Amino acid dipepetide frequency for Cordyceps sp. RAO-2017

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.428AlaAla: 14.428 ± 0.089	1.497AlaCys: 1.497 ± 0.022	5.758AlaAsp: 5.758 ± 0.038	5.849AlaGlu: 5.849 ± 0.053	3.177AlaPhe: 3.177 ± 0.032	7.874AlaGly: 7.874 ± 0.059	2.142AlaHis: 2.142 ± 0.022	3.69AlaIle: 3.69 ± 0.028	4.065AlaLys: 4.065 ± 0.039	8.841AlaLeu: 8.841 ± 0.048	2.228AlaMet: 2.228 ± 0.023	2.749AlaAsn: 2.749 ± 0.025	6.186AlaPro: 6.186 ± 0.054	3.705AlaGln: 3.705 ± 0.034	7.547AlaArg: 7.547 ± 0.049	8.663AlaSer: 8.663 ± 0.057	5.402AlaThr: 5.402 ± 0.037	6.677AlaVal: 6.677 ± 0.049	1.406AlaTrp: 1.406 ± 0.021	2.106AlaTyr: 2.106 ± 0.027	0.002AlaXaa: 0.002 ± 0.001
Cys	1.251CysAla: 1.251 ± 0.021	0.317CysCys: 0.317 ± 0.009	0.717CysAsp: 0.717 ± 0.014	0.612CysGlu: 0.612 ± 0.013	0.563CysPhe: 0.563 ± 0.012	1.098CysGly: 1.098 ± 0.018	0.395CysHis: 0.395 ± 0.011	0.616CysIle: 0.616 ± 0.013	0.482CysLys: 0.482 ± 0.012	1.514CysLeu: 1.514 ± 0.021	0.306CysMet: 0.306 ± 0.008	0.395CysAsn: 0.395 ± 0.009	0.897CysPro: 0.897 ± 0.017	0.502CysGln: 0.502 ± 0.01	1.172CysArg: 1.172 ± 0.018	1.069CysSer: 1.069 ± 0.018	0.672CysThr: 0.672 ± 0.013	0.914CysVal: 0.914 ± 0.016	0.229CysTrp: 0.229 ± 0.008	0.354CysTyr: 0.354 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	5.919AspAla: 5.919 ± 0.036	0.739AspCys: 0.739 ± 0.012	5.496AspAsp: 5.496 ± 0.064	4.708AspGlu: 4.708 ± 0.047	2.128AspPhe: 2.128 ± 0.023	5.399AspGly: 5.399 ± 0.044	1.198AspHis: 1.198 ± 0.017	2.404AspIle: 2.404 ± 0.027	2.467AspLys: 2.467 ± 0.031	4.866AspLeu: 4.866 ± 0.04	1.336AspMet: 1.336 ± 0.019	1.54AspAsn: 1.54 ± 0.019	3.181AspPro: 3.181 ± 0.025	1.815AspGln: 1.815 ± 0.02	3.78AspArg: 3.78 ± 0.034	3.913AspSer: 3.913 ± 0.037	2.452AspThr: 2.452 ± 0.026	3.953AspVal: 3.953 ± 0.033	0.905AspTrp: 0.905 ± 0.016	1.371AspTyr: 1.371 ± 0.019	0.002AspXaa: 0.002 ± 0.001
Glu	6.521GluAla: 6.521 ± 0.053	0.639GluCys: 0.639 ± 0.014	3.63GluAsp: 3.63 ± 0.038	4.636GluGlu: 4.636 ± 0.061	1.64GluPhe: 1.64 ± 0.021	3.532GluGly: 3.532 ± 0.035	1.34GluHis: 1.34 ± 0.018	2.178GluIle: 2.178 ± 0.023	2.853GluLys: 2.853 ± 0.031	5.045GluLeu: 5.045 ± 0.04	1.388GluMet: 1.388 ± 0.018	1.629GluAsn: 1.629 ± 0.022	3.21GluPro: 3.21 ± 0.038	2.407GluGln: 2.407 ± 0.026	4.373GluArg: 4.373 ± 0.039	3.886GluSer: 3.886 ± 0.034	3.133GluThr: 3.133 ± 0.028	3.093GluVal: 3.093 ± 0.03	0.769GluTrp: 0.769 ± 0.016	1.351GluTyr: 1.351 ± 0.021	0.001GluXaa: 0.001 ± 0.001
Phe	3.137PheAla: 3.137 ± 0.03	0.574PheCys: 0.574 ± 0.013	2.202PheAsp: 2.202 ± 0.026	1.885PheGlu: 1.885 ± 0.023	1.534PhePhe: 1.534 ± 0.023	2.659PheGly: 2.659 ± 0.033	0.858PheHis: 0.858 ± 0.014	1.33PheIle: 1.33 ± 0.019	1.22PheLys: 1.22 ± 0.018	3.238PheLeu: 3.238 ± 0.029	0.701PheMet: 0.701 ± 0.013	1.113PheAsn: 1.113 ± 0.019	1.814PhePro: 1.814 ± 0.02	1.204PheGln: 1.204 ± 0.019	2.181PheArg: 2.181 ± 0.026	2.61PheSer: 2.61 ± 0.028	1.666PheThr: 1.666 ± 0.02	2.395PheVal: 2.395 ± 0.03	0.567PheTrp: 0.567 ± 0.012	0.93PheTyr: 0.93 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	6.757GlyAla: 6.757 ± 0.049	1.06GlyCys: 1.06 ± 0.017	4.171GlyAsp: 4.171 ± 0.034	3.836GlyGlu: 3.836 ± 0.034	2.61GlyPhe: 2.61 ± 0.027	7.298GlyGly: 7.298 ± 0.084	1.946GlyHis: 1.946 ± 0.024	2.986GlyIle: 2.986 ± 0.031	3.181GlyLys: 3.181 ± 0.034	6.641GlyLeu: 6.641 ± 0.05	1.573GlyMet: 1.573 ± 0.02	2.187GlyAsn: 2.187 ± 0.03	4.607GlyPro: 4.607 ± 0.046	2.943GlyGln: 2.943 ± 0.035	6.161GlyArg: 6.161 ± 0.047	6.123GlySer: 6.123 ± 0.049	3.8GlyThr: 3.8 ± 0.03	4.207GlyVal: 4.207 ± 0.036	1.229GlyTrp: 1.229 ± 0.018	1.855GlyTyr: 1.855 ± 0.026	0.001GlyXaa: 0.001 ± 0.0
His	2.244HisAla: 2.244 ± 0.024	0.36HisCys: 0.36 ± 0.01	1.456HisAsp: 1.456 ± 0.021	1.345HisGlu: 1.345 ± 0.018	0.874HisPhe: 0.874 ± 0.015	2.08HisGly: 2.08 ± 0.023	0.997HisHis: 0.997 ± 0.027	0.95HisIle: 0.95 ± 0.013	0.829HisLys: 0.829 ± 0.016	2.219HisLeu: 2.219 ± 0.024	0.496HisMet: 0.496 ± 0.012	0.671HisAsn: 0.671 ± 0.013	1.693HisPro: 1.693 ± 0.024	0.991HisGln: 0.991 ± 0.019	1.889HisArg: 1.889 ± 0.024	1.607HisSer: 1.607 ± 0.02	1.053HisThr: 1.053 ± 0.014	1.625HisVal: 1.625 ± 0.018	0.352HisTrp: 0.352 ± 0.008	0.592HisTyr: 0.592 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	3.429IleAla: 3.429 ± 0.027	0.641IleCys: 0.641 ± 0.012	2.3IleAsp: 2.3 ± 0.025	2.182IleGlu: 2.182 ± 0.027	1.488IlePhe: 1.488 ± 0.02	2.628IleGly: 2.628 ± 0.026	0.986IleHis: 0.986 ± 0.015	1.669IleIle: 1.669 ± 0.023	1.707IleLys: 1.707 ± 0.023	3.581IleLeu: 3.581 ± 0.032	0.81IleMet: 0.81 ± 0.014	1.269IleAsn: 1.269 ± 0.018	2.252IlePro: 2.252 ± 0.024	1.413IleGln: 1.413 ± 0.018	2.621IleArg: 2.621 ± 0.023	2.825IleSer: 2.825 ± 0.026	1.916IleThr: 1.916 ± 0.021	2.722IleVal: 2.722 ± 0.027	0.567IleTrp: 0.567 ± 0.011	1.006IleTyr: 1.006 ± 0.014	0.001IleXaa: 0.001 ± 0.0
Lys	4.246LysAla: 4.246 ± 0.039	0.463LysCys: 0.463 ± 0.012	2.332LysAsp: 2.332 ± 0.033	2.605LysGlu: 2.605 ± 0.035	1.183LysPhe: 1.183 ± 0.017	2.632LysGly: 2.632 ± 0.031	0.95LysHis: 0.95 ± 0.014	1.714LysIle: 1.714 ± 0.02	2.768LysLys: 2.768 ± 0.044	3.57LysLeu: 3.57 ± 0.032	0.943LysMet: 0.943 ± 0.017	1.298LysAsn: 1.298 ± 0.02	2.51LysPro: 2.51 ± 0.03	1.645LysGln: 1.645 ± 0.021	3.225LysArg: 3.225 ± 0.034	2.836LysSer: 2.836 ± 0.032	2.449LysThr: 2.449 ± 0.025	2.307LysVal: 2.307 ± 0.024	0.512LysTrp: 0.512 ± 0.011	1.041LysTyr: 1.041 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	9.463LeuAla: 9.463 ± 0.054	1.394LeuCys: 1.394 ± 0.021	5.495LeuAsp: 5.495 ± 0.039	5.099LeuGlu: 5.099 ± 0.041	3.241LeuPhe: 3.241 ± 0.034	6.42LeuGly: 6.42 ± 0.047	2.23LeuHis: 2.23 ± 0.024	3.084LeuIle: 3.084 ± 0.03	3.402LeuLys: 3.402 ± 0.032	8.798LeuLeu: 8.798 ± 0.058	1.757LeuMet: 1.757 ± 0.024	2.459LeuAsn: 2.459 ± 0.026	5.898LeuPro: 5.898 ± 0.05	3.525LeuGln: 3.525 ± 0.03	6.833LeuArg: 6.833 ± 0.049	7.217LeuSer: 7.217 ± 0.05	4.38LeuThr: 4.38 ± 0.034	5.99LeuVal: 5.99 ± 0.041	1.2LeuTrp: 1.2 ± 0.019	2.12LeuTyr: 2.12 ± 0.021	0.001LeuXaa: 0.001 ± 0.0
Met	2.619MetAla: 2.619 ± 0.026	0.255MetCys: 0.255 ± 0.007	1.246MetAsp: 1.246 ± 0.018	1.167MetGlu: 1.167 ± 0.017	0.628MetPhe: 0.628 ± 0.012	1.471MetGly: 1.471 ± 0.018	0.474MetHis: 0.474 ± 0.011	0.779MetIle: 0.779 ± 0.013	0.871MetLys: 0.871 ± 0.015	1.861MetLeu: 1.861 ± 0.02	0.592MetMet: 0.592 ± 0.013	0.63MetAsn: 0.63 ± 0.012	1.467MetPro: 1.467 ± 0.02	0.834MetGln: 0.834 ± 0.016	1.462MetArg: 1.462 ± 0.018	1.708MetSer: 1.708 ± 0.019	1.3MetThr: 1.3 ± 0.02	1.252MetVal: 1.252 ± 0.018	0.25MetTrp: 0.25 ± 0.008	0.471MetTyr: 0.471 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.647AsnAla: 2.647 ± 0.024	0.403AsnCys: 0.403 ± 0.01	1.587AsnAsp: 1.587 ± 0.022	1.521AsnGlu: 1.521 ± 0.021	1.088AsnPhe: 1.088 ± 0.017	2.531AsnGly: 2.531 ± 0.029	0.656AsnHis: 0.656 ± 0.013	1.334AsnIle: 1.334 ± 0.018	1.253AsnLys: 1.253 ± 0.018	2.618AsnLeu: 2.618 ± 0.027	0.696AsnMet: 0.696 ± 0.013	0.995AsnAsn: 0.995 ± 0.021	1.907AsnPro: 1.907 ± 0.025	1.035AsnGln: 1.035 ± 0.019	1.839AsnArg: 1.839 ± 0.023	2.023AsnSer: 2.023 ± 0.029	1.412AsnThr: 1.412 ± 0.02	1.929AsnVal: 1.929 ± 0.022	0.449AsnTrp: 0.449 ± 0.01	0.764AsnTyr: 0.764 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	7.408ProAla: 7.408 ± 0.062	0.805ProCys: 0.805 ± 0.016	3.808ProAsp: 3.808 ± 0.032	3.589ProGlu: 3.589 ± 0.033	2.021ProPhe: 2.021 ± 0.024	5.024ProGly: 5.024 ± 0.05	1.463ProHis: 1.463 ± 0.02	1.951ProIle: 1.951 ± 0.021	2.255ProLys: 2.255 ± 0.029	5.225ProLeu: 5.225 ± 0.039	1.128ProMet: 1.128 ± 0.014	1.7ProAsn: 1.7 ± 0.02	7.055ProPro: 7.055 ± 0.097	2.455ProGln: 2.455 ± 0.034	4.796ProArg: 4.796 ± 0.044	6.444ProSer: 6.444 ± 0.055	3.551ProThr: 3.551 ± 0.038	3.884ProVal: 3.884 ± 0.031	0.857ProTrp: 0.857 ± 0.015	1.331ProTyr: 1.331 ± 0.02	0.001ProXaa: 0.001 ± 0.0
Gln	4.003GlnAla: 4.003 ± 0.039	0.442GlnCys: 0.442 ± 0.011	2.031GlnAsp: 2.031 ± 0.021	2.06GlnGlu: 2.06 ± 0.026	1.069GlnPhe: 1.069 ± 0.017	2.565GlnGly: 2.565 ± 0.028	1.105GlnHis: 1.105 ± 0.021	1.434GlnIle: 1.434 ± 0.019	1.6GlnLys: 1.6 ± 0.019	3.48GlnLeu: 3.48 ± 0.03	0.868GlnMet: 0.868 ± 0.015	1.138GlnAsn: 1.138 ± 0.02	2.865GlnPro: 2.865 ± 0.035	2.734GlnGln: 2.734 ± 0.066	3.026GlnArg: 3.026 ± 0.026	2.733GlnSer: 2.733 ± 0.028	2.027GlnThr: 2.027 ± 0.021	2.121GlnVal: 2.121 ± 0.025	0.51GlnTrp: 0.51 ± 0.01	0.932GlnTyr: 0.932 ± 0.015	0.001GlnXaa: 0.001 ± 0.0
Arg	7.016ArgAla: 7.016 ± 0.045	1.057ArgCys: 1.057 ± 0.018	4.368ArgAsp: 4.368 ± 0.036	4.198ArgGlu: 4.198 ± 0.037	2.336ArgPhe: 2.336 ± 0.024	5.056ArgGly: 5.056 ± 0.041	2.136ArgHis: 2.136 ± 0.025	2.724ArgIle: 2.724 ± 0.027	3.185ArgLys: 3.185 ± 0.031	7.169ArgLeu: 7.169 ± 0.053	1.501ArgMet: 1.501 ± 0.02	2.106ArgAsn: 2.106 ± 0.023	5.559ArgPro: 5.559 ± 0.053	3.263ArgGln: 3.263 ± 0.034	7.938ArgArg: 7.938 ± 0.07	5.452ArgSer: 5.452 ± 0.042	3.591ArgThr: 3.591 ± 0.027	3.936ArgVal: 3.936 ± 0.035	1.151ArgTrp: 1.151 ± 0.018	1.667ArgTyr: 1.667 ± 0.021	0.0ArgXaa: 0.0 ± 0.0
Ser	7.641SerAla: 7.641 ± 0.049	1.068SerCys: 1.068 ± 0.018	4.019SerAsp: 4.019 ± 0.041	3.562SerGlu: 3.562 ± 0.033	2.705SerPhe: 2.705 ± 0.03	5.83SerGly: 5.83 ± 0.046	1.878SerHis: 1.878 ± 0.023	3.08SerIle: 3.08 ± 0.028	3.036SerLys: 3.036 ± 0.031	7.262SerLeu: 7.262 ± 0.051	1.658SerMet: 1.658 ± 0.02	2.17SerAsn: 2.17 ± 0.025	5.938SerPro: 5.938 ± 0.054	2.888SerGln: 2.888 ± 0.029	5.971SerArg: 5.971 ± 0.038	8.514SerSer: 8.514 ± 0.069	4.525SerThr: 4.525 ± 0.037	4.572SerVal: 4.572 ± 0.031	1.114SerTrp: 1.114 ± 0.017	1.714SerTyr: 1.714 ± 0.024	0.002SerXaa: 0.002 ± 0.001
Thr	5.604ThrAla: 5.604 ± 0.035	0.773ThrCys: 0.773 ± 0.015	2.6ThrAsp: 2.6 ± 0.024	2.591ThrGlu: 2.591 ± 0.027	1.76ThrPhe: 1.76 ± 0.022	3.958ThrGly: 3.958 ± 0.034	1.143ThrHis: 1.143 ± 0.016	2.182ThrIle: 2.182 ± 0.023	2.045ThrLys: 2.045 ± 0.023	4.587ThrLeu: 4.587 ± 0.034	1.138ThrMet: 1.138 ± 0.017	1.479ThrAsn: 1.479 ± 0.02	3.776ThrPro: 3.776 ± 0.041	1.672ThrGln: 1.672 ± 0.023	3.379ThrArg: 3.379 ± 0.03	4.337ThrSer: 4.337 ± 0.035	3.548ThrThr: 3.548 ± 0.051	3.471ThrVal: 3.471 ± 0.033	0.764ThrTrp: 0.764 ± 0.013	1.305ThrTyr: 1.305 ± 0.017	0.0ThrXaa: 0.0 ± 0.0
Val	6.291ValAla: 6.291 ± 0.045	0.982ValCys: 0.982 ± 0.019	3.978ValAsp: 3.978 ± 0.033	3.748ValGlu: 3.748 ± 0.033	2.34ValPhe: 2.34 ± 0.027	4.31ValGly: 4.31 ± 0.035	1.393ValHis: 1.393 ± 0.019	2.308ValIle: 2.308 ± 0.026	2.493ValLys: 2.493 ± 0.028	5.777ValLeu: 5.777 ± 0.041	1.309ValMet: 1.309 ± 0.017	1.847ValAsn: 1.847 ± 0.021	3.837ValPro: 3.837 ± 0.034	2.262ValGln: 2.262 ± 0.025	4.365ValArg: 4.365 ± 0.036	4.532ValSer: 4.532 ± 0.038	3.174ValThr: 3.174 ± 0.032	4.743ValVal: 4.743 ± 0.041	0.864ValTrp: 0.864 ± 0.015	1.558ValTyr: 1.558 ± 0.02	0.001ValXaa: 0.001 ± 0.001
Trp	1.334TrpAla: 1.334 ± 0.02	0.211TrpCys: 0.211 ± 0.007	0.888TrpAsp: 0.888 ± 0.017	0.774TrpGlu: 0.774 ± 0.013	0.479TrpPhe: 0.479 ± 0.011	0.861TrpGly: 0.861 ± 0.015	0.39TrpHis: 0.39 ± 0.01	0.609TrpIle: 0.609 ± 0.014	0.664TrpLys: 0.664 ± 0.013	1.401TrpLeu: 1.401 ± 0.018	0.36TrpMet: 0.36 ± 0.01	0.533TrpAsn: 0.533 ± 0.012	0.811TrpPro: 0.811 ± 0.014	0.561TrpGln: 0.561 ± 0.011	1.143TrpArg: 1.143 ± 0.015	1.015TrpSer: 1.015 ± 0.017	0.888TrpThr: 0.888 ± 0.016	0.795TrpVal: 0.795 ± 0.014	0.27TrpTrp: 0.27 ± 0.009	0.362TrpTyr: 0.362 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.033TyrAla: 2.033 ± 0.024	0.395TyrCys: 0.395 ± 0.011	1.489TyrAsp: 1.489 ± 0.019	1.288TyrGlu: 1.288 ± 0.017	0.951TyrPhe: 0.951 ± 0.013	1.944TyrGly: 1.944 ± 0.024	0.644TyrHis: 0.644 ± 0.013	0.992TyrIle: 0.992 ± 0.015	0.853TyrLys: 0.853 ± 0.013	2.314TyrLeu: 2.314 ± 0.025	0.548TyrMet: 0.548 ± 0.011	0.779TyrAsn: 0.779 ± 0.014	1.284TyrPro: 1.284 ± 0.022	0.892TyrGln: 0.892 ± 0.012	1.705TyrArg: 1.705 ± 0.018	1.641TyrSer: 1.641 ± 0.021	1.172TyrThr: 1.172 ± 0.018	1.523TyrVal: 1.523 ± 0.017	0.386TyrTrp: 0.386 ± 0.009	0.724TyrTyr: 0.724 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.001XaaPhe: 0.001 ± 0.0	0.003XaaGly: 0.003 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.0	0.001XaaLeu: 0.001 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.003XaaPro: 0.003 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.002XaaArg: 0.002 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.001XaaThr: 0.001 ± 0.001	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.324XaaXaa: 0.324 ± 0.054

Statistics based on 11255 proteins (4341397 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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