Amino acid dipepetide frequency for Ligilactobacillus animalis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.433AlaAla: 6.433 ± 0.146
0.492AlaCys: 0.492 ± 0.028
5.167AlaAsp: 5.167 ± 0.103
5.053AlaGlu: 5.053 ± 0.117
3.281AlaPhe: 3.281 ± 0.078
5.955AlaGly: 5.955 ± 0.136
1.393AlaHis: 1.393 ± 0.06
5.215AlaIle: 5.215 ± 0.105
7.558AlaLys: 7.558 ± 0.139
8.964AlaLeu: 8.964 ± 0.15
1.938AlaMet: 1.938 ± 0.062
3.386AlaAsn: 3.386 ± 0.093
2.57AlaPro: 2.57 ± 0.075
4.222AlaGln: 4.222 ± 0.116
2.955AlaArg: 2.955 ± 0.076
4.161AlaSer: 4.161 ± 0.092
5.003AlaThr: 5.003 ± 0.112
5.806AlaVal: 5.806 ± 0.109
0.774AlaTrp: 0.774 ± 0.043
2.855AlaTyr: 2.855 ± 0.068
0.0AlaXaa: 0.0 ± 0.0
Cys
0.503CysAla: 0.503 ± 0.034
0.063CysCys: 0.063 ± 0.013
0.422CysAsp: 0.422 ± 0.03
0.354CysGlu: 0.354 ± 0.023
0.321CysPhe: 0.321 ± 0.022
0.613CysGly: 0.613 ± 0.042
0.144CysHis: 0.144 ± 0.017
0.365CysIle: 0.365 ± 0.028
0.271CysLys: 0.271 ± 0.022
0.764CysLeu: 0.764 ± 0.04
0.114CysMet: 0.114 ± 0.015
0.212CysAsn: 0.212 ± 0.018
0.289CysPro: 0.289 ± 0.028
0.273CysGln: 0.273 ± 0.025
0.238CysArg: 0.238 ± 0.024
0.367CysSer: 0.367 ± 0.026
0.265CysThr: 0.265 ± 0.022
0.409CysVal: 0.409 ± 0.029
0.066CysTrp: 0.066 ± 0.012
0.263CysTyr: 0.263 ± 0.022
0.0CysXaa: 0.0 ± 0.0
Asp
3.852AspAla: 3.852 ± 0.093
0.308AspCys: 0.308 ± 0.02
3.119AspAsp: 3.119 ± 0.083
4.345AspGlu: 4.345 ± 0.116
2.782AspPhe: 2.782 ± 0.073
3.703AspGly: 3.703 ± 0.104
1.214AspHis: 1.214 ± 0.052
3.688AspIle: 3.688 ± 0.081
4.137AspLys: 4.137 ± 0.101
5.86AspLeu: 5.86 ± 0.115
1.306AspMet: 1.306 ± 0.047
2.166AspAsn: 2.166 ± 0.072
2.951AspPro: 2.951 ± 0.088
2.671AspGln: 2.671 ± 0.071
2.133AspArg: 2.133 ± 0.063
2.656AspSer: 2.656 ± 0.07
2.931AspThr: 2.931 ± 0.082
3.896AspVal: 3.896 ± 0.098
0.624AspTrp: 0.624 ± 0.034
2.292AspTyr: 2.292 ± 0.068
0.0AspXaa: 0.0 ± 0.0
Glu
5.314GluAla: 5.314 ± 0.109
0.286GluCys: 0.286 ± 0.024
3.021GluAsp: 3.021 ± 0.092
4.202GluGlu: 4.202 ± 0.11
2.697GluPhe: 2.697 ± 0.085
3.015GluGly: 3.015 ± 0.086
1.328GluHis: 1.328 ± 0.048
4.373GluIle: 4.373 ± 0.104
5.344GluLys: 5.344 ± 0.113
7.923GluLeu: 7.923 ± 0.166
1.936GluMet: 1.936 ± 0.066
3.283GluAsn: 3.283 ± 0.084
2.074GluPro: 2.074 ± 0.064
3.437GluGln: 3.437 ± 0.111
2.968GluArg: 2.968 ± 0.098
2.647GluSer: 2.647 ± 0.082
3.655GluThr: 3.655 ± 0.1
4.705GluVal: 4.705 ± 0.126
0.542GluTrp: 0.542 ± 0.03
2.275GluTyr: 2.275 ± 0.062
0.0GluXaa: 0.0 ± 0.0
Phe
3.351PheAla: 3.351 ± 0.089
0.339PheCys: 0.339 ± 0.025
2.831PheAsp: 2.831 ± 0.083
2.925PheGlu: 2.925 ± 0.081
2.109PhePhe: 2.109 ± 0.077
3.222PheGly: 3.222 ± 0.078
0.63PheHis: 0.63 ± 0.035
3.08PheIle: 3.08 ± 0.084
2.811PheLys: 2.811 ± 0.087
3.935PheLeu: 3.935 ± 0.104
1.105PheMet: 1.105 ± 0.044
1.986PheAsn: 1.986 ± 0.06
1.339PhePro: 1.339 ± 0.048
1.052PheGln: 1.052 ± 0.042
1.258PheArg: 1.258 ± 0.048
3.03PheSer: 3.03 ± 0.083
2.47PheThr: 2.47 ± 0.074
2.896PheVal: 2.896 ± 0.082
0.527PheTrp: 0.527 ± 0.033
1.709PheTyr: 1.709 ± 0.056
0.0PheXaa: 0.0 ± 0.0
Gly
5.073GlyAla: 5.073 ± 0.116
0.47GlyCys: 0.47 ± 0.028
3.24GlyAsp: 3.24 ± 0.091
3.642GlyGlu: 3.642 ± 0.095
3.032GlyPhe: 3.032 ± 0.075
4.135GlyGly: 4.135 ± 0.107
1.33GlyHis: 1.33 ± 0.049
4.972GlyIle: 4.972 ± 0.125
5.222GlyLys: 5.222 ± 0.103
6.567GlyLeu: 6.567 ± 0.135
1.824GlyMet: 1.824 ± 0.06
2.741GlyAsn: 2.741 ± 0.083
1.485GlyPro: 1.485 ± 0.061
2.993GlyGln: 2.993 ± 0.085
2.564GlyArg: 2.564 ± 0.072
3.784GlySer: 3.784 ± 0.085
4.045GlyThr: 4.045 ± 0.124
4.8GlyVal: 4.8 ± 0.111
0.696GlyTrp: 0.696 ± 0.043
2.883GlyTyr: 2.883 ± 0.078
0.0GlyXaa: 0.0 ± 0.0
His
1.359HisAla: 1.359 ± 0.051
0.123HisCys: 0.123 ± 0.016
1.044HisAsp: 1.044 ± 0.048
1.159HisGlu: 1.159 ± 0.05
0.971HisPhe: 0.971 ± 0.04
1.319HisGly: 1.319 ± 0.057
0.521HisHis: 0.521 ± 0.032
1.021HisIle: 1.021 ± 0.042
1.068HisLys: 1.068 ± 0.044
1.872HisLeu: 1.872 ± 0.063
0.372HisMet: 0.372 ± 0.025
0.731HisAsn: 0.731 ± 0.039
0.903HisPro: 0.903 ± 0.041
0.921HisGln: 0.921 ± 0.045
0.752HisArg: 0.752 ± 0.041
0.807HisSer: 0.807 ± 0.036
0.917HisThr: 0.917 ± 0.042
1.218HisVal: 1.218 ± 0.058
0.149HisTrp: 0.149 ± 0.018
0.871HisTyr: 0.871 ± 0.039
0.0HisXaa: 0.0 ± 0.0
Ile
5.876IleAla: 5.876 ± 0.117
0.595IleCys: 0.595 ± 0.034
3.738IleAsp: 3.738 ± 0.089
4.036IleGlu: 4.036 ± 0.104
3.015IlePhe: 3.015 ± 0.092
4.495IleGly: 4.495 ± 0.106
0.991IleHis: 0.991 ± 0.04
4.193IleIle: 4.193 ± 0.101
4.484IleLys: 4.484 ± 0.083
6.41IleLeu: 6.41 ± 0.134
1.608IleMet: 1.608 ± 0.066
2.887IleAsn: 2.887 ± 0.077
2.52IlePro: 2.52 ± 0.068
2.122IleGln: 2.122 ± 0.067
2.19IleArg: 2.19 ± 0.07
3.892IleSer: 3.892 ± 0.09
3.82IleThr: 3.82 ± 0.092
4.824IleVal: 4.824 ± 0.094
0.567IleTrp: 0.567 ± 0.035
2.371IleTyr: 2.371 ± 0.058
0.0IleXaa: 0.0 ± 0.0
Lys
5.861LysAla: 5.861 ± 0.126
0.278LysCys: 0.278 ± 0.025
4.299LysAsp: 4.299 ± 0.089
5.342LysGlu: 5.342 ± 0.101
2.417LysPhe: 2.417 ± 0.073
3.533LysGly: 3.533 ± 0.096
1.378LysHis: 1.378 ± 0.053
4.602LysIle: 4.602 ± 0.089
5.893LysLys: 5.893 ± 0.126
7.33LysLeu: 7.33 ± 0.112
2.349LysMet: 2.349 ± 0.057
3.859LysAsn: 3.859 ± 0.095
2.122LysPro: 2.122 ± 0.071
4.051LysGln: 4.051 ± 0.095
3.727LysArg: 3.727 ± 0.098
3.036LysSer: 3.036 ± 0.078
4.57LysThr: 4.57 ± 0.093
5.136LysVal: 5.136 ± 0.131
0.589LysTrp: 0.589 ± 0.039
2.853LysTyr: 2.853 ± 0.079
0.0LysXaa: 0.0 ± 0.0
Leu
10.515LeuAla: 10.515 ± 0.188
0.774LeuCys: 0.774 ± 0.042
6.029LeuAsp: 6.029 ± 0.124
6.84LeuGlu: 6.84 ± 0.14
4.152LeuPhe: 4.152 ± 0.112
7.214LeuGly: 7.214 ± 0.145
1.678LeuHis: 1.678 ± 0.06
5.944LeuIle: 5.944 ± 0.134
7.057LeuLys: 7.057 ± 0.124
10.627LeuLeu: 10.627 ± 0.211
2.345LeuMet: 2.345 ± 0.068
4.458LeuAsn: 4.458 ± 0.084
4.366LeuPro: 4.366 ± 0.107
3.979LeuGln: 3.979 ± 0.099
4.01LeuArg: 4.01 ± 0.09
6.237LeuSer: 6.237 ± 0.115
6.635LeuThr: 6.635 ± 0.113
7.44LeuVal: 7.44 ± 0.129
0.952LeuTrp: 0.952 ± 0.049
3.113LeuTyr: 3.113 ± 0.081
0.0LeuXaa: 0.0 ± 0.0
Met
1.96MetAla: 1.96 ± 0.061
0.157MetCys: 0.157 ± 0.022
1.324MetAsp: 1.324 ± 0.054
1.417MetGlu: 1.417 ± 0.057
0.857MetPhe: 0.857 ± 0.043
1.662MetGly: 1.662 ± 0.055
0.411MetHis: 0.411 ± 0.031
1.84MetIle: 1.84 ± 0.061
1.735MetLys: 1.735 ± 0.051
2.603MetLeu: 2.603 ± 0.067
0.652MetMet: 0.652 ± 0.035
1.067MetAsn: 1.067 ± 0.048
1.035MetPro: 1.035 ± 0.046
1.262MetGln: 1.262 ± 0.046
1.096MetArg: 1.096 ± 0.05
1.487MetSer: 1.487 ± 0.055
1.665MetThr: 1.665 ± 0.059
1.639MetVal: 1.639 ± 0.052
0.184MetTrp: 0.184 ± 0.02
0.785MetTyr: 0.785 ± 0.044
0.0MetXaa: 0.0 ± 0.0
Asn
3.255AsnAla: 3.255 ± 0.088
0.304AsnCys: 0.304 ± 0.025
2.71AsnAsp: 2.71 ± 0.088
3.062AsnGlu: 3.062 ± 0.077
1.997AsnPhe: 1.997 ± 0.064
3.43AsnGly: 3.43 ± 0.096
0.746AsnHis: 0.746 ± 0.041
2.909AsnIle: 2.909 ± 0.069
2.933AsnLys: 2.933 ± 0.077
4.047AsnLeu: 4.047 ± 0.078
1.151AsnMet: 1.151 ± 0.043
2.255AsnAsn: 2.255 ± 0.067
1.394AsnPro: 1.394 ± 0.052
1.512AsnGln: 1.512 ± 0.064
1.487AsnArg: 1.487 ± 0.052
2.452AsnSer: 2.452 ± 0.078
2.31AsnThr: 2.31 ± 0.071
3.014AsnVal: 3.014 ± 0.084
0.586AsnTrp: 0.586 ± 0.035
2.065AsnTyr: 2.065 ± 0.078
0.0AsnXaa: 0.0 ± 0.0
Pro
3.017ProAla: 3.017 ± 0.083
0.179ProCys: 0.179 ± 0.019
2.271ProAsp: 2.271 ± 0.083
3.183ProGlu: 3.183 ± 0.091
1.577ProPhe: 1.577 ± 0.066
2.117ProGly: 2.117 ± 0.068
0.689ProHis: 0.689 ± 0.033
2.023ProIle: 2.023 ± 0.068
2.804ProLys: 2.804 ± 0.079
3.529ProLeu: 3.529 ± 0.089
0.683ProMet: 0.683 ± 0.043
1.628ProAsn: 1.628 ± 0.06
0.693ProPro: 0.693 ± 0.038
1.514ProGln: 1.514 ± 0.06
1.159ProArg: 1.159 ± 0.047
1.925ProSer: 1.925 ± 0.064
2.382ProThr: 2.382 ± 0.071
2.894ProVal: 2.894 ± 0.104
0.322ProTrp: 0.322 ± 0.024
1.396ProTyr: 1.396 ± 0.045
0.0ProXaa: 0.0 ± 0.0
Gln
4.944GlnAla: 4.944 ± 0.124
0.153GlnCys: 0.153 ± 0.018
1.942GlnAsp: 1.942 ± 0.063
2.579GlnGlu: 2.579 ± 0.072
1.376GlnPhe: 1.376 ± 0.056
2.323GlnGly: 2.323 ± 0.062
0.726GlnHis: 0.726 ± 0.041
3.03GlnIle: 3.03 ± 0.075
3.778GlnLys: 3.778 ± 0.101
4.657GlnLeu: 4.657 ± 0.128
1.153GlnMet: 1.153 ± 0.052
2.153GlnAsn: 2.153 ± 0.071
1.31GlnPro: 1.31 ± 0.069
2.233GlnGln: 2.233 ± 0.102
1.73GlnArg: 1.73 ± 0.062
1.811GlnSer: 1.811 ± 0.055
3.074GlnThr: 3.074 ± 0.082
3.323GlnVal: 3.323 ± 0.092
0.339GlnTrp: 0.339 ± 0.025
1.411GlnTyr: 1.411 ± 0.053
0.0GlnXaa: 0.0 ± 0.0
Arg
2.815ArgAla: 2.815 ± 0.084
0.208ArgCys: 0.208 ± 0.021
2.091ArgAsp: 2.091 ± 0.069
2.645ArgGlu: 2.645 ± 0.082
1.899ArgPhe: 1.899 ± 0.065
2.323ArgGly: 2.323 ± 0.081
0.787ArgHis: 0.787 ± 0.04
2.424ArgIle: 2.424 ± 0.068
2.822ArgLys: 2.822 ± 0.066
4.099ArgLeu: 4.099 ± 0.098
0.943ArgMet: 0.943 ± 0.049
1.573ArgAsn: 1.573 ± 0.048
1.566ArgPro: 1.566 ± 0.056
2.109ArgGln: 2.109 ± 0.062
1.916ArgArg: 1.916 ± 0.064
2.104ArgSer: 2.104 ± 0.058
1.884ArgThr: 1.884 ± 0.066
2.605ArgVal: 2.605 ± 0.076
0.356ArgTrp: 0.356 ± 0.028
1.765ArgTyr: 1.765 ± 0.06
0.0ArgXaa: 0.0 ± 0.0
Ser
4.117SerAla: 4.117 ± 0.088
0.28SerCys: 0.28 ± 0.023
3.227SerAsp: 3.227 ± 0.088
3.614SerGlu: 3.614 ± 0.082
2.529SerPhe: 2.529 ± 0.08
4.03SerGly: 4.03 ± 0.097
0.993SerHis: 0.993 ± 0.047
3.043SerIle: 3.043 ± 0.082
3.664SerLys: 3.664 ± 0.079
5.889SerLeu: 5.889 ± 0.121
1.332SerMet: 1.332 ± 0.046
2.139SerAsn: 2.139 ± 0.065
1.813SerPro: 1.813 ± 0.063
2.373SerGln: 2.373 ± 0.062
2.07SerArg: 2.07 ± 0.065
3.345SerSer: 3.345 ± 0.152
2.861SerThr: 2.861 ± 0.082
3.791SerVal: 3.791 ± 0.085
0.623SerTrp: 0.623 ± 0.038
2.201SerTyr: 2.201 ± 0.055
0.0SerXaa: 0.0 ± 0.0
Thr
5.173ThrAla: 5.173 ± 0.114
0.363ThrCys: 0.363 ± 0.025
3.406ThrAsp: 3.406 ± 0.088
3.528ThrGlu: 3.528 ± 0.089
2.433ThrPhe: 2.433 ± 0.078
4.428ThrGly: 4.428 ± 0.1
1.006ThrHis: 1.006 ± 0.041
3.813ThrIle: 3.813 ± 0.08
4.345ThrLys: 4.345 ± 0.096
6.329ThrLeu: 6.329 ± 0.125
1.221ThrMet: 1.221 ± 0.045
2.315ThrAsn: 2.315 ± 0.072
3.067ThrPro: 3.067 ± 0.11
2.385ThrGln: 2.385 ± 0.071
2.032ThrArg: 2.032 ± 0.066
3.268ThrSer: 3.268 ± 0.088
4.303ThrThr: 4.303 ± 0.133
4.452ThrVal: 4.452 ± 0.11
0.54ThrTrp: 0.54 ± 0.032
2.135ThrTyr: 2.135 ± 0.061
0.0ThrXaa: 0.0 ± 0.0
Val
6.328ValAla: 6.328 ± 0.126
0.582ValCys: 0.582 ± 0.035
4.108ValAsp: 4.108 ± 0.08
4.421ValGlu: 4.421 ± 0.11
2.769ValPhe: 2.769 ± 0.073
4.758ValGly: 4.758 ± 0.106
1.059ValHis: 1.059 ± 0.042
5.335ValIle: 5.335 ± 0.109
5.069ValLys: 5.069 ± 0.104
7.145ValLeu: 7.145 ± 0.127
1.752ValMet: 1.752 ± 0.06
2.785ValAsn: 2.785 ± 0.076
2.623ValPro: 2.623 ± 0.076
2.209ValGln: 2.209 ± 0.073
2.301ValArg: 2.301 ± 0.081
4.38ValSer: 4.38 ± 0.092
5.049ValThr: 5.049 ± 0.154
5.41ValVal: 5.41 ± 0.133
0.584ValTrp: 0.584 ± 0.036
2.518ValTyr: 2.518 ± 0.066
0.0ValXaa: 0.0 ± 0.0
Trp
0.619TrpAla: 0.619 ± 0.036
0.063TrpCys: 0.063 ± 0.012
0.508TrpAsp: 0.508 ± 0.035
0.472TrpGlu: 0.472 ± 0.032
0.453TrpPhe: 0.453 ± 0.032
0.671TrpGly: 0.671 ± 0.036
0.217TrpHis: 0.217 ± 0.027
0.643TrpIle: 0.643 ± 0.036
0.577TrpLys: 0.577 ± 0.038
1.223TrpLeu: 1.223 ± 0.056
0.269TrpMet: 0.269 ± 0.022
0.414TrpAsn: 0.414 ± 0.027
0.247TrpPro: 0.247 ± 0.021
0.647TrpGln: 0.647 ± 0.032
0.426TrpArg: 0.426 ± 0.029
0.571TrpSer: 0.571 ± 0.036
0.494TrpThr: 0.494 ± 0.031
0.577TrpVal: 0.577 ± 0.03
0.147TrpTrp: 0.147 ± 0.017
0.352TrpTyr: 0.352 ± 0.029
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.815TyrAla: 2.815 ± 0.078
0.3TyrCys: 0.3 ± 0.025
2.135TyrAsp: 2.135 ± 0.064
2.207TyrGlu: 2.207 ± 0.062
1.94TyrPhe: 1.94 ± 0.07
2.555TyrGly: 2.555 ± 0.075
0.858TyrHis: 0.858 ± 0.035
2.124TyrIle: 2.124 ± 0.064
1.652TyrLys: 1.652 ± 0.061
4.592TyrLeu: 4.592 ± 0.109
0.781TyrMet: 0.781 ± 0.035
1.579TyrAsn: 1.579 ± 0.051
1.619TyrPro: 1.619 ± 0.063
2.08TyrGln: 2.08 ± 0.069
1.923TyrArg: 1.923 ± 0.06
1.975TyrSer: 1.975 ± 0.063
2.209TyrThr: 2.209 ± 0.062
2.35TyrVal: 2.35 ± 0.06
0.42TyrTrp: 0.42 ± 0.03
1.645TyrTyr: 1.645 ± 0.058
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1844 proteins (542867 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski