Amino acid dipepetide frequency for Rhodoplanes roseus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.592AlaAla: 21.592 ± 0.195	1.267AlaCys: 1.267 ± 0.026	7.145AlaAsp: 7.145 ± 0.069	7.879AlaGlu: 7.879 ± 0.075	4.566AlaPhe: 4.566 ± 0.059	12.136AlaGly: 12.136 ± 0.104	2.322AlaHis: 2.322 ± 0.039	6.068AlaIle: 6.068 ± 0.062	3.658AlaLys: 3.658 ± 0.051	14.379AlaLeu: 14.379 ± 0.136	3.436AlaMet: 3.436 ± 0.043	2.322AlaAsn: 2.322 ± 0.035	6.878AlaPro: 6.878 ± 0.079	3.704AlaGln: 3.704 ± 0.049	10.065AlaArg: 10.065 ± 0.095	6.249AlaSer: 6.249 ± 0.071	7.263AlaThr: 7.263 ± 0.077	11.418AlaVal: 11.418 ± 0.097	1.687AlaTrp: 1.687 ± 0.032	2.467AlaTyr: 2.467 ± 0.038	0.001AlaXaa: 0.001 ± 0.001
Cys	1.049CysAla: 1.049 ± 0.024	0.127CysCys: 0.127 ± 0.008	0.555CysAsp: 0.555 ± 0.018	0.432CysGlu: 0.432 ± 0.016	0.315CysPhe: 0.315 ± 0.012	0.965CysGly: 0.965 ± 0.023	0.216CysHis: 0.216 ± 0.012	0.362CysIle: 0.362 ± 0.015	0.156CysLys: 0.156 ± 0.009	0.743CysLeu: 0.743 ± 0.019	0.167CysMet: 0.167 ± 0.009	0.203CysAsn: 0.203 ± 0.01	0.484CysPro: 0.484 ± 0.019	0.179CysGln: 0.179 ± 0.01	0.78CysArg: 0.78 ± 0.021	0.419CysSer: 0.419 ± 0.015	0.45CysThr: 0.45 ± 0.016	0.657CysVal: 0.657 ± 0.019	0.107CysTrp: 0.107 ± 0.007	0.18CysTyr: 0.18 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.09AspAla: 7.09 ± 0.074	0.46AspCys: 0.46 ± 0.015	3.111AspAsp: 3.111 ± 0.044	3.175AspGlu: 3.175 ± 0.047	1.868AspPhe: 1.868 ± 0.033	5.17AspGly: 5.17 ± 0.059	1.211AspHis: 1.211 ± 0.031	2.588AspIle: 2.588 ± 0.041	1.512AspLys: 1.512 ± 0.032	6.088AspLeu: 6.088 ± 0.057	1.129AspMet: 1.129 ± 0.026	1.022AspAsn: 1.022 ± 0.026	3.871AspPro: 3.871 ± 0.053	1.605AspGln: 1.605 ± 0.03	4.848AspArg: 4.848 ± 0.06	1.895AspSer: 1.895 ± 0.035	2.706AspThr: 2.706 ± 0.036	4.615AspVal: 4.615 ± 0.051	0.86AspTrp: 0.86 ± 0.021	1.305AspTyr: 1.305 ± 0.029	0.0AspXaa: 0.0 ± 0.0
Glu	7.312GluAla: 7.312 ± 0.073	0.323GluCys: 0.323 ± 0.013	2.23GluAsp: 2.23 ± 0.034	2.549GluGlu: 2.549 ± 0.044	1.537GluPhe: 1.537 ± 0.03	3.506GluGly: 3.506 ± 0.047	1.129GluHis: 1.129 ± 0.024	3.309GluIle: 3.309 ± 0.05	1.851GluLys: 1.851 ± 0.036	4.86GluLeu: 4.86 ± 0.058	1.326GluMet: 1.326 ± 0.028	1.194GluAsn: 1.194 ± 0.025	2.924GluPro: 2.924 ± 0.041	1.886GluGln: 1.886 ± 0.037	5.084GluArg: 5.084 ± 0.058	2.26GluSer: 2.26 ± 0.036	3.545GluThr: 3.545 ± 0.048	3.81GluVal: 3.81 ± 0.051	0.614GluTrp: 0.614 ± 0.018	0.83GluTyr: 0.83 ± 0.024	0.0GluXaa: 0.0 ± 0.0
Phe	4.694PheAla: 4.694 ± 0.053	0.382PheCys: 0.382 ± 0.012	2.427PheAsp: 2.427 ± 0.032	1.88PheGlu: 1.88 ± 0.033	1.286PhePhe: 1.286 ± 0.029	3.73PheGly: 3.73 ± 0.047	0.66PheHis: 0.66 ± 0.018	1.225PheIle: 1.225 ± 0.029	0.87PheLys: 0.87 ± 0.021	3.071PheLeu: 3.071 ± 0.048	0.693PheMet: 0.693 ± 0.019	0.837PheAsn: 0.837 ± 0.023	1.625PhePro: 1.625 ± 0.03	0.823PheGln: 0.823 ± 0.02	2.37PheArg: 2.37 ± 0.04	1.939PheSer: 1.939 ± 0.033	1.881PheThr: 1.881 ± 0.036	3.218PheVal: 3.218 ± 0.047	0.494PheTrp: 0.494 ± 0.019	0.763PheTyr: 0.763 ± 0.021	0.0PheXaa: 0.0 ± 0.0
Gly	10.274GlyAla: 10.274 ± 0.092	0.922GlyCys: 0.922 ± 0.024	4.321GlyAsp: 4.321 ± 0.058	4.349GlyGlu: 4.349 ± 0.051	3.69GlyPhe: 3.69 ± 0.053	7.786GlyGly: 7.786 ± 0.147	1.887GlyHis: 1.887 ± 0.032	4.349GlyIle: 4.349 ± 0.05	2.693GlyLys: 2.693 ± 0.045	9.431GlyLeu: 9.431 ± 0.084	2.106GlyMet: 2.106 ± 0.037	1.84GlyAsn: 1.84 ± 0.042	4.369GlyPro: 4.369 ± 0.056	2.479GlyGln: 2.479 ± 0.037	7.286GlyArg: 7.286 ± 0.068	4.627GlySer: 4.627 ± 0.065	5.342GlyThr: 5.342 ± 0.076	6.77GlyVal: 6.77 ± 0.066	1.404GlyTrp: 1.404 ± 0.029	2.162GlyTyr: 2.162 ± 0.036	0.001GlyXaa: 0.001 ± 0.001
His	2.422HisAla: 2.422 ± 0.039	0.207HisCys: 0.207 ± 0.01	1.247HisAsp: 1.247 ± 0.026	0.969HisGlu: 0.969 ± 0.025	0.703HisPhe: 0.703 ± 0.02	2.048HisGly: 2.048 ± 0.039	0.558HisHis: 0.558 ± 0.023	0.723HisIle: 0.723 ± 0.021	0.407HisLys: 0.407 ± 0.015	1.866HisLeu: 1.866 ± 0.034	0.421HisMet: 0.421 ± 0.014	0.345HisAsn: 0.345 ± 0.014	1.403HisPro: 1.403 ± 0.028	0.467HisGln: 0.467 ± 0.016	1.542HisArg: 1.542 ± 0.032	0.774HisSer: 0.774 ± 0.021	0.848HisThr: 0.848 ± 0.023	1.756HisVal: 1.756 ± 0.033	0.323HisTrp: 0.323 ± 0.013	0.463HisTyr: 0.463 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	7.471IleAla: 7.471 ± 0.072	0.372IleCys: 0.372 ± 0.015	3.363IleAsp: 3.363 ± 0.049	3.229IleGlu: 3.229 ± 0.042	1.23IlePhe: 1.23 ± 0.027	5.143IleGly: 5.143 ± 0.055	0.76IleHis: 0.76 ± 0.02	1.445IleIle: 1.445 ± 0.032	1.239IleLys: 1.239 ± 0.029	3.746IleLeu: 3.746 ± 0.047	0.788IleMet: 0.788 ± 0.024	1.044IleAsn: 1.044 ± 0.022	2.212IlePro: 2.212 ± 0.036	0.951IleGln: 0.951 ± 0.022	3.014IleArg: 3.014 ± 0.041	2.182IleSer: 2.182 ± 0.036	2.502IleThr: 2.502 ± 0.043	4.709IleVal: 4.709 ± 0.055	0.483IleTrp: 0.483 ± 0.017	0.875IleTyr: 0.875 ± 0.022	0.0IleXaa: 0.0 ± 0.0
Lys	3.852LysAla: 3.852 ± 0.056	0.145LysCys: 0.145 ± 0.009	1.461LysAsp: 1.461 ± 0.035	1.265LysGlu: 1.265 ± 0.029	0.734LysPhe: 0.734 ± 0.023	2.247LysGly: 2.247 ± 0.036	0.474LysHis: 0.474 ± 0.018	1.525LysIle: 1.525 ± 0.029	1.028LysLys: 1.028 ± 0.029	2.81LysLeu: 2.81 ± 0.044	0.623LysMet: 0.623 ± 0.022	0.674LysAsn: 0.674 ± 0.021	1.892LysPro: 1.892 ± 0.039	0.855LysGln: 0.855 ± 0.024	2.151LysArg: 2.151 ± 0.038	1.514LysSer: 1.514 ± 0.028	1.846LysThr: 1.846 ± 0.038	2.203LysVal: 2.203 ± 0.042	0.289LysTrp: 0.289 ± 0.013	0.525LysTyr: 0.525 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	15.432LeuAla: 15.432 ± 0.112	0.843LeuCys: 0.843 ± 0.023	6.275LeuAsp: 6.275 ± 0.064	4.507LeuGlu: 4.507 ± 0.047	3.475LeuPhe: 3.475 ± 0.051	8.897LeuGly: 8.897 ± 0.082	1.809LeuHis: 1.809 ± 0.031	4.342LeuIle: 4.342 ± 0.061	3.026LeuLys: 3.026 ± 0.049	9.654LeuLeu: 9.654 ± 0.108	2.18LeuMet: 2.18 ± 0.039	1.877LeuAsn: 1.877 ± 0.034	5.779LeuPro: 5.779 ± 0.061	2.517LeuGln: 2.517 ± 0.04	7.055LeuArg: 7.055 ± 0.074	5.532LeuSer: 5.532 ± 0.062	5.361LeuThr: 5.361 ± 0.105	8.96LeuVal: 8.96 ± 0.082	1.163LeuTrp: 1.163 ± 0.024	1.939LeuTyr: 1.939 ± 0.034	0.0LeuXaa: 0.0 ± 0.0
Met	2.86MetAla: 2.86 ± 0.041	0.151MetCys: 0.151 ± 0.01	0.953MetAsp: 0.953 ± 0.02	0.863MetGlu: 0.863 ± 0.02	0.657MetPhe: 0.657 ± 0.019	1.584MetGly: 1.584 ± 0.032	0.393MetHis: 0.393 ± 0.015	1.21MetIle: 1.21 ± 0.03	0.764MetLys: 0.764 ± 0.022	2.395MetLeu: 2.395 ± 0.038	0.584MetMet: 0.584 ± 0.022	0.561MetAsn: 0.561 ± 0.018	1.561MetPro: 1.561 ± 0.029	0.683MetGln: 0.683 ± 0.02	1.906MetArg: 1.906 ± 0.032	1.507MetSer: 1.507 ± 0.031	1.745MetThr: 1.745 ± 0.031	1.728MetVal: 1.728 ± 0.031	0.21MetTrp: 0.21 ± 0.01	0.29MetTyr: 0.29 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.653AsnAla: 2.653 ± 0.038	0.193AsnCys: 0.193 ± 0.01	1.102AsnAsp: 1.102 ± 0.027	0.939AsnGlu: 0.939 ± 0.026	0.713AsnPhe: 0.713 ± 0.018	1.937AsnGly: 1.937 ± 0.04	0.395AsnHis: 0.395 ± 0.014	1.022AsnIle: 1.022 ± 0.026	0.542AsnLys: 0.542 ± 0.018	2.142AsnLeu: 2.142 ± 0.035	0.439AsnMet: 0.439 ± 0.017	0.509AsnAsn: 0.509 ± 0.02	1.546AsnPro: 1.546 ± 0.028	0.596AsnGln: 0.596 ± 0.017	1.546AsnArg: 1.546 ± 0.03	0.871AsnSer: 0.871 ± 0.024	1.069AsnThr: 1.069 ± 0.029	1.779AsnVal: 1.779 ± 0.032	0.304AsnTrp: 0.304 ± 0.012	0.514AsnTyr: 0.514 ± 0.019	0.0AsnXaa: 0.0 ± 0.0
Pro	7.887ProAla: 7.887 ± 0.07	0.366ProCys: 0.366 ± 0.018	4.088ProAsp: 4.088 ± 0.052	3.554ProGlu: 3.554 ± 0.042	2.06ProPhe: 2.06 ± 0.032	5.326ProGly: 5.326 ± 0.052	1.148ProHis: 1.148 ± 0.022	2.371ProIle: 2.371 ± 0.039	1.596ProLys: 1.596 ± 0.033	5.084ProLeu: 5.084 ± 0.06	1.192ProMet: 1.192 ± 0.027	1.251ProAsn: 1.251 ± 0.024	3.527ProPro: 3.527 ± 0.069	1.525ProGln: 1.525 ± 0.027	3.71ProArg: 3.71 ± 0.055	2.965ProSer: 2.965 ± 0.042	2.92ProThr: 2.92 ± 0.04	4.843ProVal: 4.843 ± 0.048	0.799ProTrp: 0.799 ± 0.024	1.23ProTyr: 1.23 ± 0.026	0.001ProXaa: 0.001 ± 0.001
Gln	3.838GlnAla: 3.838 ± 0.051	0.185GlnCys: 0.185 ± 0.01	1.333GlnAsp: 1.333 ± 0.028	1.274GlnGlu: 1.274 ± 0.032	0.903GlnPhe: 0.903 ± 0.023	2.124GlnGly: 2.124 ± 0.038	0.566GlnHis: 0.566 ± 0.015	1.562GlnIle: 1.562 ± 0.055	0.911GlnLys: 0.911 ± 0.022	2.38GlnLeu: 2.38 ± 0.056	0.677GlnMet: 0.677 ± 0.019	0.666GlnAsn: 0.666 ± 0.021	1.564GlnPro: 1.564 ± 0.027	1.037GlnGln: 1.037 ± 0.03	2.203GlnArg: 2.203 ± 0.034	1.425GlnSer: 1.425 ± 0.033	1.565GlnThr: 1.565 ± 0.033	2.177GlnVal: 2.177 ± 0.048	0.347GlnTrp: 0.347 ± 0.014	0.517GlnTyr: 0.517 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	9.367ArgAla: 9.367 ± 0.086	0.645ArgCys: 0.645 ± 0.018	4.584ArgAsp: 4.584 ± 0.057	4.139ArgGlu: 4.139 ± 0.051	2.976ArgPhe: 2.976 ± 0.036	5.492ArgGly: 5.492 ± 0.059	1.811ArgHis: 1.811 ± 0.036	4.076ArgIle: 4.076 ± 0.044	2.088ArgLys: 2.088 ± 0.036	8.753ArgLeu: 8.753 ± 0.09	1.898ArgMet: 1.898 ± 0.037	1.622ArgAsn: 1.622 ± 0.031	4.493ArgPro: 4.493 ± 0.057	2.17ArgGln: 2.17 ± 0.042	7.164ArgArg: 7.164 ± 0.078	3.935ArgSer: 3.935 ± 0.05	4.014ArgThr: 4.014 ± 0.048	5.518ArgVal: 5.518 ± 0.054	1.115ArgTrp: 1.115 ± 0.025	1.564ArgTyr: 1.564 ± 0.029	0.0ArgXaa: 0.0 ± 0.0
Ser	6.088SerAla: 6.088 ± 0.061	0.425SerCys: 0.425 ± 0.015	2.664SerAsp: 2.664 ± 0.041	2.417SerGlu: 2.417 ± 0.038	1.969SerPhe: 1.969 ± 0.033	5.183SerGly: 5.183 ± 0.079	0.958SerHis: 0.958 ± 0.021	2.364SerIle: 2.364 ± 0.041	1.273SerLys: 1.273 ± 0.028	4.87SerLeu: 4.87 ± 0.052	1.076SerMet: 1.076 ± 0.022	1.094SerAsn: 1.094 ± 0.027	2.945SerPro: 2.945 ± 0.042	1.306SerGln: 1.306 ± 0.03	3.855SerArg: 3.855 ± 0.051	2.796SerSer: 2.796 ± 0.064	2.773SerThr: 2.773 ± 0.056	3.929SerVal: 3.929 ± 0.049	0.679SerTrp: 0.679 ± 0.02	1.165SerTyr: 1.165 ± 0.028	0.001SerXaa: 0.001 ± 0.001
Thr	7.343ThrAla: 7.343 ± 0.075	0.459ThrCys: 0.459 ± 0.016	2.748ThrAsp: 2.748 ± 0.038	2.568ThrGlu: 2.568 ± 0.045	1.978ThrPhe: 1.978 ± 0.032	5.393ThrGly: 5.393 ± 0.071	0.969ThrHis: 0.969 ± 0.025	3.021ThrIle: 3.021 ± 0.043	1.342ThrLys: 1.342 ± 0.032	6.147ThrLeu: 6.147 ± 0.064	1.184ThrMet: 1.184 ± 0.027	1.153ThrAsn: 1.153 ± 0.029	3.699ThrPro: 3.699 ± 0.051	1.336ThrGln: 1.336 ± 0.102	3.791ThrArg: 3.791 ± 0.047	2.787ThrSer: 2.787 ± 0.05	3.409ThrThr: 3.409 ± 0.122	5.148ThrVal: 5.148 ± 0.057	0.727ThrTrp: 0.727 ± 0.018	1.142ThrTyr: 1.142 ± 0.025	0.0ThrXaa: 0.0 ± 0.0
Val	11.505ValAla: 11.505 ± 0.092	0.719ValCys: 0.719 ± 0.019	4.599ValAsp: 4.599 ± 0.052	4.54ValGlu: 4.54 ± 0.049	2.905ValPhe: 2.905 ± 0.042	6.441ValGly: 6.441 ± 0.066	1.517ValHis: 1.517 ± 0.032	3.835ValIle: 3.835 ± 0.046	2.259ValLys: 2.259 ± 0.038	8.623ValLeu: 8.623 ± 0.091	1.966ValMet: 1.966 ± 0.037	1.761ValAsn: 1.761 ± 0.036	4.852ValPro: 4.852 ± 0.057	2.07ValGln: 2.07 ± 0.037	6.069ValArg: 6.069 ± 0.067	4.393ValSer: 4.393 ± 0.05	5.232ValThr: 5.232 ± 0.063	7.815ValVal: 7.815 ± 0.089	0.991ValTrp: 0.991 ± 0.024	1.535ValTyr: 1.535 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.295TrpAla: 1.295 ± 0.026	0.145TrpCys: 0.145 ± 0.009	0.596TrpAsp: 0.596 ± 0.017	0.5TrpGlu: 0.5 ± 0.017	0.546TrpPhe: 0.546 ± 0.019	0.911TrpGly: 0.911 ± 0.023	0.324TrpHis: 0.324 ± 0.015	0.675TrpIle: 0.675 ± 0.02	0.35TrpLys: 0.35 ± 0.015	1.622TrpLeu: 1.622 ± 0.036	0.315TrpMet: 0.315 ± 0.013	0.367TrpAsn: 0.367 ± 0.016	0.748TrpPro: 0.748 ± 0.021	0.479TrpGln: 0.479 ± 0.016	1.286TrpArg: 1.286 ± 0.025	0.844TrpSer: 0.844 ± 0.024	0.805TrpThr: 0.805 ± 0.021	0.831TrpVal: 0.831 ± 0.023	0.258TrpTrp: 0.258 ± 0.011	0.271TrpTyr: 0.271 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.473TyrAla: 2.473 ± 0.038	0.212TyrCys: 0.212 ± 0.01	1.329TyrAsp: 1.329 ± 0.027	1.054TyrGlu: 1.054 ± 0.023	0.758TyrPhe: 0.758 ± 0.019	2.069TyrGly: 2.069 ± 0.038	0.385TyrHis: 0.385 ± 0.014	0.688TyrIle: 0.688 ± 0.021	0.548TyrLys: 0.548 ± 0.018	1.958TyrLeu: 1.958 ± 0.033	0.405TyrMet: 0.405 ± 0.016	0.47TyrAsn: 0.47 ± 0.019	1.069TyrPro: 1.069 ± 0.023	0.588TyrGln: 0.588 ± 0.018	1.698TyrArg: 1.698 ± 0.03	0.91TyrSer: 0.91 ± 0.024	1.069TyrThr: 1.069 ± 0.022	1.742TyrVal: 1.742 ± 0.031	0.317TyrTrp: 0.317 ± 0.012	0.537TyrTyr: 0.537 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.002XaaAla: 0.002 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.0	0.001XaaSer: 0.001 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.006XaaXaa: 0.006 ± 0.002

Statistics based on 6350 proteins (1912495 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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