Amino acid dipepetide frequency for Kurthia sp. 11kri321

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.108AlaAla: 6.108 ± 0.128
0.65AlaCys: 0.65 ± 0.03
3.628AlaAsp: 3.628 ± 0.063
4.93AlaGlu: 4.93 ± 0.102
3.546AlaPhe: 3.546 ± 0.074
5.05AlaGly: 5.05 ± 0.085
1.533AlaHis: 1.533 ± 0.051
6.815AlaIle: 6.815 ± 0.099
5.31AlaLys: 5.31 ± 0.087
7.725AlaLeu: 7.725 ± 0.11
2.307AlaMet: 2.307 ± 0.055
2.913AlaAsn: 2.913 ± 0.06
2.185AlaPro: 2.185 ± 0.054
2.96AlaGln: 2.96 ± 0.066
2.789AlaArg: 2.789 ± 0.062
4.062AlaSer: 4.062 ± 0.079
4.481AlaThr: 4.481 ± 0.074
5.582AlaVal: 5.582 ± 0.091
0.586AlaTrp: 0.586 ± 0.028
2.821AlaTyr: 2.821 ± 0.054
0.0AlaXaa: 0.0 ± 0.0
Cys
0.455CysAla: 0.455 ± 0.024
0.088CysCys: 0.088 ± 0.01
0.359CysAsp: 0.359 ± 0.022
0.468CysGlu: 0.468 ± 0.026
0.315CysPhe: 0.315 ± 0.022
0.623CysGly: 0.623 ± 0.029
0.198CysHis: 0.198 ± 0.015
0.546CysIle: 0.546 ± 0.027
0.327CysLys: 0.327 ± 0.023
0.613CysLeu: 0.613 ± 0.026
0.185CysMet: 0.185 ± 0.014
0.248CysAsn: 0.248 ± 0.018
0.339CysPro: 0.339 ± 0.023
0.224CysGln: 0.224 ± 0.017
0.262CysArg: 0.262 ± 0.015
0.459CysSer: 0.459 ± 0.025
0.445CysThr: 0.445 ± 0.023
0.433CysVal: 0.433 ± 0.024
0.059CysTrp: 0.059 ± 0.008
0.248CysTyr: 0.248 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
4.211AspAla: 4.211 ± 0.086
0.348AspCys: 0.348 ± 0.019
2.53AspAsp: 2.53 ± 0.069
4.924AspGlu: 4.924 ± 0.081
2.595AspPhe: 2.595 ± 0.055
3.438AspGly: 3.438 ± 0.07
1.031AspHis: 1.031 ± 0.033
3.428AspIle: 3.428 ± 0.062
2.24AspLys: 2.24 ± 0.068
5.352AspLeu: 5.352 ± 0.074
1.212AspMet: 1.212 ± 0.042
1.327AspAsn: 1.327 ± 0.043
1.586AspPro: 1.586 ± 0.04
2.015AspGln: 2.015 ± 0.048
2.065AspArg: 2.065 ± 0.051
2.27AspSer: 2.27 ± 0.053
2.6AspThr: 2.6 ± 0.062
4.33AspVal: 4.33 ± 0.077
0.517AspTrp: 0.517 ± 0.027
2.221AspTyr: 2.221 ± 0.051
0.0AspXaa: 0.0 ± 0.0
Glu
6.053GluAla: 6.053 ± 0.103
0.347GluCys: 0.347 ± 0.019
3.799GluAsp: 3.799 ± 0.077
6.959GluGlu: 6.959 ± 0.111
2.414GluPhe: 2.414 ± 0.055
4.102GluGly: 4.102 ± 0.075
1.715GluHis: 1.715 ± 0.049
5.296GluIle: 5.296 ± 0.097
6.608GluLys: 6.608 ± 0.101
6.939GluLeu: 6.939 ± 0.089
2.285GluMet: 2.285 ± 0.051
3.261GluAsn: 3.261 ± 0.059
2.012GluPro: 2.012 ± 0.05
4.764GluGln: 4.764 ± 0.095
3.716GluArg: 3.716 ± 0.078
3.033GluSer: 3.033 ± 0.065
3.621GluThr: 3.621 ± 0.064
5.564GluVal: 5.564 ± 0.088
0.798GluTrp: 0.798 ± 0.03
2.057GluTyr: 2.057 ± 0.043
0.0GluXaa: 0.0 ± 0.0
Phe
3.192PheAla: 3.192 ± 0.065
0.338PheCys: 0.338 ± 0.022
2.394PheAsp: 2.394 ± 0.052
3.258PheGlu: 3.258 ± 0.07
2.252PhePhe: 2.252 ± 0.067
3.035PheGly: 3.035 ± 0.069
0.869PheHis: 0.869 ± 0.033
3.814PheIle: 3.814 ± 0.081
2.643PheLys: 2.643 ± 0.053
4.181PheLeu: 4.181 ± 0.08
1.237PheMet: 1.237 ± 0.041
1.794PheAsn: 1.794 ± 0.049
1.376PhePro: 1.376 ± 0.044
1.659PheGln: 1.659 ± 0.048
1.362PheArg: 1.362 ± 0.04
2.862PheSer: 2.862 ± 0.072
2.799PheThr: 2.799 ± 0.058
3.254PheVal: 3.254 ± 0.072
0.401PheTrp: 0.401 ± 0.025
1.71PheTyr: 1.71 ± 0.048
0.0PheXaa: 0.0 ± 0.0
Gly
4.856GlyAla: 4.856 ± 0.094
0.475GlyCys: 0.475 ± 0.024
3.016GlyAsp: 3.016 ± 0.065
4.228GlyGlu: 4.228 ± 0.075
3.143GlyPhe: 3.143 ± 0.07
4.42GlyGly: 4.42 ± 0.093
1.365GlyHis: 1.365 ± 0.045
5.542GlyIle: 5.542 ± 0.088
4.493GlyLys: 4.493 ± 0.081
5.941GlyLeu: 5.941 ± 0.088
1.949GlyMet: 1.949 ± 0.053
2.244GlyAsn: 2.244 ± 0.054
1.464GlyPro: 1.464 ± 0.041
2.296GlyGln: 2.296 ± 0.055
2.587GlyArg: 2.587 ± 0.061
3.589GlySer: 3.589 ± 0.075
3.978GlyThr: 3.978 ± 0.076
4.978GlyVal: 4.978 ± 0.083
0.634GlyTrp: 0.634 ± 0.025
2.72GlyTyr: 2.72 ± 0.053
0.0GlyXaa: 0.0 ± 0.0
His
1.638HisAla: 1.638 ± 0.045
0.191HisCys: 0.191 ± 0.015
1.134HisAsp: 1.134 ± 0.039
1.633HisGlu: 1.633 ± 0.047
1.042HisPhe: 1.042 ± 0.039
1.287HisGly: 1.287 ± 0.039
0.691HisHis: 0.691 ± 0.029
1.726HisIle: 1.726 ± 0.047
0.993HisLys: 0.993 ± 0.035
2.144HisLeu: 2.144 ± 0.059
0.618HisMet: 0.618 ± 0.03
0.701HisAsn: 0.701 ± 0.029
1.017HisPro: 1.017 ± 0.036
0.983HisGln: 0.983 ± 0.043
0.858HisArg: 0.858 ± 0.032
1.017HisSer: 1.017 ± 0.036
1.313HisThr: 1.313 ± 0.037
1.688HisVal: 1.688 ± 0.043
0.173HisTrp: 0.173 ± 0.015
0.936HisTyr: 0.936 ± 0.035
0.0HisXaa: 0.0 ± 0.0
Ile
6.516IleAla: 6.516 ± 0.096
0.647IleCys: 0.647 ± 0.027
4.212IleAsp: 4.212 ± 0.073
6.089IleGlu: 6.089 ± 0.094
3.273IlePhe: 3.273 ± 0.075
5.511IleGly: 5.511 ± 0.093
1.765IleHis: 1.765 ± 0.045
5.55IleIle: 5.55 ± 0.102
3.825IleLys: 3.825 ± 0.066
7.228IleLeu: 7.228 ± 0.114
1.85IleMet: 1.85 ± 0.049
2.531IleAsn: 2.531 ± 0.064
3.272IlePro: 3.272 ± 0.067
3.817IleGln: 3.817 ± 0.071
3.215IleArg: 3.215 ± 0.057
4.534IleSer: 4.534 ± 0.079
4.443IleThr: 4.443 ± 0.076
5.857IleVal: 5.857 ± 0.09
0.603IleTrp: 0.603 ± 0.03
2.508IleTyr: 2.508 ± 0.061
0.0IleXaa: 0.0 ± 0.0
Lys
4.689LysAla: 4.689 ± 0.088
0.285LysCys: 0.285 ± 0.02
3.501LysAsp: 3.501 ± 0.078
6.669LysGlu: 6.669 ± 0.093
1.917LysPhe: 1.917 ± 0.047
4.232LysGly: 4.232 ± 0.084
1.238LysHis: 1.238 ± 0.042
4.625LysIle: 4.625 ± 0.09
6.393LysLys: 6.393 ± 0.12
5.395LysLeu: 5.395 ± 0.089
2.383LysMet: 2.383 ± 0.057
3.283LysAsn: 3.283 ± 0.067
2.294LysPro: 2.294 ± 0.056
3.553LysGln: 3.553 ± 0.072
3.06LysArg: 3.06 ± 0.064
3.469LysSer: 3.469 ± 0.075
4.014LysThr: 4.014 ± 0.076
4.563LysVal: 4.563 ± 0.086
0.747LysTrp: 0.747 ± 0.031
2.31LysTyr: 2.31 ± 0.057
0.0LysXaa: 0.0 ± 0.0
Leu
7.568LeuAla: 7.568 ± 0.101
0.646LeuCys: 0.646 ± 0.026
4.759LeuAsp: 4.759 ± 0.082
6.473LeuGlu: 6.473 ± 0.091
4.559LeuPhe: 4.559 ± 0.086
5.87LeuGly: 5.87 ± 0.1
2.162LeuHis: 2.162 ± 0.056
6.843LeuIle: 6.843 ± 0.112
6.48LeuLys: 6.48 ± 0.107
9.511LeuLeu: 9.511 ± 0.152
2.504LeuMet: 2.504 ± 0.052
4.019LeuAsn: 4.019 ± 0.072
3.861LeuPro: 3.861 ± 0.067
4.709LeuGln: 4.709 ± 0.101
3.684LeuArg: 3.684 ± 0.07
5.975LeuSer: 5.975 ± 0.101
5.791LeuThr: 5.791 ± 0.083
6.243LeuVal: 6.243 ± 0.096
0.738LeuTrp: 0.738 ± 0.033
3.236LeuTyr: 3.236 ± 0.058
0.0LeuXaa: 0.0 ± 0.0
Met
2.022MetAla: 2.022 ± 0.053
0.16MetCys: 0.16 ± 0.015
1.509MetAsp: 1.509 ± 0.039
1.781MetGlu: 1.781 ± 0.05
0.998MetPhe: 0.998 ± 0.037
1.677MetGly: 1.677 ± 0.05
0.532MetHis: 0.532 ± 0.025
2.14MetIle: 2.14 ± 0.05
2.598MetLys: 2.598 ± 0.054
2.57MetLeu: 2.57 ± 0.053
1.029MetMet: 1.029 ± 0.036
1.704MetAsn: 1.704 ± 0.044
0.989MetPro: 0.989 ± 0.033
1.129MetGln: 1.129 ± 0.037
1.247MetArg: 1.247 ± 0.036
1.653MetSer: 1.653 ± 0.046
2.038MetThr: 2.038 ± 0.05
1.744MetVal: 1.744 ± 0.044
0.205MetTrp: 0.205 ± 0.016
0.892MetTyr: 0.892 ± 0.034
0.0MetXaa: 0.0 ± 0.0
Asn
2.869AsnAla: 2.869 ± 0.059
0.267AsnCys: 0.267 ± 0.021
1.941AsnAsp: 1.941 ± 0.05
3.167AsnGlu: 3.167 ± 0.062
1.531AsnPhe: 1.531 ± 0.045
2.811AsnGly: 2.811 ± 0.06
0.967AsnHis: 0.967 ± 0.031
2.977AsnIle: 2.977 ± 0.07
2.501AsnLys: 2.501 ± 0.059
3.538AsnLeu: 3.538 ± 0.069
1.122AsnMet: 1.122 ± 0.034
1.598AsnAsn: 1.598 ± 0.059
1.923AsnPro: 1.923 ± 0.052
1.968AsnGln: 1.968 ± 0.055
2.012AsnArg: 2.012 ± 0.047
1.889AsnSer: 1.889 ± 0.057
2.317AsnThr: 2.317 ± 0.051
2.789AsnVal: 2.789 ± 0.06
0.408AsnTrp: 0.408 ± 0.022
1.542AsnTyr: 1.542 ± 0.049
0.0AsnXaa: 0.0 ± 0.0
Pro
2.276ProAla: 2.276 ± 0.056
0.218ProCys: 0.218 ± 0.015
1.681ProAsp: 1.681 ± 0.05
2.737ProGlu: 2.737 ± 0.059
2.003ProPhe: 2.003 ± 0.076
1.905ProGly: 1.905 ± 0.057
0.819ProHis: 0.819 ± 0.032
2.908ProIle: 2.908 ± 0.062
2.453ProLys: 2.453 ± 0.053
3.281ProLeu: 3.281 ± 0.064
0.872ProMet: 0.872 ± 0.034
1.592ProAsn: 1.592 ± 0.048
0.85ProPro: 0.85 ± 0.033
1.152ProGln: 1.152 ± 0.035
1.019ProArg: 1.019 ± 0.036
1.995ProSer: 1.995 ± 0.047
2.338ProThr: 2.338 ± 0.057
2.609ProVal: 2.609 ± 0.054
0.282ProTrp: 0.282 ± 0.018
1.402ProTyr: 1.402 ± 0.041
0.0ProXaa: 0.0 ± 0.0
Gln
3.434GlnAla: 3.434 ± 0.069
0.24GlnCys: 0.24 ± 0.019
1.995GlnAsp: 1.995 ± 0.045
2.972GlnGlu: 2.972 ± 0.069
1.934GlnPhe: 1.934 ± 0.051
2.208GlnGly: 2.208 ± 0.054
1.047GlnHis: 1.047 ± 0.035
3.177GlnIle: 3.177 ± 0.062
3.323GlnLys: 3.323 ± 0.068
4.973GlnLeu: 4.973 ± 0.091
1.367GlnMet: 1.367 ± 0.043
1.722GlnAsn: 1.722 ± 0.046
1.531GlnPro: 1.531 ± 0.045
2.995GlnGln: 2.995 ± 0.089
1.759GlnArg: 1.759 ± 0.044
2.288GlnSer: 2.288 ± 0.059
2.595GlnThr: 2.595 ± 0.063
2.866GlnVal: 2.866 ± 0.066
0.438GlnTrp: 0.438 ± 0.022
1.653GlnTyr: 1.653 ± 0.051
0.0GlnXaa: 0.0 ± 0.0
Arg
2.768ArgAla: 2.768 ± 0.057
0.234ArgCys: 0.234 ± 0.018
2.084ArgAsp: 2.084 ± 0.057
3.037ArgGlu: 3.037 ± 0.075
1.962ArgPhe: 1.962 ± 0.054
2.251ArgGly: 2.251 ± 0.053
0.886ArgHis: 0.886 ± 0.028
3.236ArgIle: 3.236 ± 0.066
2.983ArgLys: 2.983 ± 0.061
3.912ArgLeu: 3.912 ± 0.073
1.272ArgMet: 1.272 ± 0.038
1.624ArgAsn: 1.624 ± 0.044
1.34ArgPro: 1.34 ± 0.041
1.73ArgGln: 1.73 ± 0.046
1.699ArgArg: 1.699 ± 0.047
2.022ArgSer: 2.022 ± 0.048
2.223ArgThr: 2.223 ± 0.051
2.87ArgVal: 2.87 ± 0.063
0.327ArgTrp: 0.327 ± 0.021
1.65ArgTyr: 1.65 ± 0.044
0.0ArgXaa: 0.0 ± 0.0
Ser
3.675SerAla: 3.675 ± 0.067
0.374SerCys: 0.374 ± 0.022
2.482SerAsp: 2.482 ± 0.059
3.396SerGlu: 3.396 ± 0.07
2.888SerPhe: 2.888 ± 0.057
3.789SerGly: 3.789 ± 0.077
1.105SerHis: 1.105 ± 0.035
4.647SerIle: 4.647 ± 0.095
4.013SerLys: 4.013 ± 0.082
5.348SerLeu: 5.348 ± 0.087
1.652SerMet: 1.652 ± 0.043
2.36SerAsn: 2.36 ± 0.063
1.801SerPro: 1.801 ± 0.046
1.841SerGln: 1.841 ± 0.049
1.959SerArg: 1.959 ± 0.051
3.452SerSer: 3.452 ± 0.069
3.283SerThr: 3.283 ± 0.065
3.845SerVal: 3.845 ± 0.073
0.485SerTrp: 0.485 ± 0.025
2.15SerTyr: 2.15 ± 0.054
0.0SerXaa: 0.0 ± 0.0
Thr
4.576ThrAla: 4.576 ± 0.09
0.385ThrCys: 0.385 ± 0.025
2.807ThrAsp: 2.807 ± 0.062
3.837ThrGlu: 3.837 ± 0.063
2.8ThrPhe: 2.8 ± 0.057
3.921ThrGly: 3.921 ± 0.074
1.339ThrHis: 1.339 ± 0.038
5.039ThrIle: 5.039 ± 0.083
4.058ThrLys: 4.058 ± 0.075
5.741ThrLeu: 5.741 ± 0.082
1.528ThrMet: 1.528 ± 0.035
2.562ThrAsn: 2.562 ± 0.062
2.453ThrPro: 2.453 ± 0.055
1.892ThrGln: 1.892 ± 0.055
1.987ThrArg: 1.987 ± 0.048
3.414ThrSer: 3.414 ± 0.055
3.842ThrThr: 3.842 ± 0.091
4.543ThrVal: 4.543 ± 0.08
0.537ThrTrp: 0.537 ± 0.026
2.25ThrTyr: 2.25 ± 0.055
0.0ThrXaa: 0.0 ± 0.0
Val
5.81ValAla: 5.81 ± 0.1
0.614ValCys: 0.614 ± 0.027
3.769ValAsp: 3.769 ± 0.079
5.489ValGlu: 5.489 ± 0.093
2.957ValPhe: 2.957 ± 0.066
4.809ValGly: 4.809 ± 0.086
1.471ValHis: 1.471 ± 0.041
5.564ValIle: 5.564 ± 0.085
4.692ValLys: 4.692 ± 0.082
6.828ValLeu: 6.828 ± 0.103
1.945ValMet: 1.945 ± 0.051
2.764ValAsn: 2.764 ± 0.059
2.62ValPro: 2.62 ± 0.054
3.019ValGln: 3.019 ± 0.06
2.797ValArg: 2.797 ± 0.062
4.197ValSer: 4.197 ± 0.069
4.586ValThr: 4.586 ± 0.071
5.604ValVal: 5.604 ± 0.089
0.58ValTrp: 0.58 ± 0.029
2.43ValTyr: 2.43 ± 0.047
0.0ValXaa: 0.0 ± 0.0
Trp
0.511TrpAla: 0.511 ± 0.023
0.079TrpCys: 0.079 ± 0.01
0.413TrpAsp: 0.413 ± 0.018
0.444TrpGlu: 0.444 ± 0.026
0.48TrpPhe: 0.48 ± 0.027
0.54TrpGly: 0.54 ± 0.031
0.252TrpHis: 0.252 ± 0.019
0.777TrpIle: 0.777 ± 0.034
0.548TrpLys: 0.548 ± 0.028
1.058TrpLeu: 1.058 ± 0.041
0.328TrpMet: 0.328 ± 0.017
0.424TrpAsn: 0.424 ± 0.027
0.2TrpPro: 0.2 ± 0.017
0.444TrpGln: 0.444 ± 0.024
0.388TrpArg: 0.388 ± 0.02
0.577TrpSer: 0.577 ± 0.022
0.481TrpThr: 0.481 ± 0.021
0.587TrpVal: 0.587 ± 0.029
0.097TrpTrp: 0.097 ± 0.012
0.333TrpTyr: 0.333 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.755TyrAla: 2.755 ± 0.059
0.308TyrCys: 0.308 ± 0.021
2.227TyrAsp: 2.227 ± 0.046
2.853TyrGlu: 2.853 ± 0.064
1.819TyrPhe: 1.819 ± 0.045
2.438TyrGly: 2.438 ± 0.05
0.798TyrHis: 0.798 ± 0.03
2.594TyrIle: 2.594 ± 0.048
2.138TyrLys: 2.138 ± 0.066
3.354TyrLeu: 3.354 ± 0.07
0.97TyrMet: 0.97 ± 0.033
1.465TyrAsn: 1.465 ± 0.041
1.28TyrPro: 1.28 ± 0.039
1.371TyrGln: 1.371 ± 0.037
1.645TyrArg: 1.645 ± 0.051
1.79TyrSer: 1.79 ± 0.053
2.318TyrThr: 2.318 ± 0.06
2.598TyrVal: 2.598 ± 0.057
0.346TyrTrp: 0.346 ± 0.022
1.509TyrTyr: 1.509 ± 0.048
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2893 proteins (849731 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski