Amino acid dipepetide frequency for Postia placenta MAD-698-R-SB12

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.961AlaAla: 9.961 ± 0.062	1.26AlaCys: 1.26 ± 0.018	4.834AlaAsp: 4.834 ± 0.034	5.341AlaGlu: 5.341 ± 0.04	3.348AlaPhe: 3.348 ± 0.028	5.855AlaGly: 5.855 ± 0.047	2.439AlaHis: 2.439 ± 0.024	4.186AlaIle: 4.186 ± 0.03	3.653AlaLys: 3.653 ± 0.037	9.085AlaLeu: 9.085 ± 0.043	2.015AlaMet: 2.015 ± 0.018	2.72AlaAsn: 2.72 ± 0.026	5.799AlaPro: 5.799 ± 0.047	3.778AlaGln: 3.778 ± 0.032	6.353AlaArg: 6.353 ± 0.046	8.079AlaSer: 8.079 ± 0.054	5.465AlaThr: 5.465 ± 0.035	6.003AlaVal: 6.003 ± 0.035	1.277AlaTrp: 1.277 ± 0.017	2.32AlaTyr: 2.32 ± 0.023	0.0AlaXaa: 0.0 ± 0.0
Cys	1.276CysAla: 1.276 ± 0.016	0.27CysCys: 0.27 ± 0.007	0.715CysAsp: 0.715 ± 0.013	0.653CysGlu: 0.653 ± 0.009	0.529CysPhe: 0.529 ± 0.011	1.048CysGly: 1.048 ± 0.017	0.364CysHis: 0.364 ± 0.009	0.737CysIle: 0.737 ± 0.013	0.527CysLys: 0.527 ± 0.011	1.283CysLeu: 1.283 ± 0.017	0.309CysMet: 0.309 ± 0.006	0.401CysAsn: 0.401 ± 0.009	0.836CysPro: 0.836 ± 0.015	0.458CysGln: 0.458 ± 0.009	0.912CysArg: 0.912 ± 0.012	1.038CysSer: 1.038 ± 0.017	0.805CysThr: 0.805 ± 0.014	0.95CysVal: 0.95 ± 0.015	0.2CysTrp: 0.2 ± 0.007	0.403CysTyr: 0.403 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	5.609AspAla: 5.609 ± 0.035	0.656AspCys: 0.656 ± 0.01	4.21AspAsp: 4.21 ± 0.042	4.47AspGlu: 4.47 ± 0.042	1.946AspPhe: 1.946 ± 0.018	3.972AspGly: 3.972 ± 0.025	1.192AspHis: 1.192 ± 0.017	3.013AspIle: 3.013 ± 0.027	2.128AspLys: 2.128 ± 0.02	5.012AspLeu: 5.012 ± 0.033	1.275AspMet: 1.275 ± 0.017	1.578AspAsn: 1.578 ± 0.019	3.346AspPro: 3.346 ± 0.024	1.567AspGln: 1.567 ± 0.019	3.026AspArg: 3.026 ± 0.026	3.745AspSer: 3.745 ± 0.03	3.067AspThr: 3.067 ± 0.027	4.423AspVal: 4.423 ± 0.035	0.93AspTrp: 0.93 ± 0.014	1.44AspTyr: 1.44 ± 0.016	0.0AspXaa: 0.0 ± 0.0
Glu	5.258GluAla: 5.258 ± 0.045	0.744GluCys: 0.744 ± 0.012	4.205GluAsp: 4.205 ± 0.034	5.154GluGlu: 5.154 ± 0.051	1.726GluPhe: 1.726 ± 0.018	3.664GluGly: 3.664 ± 0.03	1.61GluHis: 1.61 ± 0.021	2.687GluIle: 2.687 ± 0.027	2.784GluLys: 2.784 ± 0.028	5.488GluLeu: 5.488 ± 0.042	1.349GluMet: 1.349 ± 0.016	1.795GluAsn: 1.795 ± 0.02	2.839GluPro: 2.839 ± 0.026	2.388GluGln: 2.388 ± 0.022	4.335GluArg: 4.335 ± 0.035	3.771GluSer: 3.771 ± 0.029	3.085GluThr: 3.085 ± 0.024	3.733GluVal: 3.733 ± 0.028	0.972GluTrp: 0.972 ± 0.014	1.553GluTyr: 1.553 ± 0.016	0.0GluXaa: 0.0 ± 0.0
Phe	3.217PheAla: 3.217 ± 0.026	0.542PheCys: 0.542 ± 0.01	2.151PheAsp: 2.151 ± 0.022	1.868PheGlu: 1.868 ± 0.021	1.367PhePhe: 1.367 ± 0.018	2.537PheGly: 2.537 ± 0.027	0.832PheHis: 0.832 ± 0.013	1.667PheIle: 1.667 ± 0.019	1.326PheLys: 1.326 ± 0.019	3.303PheLeu: 3.303 ± 0.025	0.78PheMet: 0.78 ± 0.012	1.173PheAsn: 1.173 ± 0.015	1.94PhePro: 1.94 ± 0.02	1.144PheGln: 1.144 ± 0.013	1.937PheArg: 1.937 ± 0.019	2.846PheSer: 2.846 ± 0.026	2.058PheThr: 2.058 ± 0.021	2.52PheVal: 2.52 ± 0.024	0.556PheTrp: 0.556 ± 0.01	0.988PheTyr: 0.988 ± 0.013	0.0PheXaa: 0.0 ± 0.0
Gly	5.56GlyAla: 5.56 ± 0.044	0.955GlyCys: 0.955 ± 0.013	3.468GlyAsp: 3.468 ± 0.027	3.514GlyGlu: 3.514 ± 0.033	2.369GlyPhe: 2.369 ± 0.022	5.242GlyGly: 5.242 ± 0.055	1.682GlyHis: 1.682 ± 0.018	3.085GlyIle: 3.085 ± 0.027	3.08GlyLys: 3.08 ± 0.032	5.626GlyLeu: 5.626 ± 0.038	1.492GlyMet: 1.492 ± 0.021	2.082GlyAsn: 2.082 ± 0.024	3.397GlyPro: 3.397 ± 0.025	2.326GlyGln: 2.326 ± 0.022	4.414GlyArg: 4.414 ± 0.035	5.35GlySer: 5.35 ± 0.033	3.97GlyThr: 3.97 ± 0.028	4.357GlyVal: 4.357 ± 0.036	1.126GlyTrp: 1.126 ± 0.016	1.896GlyTyr: 1.896 ± 0.021	0.0GlyXaa: 0.0 ± 0.0
His	2.453HisAla: 2.453 ± 0.025	0.379HisCys: 0.379 ± 0.008	1.36HisAsp: 1.36 ± 0.019	1.361HisGlu: 1.361 ± 0.017	0.949HisPhe: 0.949 ± 0.015	1.721HisGly: 1.721 ± 0.019	0.813HisHis: 0.813 ± 0.014	1.393HisIle: 1.393 ± 0.016	0.878HisLys: 0.878 ± 0.014	2.571HisLeu: 2.571 ± 0.027	0.53HisMet: 0.53 ± 0.011	0.83HisAsn: 0.83 ± 0.011	1.931HisPro: 1.931 ± 0.023	0.849HisGln: 0.849 ± 0.014	1.72HisArg: 1.72 ± 0.023	2.007HisSer: 2.007 ± 0.02	1.507HisThr: 1.507 ± 0.019	1.78HisVal: 1.78 ± 0.02	0.358HisTrp: 0.358 ± 0.008	0.726HisTyr: 0.726 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.278IleAla: 4.278 ± 0.03	0.731IleCys: 0.731 ± 0.013	2.714IleAsp: 2.714 ± 0.025	2.605IleGlu: 2.605 ± 0.023	1.709IlePhe: 1.709 ± 0.017	2.881IleGly: 2.881 ± 0.03	1.187IleHis: 1.187 ± 0.015	2.251IleIle: 2.251 ± 0.023	1.804IleLys: 1.804 ± 0.02	4.418IleLeu: 4.418 ± 0.03	0.945IleMet: 0.945 ± 0.012	1.447IleAsn: 1.447 ± 0.016	3.196IlePro: 3.196 ± 0.028	1.618IleGln: 1.618 ± 0.019	2.824IleArg: 2.824 ± 0.023	3.547IleSer: 3.547 ± 0.027	2.629IleThr: 2.629 ± 0.024	3.443IleVal: 3.443 ± 0.032	0.688IleTrp: 0.688 ± 0.012	1.284IleTyr: 1.284 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	4.005LysAla: 4.005 ± 0.034	0.491LysCys: 0.491 ± 0.009	2.294LysAsp: 2.294 ± 0.024	2.797LysGlu: 2.797 ± 0.024	1.126LysPhe: 1.126 ± 0.017	2.641LysGly: 2.641 ± 0.027	1.068LysHis: 1.068 ± 0.014	1.747LysIle: 1.747 ± 0.021	2.42LysLys: 2.42 ± 0.034	3.608LysLeu: 3.608 ± 0.032	0.854LysMet: 0.854 ± 0.014	1.211LysAsn: 1.211 ± 0.017	2.271LysPro: 2.271 ± 0.022	1.518LysGln: 1.518 ± 0.019	3.327LysArg: 3.327 ± 0.034	2.763LysSer: 2.763 ± 0.025	2.424LysThr: 2.424 ± 0.024	2.488LysVal: 2.488 ± 0.024	0.607LysTrp: 0.607 ± 0.011	1.163LysTyr: 1.163 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	8.685LeuAla: 8.685 ± 0.041	1.483LeuCys: 1.483 ± 0.016	5.276LeuAsp: 5.276 ± 0.036	5.446LeuGlu: 5.446 ± 0.037	3.226LeuPhe: 3.226 ± 0.028	5.652LeuGly: 5.652 ± 0.039	2.59LeuHis: 2.59 ± 0.024	3.717LeuIle: 3.717 ± 0.029	3.671LeuLys: 3.671 ± 0.028	8.791LeuLeu: 8.791 ± 0.051	1.811LeuMet: 1.811 ± 0.018	2.831LeuAsn: 2.831 ± 0.022	6.222LeuPro: 6.222 ± 0.039	3.714LeuGln: 3.714 ± 0.029	6.653LeuArg: 6.653 ± 0.047	7.798LeuSer: 7.798 ± 0.047	5.181LeuThr: 5.181 ± 0.035	5.96LeuVal: 5.96 ± 0.04	1.277LeuTrp: 1.277 ± 0.018	2.424LeuTyr: 2.424 ± 0.024	0.0LeuXaa: 0.0 ± 0.0
Met	1.943MetAla: 1.943 ± 0.018	0.267MetCys: 0.267 ± 0.007	1.216MetAsp: 1.216 ± 0.014	1.137MetGlu: 1.137 ± 0.014	0.738MetPhe: 0.738 ± 0.012	1.249MetGly: 1.249 ± 0.019	0.585MetHis: 0.585 ± 0.011	0.902MetIle: 0.902 ± 0.014	0.895MetLys: 0.895 ± 0.013	1.983MetLeu: 1.983 ± 0.018	0.49MetMet: 0.49 ± 0.01	0.675MetAsn: 0.675 ± 0.013	1.383MetPro: 1.383 ± 0.017	0.915MetGln: 0.915 ± 0.013	1.47MetArg: 1.47 ± 0.02	2.107MetSer: 2.107 ± 0.017	1.253MetThr: 1.253 ± 0.018	1.196MetVal: 1.196 ± 0.017	0.289MetTrp: 0.289 ± 0.008	0.537MetTyr: 0.537 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.144AsnAla: 3.144 ± 0.025	0.379AsnCys: 0.379 ± 0.009	1.611AsnAsp: 1.611 ± 0.017	1.653AsnGlu: 1.653 ± 0.02	1.06AsnPhe: 1.06 ± 0.014	2.327AsnGly: 2.327 ± 0.024	0.685AsnHis: 0.685 ± 0.011	1.706AsnIle: 1.706 ± 0.02	1.176AsnLys: 1.176 ± 0.015	2.856AsnLeu: 2.856 ± 0.025	0.714AsnMet: 0.714 ± 0.012	1.063AsnAsn: 1.063 ± 0.017	2.047AsnPro: 2.047 ± 0.021	0.952AsnGln: 0.952 ± 0.016	1.654AsnArg: 1.654 ± 0.018	2.081AsnSer: 2.081 ± 0.023	1.962AsnThr: 1.962 ± 0.021	2.338AsnVal: 2.338 ± 0.02	0.429AsnTrp: 0.429 ± 0.009	0.828AsnTyr: 0.828 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	6.181ProAla: 6.181 ± 0.044	0.636ProCys: 0.636 ± 0.013	3.416ProAsp: 3.416 ± 0.028	3.751ProGlu: 3.751 ± 0.028	2.164ProPhe: 2.164 ± 0.02	3.846ProGly: 3.846 ± 0.028	1.693ProHis: 1.693 ± 0.02	2.592ProIle: 2.592 ± 0.024	2.17ProLys: 2.17 ± 0.022	5.379ProLeu: 5.379 ± 0.034	1.135ProMet: 1.135 ± 0.014	1.933ProAsn: 1.933 ± 0.02	6.309ProPro: 6.309 ± 0.071	2.381ProGln: 2.381 ± 0.026	4.145ProArg: 4.145 ± 0.033	6.853ProSer: 6.853 ± 0.053	4.211ProThr: 4.211 ± 0.031	4.013ProVal: 4.013 ± 0.034	0.738ProTrp: 0.738 ± 0.013	1.626ProTyr: 1.626 ± 0.02	0.0ProXaa: 0.0 ± 0.0
Gln	3.464GlnAla: 3.464 ± 0.024	0.503GlnCys: 0.503 ± 0.011	1.993GlnAsp: 1.993 ± 0.019	2.141GlnGlu: 2.141 ± 0.02	1.165GlnPhe: 1.165 ± 0.016	2.231GlnGly: 2.231 ± 0.02	1.125GlnHis: 1.125 ± 0.014	1.686GlnIle: 1.686 ± 0.017	1.495GlnLys: 1.495 ± 0.02	3.513GlnLeu: 3.513 ± 0.031	0.8GlnMet: 0.8 ± 0.012	1.167GlnAsn: 1.167 ± 0.015	2.412GlnPro: 2.412 ± 0.027	1.819GlnGln: 1.819 ± 0.03	2.611GlnArg: 2.611 ± 0.026	2.935GlnSer: 2.935 ± 0.028	2.137GlnThr: 2.137 ± 0.021	2.159GlnVal: 2.159 ± 0.021	0.572GlnTrp: 0.572 ± 0.011	1.084GlnTyr: 1.084 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	6.211ArgAla: 6.211 ± 0.042	0.981ArgCys: 0.981 ± 0.013	3.538ArgAsp: 3.538 ± 0.031	4.052ArgGlu: 4.052 ± 0.034	2.17ArgPhe: 2.17 ± 0.021	4.062ArgGly: 4.062 ± 0.029	1.826ArgHis: 1.826 ± 0.02	3.062ArgIle: 3.062 ± 0.022	3.282ArgLys: 3.282 ± 0.025	6.216ArgLeu: 6.216 ± 0.039	1.459ArgMet: 1.459 ± 0.018	1.945ArgAsn: 1.945 ± 0.019	4.102ArgPro: 4.102 ± 0.03	2.504ArgGln: 2.504 ± 0.023	6.035ArgArg: 6.035 ± 0.054	5.288ArgSer: 5.288 ± 0.042	3.907ArgThr: 3.907 ± 0.029	4.1ArgVal: 4.1 ± 0.028	1.057ArgTrp: 1.057 ± 0.015	1.716ArgTyr: 1.716 ± 0.021	0.0ArgXaa: 0.0 ± 0.0
Ser	7.619SerAla: 7.619 ± 0.048	0.988SerCys: 0.988 ± 0.014	4.187SerAsp: 4.187 ± 0.031	3.934SerGlu: 3.934 ± 0.029	2.753SerPhe: 2.753 ± 0.024	5.498SerGly: 5.498 ± 0.035	1.994SerHis: 1.994 ± 0.022	3.725SerIle: 3.725 ± 0.031	2.933SerLys: 2.933 ± 0.03	7.424SerLeu: 7.424 ± 0.044	1.756SerMet: 1.756 ± 0.021	2.443SerAsn: 2.443 ± 0.023	6.108SerPro: 6.108 ± 0.055	2.985SerGln: 2.985 ± 0.023	5.413SerArg: 5.413 ± 0.038	9.033SerSer: 9.033 ± 0.076	5.783SerThr: 5.783 ± 0.042	5.124SerVal: 5.124 ± 0.034	1.086SerTrp: 1.086 ± 0.015	1.96SerTyr: 1.96 ± 0.019	0.0SerXaa: 0.0 ± 0.0
Thr	5.4ThrAla: 5.4 ± 0.033	0.821ThrCys: 0.821 ± 0.013	2.825ThrAsp: 2.825 ± 0.023	2.915ThrGlu: 2.915 ± 0.026	2.299ThrPhe: 2.299 ± 0.021	3.769ThrGly: 3.769 ± 0.03	1.526ThrHis: 1.526 ± 0.018	2.995ThrIle: 2.995 ± 0.03	2.145ThrLys: 2.145 ± 0.021	5.705ThrLeu: 5.705 ± 0.031	1.233ThrMet: 1.233 ± 0.017	1.8ThrAsn: 1.8 ± 0.023	4.639ThrPro: 4.639 ± 0.04	2.033ThrGln: 2.033 ± 0.021	3.726ThrArg: 3.726 ± 0.028	5.451ThrSer: 5.451 ± 0.038	3.955ThrThr: 3.955 ± 0.03	3.921ThrVal: 3.921 ± 0.027	0.876ThrTrp: 0.876 ± 0.012	1.609ThrTyr: 1.609 ± 0.017	0.0ThrXaa: 0.0 ± 0.0
Val	5.874ValAla: 5.874 ± 0.04	0.97ValCys: 0.97 ± 0.016	4.044ValAsp: 4.044 ± 0.032	4.038ValGlu: 4.038 ± 0.037	2.487ValPhe: 2.487 ± 0.024	3.997ValGly: 3.997 ± 0.032	1.818ValHis: 1.818 ± 0.018	3.011ValIle: 3.011 ± 0.028	2.706ValLys: 2.706 ± 0.023	6.288ValLeu: 6.288 ± 0.043	1.33ValMet: 1.33 ± 0.015	2.077ValAsn: 2.077 ± 0.024	4.196ValPro: 4.196 ± 0.029	2.575ValGln: 2.575 ± 0.023	4.201ValArg: 4.201 ± 0.03	5.061ValSer: 5.061 ± 0.033	3.64ValThr: 3.64 ± 0.03	4.797ValVal: 4.797 ± 0.038	1.031ValTrp: 1.031 ± 0.014	1.858ValTyr: 1.858 ± 0.019	0.0ValXaa: 0.0 ± 0.0
Trp	1.257TrpAla: 1.257 ± 0.016	0.221TrpCys: 0.221 ± 0.007	0.902TrpAsp: 0.902 ± 0.015	0.872TrpGlu: 0.872 ± 0.013	0.534TrpPhe: 0.534 ± 0.011	0.878TrpGly: 0.878 ± 0.013	0.391TrpHis: 0.391 ± 0.009	0.694TrpIle: 0.694 ± 0.011	0.738TrpLys: 0.738 ± 0.011	1.366TrpLeu: 1.366 ± 0.018	0.374TrpMet: 0.374 ± 0.009	0.528TrpAsn: 0.528 ± 0.01	0.675TrpPro: 0.675 ± 0.011	0.575TrpGln: 0.575 ± 0.011	1.12TrpArg: 1.12 ± 0.016	1.093TrpSer: 1.093 ± 0.016	0.944TrpThr: 0.944 ± 0.015	0.889TrpVal: 0.889 ± 0.013	0.29TrpTrp: 0.29 ± 0.009	0.438TrpTyr: 0.438 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.376TyrAla: 2.376 ± 0.023	0.438TyrCys: 0.438 ± 0.01	1.645TyrAsp: 1.645 ± 0.018	1.438TyrGlu: 1.438 ± 0.016	1.086TyrPhe: 1.086 ± 0.015	1.921TyrGly: 1.921 ± 0.022	0.698TyrHis: 0.698 ± 0.011	1.342TyrIle: 1.342 ± 0.018	1.013TyrLys: 1.013 ± 0.015	2.492TyrLeu: 2.492 ± 0.024	0.578TyrMet: 0.578 ± 0.013	0.964TyrAsn: 0.964 ± 0.014	1.525TyrPro: 1.525 ± 0.021	0.914TyrGln: 0.914 ± 0.015	1.637TyrArg: 1.637 ± 0.017	1.9TyrSer: 1.9 ± 0.02	1.66TyrThr: 1.66 ± 0.017	1.805TyrVal: 1.805 ± 0.018	0.423TyrTrp: 0.423 ± 0.011	0.87TyrTyr: 0.87 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 12517 proteins (5369358 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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