Amino acid dipepetide frequency for Canine adenovirus 1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.325AlaAla: 6.325 ± 3.611
2.3AlaCys: 2.3 ± 1.834
5.75AlaAsp: 5.75 ± 1.706
5.175AlaGlu: 5.175 ± 1.24
2.3AlaPhe: 2.3 ± 1.419
3.45AlaGly: 3.45 ± 0.967
2.3AlaHis: 2.3 ± 2.358
4.025AlaIle: 4.025 ± 1.538
4.6AlaLys: 4.6 ± 1.544
8.051AlaLeu: 8.051 ± 3.146
0.0AlaMet: 0.0 ± 0.0
1.725AlaAsn: 1.725 ± 1.003
2.875AlaPro: 2.875 ± 1.672
2.875AlaGln: 2.875 ± 1.17
1.15AlaArg: 1.15 ± 0.699
4.6AlaSer: 4.6 ± 1.379
2.875AlaThr: 2.875 ± 1.028
4.025AlaVal: 4.025 ± 1.948
0.575AlaTrp: 0.575 ± 0.334
3.45AlaTyr: 3.45 ± 2.006
0.0AlaXaa: 0.0 ± 0.0
Cys
2.875CysAla: 2.875 ± 1.863
0.575CysCys: 0.575 ± 0.334
0.0CysAsp: 0.0 ± 0.0
1.725CysGlu: 1.725 ± 1.003
2.3CysPhe: 2.3 ± 1.834
1.725CysGly: 1.725 ± 1.003
0.575CysHis: 0.575 ± 0.82
1.15CysIle: 1.15 ± 0.708
0.0CysLys: 0.0 ± 0.0
2.875CysLeu: 2.875 ± 1.25
0.575CysMet: 0.575 ± 0.652
0.575CysAsn: 0.575 ± 0.716
1.725CysPro: 1.725 ± 0.725
1.15CysGln: 1.15 ± 0.669
0.575CysArg: 0.575 ± 0.716
1.15CysSer: 1.15 ± 0.708
1.15CysThr: 1.15 ± 0.708
0.575CysVal: 0.575 ± 0.819
0.575CysTrp: 0.575 ± 0.334
1.15CysTyr: 1.15 ± 0.669
0.0CysXaa: 0.0 ± 0.0
Asp
5.175AspAla: 5.175 ± 1.631
0.575AspCys: 0.575 ± 0.956
3.45AspAsp: 3.45 ± 1.642
2.3AspGlu: 2.3 ± 1.02
4.025AspPhe: 4.025 ± 2.35
1.725AspGly: 1.725 ± 1.168
0.575AspHis: 0.575 ± 0.716
5.175AspIle: 5.175 ± 1.26
2.3AspLys: 2.3 ± 0.861
6.901AspLeu: 6.901 ± 1.825
0.575AspMet: 0.575 ± 0.334
1.15AspAsn: 1.15 ± 0.669
1.725AspPro: 1.725 ± 0.761
1.725AspGln: 1.725 ± 0.8
0.575AspArg: 0.575 ± 0.716
1.15AspSer: 1.15 ± 0.708
4.6AspThr: 4.6 ± 1.245
4.025AspVal: 4.025 ± 1.735
0.575AspTrp: 0.575 ± 0.334
1.725AspTyr: 1.725 ± 0.848
0.0AspXaa: 0.0 ± 0.0
Glu
1.725GluAla: 1.725 ± 1.086
1.725GluCys: 1.725 ± 0.725
5.175GluAsp: 5.175 ± 2.84
5.75GluGlu: 5.75 ± 2.552
2.875GluPhe: 2.875 ± 1.156
4.025GluGly: 4.025 ± 1.708
2.875GluHis: 2.875 ± 0.859
2.3GluIle: 2.3 ± 1.338
5.175GluLys: 5.175 ± 3.01
4.025GluLeu: 4.025 ± 3.151
2.3GluMet: 2.3 ± 2.01
1.725GluAsn: 1.725 ± 1.003
4.6GluPro: 4.6 ± 2.881
2.3GluGln: 2.3 ± 0.936
1.725GluArg: 1.725 ± 0.8
6.325GluSer: 6.325 ± 3.434
6.901GluThr: 6.901 ± 1.927
3.45GluVal: 3.45 ± 1.683
1.15GluTrp: 1.15 ± 0.669
2.3GluTyr: 2.3 ± 1.338
0.0GluXaa: 0.0 ± 0.0
Phe
1.725PheAla: 1.725 ± 0.848
2.3PheCys: 2.3 ± 0.913
2.875PheAsp: 2.875 ± 1.672
0.0PheGlu: 0.0 ± 0.0
2.875PhePhe: 2.875 ± 2.049
1.725PheGly: 1.725 ± 1.767
0.575PheHis: 0.575 ± 0.334
2.875PheIle: 2.875 ± 1.192
5.75PheLys: 5.75 ± 1.47
4.025PheLeu: 4.025 ± 2.35
2.3PheMet: 2.3 ± 1.338
3.45PheAsn: 3.45 ± 0.979
1.725PhePro: 1.725 ± 1.003
1.15PheGln: 1.15 ± 0.669
2.875PheArg: 2.875 ± 2.01
3.45PheSer: 3.45 ± 1.516
3.45PheThr: 3.45 ± 1.497
4.025PheVal: 4.025 ± 0.943
0.0PheTrp: 0.0 ± 0.0
2.875PheTyr: 2.875 ± 1.148
0.0PheXaa: 0.0 ± 0.0
Gly
4.025GlyAla: 4.025 ± 1.24
0.575GlyCys: 0.575 ± 0.334
1.725GlyAsp: 1.725 ± 0.848
1.725GlyGlu: 1.725 ± 1.275
2.3GlyPhe: 2.3 ± 1.679
2.3GlyGly: 2.3 ± 0.931
1.725GlyHis: 1.725 ± 0.745
1.725GlyIle: 1.725 ± 0.725
4.025GlyLys: 4.025 ± 1.251
3.45GlyLeu: 3.45 ± 2.174
2.3GlyMet: 2.3 ± 2.203
1.15GlyAsn: 1.15 ± 0.826
1.15GlyPro: 1.15 ± 0.638
1.15GlyGln: 1.15 ± 0.839
2.3GlyArg: 2.3 ± 0.914
6.325GlySer: 6.325 ± 2.032
1.725GlyThr: 1.725 ± 1.497
4.6GlyVal: 4.6 ± 2.76
1.15GlyTrp: 1.15 ± 0.638
0.575GlyTyr: 0.575 ± 0.334
0.0GlyXaa: 0.0 ± 0.0
His
2.3HisAla: 2.3 ± 1.338
0.0HisCys: 0.0 ± 0.0
0.575HisAsp: 0.575 ± 0.956
0.0HisGlu: 0.0 ± 0.0
1.15HisPhe: 1.15 ± 0.638
1.15HisGly: 1.15 ± 0.708
1.15HisHis: 1.15 ± 0.709
0.0HisIle: 0.0 ± 0.0
2.875HisLys: 2.875 ± 1.283
4.025HisLeu: 4.025 ± 2.228
0.575HisMet: 0.575 ± 0.716
1.725HisAsn: 1.725 ± 0.745
0.575HisPro: 0.575 ± 0.334
0.0HisGln: 0.0 ± 0.0
1.15HisArg: 1.15 ± 0.709
2.3HisSer: 2.3 ± 1.721
1.725HisThr: 1.725 ± 1.003
2.875HisVal: 2.875 ± 0.933
0.575HisTrp: 0.575 ± 0.334
1.725HisTyr: 1.725 ± 1.728
0.0HisXaa: 0.0 ± 0.0
Ile
2.3IleAla: 2.3 ± 1.338
0.575IleCys: 0.575 ± 0.334
2.875IleAsp: 2.875 ± 0.954
4.025IleGlu: 4.025 ± 0.966
3.45IlePhe: 3.45 ± 1.212
2.875IleGly: 2.875 ± 1.028
0.575IleHis: 0.575 ± 0.974
1.725IleIle: 1.725 ± 0.8
2.3IleLys: 2.3 ± 0.913
2.3IleLeu: 2.3 ± 0.906
2.875IleMet: 2.875 ± 0.885
0.575IleAsn: 0.575 ± 0.334
2.875IlePro: 2.875 ± 1.192
0.575IleGln: 0.575 ± 0.334
3.45IleArg: 3.45 ± 2.374
4.6IleSer: 4.6 ± 1.479
5.175IleThr: 5.175 ± 1.65
3.45IleVal: 3.45 ± 2.274
0.0IleTrp: 0.0 ± 0.0
0.0IleTyr: 0.0 ± 0.0
0.0IleXaa: 0.0 ± 0.0
Lys
3.45LysAla: 3.45 ± 1.087
3.45LysCys: 3.45 ± 1.491
4.6LysAsp: 4.6 ± 1.507
3.45LysGlu: 3.45 ± 1.025
2.875LysPhe: 2.875 ± 1.107
4.6LysGly: 4.6 ± 1.448
0.575LysHis: 0.575 ± 0.788
2.3LysIle: 2.3 ± 1.481
4.6LysLys: 4.6 ± 1.648
6.325LysLeu: 6.325 ± 2.068
0.575LysMet: 0.575 ± 0.334
3.45LysAsn: 3.45 ± 1.436
2.875LysPro: 2.875 ± 1.657
1.15LysGln: 1.15 ± 0.669
4.6LysArg: 4.6 ± 1.889
2.875LysSer: 2.875 ± 1.192
3.45LysThr: 3.45 ± 2.006
2.3LysVal: 2.3 ± 0.922
0.575LysTrp: 0.575 ± 0.788
2.3LysTyr: 2.3 ± 0.952
0.0LysXaa: 0.0 ± 0.0
Leu
5.75LeuAla: 5.75 ± 1.52
2.875LeuCys: 2.875 ± 0.885
5.175LeuAsp: 5.175 ± 1.551
4.6LeuGlu: 4.6 ± 1.754
4.6LeuPhe: 4.6 ± 1.338
6.325LeuGly: 6.325 ± 3.133
2.3LeuHis: 2.3 ± 0.931
4.025LeuIle: 4.025 ± 1.011
9.201LeuLys: 9.201 ± 1.901
8.051LeuLeu: 8.051 ± 2.97
1.15LeuMet: 1.15 ± 0.669
1.725LeuAsn: 1.725 ± 1.003
5.175LeuPro: 5.175 ± 1.757
4.6LeuGln: 4.6 ± 1.665
5.75LeuArg: 5.75 ± 2.548
9.201LeuSer: 9.201 ± 4.643
5.175LeuThr: 5.175 ± 1.305
8.051LeuVal: 8.051 ± 2.599
1.15LeuTrp: 1.15 ± 0.669
2.875LeuTyr: 2.875 ± 1.672
0.0LeuXaa: 0.0 ± 0.0
Met
2.875MetAla: 2.875 ± 1.724
0.0MetCys: 0.0 ± 0.0
0.575MetAsp: 0.575 ± 0.716
3.45MetGlu: 3.45 ± 0.992
1.725MetPhe: 1.725 ± 1.497
0.575MetGly: 0.575 ± 0.956
0.0MetHis: 0.0 ± 0.0
0.575MetIle: 0.575 ± 0.819
0.0MetLys: 0.0 ± 0.0
3.45MetLeu: 3.45 ± 1.803
0.0MetMet: 0.0 ± 0.0
1.15MetAsn: 1.15 ± 0.708
2.3MetPro: 2.3 ± 1.098
2.3MetGln: 2.3 ± 0.931
0.575MetArg: 0.575 ± 0.334
2.3MetSer: 2.3 ± 1.981
1.15MetThr: 1.15 ± 0.669
0.575MetVal: 0.575 ± 0.334
0.0MetTrp: 0.0 ± 0.0
1.15MetTyr: 1.15 ± 0.669
0.0MetXaa: 0.0 ± 0.0
Asn
3.45AsnAla: 3.45 ± 1.436
0.575AsnCys: 0.575 ± 0.819
1.15AsnAsp: 1.15 ± 0.669
2.875AsnGlu: 2.875 ± 1.672
2.3AsnPhe: 2.3 ± 0.913
1.15AsnGly: 1.15 ± 0.699
0.575AsnHis: 0.575 ± 0.82
4.6AsnIle: 4.6 ± 1.734
2.3AsnLys: 2.3 ± 0.914
5.175AsnLeu: 5.175 ± 1.216
0.575AsnMet: 0.575 ± 0.334
4.025AsnAsn: 4.025 ± 1.575
4.025AsnPro: 4.025 ± 2.341
1.15AsnGln: 1.15 ± 0.669
1.725AsnArg: 1.725 ± 1.003
2.875AsnSer: 2.875 ± 1.591
1.725AsnThr: 1.725 ± 0.746
1.15AsnVal: 1.15 ± 0.709
0.575AsnTrp: 0.575 ± 0.334
0.575AsnTyr: 0.575 ± 0.974
0.0AsnXaa: 0.0 ± 0.0
Pro
2.875ProAla: 2.875 ± 0.859
0.575ProCys: 0.575 ± 0.856
1.15ProAsp: 1.15 ± 0.669
7.476ProGlu: 7.476 ± 2.227
2.875ProPhe: 2.875 ± 1.672
1.725ProGly: 1.725 ± 1.048
1.15ProHis: 1.15 ± 0.669
1.15ProIle: 1.15 ± 0.669
1.725ProLys: 1.725 ± 0.8
2.875ProLeu: 2.875 ± 1.261
0.575ProMet: 0.575 ± 0.974
4.025ProAsn: 4.025 ± 0.804
3.45ProPro: 3.45 ± 1.361
0.575ProGln: 0.575 ± 0.856
4.025ProArg: 4.025 ± 1.976
2.3ProSer: 2.3 ± 1.338
4.025ProThr: 4.025 ± 1.569
2.875ProVal: 2.875 ± 1.594
1.15ProTrp: 1.15 ± 0.839
1.725ProTyr: 1.725 ± 1.003
0.0ProXaa: 0.0 ± 0.0
Gln
2.3GlnAla: 2.3 ± 1.419
0.0GlnCys: 0.0 ± 0.0
1.725GlnAsp: 1.725 ± 0.887
3.45GlnGlu: 3.45 ± 1.763
0.575GlnPhe: 0.575 ± 0.334
1.725GlnGly: 1.725 ± 1.003
0.575GlnHis: 0.575 ± 0.334
2.875GlnIle: 2.875 ± 1.197
1.15GlnLys: 1.15 ± 0.826
5.175GlnLeu: 5.175 ± 1.356
1.15GlnMet: 1.15 ± 1.311
1.725GlnAsn: 1.725 ± 1.003
0.575GlnPro: 0.575 ± 0.334
2.3GlnGln: 2.3 ± 1.338
0.575GlnArg: 0.575 ± 0.334
1.725GlnSer: 1.725 ± 1.624
3.45GlnThr: 3.45 ± 1.152
1.725GlnVal: 1.725 ± 1.003
1.15GlnTrp: 1.15 ± 0.638
1.15GlnTyr: 1.15 ± 0.669
0.0GlnXaa: 0.0 ± 0.0
Arg
6.325ArgAla: 6.325 ± 1.149
0.575ArgCys: 0.575 ± 0.334
1.725ArgAsp: 1.725 ± 1.003
2.3ArgGlu: 2.3 ± 1.667
0.575ArgPhe: 0.575 ± 0.334
3.45ArgGly: 3.45 ± 1.397
1.725ArgHis: 1.725 ± 1.767
0.575ArgIle: 0.575 ± 0.334
2.875ArgLys: 2.875 ± 1.251
5.75ArgLeu: 5.75 ± 2.137
2.3ArgMet: 2.3 ± 1.307
2.3ArgAsn: 2.3 ± 1.076
4.025ArgPro: 4.025 ± 2.53
0.575ArgGln: 0.575 ± 0.82
4.025ArgArg: 4.025 ± 1.638
2.3ArgSer: 2.3 ± 1.542
2.875ArgThr: 2.875 ± 1.283
1.725ArgVal: 1.725 ± 1.565
1.15ArgTrp: 1.15 ± 1.353
2.3ArgTyr: 2.3 ± 1.652
0.0ArgXaa: 0.0 ± 0.0
Ser
3.45SerAla: 3.45 ± 1.913
1.725SerCys: 1.725 ± 1.866
2.3SerAsp: 2.3 ± 0.979
5.75SerGlu: 5.75 ± 3.171
3.45SerPhe: 3.45 ± 1.095
4.6SerGly: 4.6 ± 3.296
2.875SerHis: 2.875 ± 0.885
1.725SerIle: 1.725 ± 1.003
2.875SerLys: 2.875 ± 1.074
9.201SerLeu: 9.201 ± 3.395
1.725SerMet: 1.725 ± 1.53
3.45SerAsn: 3.45 ± 1.436
2.3SerPro: 2.3 ± 1.076
2.875SerGln: 2.875 ± 1.3
5.175SerArg: 5.175 ± 2.942
5.75SerSer: 5.75 ± 1.889
2.3SerThr: 2.3 ± 0.931
6.325SerVal: 6.325 ± 2.812
1.725SerTrp: 1.725 ± 1.727
5.75SerTyr: 5.75 ± 2.137
0.0SerXaa: 0.0 ± 0.0
Thr
5.175ThrAla: 5.175 ± 2.409
1.15ThrCys: 1.15 ± 0.669
4.025ThrAsp: 4.025 ± 1.919
5.75ThrGlu: 5.75 ± 3.44
2.875ThrPhe: 2.875 ± 1.17
0.575ThrGly: 0.575 ± 0.334
2.875ThrHis: 2.875 ± 1.197
4.025ThrIle: 4.025 ± 1.011
1.725ThrLys: 1.725 ± 0.761
6.901ThrLeu: 6.901 ± 2.775
2.3ThrMet: 2.3 ± 0.89
1.15ThrAsn: 1.15 ± 0.669
2.3ThrPro: 2.3 ± 0.906
2.875ThrGln: 2.875 ± 1.274
2.875ThrArg: 2.875 ± 1.107
4.6ThrSer: 4.6 ± 1.53
6.325ThrThr: 6.325 ± 1.257
3.45ThrVal: 3.45 ± 0.979
2.875ThrTrp: 2.875 ± 1.192
3.45ThrTyr: 3.45 ± 1.093
0.0ThrXaa: 0.0 ± 0.0
Val
4.025ValAla: 4.025 ± 1.609
1.725ValCys: 1.725 ± 1.639
1.725ValAsp: 1.725 ± 1.669
3.45ValGlu: 3.45 ± 1.425
4.025ValPhe: 4.025 ± 2.341
1.15ValGly: 1.15 ± 0.669
2.3ValHis: 2.3 ± 1.319
1.15ValIle: 1.15 ± 0.782
2.875ValLys: 2.875 ± 1.059
5.75ValLeu: 5.75 ± 1.644
0.0ValMet: 0.0 ± 0.0
5.75ValAsn: 5.75 ± 1.552
1.15ValPro: 1.15 ± 0.669
2.875ValGln: 2.875 ± 1.156
2.875ValArg: 2.875 ± 1.138
6.901ValSer: 6.901 ± 3.782
7.476ValThr: 7.476 ± 2.292
2.875ValVal: 2.875 ± 1.156
0.0ValTrp: 0.0 ± 0.0
4.6ValTyr: 4.6 ± 2.037
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.0TrpCys: 0.0 ± 0.0
1.15TrpAsp: 1.15 ± 0.826
2.3TrpGlu: 2.3 ± 1.135
0.0TrpPhe: 0.0 ± 0.0
0.0TrpGly: 0.0 ± 0.0
1.15TrpHis: 1.15 ± 0.708
1.15TrpIle: 1.15 ± 1.127
3.45TrpLys: 3.45 ± 1.481
1.15TrpLeu: 1.15 ± 0.638
1.15TrpMet: 1.15 ± 0.669
0.575TrpAsn: 0.575 ± 0.334
0.575TrpPro: 0.575 ± 0.956
0.0TrpGln: 0.0 ± 0.0
0.575TrpArg: 0.575 ± 0.974
1.15TrpSer: 1.15 ± 0.669
1.15TrpThr: 1.15 ± 0.669
0.0TrpVal: 0.0 ± 0.0
0.575TrpTrp: 0.575 ± 0.334
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.3TyrAla: 2.3 ± 1.338
1.725TyrCys: 1.725 ± 1.003
2.3TyrAsp: 2.3 ± 1.338
3.45TyrGlu: 3.45 ± 1.093
2.875TyrPhe: 2.875 ± 0.954
1.15TyrGly: 1.15 ± 0.669
0.0TyrHis: 0.0 ± 0.0
3.45TyrIle: 3.45 ± 1.028
0.575TyrLys: 0.575 ± 0.334
2.3TyrLeu: 2.3 ± 1.342
1.15TyrMet: 1.15 ± 0.826
1.15TyrAsn: 1.15 ± 1.305
2.3TyrPro: 2.3 ± 1.338
2.875TyrGln: 2.875 ± 1.01
2.875TyrArg: 2.875 ± 1.107
3.45TyrSer: 3.45 ± 1.49
0.575TyrThr: 0.575 ± 0.334
4.6TyrVal: 4.6 ± 1.439
0.575TyrTrp: 0.575 ± 0.334
1.725TyrTyr: 1.725 ± 0.8
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 8 proteins (1740 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski