Amino acid dipepetide frequency for Listeria phage B025

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.816AlaAla: 4.816 ± 1.684
0.459AlaCys: 0.459 ± 0.177
4.281AlaAsp: 4.281 ± 0.978
5.351AlaGlu: 5.351 ± 0.577
3.211AlaPhe: 3.211 ± 0.549
4.357AlaGly: 4.357 ± 1.651
0.841AlaHis: 0.841 ± 0.228
4.128AlaIle: 4.128 ± 0.792
6.421AlaLys: 6.421 ± 1.163
4.281AlaLeu: 4.281 ± 0.713
1.376AlaMet: 1.376 ± 0.306
4.586AlaAsn: 4.586 ± 0.705
1.376AlaPro: 1.376 ± 0.313
2.217AlaGln: 2.217 ± 0.32
1.835AlaArg: 1.835 ± 0.414
4.357AlaSer: 4.357 ± 0.638
3.516AlaThr: 3.516 ± 0.534
4.357AlaVal: 4.357 ± 0.836
1.223AlaTrp: 1.223 ± 0.275
2.37AlaTyr: 2.37 ± 0.478
0.0AlaXaa: 0.0 ± 0.0
Cys
0.306CysAla: 0.306 ± 0.2
0.306CysCys: 0.306 ± 0.171
0.382CysAsp: 0.382 ± 0.153
0.459CysGlu: 0.459 ± 0.207
0.688CysPhe: 0.688 ± 0.307
0.382CysGly: 0.382 ± 0.189
0.229CysHis: 0.229 ± 0.187
0.306CysIle: 0.306 ± 0.166
0.764CysLys: 0.764 ± 0.256
0.459CysLeu: 0.459 ± 0.228
0.076CysMet: 0.076 ± 0.068
0.459CysAsn: 0.459 ± 0.203
0.306CysPro: 0.306 ± 0.152
0.306CysGln: 0.306 ± 0.15
0.382CysArg: 0.382 ± 0.223
0.306CysSer: 0.306 ± 0.177
0.382CysThr: 0.382 ± 0.187
0.612CysVal: 0.612 ± 0.228
0.0CysTrp: 0.0 ± 0.0
0.153CysTyr: 0.153 ± 0.118
0.0CysXaa: 0.0 ± 0.0
Asp
3.287AspAla: 3.287 ± 0.635
0.382AspCys: 0.382 ± 0.184
3.898AspAsp: 3.898 ± 0.618
5.657AspGlu: 5.657 ± 0.902
2.981AspPhe: 2.981 ± 0.523
4.281AspGly: 4.281 ± 0.51
0.764AspHis: 0.764 ± 0.284
4.892AspIle: 4.892 ± 0.599
5.045AspLys: 5.045 ± 0.727
6.192AspLeu: 6.192 ± 1.053
1.452AspMet: 1.452 ± 0.303
3.822AspAsn: 3.822 ± 0.75
1.147AspPro: 1.147 ± 0.329
1.07AspGln: 1.07 ± 0.266
1.987AspArg: 1.987 ± 0.407
2.905AspSer: 2.905 ± 0.566
3.134AspThr: 3.134 ± 0.402
4.969AspVal: 4.969 ± 0.621
1.223AspTrp: 1.223 ± 0.331
2.828AspTyr: 2.828 ± 0.609
0.0AspXaa: 0.0 ± 0.0
Glu
4.663GluAla: 4.663 ± 0.575
0.535GluCys: 0.535 ± 0.258
4.663GluAsp: 4.663 ± 0.897
6.039GluGlu: 6.039 ± 0.947
2.905GluPhe: 2.905 ± 0.539
3.44GluGly: 3.44 ± 0.509
1.376GluHis: 1.376 ± 0.272
6.192GluIle: 6.192 ± 0.739
6.727GluLys: 6.727 ± 0.876
7.109GluLeu: 7.109 ± 0.732
3.211GluMet: 3.211 ± 0.487
3.516GluAsn: 3.516 ± 0.406
1.299GluPro: 1.299 ± 0.333
2.599GluGln: 2.599 ± 0.519
3.287GluArg: 3.287 ± 0.562
3.44GluSer: 3.44 ± 0.629
4.357GluThr: 4.357 ± 0.453
5.045GluVal: 5.045 ± 0.742
1.147GluTrp: 1.147 ± 0.235
3.746GluTyr: 3.746 ± 0.575
0.0GluXaa: 0.0 ± 0.0
Phe
2.752PheAla: 2.752 ± 0.462
0.153PheCys: 0.153 ± 0.103
3.211PheAsp: 3.211 ± 0.465
2.905PheGlu: 2.905 ± 0.456
1.987PhePhe: 1.987 ± 0.325
2.828PheGly: 2.828 ± 0.439
0.917PheHis: 0.917 ± 0.282
3.363PheIle: 3.363 ± 0.643
4.051PheLys: 4.051 ± 0.578
4.357PheLeu: 4.357 ± 0.662
1.299PheMet: 1.299 ± 0.27
2.752PheAsn: 2.752 ± 0.429
1.147PhePro: 1.147 ± 0.289
1.835PheGln: 1.835 ± 0.369
1.452PheArg: 1.452 ± 0.387
2.981PheSer: 2.981 ± 0.453
2.064PheThr: 2.064 ± 0.482
3.058PheVal: 3.058 ± 0.583
0.306PheTrp: 0.306 ± 0.159
1.376PheTyr: 1.376 ± 0.338
0.0PheXaa: 0.0 ± 0.0
Gly
4.51GlyAla: 4.51 ± 1.187
0.841GlyCys: 0.841 ± 0.264
3.287GlyAsp: 3.287 ± 0.416
3.44GlyGlu: 3.44 ± 0.591
3.287GlyPhe: 3.287 ± 0.449
3.669GlyGly: 3.669 ± 0.624
0.764GlyHis: 0.764 ± 0.211
3.593GlyIle: 3.593 ± 0.444
5.81GlyLys: 5.81 ± 1.032
5.733GlyLeu: 5.733 ± 1.029
1.911GlyMet: 1.911 ± 0.31
3.44GlyAsn: 3.44 ± 0.539
0.841GlyPro: 0.841 ± 0.281
1.758GlyGln: 1.758 ± 0.314
1.605GlyArg: 1.605 ± 0.41
3.516GlySer: 3.516 ± 0.755
3.822GlyThr: 3.822 ± 0.63
3.898GlyVal: 3.898 ± 0.549
1.223GlyTrp: 1.223 ± 0.402
2.293GlyTyr: 2.293 ± 0.451
0.0GlyXaa: 0.0 ± 0.0
His
0.764HisAla: 0.764 ± 0.305
0.153HisCys: 0.153 ± 0.106
0.994HisAsp: 0.994 ± 0.299
1.07HisGlu: 1.07 ± 0.291
0.306HisPhe: 0.306 ± 0.212
1.147HisGly: 1.147 ± 0.341
0.612HisHis: 0.612 ± 0.257
1.682HisIle: 1.682 ± 0.417
0.841HisLys: 0.841 ± 0.278
1.376HisLeu: 1.376 ± 0.406
0.306HisMet: 0.306 ± 0.153
0.994HisAsn: 0.994 ± 0.278
0.612HisPro: 0.612 ± 0.287
0.306HisGln: 0.306 ± 0.146
0.841HisArg: 0.841 ± 0.238
1.529HisSer: 1.529 ± 0.323
1.147HisThr: 1.147 ± 0.335
1.223HisVal: 1.223 ± 0.349
0.076HisTrp: 0.076 ± 0.067
0.688HisTyr: 0.688 ± 0.242
0.0HisXaa: 0.0 ± 0.0
Ile
4.128IleAla: 4.128 ± 0.51
0.841IleCys: 0.841 ± 0.275
5.427IleAsp: 5.427 ± 0.837
5.427IleGlu: 5.427 ± 0.845
2.675IlePhe: 2.675 ± 0.433
3.975IleGly: 3.975 ± 0.598
1.452IleHis: 1.452 ± 0.31
5.274IleIle: 5.274 ± 0.807
6.574IleLys: 6.574 ± 0.702
4.434IleLeu: 4.434 ± 0.499
0.917IleMet: 0.917 ± 0.23
5.962IleAsn: 5.962 ± 0.634
1.987IlePro: 1.987 ± 0.434
3.363IleGln: 3.363 ± 0.599
3.669IleArg: 3.669 ± 0.812
5.122IleSer: 5.122 ± 0.687
3.975IleThr: 3.975 ± 0.562
3.058IleVal: 3.058 ± 0.488
0.612IleTrp: 0.612 ± 0.186
2.905IleTyr: 2.905 ± 0.596
0.0IleXaa: 0.0 ± 0.0
Lys
6.956LysAla: 6.956 ± 1.368
0.306LysCys: 0.306 ± 0.156
5.504LysAsp: 5.504 ± 0.577
8.103LysGlu: 8.103 ± 0.811
2.981LysPhe: 2.981 ± 0.428
5.045LysGly: 5.045 ± 0.91
1.452LysHis: 1.452 ± 0.404
6.115LysIle: 6.115 ± 0.828
9.555LysLys: 9.555 ± 1.26
6.497LysLeu: 6.497 ± 0.847
3.058LysMet: 3.058 ± 0.492
6.421LysAsn: 6.421 ± 0.721
1.758LysPro: 1.758 ± 0.329
4.204LysGln: 4.204 ± 0.529
3.746LysArg: 3.746 ± 0.525
4.204LysSer: 4.204 ± 0.664
5.274LysThr: 5.274 ± 0.627
6.803LysVal: 6.803 ± 0.67
1.223LysTrp: 1.223 ± 0.311
4.204LysTyr: 4.204 ± 0.568
0.0LysXaa: 0.0 ± 0.0
Leu
4.663LeuAla: 4.663 ± 0.788
0.764LeuCys: 0.764 ± 0.263
4.357LeuAsp: 4.357 ± 0.508
6.421LeuGlu: 6.421 ± 0.887
3.898LeuPhe: 3.898 ± 0.807
3.669LeuGly: 3.669 ± 0.661
0.994LeuHis: 0.994 ± 0.276
4.969LeuIle: 4.969 ± 0.674
7.644LeuLys: 7.644 ± 0.954
5.733LeuLeu: 5.733 ± 0.721
1.376LeuMet: 1.376 ± 0.33
6.727LeuAsn: 6.727 ± 0.946
2.828LeuPro: 2.828 ± 0.467
3.363LeuGln: 3.363 ± 0.392
3.058LeuArg: 3.058 ± 0.598
6.039LeuSer: 6.039 ± 1.363
4.892LeuThr: 4.892 ± 0.541
4.051LeuVal: 4.051 ± 0.638
0.688LeuTrp: 0.688 ± 0.272
3.134LeuTyr: 3.134 ± 0.652
0.0LeuXaa: 0.0 ± 0.0
Met
1.758MetAla: 1.758 ± 0.41
0.0MetCys: 0.0 ± 0.0
1.223MetAsp: 1.223 ± 0.288
1.223MetGlu: 1.223 ± 0.398
1.07MetPhe: 1.07 ± 0.271
0.764MetGly: 0.764 ± 0.248
0.306MetHis: 0.306 ± 0.145
1.07MetIle: 1.07 ± 0.286
3.669MetLys: 3.669 ± 0.528
1.605MetLeu: 1.605 ± 0.26
0.153MetMet: 0.153 ± 0.125
1.605MetAsn: 1.605 ± 0.346
0.764MetPro: 0.764 ± 0.204
0.764MetGln: 0.764 ± 0.219
1.223MetArg: 1.223 ± 0.3
1.605MetSer: 1.605 ± 0.311
1.682MetThr: 1.682 ± 0.359
0.764MetVal: 0.764 ± 0.233
0.382MetTrp: 0.382 ± 0.178
0.841MetTyr: 0.841 ± 0.246
0.0MetXaa: 0.0 ± 0.0
Asn
3.593AsnAla: 3.593 ± 0.644
0.459AsnCys: 0.459 ± 0.431
4.51AsnAsp: 4.51 ± 0.506
4.204AsnGlu: 4.204 ± 0.565
2.14AsnPhe: 2.14 ± 0.473
6.497AsnGly: 6.497 ± 1.161
0.994AsnHis: 0.994 ± 0.282
4.51AsnIle: 4.51 ± 0.803
5.733AsnLys: 5.733 ± 0.632
4.969AsnLeu: 4.969 ± 0.714
1.223AsnMet: 1.223 ± 0.321
5.657AsnAsn: 5.657 ± 0.841
2.217AsnPro: 2.217 ± 0.494
2.217AsnGln: 2.217 ± 0.374
1.376AsnArg: 1.376 ± 0.389
4.204AsnSer: 4.204 ± 0.578
3.898AsnThr: 3.898 ± 0.547
3.593AsnVal: 3.593 ± 0.735
1.147AsnTrp: 1.147 ± 0.346
3.287AsnTyr: 3.287 ± 0.701
0.0AsnXaa: 0.0 ± 0.0
Pro
1.682ProAla: 1.682 ± 0.317
0.306ProCys: 0.306 ± 0.165
1.452ProAsp: 1.452 ± 0.379
2.37ProGlu: 2.37 ± 0.394
1.07ProPhe: 1.07 ± 0.334
1.147ProGly: 1.147 ± 0.353
0.535ProHis: 0.535 ± 0.184
1.605ProIle: 1.605 ± 0.311
1.529ProLys: 1.529 ± 0.325
2.14ProLeu: 2.14 ± 0.38
0.229ProMet: 0.229 ± 0.126
1.452ProAsn: 1.452 ± 0.357
0.306ProPro: 0.306 ± 0.171
0.994ProGln: 0.994 ± 0.276
0.994ProArg: 0.994 ± 0.335
1.376ProSer: 1.376 ± 0.39
1.758ProThr: 1.758 ± 0.31
2.14ProVal: 2.14 ± 0.432
0.229ProTrp: 0.229 ± 0.118
0.994ProTyr: 0.994 ± 0.283
0.0ProXaa: 0.0 ± 0.0
Gln
2.828GlnAla: 2.828 ± 0.579
0.229GlnCys: 0.229 ± 0.125
1.376GlnAsp: 1.376 ± 0.245
2.905GlnGlu: 2.905 ± 0.522
2.064GlnPhe: 2.064 ± 0.398
1.529GlnGly: 1.529 ± 0.327
0.764GlnHis: 0.764 ± 0.209
3.44GlnIle: 3.44 ± 0.524
3.287GlnLys: 3.287 ± 0.472
3.211GlnLeu: 3.211 ± 0.513
0.612GlnMet: 0.612 ± 0.213
1.911GlnAsn: 1.911 ± 0.281
0.688GlnPro: 0.688 ± 0.227
1.682GlnGln: 1.682 ± 0.438
1.299GlnArg: 1.299 ± 0.313
2.599GlnSer: 2.599 ± 0.425
2.217GlnThr: 2.217 ± 0.371
1.299GlnVal: 1.299 ± 0.331
0.229GlnTrp: 0.229 ± 0.126
1.147GlnTyr: 1.147 ± 0.256
0.0GlnXaa: 0.0 ± 0.0
Arg
2.14ArgAla: 2.14 ± 0.411
0.229ArgCys: 0.229 ± 0.142
1.682ArgAsp: 1.682 ± 0.373
2.752ArgGlu: 2.752 ± 0.483
2.064ArgPhe: 2.064 ± 0.432
1.835ArgGly: 1.835 ± 0.368
1.223ArgHis: 1.223 ± 0.306
2.293ArgIle: 2.293 ± 0.518
3.44ArgLys: 3.44 ± 0.542
3.44ArgLeu: 3.44 ± 0.629
1.299ArgMet: 1.299 ± 0.34
1.987ArgAsn: 1.987 ± 0.47
0.764ArgPro: 0.764 ± 0.243
1.376ArgGln: 1.376 ± 0.318
1.223ArgArg: 1.223 ± 0.345
1.835ArgSer: 1.835 ± 0.387
2.523ArgThr: 2.523 ± 0.418
2.064ArgVal: 2.064 ± 0.393
0.382ArgTrp: 0.382 ± 0.152
1.987ArgTyr: 1.987 ± 0.423
0.0ArgXaa: 0.0 ± 0.0
Ser
3.746SerAla: 3.746 ± 0.976
0.306SerCys: 0.306 ± 0.183
3.898SerAsp: 3.898 ± 0.58
4.739SerGlu: 4.739 ± 0.624
3.746SerPhe: 3.746 ± 0.763
4.586SerGly: 4.586 ± 0.735
0.841SerHis: 0.841 ± 0.261
4.969SerIle: 4.969 ± 0.621
5.657SerLys: 5.657 ± 0.931
4.51SerLeu: 4.51 ± 0.517
0.841SerMet: 0.841 ± 0.229
4.128SerAsn: 4.128 ± 0.459
1.529SerPro: 1.529 ± 0.347
1.987SerGln: 1.987 ± 0.424
2.293SerArg: 2.293 ± 0.457
5.274SerSer: 5.274 ± 0.652
2.828SerThr: 2.828 ± 0.438
4.357SerVal: 4.357 ± 0.532
0.612SerTrp: 0.612 ± 0.187
3.211SerTyr: 3.211 ± 0.495
0.0SerXaa: 0.0 ± 0.0
Thr
4.434ThrAla: 4.434 ± 0.705
0.382ThrCys: 0.382 ± 0.181
2.828ThrAsp: 2.828 ± 0.443
3.516ThrGlu: 3.516 ± 0.447
1.835ThrPhe: 1.835 ± 0.293
4.281ThrGly: 4.281 ± 0.664
1.147ThrHis: 1.147 ± 0.295
3.975ThrIle: 3.975 ± 0.521
6.039ThrLys: 6.039 ± 0.732
5.198ThrLeu: 5.198 ± 0.546
0.917ThrMet: 0.917 ± 0.274
3.516ThrAsn: 3.516 ± 0.691
1.682ThrPro: 1.682 ± 0.439
1.376ThrGln: 1.376 ± 0.307
1.529ThrArg: 1.529 ± 0.307
4.434ThrSer: 4.434 ± 0.649
3.363ThrThr: 3.363 ± 0.516
4.51ThrVal: 4.51 ± 0.641
0.841ThrTrp: 0.841 ± 0.235
1.605ThrTyr: 1.605 ± 0.443
0.0ThrXaa: 0.0 ± 0.0
Val
5.198ValAla: 5.198 ± 0.948
0.306ValCys: 0.306 ± 0.151
4.739ValAsp: 4.739 ± 0.453
4.204ValGlu: 4.204 ± 0.767
2.981ValPhe: 2.981 ± 0.621
2.828ValGly: 2.828 ± 0.492
0.612ValHis: 0.612 ± 0.184
4.969ValIle: 4.969 ± 0.592
5.657ValLys: 5.657 ± 0.614
4.051ValLeu: 4.051 ± 0.531
1.147ValMet: 1.147 ± 0.365
4.586ValAsn: 4.586 ± 0.665
1.758ValPro: 1.758 ± 0.389
1.987ValGln: 1.987 ± 0.466
2.675ValArg: 2.675 ± 0.472
4.281ValSer: 4.281 ± 0.665
3.746ValThr: 3.746 ± 0.43
4.281ValVal: 4.281 ± 0.707
0.764ValTrp: 0.764 ± 0.256
2.599ValTyr: 2.599 ± 0.519
0.0ValXaa: 0.0 ± 0.0
Trp
0.688TrpAla: 0.688 ± 0.27
0.153TrpCys: 0.153 ± 0.091
1.147TrpAsp: 1.147 ± 0.29
0.917TrpGlu: 0.917 ± 0.282
0.688TrpPhe: 0.688 ± 0.214
0.688TrpGly: 0.688 ± 0.227
0.229TrpHis: 0.229 ± 0.131
0.306TrpIle: 0.306 ± 0.148
1.07TrpLys: 1.07 ± 0.286
0.994TrpLeu: 0.994 ± 0.302
0.459TrpMet: 0.459 ± 0.205
0.306TrpAsn: 0.306 ± 0.152
0.076TrpPro: 0.076 ± 0.088
0.459TrpGln: 0.459 ± 0.176
0.612TrpArg: 0.612 ± 0.187
1.376TrpSer: 1.376 ± 0.357
0.841TrpThr: 0.841 ± 0.307
0.841TrpVal: 0.841 ± 0.296
0.229TrpTrp: 0.229 ± 0.144
0.688TrpTyr: 0.688 ± 0.243
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.446TyrAla: 2.446 ± 0.451
0.153TyrCys: 0.153 ± 0.114
3.058TyrAsp: 3.058 ± 0.395
3.593TyrGlu: 3.593 ± 0.573
2.217TyrPhe: 2.217 ± 0.524
2.293TyrGly: 2.293 ± 0.403
0.612TyrHis: 0.612 ± 0.184
4.128TyrIle: 4.128 ± 0.574
3.898TyrLys: 3.898 ± 0.516
2.981TyrLeu: 2.981 ± 0.465
0.535TyrMet: 0.535 ± 0.18
2.599TyrAsn: 2.599 ± 0.47
1.223TyrPro: 1.223 ± 0.375
1.452TyrGln: 1.452 ± 0.343
1.452TyrArg: 1.452 ± 0.332
2.675TyrSer: 2.675 ± 0.48
1.987TyrThr: 1.987 ± 0.409
2.446TyrVal: 2.446 ± 0.511
0.306TyrTrp: 0.306 ± 0.138
2.293TyrTyr: 2.293 ± 0.439
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 65 proteins (13083 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski