Amino acid dipepetide frequency for Polymorphum gilvum (strain LMG 25793 / CGMCC 1.9160 / SL003B-26A1)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.624AlaAla: 19.624 ± 0.182	1.211AlaCys: 1.211 ± 0.032	7.921AlaAsp: 7.921 ± 0.078	8.473AlaGlu: 8.473 ± 0.096	4.848AlaPhe: 4.848 ± 0.069	12.172AlaGly: 12.172 ± 0.125	2.323AlaHis: 2.323 ± 0.047	6.153AlaIle: 6.153 ± 0.077	3.266AlaLys: 3.266 ± 0.059	14.462AlaLeu: 14.462 ± 0.141	3.533AlaMet: 3.533 ± 0.051	2.648AlaAsn: 2.648 ± 0.042	5.964AlaPro: 5.964 ± 0.087	3.648AlaGln: 3.648 ± 0.06	10.645AlaArg: 10.645 ± 0.106	6.136AlaSer: 6.136 ± 0.074	6.141AlaThr: 6.141 ± 0.074	9.989AlaVal: 9.989 ± 0.085	1.621AlaTrp: 1.621 ± 0.036	2.644AlaTyr: 2.644 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	1.02CysAla: 1.02 ± 0.029	0.105CysCys: 0.105 ± 0.009	0.546CysAsp: 0.546 ± 0.02	0.417CysGlu: 0.417 ± 0.015	0.313CysPhe: 0.313 ± 0.015	0.923CysGly: 0.923 ± 0.026	0.225CysHis: 0.225 ± 0.013	0.325CysIle: 0.325 ± 0.017	0.175CysLys: 0.175 ± 0.012	0.872CysLeu: 0.872 ± 0.028	0.155CysMet: 0.155 ± 0.012	0.181CysAsn: 0.181 ± 0.013	0.477CysPro: 0.477 ± 0.018	0.232CysGln: 0.232 ± 0.013	0.764CysArg: 0.764 ± 0.024	0.433CysSer: 0.433 ± 0.017	0.364CysThr: 0.364 ± 0.018	0.599CysVal: 0.599 ± 0.022	0.106CysTrp: 0.106 ± 0.008	0.195CysTyr: 0.195 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.518AspAla: 7.518 ± 0.094	0.53AspCys: 0.53 ± 0.021	3.376AspAsp: 3.376 ± 0.058	3.51AspGlu: 3.51 ± 0.056	2.132AspPhe: 2.132 ± 0.038	5.709AspGly: 5.709 ± 0.062	1.275AspHis: 1.275 ± 0.034	3.004AspIle: 3.004 ± 0.048	1.544AspLys: 1.544 ± 0.033	6.921AspLeu: 6.921 ± 0.082	1.462AspMet: 1.462 ± 0.035	1.146AspAsn: 1.146 ± 0.031	3.815AspPro: 3.815 ± 0.05	1.539AspGln: 1.539 ± 0.031	4.91AspArg: 4.91 ± 0.07	2.095AspSer: 2.095 ± 0.039	2.835AspThr: 2.835 ± 0.046	4.134AspVal: 4.134 ± 0.053	1.028AspTrp: 1.028 ± 0.025	1.485AspTyr: 1.485 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	8.711GluAla: 8.711 ± 0.094	0.335GluCys: 0.335 ± 0.017	3.116GluAsp: 3.116 ± 0.057	3.277GluGlu: 3.277 ± 0.065	1.679GluPhe: 1.679 ± 0.037	4.249GluGly: 4.249 ± 0.054	1.15GluHis: 1.15 ± 0.033	3.577GluIle: 3.577 ± 0.057	1.917GluLys: 1.917 ± 0.046	5.104GluLeu: 5.104 ± 0.072	1.439GluMet: 1.439 ± 0.036	1.365GluAsn: 1.365 ± 0.036	2.79GluPro: 2.79 ± 0.04	1.943GluGln: 1.943 ± 0.041	5.549GluArg: 5.549 ± 0.068	2.086GluSer: 2.086 ± 0.044	3.899GluThr: 3.899 ± 0.059	4.076GluVal: 4.076 ± 0.05	0.603GluTrp: 0.603 ± 0.022	0.84GluTyr: 0.84 ± 0.025	0.0GluXaa: 0.0 ± 0.0
Phe	4.749PheAla: 4.749 ± 0.071	0.403PheCys: 0.403 ± 0.016	2.64PheAsp: 2.64 ± 0.044	2.163PheGlu: 2.163 ± 0.04	1.366PhePhe: 1.366 ± 0.031	3.701PheGly: 3.701 ± 0.059	0.703PheHis: 0.703 ± 0.02	1.436PheIle: 1.436 ± 0.038	0.889PheLys: 0.889 ± 0.025	3.642PheLeu: 3.642 ± 0.062	0.744PheMet: 0.744 ± 0.023	0.915PheAsn: 0.915 ± 0.025	1.501PhePro: 1.501 ± 0.036	1.009PheGln: 1.009 ± 0.029	2.421PheArg: 2.421 ± 0.043	2.046PheSer: 2.046 ± 0.042	1.819PheThr: 1.819 ± 0.037	2.98PheVal: 2.98 ± 0.048	0.476PheTrp: 0.476 ± 0.02	0.864PheTyr: 0.864 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	10.172GlyAla: 10.172 ± 0.095	0.859GlyCys: 0.859 ± 0.029	4.602GlyAsp: 4.602 ± 0.068	4.934GlyGlu: 4.934 ± 0.06	3.612GlyPhe: 3.612 ± 0.054	7.438GlyGly: 7.438 ± 0.1	1.949GlyHis: 1.949 ± 0.041	4.326GlyIle: 4.326 ± 0.05	2.792GlyLys: 2.792 ± 0.051	9.675GlyLeu: 9.675 ± 0.108	2.195GlyMet: 2.195 ± 0.04	1.883GlyAsn: 1.883 ± 0.047	3.741GlyPro: 3.741 ± 0.057	2.627GlyGln: 2.627 ± 0.048	7.018GlyArg: 7.018 ± 0.081	4.622GlySer: 4.622 ± 0.068	4.797GlyThr: 4.797 ± 0.066	6.141GlyVal: 6.141 ± 0.068	1.327GlyTrp: 1.327 ± 0.036	2.337GlyTyr: 2.337 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	2.39HisAla: 2.39 ± 0.048	0.205HisCys: 0.205 ± 0.013	1.222HisAsp: 1.222 ± 0.03	1.017HisGlu: 1.017 ± 0.031	0.789HisPhe: 0.789 ± 0.025	1.968HisGly: 1.968 ± 0.045	0.517HisHis: 0.517 ± 0.027	0.873HisIle: 0.873 ± 0.024	0.47HisLys: 0.47 ± 0.021	2.042HisLeu: 2.042 ± 0.041	0.47HisMet: 0.47 ± 0.017	0.409HisAsn: 0.409 ± 0.016	1.321HisPro: 1.321 ± 0.034	0.493HisGln: 0.493 ± 0.019	1.547HisArg: 1.547 ± 0.03	0.799HisSer: 0.799 ± 0.024	0.792HisThr: 0.792 ± 0.025	1.594HisVal: 1.594 ± 0.038	0.323HisTrp: 0.323 ± 0.016	0.547HisTyr: 0.547 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	7.31IleAla: 7.31 ± 0.075	0.442IleCys: 0.442 ± 0.017	3.552IleAsp: 3.552 ± 0.058	3.423IleGlu: 3.423 ± 0.053	1.478IlePhe: 1.478 ± 0.034	4.888IleGly: 4.888 ± 0.073	0.86IleHis: 0.86 ± 0.026	1.69IleIle: 1.69 ± 0.035	1.15IleLys: 1.15 ± 0.036	4.561IleLeu: 4.561 ± 0.068	0.853IleMet: 0.853 ± 0.024	1.136IleAsn: 1.136 ± 0.036	2.177IlePro: 2.177 ± 0.041	1.12IleGln: 1.12 ± 0.027	3.492IleArg: 3.492 ± 0.045	2.422IleSer: 2.422 ± 0.043	2.26IleThr: 2.26 ± 0.046	4.151IleVal: 4.151 ± 0.062	0.539IleTrp: 0.539 ± 0.019	0.983IleTyr: 0.983 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	4.089LysAla: 4.089 ± 0.067	0.142LysCys: 0.142 ± 0.01	1.689LysAsp: 1.689 ± 0.036	1.396LysGlu: 1.396 ± 0.035	0.741LysPhe: 0.741 ± 0.026	2.466LysGly: 2.466 ± 0.054	0.508LysHis: 0.508 ± 0.02	1.505LysIle: 1.505 ± 0.042	1.001LysLys: 1.001 ± 0.03	2.627LysLeu: 2.627 ± 0.047	0.635LysMet: 0.635 ± 0.023	0.611LysAsn: 0.611 ± 0.021	1.679LysPro: 1.679 ± 0.039	0.761LysGln: 0.761 ± 0.027	2.126LysArg: 2.126 ± 0.047	1.446LysSer: 1.446 ± 0.037	1.809LysThr: 1.809 ± 0.035	2.292LysVal: 2.292 ± 0.048	0.31LysTrp: 0.31 ± 0.016	0.531LysTyr: 0.531 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	15.309LeuAla: 15.309 ± 0.139	0.893LeuCys: 0.893 ± 0.028	6.731LeuAsp: 6.731 ± 0.073	5.519LeuGlu: 5.519 ± 0.073	3.733LeuPhe: 3.733 ± 0.055	8.459LeuGly: 8.459 ± 0.091	1.794LeuHis: 1.794 ± 0.037	4.799LeuIle: 4.799 ± 0.069	3.535LeuLys: 3.535 ± 0.055	9.59LeuLeu: 9.59 ± 0.117	2.351LeuMet: 2.351 ± 0.041	2.35LeuAsn: 2.35 ± 0.044	5.525LeuPro: 5.525 ± 0.068	2.587LeuGln: 2.587 ± 0.046	7.218LeuArg: 7.218 ± 0.082	6.24LeuSer: 6.24 ± 0.06	5.596LeuThr: 5.596 ± 0.062	8.253LeuVal: 8.253 ± 0.097	1.184LeuTrp: 1.184 ± 0.033	2.076LeuTyr: 2.076 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	3.128MetAla: 3.128 ± 0.052	0.126MetCys: 0.126 ± 0.009	1.15MetAsp: 1.15 ± 0.031	1.153MetGlu: 1.153 ± 0.033	0.66MetPhe: 0.66 ± 0.021	1.705MetGly: 1.705 ± 0.036	0.393MetHis: 0.393 ± 0.016	1.307MetIle: 1.307 ± 0.03	0.873MetLys: 0.873 ± 0.028	2.306MetLeu: 2.306 ± 0.044	0.594MetMet: 0.594 ± 0.021	0.658MetAsn: 0.658 ± 0.02	1.52MetPro: 1.52 ± 0.033	0.686MetGln: 0.686 ± 0.025	1.801MetArg: 1.801 ± 0.035	1.497MetSer: 1.497 ± 0.032	1.95MetThr: 1.95 ± 0.034	1.686MetVal: 1.686 ± 0.038	0.21MetTrp: 0.21 ± 0.013	0.286MetTyr: 0.286 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.918AsnAla: 2.918 ± 0.054	0.189AsnCys: 0.189 ± 0.012	1.19AsnAsp: 1.19 ± 0.033	1.092AsnGlu: 1.092 ± 0.031	0.745AsnPhe: 0.745 ± 0.023	2.068AsnGly: 2.068 ± 0.043	0.435AsnHis: 0.435 ± 0.021	1.062AsnIle: 1.062 ± 0.034	0.565AsnLys: 0.565 ± 0.022	2.291AsnLeu: 2.291 ± 0.049	0.511AsnMet: 0.511 ± 0.02	0.542AsnAsn: 0.542 ± 0.02	1.594AsnPro: 1.594 ± 0.035	0.635AsnGln: 0.635 ± 0.021	1.789AsnArg: 1.789 ± 0.036	0.954AsnSer: 0.954 ± 0.027	1.14AsnThr: 1.14 ± 0.03	1.646AsnVal: 1.646 ± 0.033	0.335AsnTrp: 0.335 ± 0.017	0.509AsnTyr: 0.509 ± 0.021	0.0AsnXaa: 0.0 ± 0.0
Pro	6.975ProAla: 6.975 ± 0.099	0.358ProCys: 0.358 ± 0.016	3.907ProAsp: 3.907 ± 0.057	3.673ProGlu: 3.673 ± 0.057	2.007ProPhe: 2.007 ± 0.038	4.651ProGly: 4.651 ± 0.07	1.104ProHis: 1.104 ± 0.031	2.138ProIle: 2.138 ± 0.041	1.469ProLys: 1.469 ± 0.042	4.768ProLeu: 4.768 ± 0.066	1.177ProMet: 1.177 ± 0.026	1.11ProAsn: 1.11 ± 0.033	2.505ProPro: 2.505 ± 0.051	1.621ProGln: 1.621 ± 0.036	3.085ProArg: 3.085 ± 0.053	2.508ProSer: 2.508 ± 0.045	2.281ProThr: 2.281 ± 0.045	4.587ProVal: 4.587 ± 0.069	0.698ProTrp: 0.698 ± 0.024	1.104ProTyr: 1.104 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	4.039GlnAla: 4.039 ± 0.061	0.176GlnCys: 0.176 ± 0.011	1.53GlnAsp: 1.53 ± 0.035	1.493GlnGlu: 1.493 ± 0.038	0.926GlnPhe: 0.926 ± 0.026	2.216GlnGly: 2.216 ± 0.041	0.533GlnHis: 0.533 ± 0.018	1.711GlnIle: 1.711 ± 0.037	0.924GlnLys: 0.924 ± 0.027	2.431GlnLeu: 2.431 ± 0.045	0.804GlnMet: 0.804 ± 0.024	0.661GlnAsn: 0.661 ± 0.023	1.495GlnPro: 1.495 ± 0.037	0.98GlnGln: 0.98 ± 0.028	2.203GlnArg: 2.203 ± 0.039	1.496GlnSer: 1.496 ± 0.032	1.639GlnThr: 1.639 ± 0.038	2.237GlnVal: 2.237 ± 0.043	0.292GlnTrp: 0.292 ± 0.013	0.504GlnTyr: 0.504 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	9.187ArgAla: 9.187 ± 0.092	0.586ArgCys: 0.586 ± 0.023	4.436ArgAsp: 4.436 ± 0.055	4.244ArgGlu: 4.244 ± 0.065	3.177ArgPhe: 3.177 ± 0.048	5.056ArgGly: 5.056 ± 0.067	1.854ArgHis: 1.854 ± 0.038	4.373ArgIle: 4.373 ± 0.062	2.396ArgLys: 2.396 ± 0.048	9.289ArgLeu: 9.289 ± 0.097	1.956ArgMet: 1.956 ± 0.038	1.72ArgAsn: 1.72 ± 0.041	4.246ArgPro: 4.246 ± 0.066	2.643ArgGln: 2.643 ± 0.051	6.928ArgArg: 6.928 ± 0.096	3.886ArgSer: 3.886 ± 0.059	3.945ArgThr: 3.945 ± 0.066	4.947ArgVal: 4.947 ± 0.062	0.942ArgTrp: 0.942 ± 0.028	1.655ArgTyr: 1.655 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	5.898SerAla: 5.898 ± 0.077	0.422SerCys: 0.422 ± 0.019	2.852SerAsp: 2.852 ± 0.046	2.682SerGlu: 2.682 ± 0.049	2.089SerPhe: 2.089 ± 0.036	5.388SerGly: 5.388 ± 0.07	0.981SerHis: 0.981 ± 0.027	2.383SerIle: 2.383 ± 0.042	1.27SerLys: 1.27 ± 0.033	5.177SerLeu: 5.177 ± 0.062	1.184SerMet: 1.184 ± 0.028	1.092SerAsn: 1.092 ± 0.029	2.495SerPro: 2.495 ± 0.046	1.362SerGln: 1.362 ± 0.032	3.653SerArg: 3.653 ± 0.051	2.51SerSer: 2.51 ± 0.053	2.414SerThr: 2.414 ± 0.044	3.986SerVal: 3.986 ± 0.058	0.629SerTrp: 0.629 ± 0.022	1.195SerTyr: 1.195 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	6.607ThrAla: 6.607 ± 0.07	0.442ThrCys: 0.442 ± 0.018	2.923ThrAsp: 2.923 ± 0.048	2.673ThrGlu: 2.673 ± 0.042	1.884ThrPhe: 1.884 ± 0.037	5.356ThrGly: 5.356 ± 0.062	0.953ThrHis: 0.953 ± 0.026	2.688ThrIle: 2.688 ± 0.043	1.148ThrLys: 1.148 ± 0.033	5.99ThrLeu: 5.99 ± 0.072	1.1ThrMet: 1.1 ± 0.028	1.102ThrAsn: 1.102 ± 0.025	3.107ThrPro: 3.107 ± 0.051	1.267ThrGln: 1.267 ± 0.03	3.724ThrArg: 3.724 ± 0.057	2.465ThrSer: 2.465 ± 0.043	2.614ThrThr: 2.614 ± 0.046	4.734ThrVal: 4.734 ± 0.056	0.69ThrTrp: 0.69 ± 0.022	1.144ThrTyr: 1.144 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	10.108ValAla: 10.108 ± 0.106	0.642ValCys: 0.642 ± 0.023	4.513ValAsp: 4.513 ± 0.06	4.824ValGlu: 4.824 ± 0.068	2.918ValPhe: 2.918 ± 0.054	5.689ValGly: 5.689 ± 0.073	1.442ValHis: 1.442 ± 0.032	3.678ValIle: 3.678 ± 0.058	2.039ValLys: 2.039 ± 0.046	8.15ValLeu: 8.15 ± 0.084	1.778ValMet: 1.778 ± 0.04	1.79ValAsn: 1.79 ± 0.039	4.031ValPro: 4.031 ± 0.06	1.904ValGln: 1.904 ± 0.041	5.515ValArg: 5.515 ± 0.063	4.224ValSer: 4.224 ± 0.062	4.537ValThr: 4.537 ± 0.068	6.48ValVal: 6.48 ± 0.087	0.955ValTrp: 0.955 ± 0.026	1.584ValTyr: 1.584 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.235TrpAla: 1.235 ± 0.032	0.126TrpCys: 0.126 ± 0.01	0.657TrpAsp: 0.657 ± 0.022	0.517TrpGlu: 0.517 ± 0.022	0.495TrpPhe: 0.495 ± 0.019	0.867TrpGly: 0.867 ± 0.025	0.319TrpHis: 0.319 ± 0.017	0.674TrpIle: 0.674 ± 0.025	0.405TrpLys: 0.405 ± 0.016	1.571TrpLeu: 1.571 ± 0.033	0.337TrpMet: 0.337 ± 0.016	0.353TrpAsn: 0.353 ± 0.017	0.734TrpPro: 0.734 ± 0.026	0.56TrpGln: 0.56 ± 0.023	1.176TrpArg: 1.176 ± 0.031	0.782TrpSer: 0.782 ± 0.027	0.787TrpThr: 0.787 ± 0.022	0.742TrpVal: 0.742 ± 0.025	0.213TrpTrp: 0.213 ± 0.015	0.262TrpTyr: 0.262 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.436TyrAla: 2.436 ± 0.045	0.235TyrCys: 0.235 ± 0.015	1.417TyrAsp: 1.417 ± 0.032	1.225TyrGlu: 1.225 ± 0.031	0.872TyrPhe: 0.872 ± 0.028	2.079TyrGly: 2.079 ± 0.04	0.472TyrHis: 0.472 ± 0.02	0.785TyrIle: 0.785 ± 0.025	0.536TyrLys: 0.536 ± 0.021	2.275TyrLeu: 2.275 ± 0.043	0.411TyrMet: 0.411 ± 0.017	0.536TyrAsn: 0.536 ± 0.022	1.007TyrPro: 1.007 ± 0.028	0.674TyrGln: 0.674 ± 0.022	1.902TyrArg: 1.902 ± 0.04	1.012TyrSer: 1.012 ± 0.026	0.99TyrThr: 0.99 ± 0.03	1.549TyrVal: 1.549 ± 0.039	0.332TyrTrp: 0.332 ± 0.015	0.565TyrTyr: 0.565 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4354 proteins (1377863 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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