Amino acid dipepetide frequency for Anaerotruncus sp. G3(2012)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.987AlaAla: 10.987 ± 0.172	1.432AlaCys: 1.432 ± 0.039	5.108AlaAsp: 5.108 ± 0.088	6.198AlaGlu: 6.198 ± 0.104	3.541AlaPhe: 3.541 ± 0.069	7.59AlaGly: 7.59 ± 0.111	1.349AlaHis: 1.349 ± 0.043	4.878AlaIle: 4.878 ± 0.082	4.208AlaLys: 4.208 ± 0.073	8.826AlaLeu: 8.826 ± 0.112	2.44AlaMet: 2.44 ± 0.058	2.678AlaAsn: 2.678 ± 0.058	3.417AlaPro: 3.417 ± 0.091	3.862AlaGln: 3.862 ± 0.069	4.572AlaArg: 4.572 ± 0.081	4.831AlaSer: 4.831 ± 0.074	3.413AlaThr: 3.413 ± 0.07	7.666AlaVal: 7.666 ± 0.088	0.737AlaTrp: 0.737 ± 0.028	2.787AlaTyr: 2.787 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	1.489CysAla: 1.489 ± 0.041	0.343CysCys: 0.343 ± 0.017	0.9CysAsp: 0.9 ± 0.031	0.967CysGlu: 0.967 ± 0.033	0.623CysPhe: 0.623 ± 0.026	1.855CysGly: 1.855 ± 0.05	0.282CysHis: 0.282 ± 0.017	0.949CysIle: 0.949 ± 0.032	0.743CysLys: 0.743 ± 0.031	1.273CysLeu: 1.273 ± 0.041	0.38CysMet: 0.38 ± 0.019	0.528CysAsn: 0.528 ± 0.022	0.806CysPro: 0.806 ± 0.031	0.455CysGln: 0.455 ± 0.023	0.978CysArg: 0.978 ± 0.033	0.94CysSer: 0.94 ± 0.028	0.85CysThr: 0.85 ± 0.031	1.015CysVal: 1.015 ± 0.033	0.164CysTrp: 0.164 ± 0.013	0.567CysTyr: 0.567 ± 0.024	0.0CysXaa: 0.0 ± 0.0
Asp	4.808AspAla: 4.808 ± 0.081	0.951AspCys: 0.951 ± 0.031	2.608AspAsp: 2.608 ± 0.065	3.788AspGlu: 3.788 ± 0.069	2.39AspPhe: 2.39 ± 0.052	5.005AspGly: 5.005 ± 0.089	0.87AspHis: 0.87 ± 0.033	3.186AspIle: 3.186 ± 0.06	2.414AspLys: 2.414 ± 0.062	5.113AspLeu: 5.113 ± 0.077	1.404AspMet: 1.404 ± 0.039	1.688AspAsn: 1.688 ± 0.046	2.552AspPro: 2.552 ± 0.054	1.608AspGln: 1.608 ± 0.044	3.477AspArg: 3.477 ± 0.068	3.064AspSer: 3.064 ± 0.056	3.004AspThr: 3.004 ± 0.062	3.322AspVal: 3.322 ± 0.064	0.662AspTrp: 0.662 ± 0.029	2.254AspTyr: 2.254 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	5.689GluAla: 5.689 ± 0.089	0.738GluCys: 0.738 ± 0.029	3.368GluAsp: 3.368 ± 0.065	5.303GluGlu: 5.303 ± 0.1	2.162GluPhe: 2.162 ± 0.044	4.409GluGly: 4.409 ± 0.072	1.236GluHis: 1.236 ± 0.04	4.783GluIle: 4.783 ± 0.078	4.489GluLys: 4.489 ± 0.086	6.789GluLeu: 6.789 ± 0.092	2.16GluMet: 2.16 ± 0.047	3.023GluAsn: 3.023 ± 0.053	2.622GluPro: 2.622 ± 0.064	3.853GluGln: 3.853 ± 0.083	4.508GluArg: 4.508 ± 0.089	3.343GluSer: 3.343 ± 0.064	3.492GluThr: 3.492 ± 0.058	4.253GluVal: 4.253 ± 0.063	0.625GluTrp: 0.625 ± 0.022	2.316GluTyr: 2.316 ± 0.047	0.0GluXaa: 0.0 ± 0.0
Phe	3.424PheAla: 3.424 ± 0.063	0.891PheCys: 0.891 ± 0.033	2.541PheAsp: 2.541 ± 0.053	2.49PheGlu: 2.49 ± 0.056	1.812PhePhe: 1.812 ± 0.051	3.192PheGly: 3.192 ± 0.072	0.722PheHis: 0.722 ± 0.028	2.001PheIle: 2.001 ± 0.05	1.436PheLys: 1.436 ± 0.041	4.061PheLeu: 4.061 ± 0.075	0.914PheMet: 0.914 ± 0.038	1.244PheAsn: 1.244 ± 0.035	1.579PhePro: 1.579 ± 0.044	1.355PheGln: 1.355 ± 0.04	2.034PheArg: 2.034 ± 0.043	3.166PheSer: 3.166 ± 0.06	2.305PheThr: 2.305 ± 0.048	2.624PheVal: 2.624 ± 0.056	0.421PheTrp: 0.421 ± 0.02	1.499PheTyr: 1.499 ± 0.036	0.0PheXaa: 0.0 ± 0.0
Gly	6.113GlyAla: 6.113 ± 0.097	1.489GlyCys: 1.489 ± 0.046	3.679GlyAsp: 3.679 ± 0.064	4.97GlyGlu: 4.97 ± 0.069	3.159GlyPhe: 3.159 ± 0.058	6.248GlyGly: 6.248 ± 0.112	1.335GlyHis: 1.335 ± 0.034	5.533GlyIle: 5.533 ± 0.084	4.631GlyLys: 4.631 ± 0.059	6.891GlyLeu: 6.891 ± 0.096	2.649GlyMet: 2.649 ± 0.049	2.702GlyAsn: 2.702 ± 0.058	1.721GlyPro: 1.721 ± 0.04	2.853GlyGln: 2.853 ± 0.061	4.442GlyArg: 4.442 ± 0.083	4.641GlySer: 4.641 ± 0.082	4.175GlyThr: 4.175 ± 0.086	5.642GlyVal: 5.642 ± 0.079	0.955GlyTrp: 0.955 ± 0.042	2.992GlyTyr: 2.992 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	1.487HisAla: 1.487 ± 0.042	0.334HisCys: 0.334 ± 0.018	0.846HisAsp: 0.846 ± 0.038	1.016HisGlu: 1.016 ± 0.033	0.782HisPhe: 0.782 ± 0.03	1.258HisGly: 1.258 ± 0.037	0.392HisHis: 0.392 ± 0.021	1.174HisIle: 1.174 ± 0.035	0.757HisLys: 0.757 ± 0.028	1.777HisLeu: 1.777 ± 0.041	0.429HisMet: 0.429 ± 0.021	0.657HisAsn: 0.657 ± 0.023	1.16HisPro: 1.16 ± 0.037	0.642HisGln: 0.642 ± 0.025	1.014HisArg: 1.014 ± 0.034	1.001HisSer: 1.001 ± 0.035	0.991HisThr: 0.991 ± 0.036	0.933HisVal: 0.933 ± 0.034	0.197HisTrp: 0.197 ± 0.014	0.717HisTyr: 0.717 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	5.645IleAla: 5.645 ± 0.091	1.111IleCys: 1.111 ± 0.038	3.699IleAsp: 3.699 ± 0.073	3.892IleGlu: 3.892 ± 0.064	2.253IlePhe: 2.253 ± 0.062	4.743IleGly: 4.743 ± 0.075	1.095IleHis: 1.095 ± 0.035	3.167IleIle: 3.167 ± 0.06	2.564IleLys: 2.564 ± 0.071	5.718IleLeu: 5.718 ± 0.1	1.376IleMet: 1.376 ± 0.039	2.151IleAsn: 2.151 ± 0.055	3.102IlePro: 3.102 ± 0.061	2.014IleGln: 2.014 ± 0.044	3.713IleArg: 3.713 ± 0.07	4.231IleSer: 4.231 ± 0.071	3.334IleThr: 3.334 ± 0.068	4.049IleVal: 4.049 ± 0.076	0.535IleTrp: 0.535 ± 0.025	1.907IleTyr: 1.907 ± 0.044	0.0IleXaa: 0.0 ± 0.0
Lys	4.281LysAla: 4.281 ± 0.085	0.543LysCys: 0.543 ± 0.023	2.387LysAsp: 2.387 ± 0.058	3.802LysGlu: 3.802 ± 0.067	1.44LysPhe: 1.44 ± 0.045	3.343LysGly: 3.343 ± 0.06	0.78LysHis: 0.78 ± 0.029	3.059LysIle: 3.059 ± 0.058	3.578LysLys: 3.578 ± 0.071	4.514LysLeu: 4.514 ± 0.058	1.443LysMet: 1.443 ± 0.042	2.167LysAsn: 2.167 ± 0.049	2.16LysPro: 2.16 ± 0.052	2.138LysGln: 2.138 ± 0.05	3.072LysArg: 3.072 ± 0.063	2.68LysSer: 2.68 ± 0.057	2.947LysThr: 2.947 ± 0.056	3.103LysVal: 3.103 ± 0.064	0.461LysTrp: 0.461 ± 0.024	1.697LysTyr: 1.697 ± 0.044	0.0LysXaa: 0.0 ± 0.0
Leu	8.605LeuAla: 8.605 ± 0.099	1.865LeuCys: 1.865 ± 0.05	5.627LeuAsp: 5.627 ± 0.072	6.523LeuGlu: 6.523 ± 0.084	4.237LeuPhe: 4.237 ± 0.092	6.582LeuGly: 6.582 ± 0.105	1.79LeuHis: 1.79 ± 0.044	5.293LeuIle: 5.293 ± 0.093	4.533LeuLys: 4.533 ± 0.075	10.635LeuLeu: 10.635 ± 0.156	2.594LeuMet: 2.594 ± 0.058	3.236LeuAsn: 3.236 ± 0.056	4.644LeuPro: 4.644 ± 0.081	3.119LeuGln: 3.119 ± 0.061	5.489LeuArg: 5.489 ± 0.092	6.925LeuSer: 6.925 ± 0.091	5.511LeuThr: 5.511 ± 0.073	6.105LeuVal: 6.105 ± 0.091	0.882LeuTrp: 0.882 ± 0.036	3.156LeuTyr: 3.156 ± 0.063	0.0LeuXaa: 0.0 ± 0.0
Met	2.582MetAla: 2.582 ± 0.055	0.312MetCys: 0.312 ± 0.017	1.553MetAsp: 1.553 ± 0.041	2.096MetGlu: 2.096 ± 0.055	0.862MetPhe: 0.862 ± 0.032	2.123MetGly: 2.123 ± 0.055	0.391MetHis: 0.391 ± 0.022	1.546MetIle: 1.546 ± 0.039	1.689MetLys: 1.689 ± 0.04	2.779MetLeu: 2.779 ± 0.058	0.821MetMet: 0.821 ± 0.028	1.111MetAsn: 1.111 ± 0.03	1.244MetPro: 1.244 ± 0.035	1.193MetGln: 1.193 ± 0.031	1.545MetArg: 1.545 ± 0.04	1.672MetSer: 1.672 ± 0.049	1.515MetThr: 1.515 ± 0.037	1.878MetVal: 1.878 ± 0.049	0.188MetTrp: 0.188 ± 0.013	0.636MetTyr: 0.636 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	3.111AsnAla: 3.111 ± 0.065	0.552AsnCys: 0.552 ± 0.026	1.591AsnAsp: 1.591 ± 0.04	1.931AsnGlu: 1.931 ± 0.043	1.285AsnPhe: 1.285 ± 0.034	3.123AsnGly: 3.123 ± 0.062	0.687AsnHis: 0.687 ± 0.025	2.308AsnIle: 2.308 ± 0.048	1.44AsnLys: 1.44 ± 0.038	3.448AsnLeu: 3.448 ± 0.064	0.934AsnMet: 0.934 ± 0.03	1.192AsnAsn: 1.192 ± 0.042	2.219AsnPro: 2.219 ± 0.051	1.327AsnGln: 1.327 ± 0.033	2.296AsnArg: 2.296 ± 0.052	1.863AsnSer: 1.863 ± 0.05	1.923AsnThr: 1.923 ± 0.045	2.045AsnVal: 2.045 ± 0.048	0.356AsnTrp: 0.356 ± 0.02	1.259AsnTyr: 1.259 ± 0.035	0.0AsnXaa: 0.0 ± 0.0
Pro	4.253ProAla: 4.253 ± 0.081	0.56ProCys: 0.56 ± 0.026	3.147ProAsp: 3.147 ± 0.069	4.071ProGlu: 4.071 ± 0.076	1.749ProPhe: 1.749 ± 0.042	2.895ProGly: 2.895 ± 0.06	0.812ProHis: 0.812 ± 0.034	2.069ProIle: 2.069 ± 0.051	1.825ProLys: 1.825 ± 0.045	3.684ProLeu: 3.684 ± 0.062	0.977ProMet: 0.977 ± 0.032	1.298ProAsn: 1.298 ± 0.042	1.882ProPro: 1.882 ± 0.061	1.7ProGln: 1.7 ± 0.042	1.796ProArg: 1.796 ± 0.046	2.507ProSer: 2.507 ± 0.057	1.892ProThr: 1.892 ± 0.047	3.785ProVal: 3.785 ± 0.062	0.343ProTrp: 0.343 ± 0.017	1.449ProTyr: 1.449 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	3.779GlnAla: 3.779 ± 0.08	0.377GlnCys: 0.377 ± 0.018	1.63GlnAsp: 1.63 ± 0.043	2.884GlnGlu: 2.884 ± 0.052	1.362GlnPhe: 1.362 ± 0.04	2.362GlnGly: 2.362 ± 0.045	0.571GlnHis: 0.571 ± 0.028	2.722GlnIle: 2.722 ± 0.055	2.444GlnLys: 2.444 ± 0.056	3.518GlnLeu: 3.518 ± 0.066	1.297GlnMet: 1.297 ± 0.036	1.598GlnAsn: 1.598 ± 0.037	1.63GlnPro: 1.63 ± 0.049	1.785GlnGln: 1.785 ± 0.056	2.162GlnArg: 2.162 ± 0.054	2.079GlnSer: 2.079 ± 0.048	2.11GlnThr: 2.11 ± 0.054	2.512GlnVal: 2.512 ± 0.053	0.368GlnTrp: 0.368 ± 0.019	1.337GlnTyr: 1.337 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	4.398ArgAla: 4.398 ± 0.08	0.874ArgCys: 0.874 ± 0.035	2.827ArgAsp: 2.827 ± 0.061	4.646ArgGlu: 4.646 ± 0.077	2.586ArgPhe: 2.586 ± 0.056	3.463ArgGly: 3.463 ± 0.068	1.109ArgHis: 1.109 ± 0.033	3.831ArgIle: 3.831 ± 0.06	2.978ArgLys: 2.978 ± 0.053	6.031ArgLeu: 6.031 ± 0.092	2.005ArgMet: 2.005 ± 0.049	1.889ArgAsn: 1.889 ± 0.043	2.223ArgPro: 2.223 ± 0.051	2.666ArgGln: 2.666 ± 0.057	3.849ArgArg: 3.849 ± 0.084	3.047ArgSer: 3.047 ± 0.044	2.917ArgThr: 2.917 ± 0.054	3.682ArgVal: 3.682 ± 0.07	0.677ArgTrp: 0.677 ± 0.026	2.245ArgTyr: 2.245 ± 0.049	0.0ArgXaa: 0.0 ± 0.0
Ser	5.5SerAla: 5.5 ± 0.098	0.899SerCys: 0.899 ± 0.03	3.319SerAsp: 3.319 ± 0.059	3.957SerGlu: 3.957 ± 0.08	2.556SerPhe: 2.556 ± 0.048	5.693SerGly: 5.693 ± 0.09	1.146SerHis: 1.146 ± 0.034	3.635SerIle: 3.635 ± 0.078	2.573SerLys: 2.573 ± 0.055	5.626SerLeu: 5.626 ± 0.082	1.644SerMet: 1.644 ± 0.044	1.916SerAsn: 1.916 ± 0.049	2.448SerPro: 2.448 ± 0.054	2.092SerGln: 2.092 ± 0.051	3.499SerArg: 3.499 ± 0.06	3.997SerSer: 3.997 ± 0.117	2.877SerThr: 2.877 ± 0.065	4.244SerVal: 4.244 ± 0.066	0.536SerTrp: 0.536 ± 0.027	2.192SerTyr: 2.192 ± 0.056	0.0SerXaa: 0.0 ± 0.0
Thr	5.334ThrAla: 5.334 ± 0.081	0.667ThrCys: 0.667 ± 0.03	2.853ThrAsp: 2.853 ± 0.058	3.075ThrGlu: 3.075 ± 0.068	2.036ThrPhe: 2.036 ± 0.047	4.826ThrGly: 4.826 ± 0.078	0.843ThrHis: 0.843 ± 0.029	3.394ThrIle: 3.394 ± 0.071	1.956ThrLys: 1.956 ± 0.048	5.288ThrLeu: 5.288 ± 0.076	1.335ThrMet: 1.335 ± 0.039	1.6ThrAsn: 1.6 ± 0.041	2.604ThrPro: 2.604 ± 0.06	1.615ThrGln: 1.615 ± 0.045	2.632ThrArg: 2.632 ± 0.057	2.892ThrSer: 2.892 ± 0.052	2.661ThrThr: 2.661 ± 0.058	4.773ThrVal: 4.773 ± 0.073	0.462ThrTrp: 0.462 ± 0.022	1.666ThrTyr: 1.666 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	5.509ValAla: 5.509 ± 0.081	1.388ValCys: 1.388 ± 0.038	3.797ValAsp: 3.797 ± 0.064	4.616ValGlu: 4.616 ± 0.073	2.899ValPhe: 2.899 ± 0.062	4.636ValGly: 4.636 ± 0.067	1.209ValHis: 1.209 ± 0.036	4.174ValIle: 4.174 ± 0.075	3.281ValLys: 3.281 ± 0.064	6.83ValLeu: 6.83 ± 0.104	1.846ValMet: 1.846 ± 0.048	2.476ValAsn: 2.476 ± 0.057	2.929ValPro: 2.929 ± 0.058	2.363ValGln: 2.363 ± 0.044	4.061ValArg: 4.061 ± 0.072	5.009ValSer: 5.009 ± 0.088	4.007ValThr: 4.007 ± 0.081	5.312ValVal: 5.312 ± 0.09	0.707ValTrp: 0.707 ± 0.03	2.421ValTyr: 2.421 ± 0.047	0.0ValXaa: 0.0 ± 0.0
Trp	0.664TrpAla: 0.664 ± 0.029	0.164TrpCys: 0.164 ± 0.013	0.524TrpAsp: 0.524 ± 0.023	0.722TrpGlu: 0.722 ± 0.029	0.482TrpPhe: 0.482 ± 0.024	0.731TrpGly: 0.731 ± 0.029	0.202TrpHis: 0.202 ± 0.016	0.544TrpIle: 0.544 ± 0.023	0.59TrpLys: 0.59 ± 0.024	1.034TrpLeu: 1.034 ± 0.039	0.321TrpMet: 0.321 ± 0.02	0.459TrpAsn: 0.459 ± 0.023	0.246TrpPro: 0.246 ± 0.016	0.417TrpGln: 0.417 ± 0.023	0.549TrpArg: 0.549 ± 0.025	0.543TrpSer: 0.543 ± 0.024	0.439TrpThr: 0.439 ± 0.018	0.595TrpVal: 0.595 ± 0.026	0.146TrpTrp: 0.146 ± 0.012	0.381TrpTyr: 0.381 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.864TyrAla: 2.864 ± 0.048	0.62TyrCys: 0.62 ± 0.028	2.163TyrAsp: 2.163 ± 0.05	2.214TyrGlu: 2.214 ± 0.05	1.494TyrPhe: 1.494 ± 0.042	2.745TyrGly: 2.745 ± 0.062	0.743TyrHis: 0.743 ± 0.029	2.055TyrIle: 2.055 ± 0.045	1.462TyrLys: 1.462 ± 0.043	3.516TyrLeu: 3.516 ± 0.059	0.767TyrMet: 0.767 ± 0.027	1.275TyrAsn: 1.275 ± 0.039	1.505TyrPro: 1.505 ± 0.037	1.468TyrGln: 1.468 ± 0.042	2.254TyrArg: 2.254 ± 0.047	1.921TyrSer: 1.921 ± 0.047	2.15TyrThr: 2.15 ± 0.049	1.933TyrVal: 1.933 ± 0.047	0.33TyrTrp: 0.33 ± 0.018	1.355TyrTyr: 1.355 ± 0.038	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3406 proteins (991676 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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