Amino acid dipepetide frequency for Torque teno mini virus 8

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.294AlaAla: 1.294 ± 0.633
5.175AlaCys: 5.175 ± 2.534
0.0AlaAsp: 0.0 ± 0.0
0.0AlaGlu: 0.0 ± 0.0
1.294AlaPhe: 1.294 ± 0.633
2.587AlaGly: 2.587 ± 3.705
1.294AlaHis: 1.294 ± 4.338
1.294AlaIle: 1.294 ± 0.633
3.881AlaLys: 3.881 ± 1.9
1.294AlaLeu: 1.294 ± 0.633
0.0AlaMet: 0.0 ± 0.0
5.175AlaAsn: 5.175 ± 2.438
1.294AlaPro: 1.294 ± 0.633
0.0AlaGln: 0.0 ± 0.0
0.0AlaArg: 0.0 ± 0.0
2.587AlaSer: 2.587 ± 1.267
3.881AlaThr: 3.881 ± 1.9
0.0AlaVal: 0.0 ± 0.0
0.0AlaTrp: 0.0 ± 0.0
0.0AlaTyr: 0.0 ± 0.0
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
2.587CysAsp: 2.587 ± 8.676
0.0CysGlu: 0.0 ± 0.0
1.294CysPhe: 1.294 ± 0.633
0.0CysGly: 0.0 ± 0.0
0.0CysHis: 0.0 ± 0.0
1.294CysIle: 1.294 ± 0.633
1.294CysLys: 1.294 ± 0.633
2.587CysLeu: 2.587 ± 3.705
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
1.294CysPro: 1.294 ± 0.633
0.0CysGln: 0.0 ± 0.0
1.294CysArg: 1.294 ± 0.633
1.294CysSer: 1.294 ± 0.633
2.587CysThr: 2.587 ± 1.267
1.294CysVal: 1.294 ± 0.633
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
1.294AspAla: 1.294 ± 0.633
2.587AspCys: 2.587 ± 3.705
1.294AspAsp: 1.294 ± 0.633
5.175AspGlu: 5.175 ± 2.534
2.587AspPhe: 2.587 ± 3.705
1.294AspGly: 1.294 ± 4.338
0.0AspHis: 0.0 ± 0.0
2.587AspIle: 2.587 ± 3.705
2.587AspLys: 2.587 ± 1.267
3.881AspLeu: 3.881 ± 8.043
0.0AspMet: 0.0 ± 0.0
5.175AspAsn: 5.175 ± 2.534
3.881AspPro: 3.881 ± 3.071
0.0AspGln: 0.0 ± 0.0
2.587AspArg: 2.587 ± 1.267
5.175AspSer: 5.175 ± 7.409
5.175AspThr: 5.175 ± 2.438
1.294AspVal: 1.294 ± 0.633
0.0AspTrp: 0.0 ± 0.0
3.881AspTyr: 3.881 ± 1.9
0.0AspXaa: 0.0 ± 0.0
Glu
1.294GluAla: 1.294 ± 0.633
0.0GluCys: 0.0 ± 0.0
6.468GluAsp: 6.468 ± 6.776
3.881GluGlu: 3.881 ± 3.071
0.0GluPhe: 0.0 ± 0.0
3.881GluGly: 3.881 ± 8.043
3.881GluHis: 3.881 ± 1.9
1.294GluIle: 1.294 ± 0.633
6.468GluLys: 6.468 ± 1.804
3.881GluLeu: 3.881 ± 1.9
0.0GluMet: 0.0 ± 0.0
2.587GluAsn: 2.587 ± 1.267
2.587GluPro: 2.587 ± 3.705
1.294GluGln: 1.294 ± 0.633
2.587GluArg: 2.587 ± 3.705
2.587GluSer: 2.587 ± 1.267
5.175GluThr: 5.175 ± 2.438
1.294GluVal: 1.294 ± 0.633
2.587GluTrp: 2.587 ± 1.267
1.294GluTyr: 1.294 ± 0.633
0.0GluXaa: 0.0 ± 0.0
Phe
0.0PheAla: 0.0 ± 0.0
1.294PheCys: 1.294 ± 4.338
1.294PheAsp: 1.294 ± 0.633
1.294PheGlu: 1.294 ± 0.633
0.0PhePhe: 0.0 ± 0.0
2.587PheGly: 2.587 ± 8.676
1.294PheHis: 1.294 ± 0.633
2.587PheIle: 2.587 ± 1.267
6.468PheLys: 6.468 ± 3.167
5.175PheLeu: 5.175 ± 2.534
0.0PheMet: 0.0 ± 0.0
1.294PheAsn: 1.294 ± 4.338
1.294PhePro: 1.294 ± 0.633
3.881PheGln: 3.881 ± 1.9
3.881PheArg: 3.881 ± 1.9
2.587PheSer: 2.587 ± 1.267
2.587PheThr: 2.587 ± 3.705
1.294PheVal: 1.294 ± 4.338
3.881PheTrp: 3.881 ± 1.9
1.294PheTyr: 1.294 ± 0.633
0.0PheXaa: 0.0 ± 0.0
Gly
1.294GlyAla: 1.294 ± 4.338
1.294GlyCys: 1.294 ± 0.633
3.881GlyAsp: 3.881 ± 13.014
2.587GlyGlu: 2.587 ± 8.676
5.175GlyPhe: 5.175 ± 2.438
5.175GlyGly: 5.175 ± 2.534
1.294GlyHis: 1.294 ± 0.633
1.294GlyIle: 1.294 ± 0.633
0.0GlyLys: 0.0 ± 0.0
0.0GlyLeu: 0.0 ± 0.0
0.0GlyMet: 0.0 ± 2.191
2.587GlyAsn: 2.587 ± 1.267
1.294GlyPro: 1.294 ± 0.633
1.294GlyGln: 1.294 ± 0.633
0.0GlyArg: 0.0 ± 0.0
2.587GlySer: 2.587 ± 1.267
2.587GlyThr: 2.587 ± 1.267
0.0GlyVal: 0.0 ± 0.0
0.0GlyTrp: 0.0 ± 0.0
3.881GlyTyr: 3.881 ± 1.9
0.0GlyXaa: 0.0 ± 0.0
His
1.294HisAla: 1.294 ± 4.338
0.0HisCys: 0.0 ± 0.0
1.294HisAsp: 1.294 ± 4.338
1.294HisGlu: 1.294 ± 0.633
2.587HisPhe: 2.587 ± 1.267
0.0HisGly: 0.0 ± 0.0
0.0HisHis: 0.0 ± 0.0
1.294HisIle: 1.294 ± 0.633
0.0HisLys: 0.0 ± 0.0
1.294HisLeu: 1.294 ± 0.633
1.294HisMet: 1.294 ± 0.633
1.294HisAsn: 1.294 ± 0.633
1.294HisPro: 1.294 ± 0.633
1.294HisGln: 1.294 ± 0.633
1.294HisArg: 1.294 ± 4.338
3.881HisSer: 3.881 ± 1.9
2.587HisThr: 2.587 ± 3.705
0.0HisVal: 0.0 ± 0.0
0.0HisTrp: 0.0 ± 0.0
3.881HisTyr: 3.881 ± 1.9
0.0HisXaa: 0.0 ± 0.0
Ile
6.468IleAla: 6.468 ± 3.167
1.294IleCys: 1.294 ± 0.633
2.587IleAsp: 2.587 ± 1.267
2.587IleGlu: 2.587 ± 1.267
3.881IlePhe: 3.881 ± 3.071
1.294IleGly: 1.294 ± 0.633
0.0IleHis: 0.0 ± 0.0
0.0IleIle: 0.0 ± 0.0
3.881IleLys: 3.881 ± 3.071
5.175IleLeu: 5.175 ± 2.438
0.0IleMet: 0.0 ± 0.0
1.294IleAsn: 1.294 ± 0.633
5.175IlePro: 5.175 ± 2.438
6.468IleGln: 6.468 ± 1.804
3.881IleArg: 3.881 ± 1.9
2.587IleSer: 2.587 ± 1.267
6.468IleThr: 6.468 ± 3.167
1.294IleVal: 1.294 ± 0.633
1.294IleTrp: 1.294 ± 0.633
1.294IleTyr: 1.294 ± 0.633
0.0IleXaa: 0.0 ± 0.0
Lys
6.468LysAla: 6.468 ± 3.167
2.587LysCys: 2.587 ± 3.705
3.881LysAsp: 3.881 ± 8.043
3.881LysGlu: 3.881 ± 1.9
2.587LysPhe: 2.587 ± 3.705
2.587LysGly: 2.587 ± 1.267
0.0LysHis: 0.0 ± 0.0
2.587LysIle: 2.587 ± 1.267
5.175LysLys: 5.175 ± 2.438
11.643LysLeu: 11.643 ± 5.701
0.0LysMet: 0.0 ± 0.0
6.468LysAsn: 6.468 ± 1.804
3.881LysPro: 3.881 ± 1.9
2.587LysGln: 2.587 ± 1.267
6.468LysArg: 6.468 ± 3.167
2.587LysSer: 2.587 ± 1.267
6.468LysThr: 6.468 ± 3.167
2.587LysVal: 2.587 ± 1.267
2.587LysTrp: 2.587 ± 3.705
5.175LysTyr: 5.175 ± 2.534
0.0LysXaa: 0.0 ± 0.0
Leu
1.294LeuAla: 1.294 ± 0.633
0.0LeuCys: 0.0 ± 0.0
6.468LeuAsp: 6.468 ± 3.167
2.587LeuGlu: 2.587 ± 3.705
3.881LeuPhe: 3.881 ± 3.071
5.175LeuGly: 5.175 ± 2.438
2.587LeuHis: 2.587 ± 1.267
5.175LeuIle: 5.175 ± 2.438
12.937LeuLys: 12.937 ± 3.608
12.937LeuLeu: 12.937 ± 1.363
1.294LeuMet: 1.294 ± 0.633
11.643LeuAsn: 11.643 ± 0.73
3.881LeuPro: 3.881 ± 1.9
9.056LeuGln: 9.056 ± 0.537
1.294LeuArg: 1.294 ± 0.633
3.881LeuSer: 3.881 ± 1.9
7.762LeuThr: 7.762 ± 3.801
0.0LeuVal: 0.0 ± 0.0
2.587LeuTrp: 2.587 ± 1.267
2.587LeuTyr: 2.587 ± 1.267
0.0LeuXaa: 0.0 ± 0.0
Met
1.294MetAla: 1.294 ± 0.633
0.0MetCys: 0.0 ± 0.0
0.0MetAsp: 0.0 ± 0.0
0.0MetGlu: 0.0 ± 0.0
0.0MetPhe: 0.0 ± 0.0
0.0MetGly: 0.0 ± 0.0
0.0MetHis: 0.0 ± 0.0
1.294MetIle: 1.294 ± 0.633
1.294MetLys: 1.294 ± 0.633
0.0MetLeu: 0.0 ± 0.0
0.0MetMet: 0.0 ± 0.0
0.0MetAsn: 0.0 ± 0.0
2.587MetPro: 2.587 ± 1.267
2.587MetGln: 2.587 ± 1.267
0.0MetArg: 0.0 ± 0.0
1.294MetSer: 1.294 ± 4.338
0.0MetThr: 0.0 ± 0.0
0.0MetVal: 0.0 ± 0.0
0.0MetTrp: 0.0 ± 0.0
1.294MetTyr: 1.294 ± 0.633
0.0MetXaa: 0.0 ± 0.0
Asn
0.0AsnAla: 0.0 ± 0.0
0.0AsnCys: 0.0 ± 0.0
1.294AsnAsp: 1.294 ± 0.633
2.587AsnGlu: 2.587 ± 1.267
3.881AsnPhe: 3.881 ± 3.071
1.294AsnGly: 1.294 ± 0.633
0.0AsnHis: 0.0 ± 0.0
7.762AsnIle: 7.762 ± 6.142
3.881AsnLys: 3.881 ± 1.9
3.881AsnLeu: 3.881 ± 3.071
1.294AsnMet: 1.294 ± 0.633
5.175AsnAsn: 5.175 ± 2.534
5.175AsnPro: 5.175 ± 2.534
2.587AsnGln: 2.587 ± 1.267
5.175AsnArg: 5.175 ± 2.534
2.587AsnSer: 2.587 ± 1.267
7.762AsnThr: 7.762 ± 1.171
1.294AsnVal: 1.294 ± 0.633
3.881AsnTrp: 3.881 ± 1.9
5.175AsnTyr: 5.175 ± 2.534
0.0AsnXaa: 0.0 ± 0.0
Pro
1.294ProAla: 1.294 ± 0.633
0.0ProCys: 0.0 ± 0.0
2.587ProAsp: 2.587 ± 1.267
6.468ProGlu: 6.468 ± 1.804
2.587ProPhe: 2.587 ± 1.267
1.294ProGly: 1.294 ± 0.633
1.294ProHis: 1.294 ± 0.633
3.881ProIle: 3.881 ± 1.9
6.468ProLys: 6.468 ± 3.167
7.762ProLeu: 7.762 ± 1.171
2.587ProMet: 2.587 ± 1.267
3.881ProAsn: 3.881 ± 3.071
7.762ProPro: 7.762 ± 3.801
2.587ProGln: 2.587 ± 1.267
1.294ProArg: 1.294 ± 0.633
5.175ProSer: 5.175 ± 2.534
7.762ProThr: 7.762 ± 1.171
0.0ProVal: 0.0 ± 0.0
1.294ProTrp: 1.294 ± 0.633
5.175ProTyr: 5.175 ± 2.534
0.0ProXaa: 0.0 ± 0.0
Gln
0.0GlnAla: 0.0 ± 0.0
0.0GlnCys: 0.0 ± 0.0
1.294GlnAsp: 1.294 ± 0.633
5.175GlnGlu: 5.175 ± 7.409
1.294GlnPhe: 1.294 ± 0.633
0.0GlnGly: 0.0 ± 0.0
1.294GlnHis: 1.294 ± 4.338
3.881GlnIle: 3.881 ± 1.9
3.881GlnLys: 3.881 ± 3.071
2.587GlnLeu: 2.587 ± 1.267
1.294GlnMet: 1.294 ± 0.51
1.294GlnAsn: 1.294 ± 0.633
3.881GlnPro: 3.881 ± 1.9
1.294GlnGln: 1.294 ± 0.633
6.468GlnArg: 6.468 ± 3.167
7.762GlnSer: 7.762 ± 3.801
6.468GlnThr: 6.468 ± 3.167
0.0GlnVal: 0.0 ± 0.0
0.0GlnTrp: 0.0 ± 0.0
1.294GlnTyr: 1.294 ± 0.633
0.0GlnXaa: 0.0 ± 0.0
Arg
0.0ArgAla: 0.0 ± 0.0
0.0ArgCys: 0.0 ± 0.0
3.881ArgAsp: 3.881 ± 1.9
0.0ArgGlu: 0.0 ± 0.0
3.881ArgPhe: 3.881 ± 1.9
2.587ArgGly: 2.587 ± 1.267
3.881ArgHis: 3.881 ± 1.9
2.587ArgIle: 2.587 ± 1.267
6.468ArgLys: 6.468 ± 3.167
6.468ArgLeu: 6.468 ± 1.804
1.294ArgMet: 1.294 ± 0.633
2.587ArgAsn: 2.587 ± 1.267
5.175ArgPro: 5.175 ± 2.534
1.294ArgGln: 1.294 ± 4.338
14.23ArgArg: 14.23 ± 6.968
0.0ArgSer: 0.0 ± 0.0
1.294ArgThr: 1.294 ± 0.633
2.587ArgVal: 2.587 ± 1.267
0.0ArgTrp: 0.0 ± 0.0
6.468ArgTyr: 6.468 ± 1.804
0.0ArgXaa: 0.0 ± 0.0
Ser
2.587SerAla: 2.587 ± 1.267
1.294SerCys: 1.294 ± 0.633
1.294SerAsp: 1.294 ± 0.633
5.175SerGlu: 5.175 ± 2.534
2.587SerPhe: 2.587 ± 1.267
0.0SerGly: 0.0 ± 0.0
2.587SerHis: 2.587 ± 3.705
6.468SerIle: 6.468 ± 3.167
1.294SerLys: 1.294 ± 0.633
9.056SerLeu: 9.056 ± 4.434
0.0SerMet: 0.0 ± 0.0
3.881SerAsn: 3.881 ± 1.9
3.881SerPro: 3.881 ± 3.071
2.587SerGln: 2.587 ± 1.267
0.0SerArg: 0.0 ± 0.0
5.175SerSer: 5.175 ± 2.534
7.762SerThr: 7.762 ± 1.171
1.294SerVal: 1.294 ± 0.633
0.0SerTrp: 0.0 ± 0.0
1.294SerTyr: 1.294 ± 0.633
0.0SerXaa: 0.0 ± 0.0
Thr
2.587ThrAla: 2.587 ± 1.267
1.294ThrCys: 1.294 ± 0.633
7.762ThrAsp: 7.762 ± 3.801
9.056ThrGlu: 9.056 ± 5.509
2.587ThrPhe: 2.587 ± 1.267
3.881ThrGly: 3.881 ± 3.071
3.881ThrHis: 3.881 ± 3.071
3.881ThrIle: 3.881 ± 1.9
7.762ThrLys: 7.762 ± 1.171
9.056ThrLeu: 9.056 ± 4.434
1.294ThrMet: 1.294 ± 0.633
5.175ThrAsn: 5.175 ± 2.534
6.468ThrPro: 6.468 ± 3.167
5.175ThrGln: 5.175 ± 2.438
5.175ThrArg: 5.175 ± 2.438
5.175ThrSer: 5.175 ± 2.534
11.643ThrThr: 11.643 ± 9.213
2.587ThrVal: 2.587 ± 3.705
0.0ThrTrp: 0.0 ± 0.0
2.587ThrTyr: 2.587 ± 1.267
0.0ThrXaa: 0.0 ± 0.0
Val
1.294ValAla: 1.294 ± 4.338
0.0ValCys: 0.0 ± 0.0
1.294ValAsp: 1.294 ± 0.633
0.0ValGlu: 0.0 ± 0.0
0.0ValPhe: 0.0 ± 0.0
1.294ValGly: 1.294 ± 0.633
0.0ValHis: 0.0 ± 0.0
1.294ValIle: 1.294 ± 0.633
1.294ValLys: 1.294 ± 0.633
1.294ValLeu: 1.294 ± 0.633
0.0ValMet: 0.0 ± 0.0
0.0ValAsn: 0.0 ± 0.0
5.175ValPro: 5.175 ± 2.534
0.0ValGln: 0.0 ± 0.0
1.294ValArg: 1.294 ± 0.633
1.294ValSer: 1.294 ± 0.633
1.294ValThr: 1.294 ± 4.338
0.0ValVal: 0.0 ± 0.0
0.0ValTrp: 0.0 ± 0.0
1.294ValTyr: 1.294 ± 0.633
0.0ValXaa: 0.0 ± 0.0
Trp
1.294TrpAla: 1.294 ± 0.633
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
0.0TrpGlu: 0.0 ± 0.0
0.0TrpPhe: 0.0 ± 0.0
2.587TrpGly: 2.587 ± 1.267
1.294TrpHis: 1.294 ± 0.633
1.294TrpIle: 1.294 ± 0.633
1.294TrpLys: 1.294 ± 0.633
1.294TrpLeu: 1.294 ± 4.338
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
1.294TrpGln: 1.294 ± 0.633
3.881TrpArg: 3.881 ± 1.9
0.0TrpSer: 0.0 ± 0.0
2.587TrpThr: 2.587 ± 1.267
0.0TrpVal: 0.0 ± 0.0
1.294TrpTrp: 1.294 ± 0.633
1.294TrpTyr: 1.294 ± 0.633
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.0TyrAla: 0.0 ± 0.0
0.0TyrCys: 0.0 ± 0.0
1.294TyrAsp: 1.294 ± 0.633
1.294TyrGlu: 1.294 ± 0.633
3.881TyrPhe: 3.881 ± 1.9
0.0TyrGly: 0.0 ± 0.0
1.294TyrHis: 1.294 ± 0.633
5.175TyrIle: 5.175 ± 2.438
3.881TyrLys: 3.881 ± 1.9
7.762TyrLeu: 7.762 ± 3.801
0.0TyrMet: 0.0 ± 0.0
5.175TyrAsn: 5.175 ± 2.534
5.175TyrPro: 5.175 ± 2.534
3.881TyrGln: 3.881 ± 1.9
3.881TyrArg: 3.881 ± 1.9
0.0TyrSer: 0.0 ± 0.0
5.175TyrThr: 5.175 ± 2.534
1.294TyrVal: 1.294 ± 0.633
0.0TyrTrp: 0.0 ± 0.0
5.175TyrTyr: 5.175 ± 2.534
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (774 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski