2622 proteins (795991 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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