Amino acid dipepetide frequency for Aerococcus urinae (strain ACS-120-V-Col10a)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.093AlaAla: 6.093 ± 0.137
0.69AlaCys: 0.69 ± 0.037
4.834AlaAsp: 4.834 ± 0.105
4.575AlaGlu: 4.575 ± 0.104
3.301AlaPhe: 3.301 ± 0.082
5.772AlaGly: 5.772 ± 0.123
1.435AlaHis: 1.435 ± 0.065
6.337AlaIle: 6.337 ± 0.129
5.516AlaLys: 5.516 ± 0.115
8.528AlaLeu: 8.528 ± 0.137
2.211AlaMet: 2.211 ± 0.074
3.557AlaAsn: 3.557 ± 0.082
2.248AlaPro: 2.248 ± 0.087
3.629AlaGln: 3.629 ± 0.101
2.816AlaArg: 2.816 ± 0.083
4.968AlaSer: 4.968 ± 0.157
3.49AlaThr: 3.49 ± 0.081
5.116AlaVal: 5.116 ± 0.105
0.66AlaTrp: 0.66 ± 0.032
3.351AlaTyr: 3.351 ± 0.085
0.0AlaXaa: 0.0 ± 0.0
Cys
0.352CysAla: 0.352 ± 0.025
0.05CysCys: 0.05 ± 0.009
0.411CysAsp: 0.411 ± 0.033
0.324CysGlu: 0.324 ± 0.025
0.343CysPhe: 0.343 ± 0.023
0.539CysGly: 0.539 ± 0.035
0.185CysHis: 0.185 ± 0.02
0.35CysIle: 0.35 ± 0.028
0.241CysLys: 0.241 ± 0.022
0.777CysLeu: 0.777 ± 0.034
0.126CysMet: 0.126 ± 0.014
0.182CysAsn: 0.182 ± 0.018
0.261CysPro: 0.261 ± 0.022
0.528CysGln: 0.528 ± 0.034
0.263CysArg: 0.263 ± 0.019
0.384CysSer: 0.384 ± 0.026
0.222CysThr: 0.222 ± 0.021
0.38CysVal: 0.38 ± 0.026
0.041CysTrp: 0.041 ± 0.008
0.258CysTyr: 0.258 ± 0.021
0.0CysXaa: 0.0 ± 0.0
Asp
3.529AspAla: 3.529 ± 0.085
0.378AspCys: 0.378 ± 0.028
3.55AspAsp: 3.55 ± 0.111
4.28AspGlu: 4.28 ± 0.123
3.19AspPhe: 3.19 ± 0.09
3.846AspGly: 3.846 ± 0.284
1.772AspHis: 1.772 ± 0.064
4.224AspIle: 4.224 ± 0.092
4.145AspLys: 4.145 ± 0.114
7.021AspLeu: 7.021 ± 0.159
1.622AspMet: 1.622 ± 0.053
2.68AspAsn: 2.68 ± 0.072
2.593AspPro: 2.593 ± 0.099
4.771AspGln: 4.771 ± 0.124
2.855AspArg: 2.855 ± 0.081
3.296AspSer: 3.296 ± 0.095
2.591AspThr: 2.591 ± 0.088
3.283AspVal: 3.283 ± 0.09
0.725AspTrp: 0.725 ± 0.042
3.468AspTyr: 3.468 ± 0.079
0.0AspXaa: 0.0 ± 0.0
Glu
6.551GluAla: 6.551 ± 0.148
0.261GluCys: 0.261 ± 0.025
4.992GluAsp: 4.992 ± 0.124
6.384GluGlu: 6.384 ± 0.148
2.041GluPhe: 2.041 ± 0.064
4.247GluGly: 4.247 ± 0.1
1.071GluHis: 1.071 ± 0.047
4.875GluIle: 4.875 ± 0.108
5.216GluLys: 5.216 ± 0.115
5.841GluLeu: 5.841 ± 0.131
1.826GluMet: 1.826 ± 0.06
3.657GluAsn: 3.657 ± 0.082
1.696GluPro: 1.696 ± 0.063
2.278GluGln: 2.278 ± 0.063
2.953GluArg: 2.953 ± 0.083
3.824GluSer: 3.824 ± 0.105
3.318GluThr: 3.318 ± 0.115
4.977GluVal: 4.977 ± 0.126
0.61GluTrp: 0.61 ± 0.035
1.817GluTyr: 1.817 ± 0.054
0.0GluXaa: 0.0 ± 0.0
Phe
2.849PheAla: 2.849 ± 0.093
0.334PheCys: 0.334 ± 0.026
2.897PheAsp: 2.897 ± 0.078
2.315PheGlu: 2.315 ± 0.069
1.848PhePhe: 1.848 ± 0.078
2.686PheGly: 2.686 ± 0.073
0.764PheHis: 0.764 ± 0.039
3.218PheIle: 3.218 ± 0.104
2.36PheLys: 2.36 ± 0.077
3.974PheLeu: 3.974 ± 0.106
1.01PheMet: 1.01 ± 0.049
2.035PheAsn: 2.035 ± 0.067
1.548PhePro: 1.548 ± 0.057
1.798PheGln: 1.798 ± 0.065
1.394PheArg: 1.394 ± 0.051
2.988PheSer: 2.988 ± 0.107
2.356PheThr: 2.356 ± 0.066
2.727PheVal: 2.727 ± 0.086
0.33PheTrp: 0.33 ± 0.024
1.804PheTyr: 1.804 ± 0.075
0.0PheXaa: 0.0 ± 0.0
Gly
4.881GlyAla: 4.881 ± 0.142
0.443GlyCys: 0.443 ± 0.031
3.728GlyAsp: 3.728 ± 0.121
4.145GlyGlu: 4.145 ± 0.132
2.905GlyPhe: 2.905 ± 0.084
4.38GlyGly: 4.38 ± 0.128
1.485GlyHis: 1.485 ± 0.053
5.262GlyIle: 5.262 ± 0.126
4.586GlyLys: 4.586 ± 0.176
7.01GlyLeu: 7.01 ± 0.14
1.744GlyMet: 1.744 ± 0.06
2.595GlyAsn: 2.595 ± 0.081
1.796GlyPro: 1.796 ± 0.075
4.124GlyGln: 4.124 ± 0.127
2.721GlyArg: 2.721 ± 0.077
3.937GlySer: 3.937 ± 0.091
3.4GlyThr: 3.4 ± 0.123
4.667GlyVal: 4.667 ± 0.114
0.567GlyTrp: 0.567 ± 0.034
2.784GlyTyr: 2.784 ± 0.072
0.0GlyXaa: 0.0 ± 0.0
His
1.294HisAla: 1.294 ± 0.047
0.185HisCys: 0.185 ± 0.02
1.199HisAsp: 1.199 ± 0.055
1.114HisGlu: 1.114 ± 0.043
1.266HisPhe: 1.266 ± 0.051
1.386HisGly: 1.386 ± 0.063
0.601HisHis: 0.601 ± 0.04
1.364HisIle: 1.364 ± 0.049
1.053HisLys: 1.053 ± 0.048
2.308HisLeu: 2.308 ± 0.078
0.452HisMet: 0.452 ± 0.027
0.756HisAsn: 0.756 ± 0.037
1.121HisPro: 1.121 ± 0.047
1.09HisGln: 1.09 ± 0.054
0.775HisArg: 0.775 ± 0.035
1.238HisSer: 1.238 ± 0.065
0.886HisThr: 0.886 ± 0.04
1.162HisVal: 1.162 ± 0.049
0.241HisTrp: 0.241 ± 0.022
1.099HisTyr: 1.099 ± 0.05
0.0HisXaa: 0.0 ± 0.0
Ile
5.906IleAla: 5.906 ± 0.115
0.602IleCys: 0.602 ± 0.032
4.973IleAsp: 4.973 ± 0.104
4.886IleGlu: 4.886 ± 0.105
2.988IlePhe: 2.988 ± 0.097
4.829IleGly: 4.829 ± 0.125
1.529IleHis: 1.529 ± 0.054
5.296IleIle: 5.296 ± 0.152
4.052IleLys: 4.052 ± 0.098
6.573IleLeu: 6.573 ± 0.146
1.537IleMet: 1.537 ± 0.065
3.325IleAsn: 3.325 ± 0.091
2.966IlePro: 2.966 ± 0.074
3.236IleGln: 3.236 ± 0.087
2.938IleArg: 2.938 ± 0.076
4.571IleSer: 4.571 ± 0.092
3.409IleThr: 3.409 ± 0.083
4.502IleVal: 4.502 ± 0.096
0.51IleTrp: 0.51 ± 0.031
2.701IleTyr: 2.701 ± 0.077
0.0IleXaa: 0.0 ± 0.0
Lys
5.327LysAla: 5.327 ± 0.11
0.169LysCys: 0.169 ± 0.016
4.754LysAsp: 4.754 ± 0.18
5.678LysGlu: 5.678 ± 0.121
1.627LysPhe: 1.627 ± 0.066
4.015LysGly: 4.015 ± 0.141
1.231LysHis: 1.231 ± 0.053
3.911LysIle: 3.911 ± 0.086
4.289LysLys: 4.289 ± 0.12
4.805LysLeu: 4.805 ± 0.11
1.574LysMet: 1.574 ± 0.058
3.285LysAsn: 3.285 ± 0.091
1.789LysPro: 1.789 ± 0.078
2.995LysGln: 2.995 ± 0.08
2.89LysArg: 2.89 ± 0.073
3.364LysSer: 3.364 ± 0.089
3.375LysThr: 3.375 ± 0.111
4.083LysVal: 4.083 ± 0.12
0.462LysTrp: 0.462 ± 0.028
2.056LysTyr: 2.056 ± 0.062
0.0LysXaa: 0.0 ± 0.0
Leu
9.665LeuAla: 9.665 ± 0.158
0.614LeuCys: 0.614 ± 0.035
6.197LeuAsp: 6.197 ± 0.137
6.362LeuGlu: 6.362 ± 0.131
4.13LeuPhe: 4.13 ± 0.122
6.749LeuGly: 6.749 ± 0.15
1.559LeuHis: 1.559 ± 0.066
7.059LeuIle: 7.059 ± 0.167
6.13LeuLys: 6.13 ± 0.128
10.037LeuLeu: 10.037 ± 0.222
2.406LeuMet: 2.406 ± 0.071
4.538LeuAsn: 4.538 ± 0.092
3.835LeuPro: 3.835 ± 0.09
3.179LeuGln: 3.179 ± 0.093
3.513LeuArg: 3.513 ± 0.086
7.261LeuSer: 7.261 ± 0.145
5.388LeuThr: 5.388 ± 0.105
6.666LeuVal: 6.666 ± 0.126
0.717LeuTrp: 0.717 ± 0.038
3.283LeuTyr: 3.283 ± 0.087
0.0LeuXaa: 0.0 ± 0.0
Met
2.228MetAla: 2.228 ± 0.067
0.098MetCys: 0.098 ± 0.014
1.461MetAsp: 1.461 ± 0.051
1.485MetGlu: 1.485 ± 0.066
0.638MetPhe: 0.638 ± 0.037
1.754MetGly: 1.754 ± 0.066
0.386MetHis: 0.386 ± 0.032
1.735MetIle: 1.735 ± 0.064
1.728MetLys: 1.728 ± 0.059
1.989MetLeu: 1.989 ± 0.07
0.601MetMet: 0.601 ± 0.033
1.236MetAsn: 1.236 ± 0.048
0.955MetPro: 0.955 ± 0.042
1.01MetGln: 1.01 ± 0.047
0.995MetArg: 0.995 ± 0.046
1.548MetSer: 1.548 ± 0.057
1.811MetThr: 1.811 ± 0.059
1.765MetVal: 1.765 ± 0.06
0.154MetTrp: 0.154 ± 0.017
0.521MetTyr: 0.521 ± 0.03
0.0MetXaa: 0.0 ± 0.0
Asn
2.784AsnAla: 2.784 ± 0.077
0.289AsnCys: 0.289 ± 0.022
2.675AsnAsp: 2.675 ± 0.073
2.823AsnGlu: 2.823 ± 0.077
1.854AsnPhe: 1.854 ± 0.062
2.88AsnGly: 2.88 ± 0.092
1.279AsnHis: 1.279 ± 0.053
3.272AsnIle: 3.272 ± 0.082
2.704AsnLys: 2.704 ± 0.085
4.273AsnLeu: 4.273 ± 0.108
1.04AsnMet: 1.04 ± 0.042
2.13AsnAsn: 2.13 ± 0.07
2.248AsnPro: 2.248 ± 0.084
2.812AsnGln: 2.812 ± 0.084
2.063AsnArg: 2.063 ± 0.073
2.347AsnSer: 2.347 ± 0.075
2.009AsnThr: 2.009 ± 0.068
2.488AsnVal: 2.488 ± 0.071
0.547AsnTrp: 0.547 ± 0.033
2.273AsnTyr: 2.273 ± 0.073
0.0AsnXaa: 0.0 ± 0.0
Pro
2.728ProAla: 2.728 ± 0.092
0.178ProCys: 0.178 ± 0.02
2.306ProAsp: 2.306 ± 0.078
2.995ProGlu: 2.995 ± 0.099
1.555ProPhe: 1.555 ± 0.056
2.552ProGly: 2.552 ± 0.108
0.769ProHis: 0.769 ± 0.042
2.565ProIle: 2.565 ± 0.07
2.3ProLys: 2.3 ± 0.066
3.461ProLeu: 3.461 ± 0.091
0.715ProMet: 0.715 ± 0.035
1.737ProAsn: 1.737 ± 0.063
0.641ProPro: 0.641 ± 0.044
1.689ProGln: 1.689 ± 0.058
1.095ProArg: 1.095 ± 0.046
2.336ProSer: 2.336 ± 0.073
1.815ProThr: 1.815 ± 0.084
2.719ProVal: 2.719 ± 0.122
0.347ProTrp: 0.347 ± 0.026
1.527ProTyr: 1.527 ± 0.051
0.0ProXaa: 0.0 ± 0.0
Gln
6.484GlnAla: 6.484 ± 0.148
0.196GlnCys: 0.196 ± 0.02
2.875GlnAsp: 2.875 ± 0.088
4.185GlnGlu: 4.185 ± 0.115
1.581GlnPhe: 1.581 ± 0.062
3.481GlnGly: 3.481 ± 0.1
0.704GlnHis: 0.704 ± 0.037
2.999GlnIle: 2.999 ± 0.076
2.823GlnLys: 2.823 ± 0.079
4.999GlnLeu: 4.999 ± 0.125
1.144GlnMet: 1.144 ± 0.045
1.867GlnAsn: 1.867 ± 0.062
1.474GlnPro: 1.474 ± 0.058
1.796GlnGln: 1.796 ± 0.07
2.057GlnArg: 2.057 ± 0.056
3.075GlnSer: 3.075 ± 0.088
2.213GlnThr: 2.213 ± 0.069
4.471GlnVal: 4.471 ± 0.121
0.48GlnTrp: 0.48 ± 0.032
1.37GlnTyr: 1.37 ± 0.051
0.0GlnXaa: 0.0 ± 0.0
Arg
2.436ArgAla: 2.436 ± 0.067
0.247ArgCys: 0.247 ± 0.021
2.456ArgAsp: 2.456 ± 0.075
2.747ArgGlu: 2.747 ± 0.087
1.922ArgPhe: 1.922 ± 0.061
2.285ArgGly: 2.285 ± 0.07
0.89ArgHis: 0.89 ± 0.042
2.923ArgIle: 2.923 ± 0.079
2.31ArgLys: 2.31 ± 0.079
4.656ArgLeu: 4.656 ± 0.103
1.018ArgMet: 1.018 ± 0.043
1.581ArgAsn: 1.581 ± 0.057
1.605ArgPro: 1.605 ± 0.053
2.708ArgGln: 2.708 ± 0.089
2.037ArgArg: 2.037 ± 0.067
2.169ArgSer: 2.169 ± 0.067
1.744ArgThr: 1.744 ± 0.054
2.649ArgVal: 2.649 ± 0.074
0.26ArgTrp: 0.26 ± 0.022
1.741ArgTyr: 1.741 ± 0.061
0.0ArgXaa: 0.0 ± 0.0
Ser
3.995SerAla: 3.995 ± 0.161
0.321SerCys: 0.321 ± 0.026
3.781SerAsp: 3.781 ± 0.091
4.072SerGlu: 4.072 ± 0.145
2.817SerPhe: 2.817 ± 0.076
4.506SerGly: 4.506 ± 0.098
1.535SerHis: 1.535 ± 0.051
3.917SerIle: 3.917 ± 0.086
3.249SerLys: 3.249 ± 0.083
6.66SerLeu: 6.66 ± 0.145
1.329SerMet: 1.329 ± 0.05
2.471SerAsn: 2.471 ± 0.078
2.343SerPro: 2.343 ± 0.071
4.45SerGln: 4.45 ± 0.129
2.545SerArg: 2.545 ± 0.069
3.674SerSer: 3.674 ± 0.089
2.665SerThr: 2.665 ± 0.093
3.72SerVal: 3.72 ± 0.12
0.617SerTrp: 0.617 ± 0.034
2.615SerTyr: 2.615 ± 0.069
0.0SerXaa: 0.0 ± 0.0
Thr
3.831ThrAla: 3.831 ± 0.079
0.339ThrCys: 0.339 ± 0.027
3.042ThrAsp: 3.042 ± 0.076
2.834ThrGlu: 2.834 ± 0.089
2.15ThrPhe: 2.15 ± 0.076
3.896ThrGly: 3.896 ± 0.125
1.014ThrHis: 1.014 ± 0.042
4.067ThrIle: 4.067 ± 0.124
2.66ThrLys: 2.66 ± 0.095
4.493ThrLeu: 4.493 ± 0.09
1.151ThrMet: 1.151 ± 0.057
2.019ThrAsn: 2.019 ± 0.073
2.369ThrPro: 2.369 ± 0.118
1.846ThrGln: 1.846 ± 0.05
1.678ThrArg: 1.678 ± 0.06
3.133ThrSer: 3.133 ± 0.105
2.719ThrThr: 2.719 ± 0.151
3.88ThrVal: 3.88 ± 0.14
0.393ThrTrp: 0.393 ± 0.026
2.154ThrTyr: 2.154 ± 0.067
0.0ThrXaa: 0.0 ± 0.0
Val
5.151ValAla: 5.151 ± 0.135
0.475ValCys: 0.475 ± 0.035
4.686ValAsp: 4.686 ± 0.11
4.614ValGlu: 4.614 ± 0.116
2.68ValPhe: 2.68 ± 0.089
4.304ValGly: 4.304 ± 0.114
1.136ValHis: 1.136 ± 0.048
5.023ValIle: 5.023 ± 0.103
4.28ValLys: 4.28 ± 0.123
6.098ValLeu: 6.098 ± 0.126
1.587ValMet: 1.587 ± 0.056
3.238ValAsn: 3.238 ± 0.092
2.488ValPro: 2.488 ± 0.1
2.417ValGln: 2.417 ± 0.077
2.365ValArg: 2.365 ± 0.072
4.499ValSer: 4.499 ± 0.095
4.035ValThr: 4.035 ± 0.165
4.825ValVal: 4.825 ± 0.137
0.45ValTrp: 0.45 ± 0.027
2.369ValTyr: 2.369 ± 0.067
0.0ValXaa: 0.0 ± 0.0
Trp
0.476TrpAla: 0.476 ± 0.03
0.043TrpCys: 0.043 ± 0.009
0.482TrpAsp: 0.482 ± 0.025
0.51TrpGlu: 0.51 ± 0.034
0.339TrpPhe: 0.339 ± 0.03
0.491TrpGly: 0.491 ± 0.029
0.198TrpHis: 0.198 ± 0.017
0.647TrpIle: 0.647 ± 0.036
0.386TrpLys: 0.386 ± 0.028
1.177TrpLeu: 1.177 ± 0.053
0.232TrpMet: 0.232 ± 0.024
0.35TrpAsn: 0.35 ± 0.023
0.298TrpPro: 0.298 ± 0.022
0.628TrpGln: 0.628 ± 0.032
0.413TrpArg: 0.413 ± 0.026
0.471TrpSer: 0.471 ± 0.028
0.475TrpThr: 0.475 ± 0.03
0.519TrpVal: 0.519 ± 0.031
0.067TrpTrp: 0.067 ± 0.011
0.341TrpTyr: 0.341 ± 0.027
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.571TyrAla: 2.571 ± 0.068
0.308TyrCys: 0.308 ± 0.025
2.521TyrAsp: 2.521 ± 0.068
2.106TyrGlu: 2.106 ± 0.064
2.057TyrPhe: 2.057 ± 0.07
2.56TyrGly: 2.56 ± 0.07
1.049TyrHis: 1.049 ± 0.051
2.284TyrIle: 2.284 ± 0.073
1.652TyrLys: 1.652 ± 0.064
4.604TyrLeu: 4.604 ± 0.118
0.769TyrMet: 0.769 ± 0.039
1.55TyrAsn: 1.55 ± 0.063
1.757TyrPro: 1.757 ± 0.076
3.288TyrGln: 3.288 ± 0.096
2.017TyrArg: 2.017 ± 0.068
2.204TyrSer: 2.204 ± 0.063
1.744TyrThr: 1.744 ± 0.058
2.122TyrVal: 2.122 ± 0.07
0.367TyrTrp: 0.367 ± 0.022
1.807TyrTyr: 1.807 ± 0.064
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1684 proteins (539492 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski