Amino acid dipepetide frequency for Varroa destructor virus 3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.461AlaAla: 2.461 ± 0.307
0.82AlaCys: 0.82 ± 0.522
4.922AlaAsp: 4.922 ± 1.089
4.102AlaGlu: 4.102 ± 1.65
1.641AlaPhe: 1.641 ± 0.444
3.281AlaGly: 3.281 ± 0.888
1.641AlaHis: 1.641 ± 0.444
2.461AlaIle: 2.461 ± 1.356
4.102AlaLys: 4.102 ± 0.933
6.563AlaLeu: 6.563 ± 1.546
3.281AlaMet: 3.281 ± 0.575
3.281AlaAsn: 3.281 ± 1.048
6.563AlaPro: 6.563 ± 0.87
1.641AlaGln: 1.641 ± 1.136
4.922AlaArg: 4.922 ± 1.63
4.102AlaSer: 4.102 ± 1.164
0.82AlaThr: 0.82 ± 0.522
3.281AlaVal: 3.281 ± 0.888
0.82AlaTrp: 0.82 ± 0.522
3.281AlaTyr: 3.281 ± 1.257
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.82CysCys: 0.82 ± 0.522
0.0CysAsp: 0.0 ± 0.0
0.0CysGlu: 0.0 ± 0.0
1.641CysPhe: 1.641 ± 0.709
0.82CysGly: 0.82 ± 0.522
0.0CysHis: 0.0 ± 0.0
1.641CysIle: 1.641 ± 0.737
0.82CysLys: 0.82 ± 0.522
2.461CysLeu: 2.461 ± 0.998
0.82CysMet: 0.82 ± 0.522
1.641CysAsn: 1.641 ± 0.737
0.82CysPro: 0.82 ± 0.744
0.82CysGln: 0.82 ± 0.568
1.641CysArg: 1.641 ± 0.444
0.0CysSer: 0.0 ± 0.0
0.82CysThr: 0.82 ± 0.568
0.82CysVal: 0.82 ± 0.522
0.0CysTrp: 0.0 ± 0.0
0.82CysTyr: 0.82 ± 0.522
0.0CysXaa: 0.0 ± 0.0
Asp
5.742AspAla: 5.742 ± 2.03
0.82AspCys: 0.82 ± 0.522
5.742AspAsp: 5.742 ± 1.935
4.102AspGlu: 4.102 ± 1.101
2.461AspPhe: 2.461 ± 0.307
1.641AspGly: 1.641 ± 0.444
0.82AspHis: 0.82 ± 0.568
4.102AspIle: 4.102 ± 2.094
4.922AspLys: 4.922 ± 1.63
4.922AspLeu: 4.922 ± 1.419
0.82AspMet: 0.82 ± 0.522
4.102AspAsn: 4.102 ± 1.267
0.0AspPro: 0.0 ± 0.0
0.82AspGln: 0.82 ± 0.568
4.102AspArg: 4.102 ± 0.933
1.641AspSer: 1.641 ± 0.737
7.383AspThr: 7.383 ± 2.416
2.461AspVal: 2.461 ± 0.307
1.641AspTrp: 1.641 ± 0.444
0.82AspTyr: 0.82 ± 0.744
0.0AspXaa: 0.0 ± 0.0
Glu
7.383GluAla: 7.383 ± 3.424
1.641GluCys: 1.641 ± 1.044
5.742GluAsp: 5.742 ± 2.636
13.946GluGlu: 13.946 ± 4.311
5.742GluPhe: 5.742 ± 0.597
3.281GluGly: 3.281 ± 0.575
0.82GluHis: 0.82 ± 0.522
4.102GluIle: 4.102 ± 0.168
4.102GluLys: 4.102 ± 2.799
7.383GluLeu: 7.383 ± 3.035
4.922GluMet: 4.922 ± 0.845
2.461GluAsn: 2.461 ± 0.876
1.641GluPro: 1.641 ± 0.709
0.0GluGln: 0.0 ± 0.0
4.102GluArg: 4.102 ± 0.933
7.383GluSer: 7.383 ± 0.92
4.102GluThr: 4.102 ± 0.911
7.383GluVal: 7.383 ± 3.424
0.82GluTrp: 0.82 ± 0.522
2.461GluTyr: 2.461 ± 1.704
0.0GluXaa: 0.0 ± 0.0
Phe
3.281PheAla: 3.281 ± 2.088
0.0PheCys: 0.0 ± 0.0
4.102PheAsp: 4.102 ± 1.96
4.922PheGlu: 4.922 ± 0.52
0.82PhePhe: 0.82 ± 0.744
3.281PheGly: 3.281 ± 1.257
0.82PheHis: 0.82 ± 0.744
1.641PheIle: 1.641 ± 1.044
2.461PheLys: 2.461 ± 0.307
4.102PheLeu: 4.102 ± 1.267
1.641PheMet: 1.641 ± 0.444
0.82PheAsn: 0.82 ± 0.522
1.641PhePro: 1.641 ± 1.136
0.82PheGln: 0.82 ± 0.522
2.461PheArg: 2.461 ± 0.785
5.742PheSer: 5.742 ± 1.731
1.641PheThr: 1.641 ± 0.444
0.82PheVal: 0.82 ± 0.568
0.82PheTrp: 0.82 ± 0.522
1.641PheTyr: 1.641 ± 0.444
0.0PheXaa: 0.0 ± 0.0
Gly
6.563GlyAla: 6.563 ± 1.935
0.82GlyCys: 0.82 ± 0.522
3.281GlyAsp: 3.281 ± 0.575
0.0GlyGlu: 0.0 ± 0.0
5.742GlyPhe: 5.742 ± 2.03
4.922GlyGly: 4.922 ± 0.716
0.0GlyHis: 0.0 ± 0.0
0.82GlyIle: 0.82 ± 0.568
5.742GlyLys: 5.742 ± 2.216
4.922GlyLeu: 4.922 ± 1.332
3.281GlyMet: 3.281 ± 0.435
1.641GlyAsn: 1.641 ± 0.737
0.0GlyPro: 0.0 ± 0.0
0.0GlyGln: 0.0 ± 0.0
1.641GlyArg: 1.641 ± 1.136
2.461GlySer: 2.461 ± 0.876
2.461GlyThr: 2.461 ± 0.307
6.563GlyVal: 6.563 ± 1.935
2.461GlyTrp: 2.461 ± 1.566
3.281GlyTyr: 3.281 ± 0.435
0.0GlyXaa: 0.0 ± 0.0
His
2.461HisAla: 2.461 ± 1.566
0.82HisCys: 0.82 ± 0.522
0.82HisAsp: 0.82 ± 0.568
0.82HisGlu: 0.82 ± 0.522
0.82HisPhe: 0.82 ± 0.522
1.641HisGly: 1.641 ± 0.709
0.0HisHis: 0.0 ± 0.0
0.82HisIle: 0.82 ± 0.568
0.82HisLys: 0.82 ± 0.522
2.461HisLeu: 2.461 ± 0.307
0.82HisMet: 0.82 ± 0.744
1.641HisAsn: 1.641 ± 0.444
0.82HisPro: 0.82 ± 0.568
0.82HisGln: 0.82 ± 0.522
0.82HisArg: 0.82 ± 0.522
0.0HisSer: 0.0 ± 0.0
0.82HisThr: 0.82 ± 0.568
2.461HisVal: 2.461 ± 0.785
0.82HisTrp: 0.82 ± 0.522
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
0.82IleAla: 0.82 ± 0.522
1.641IleCys: 1.641 ± 0.737
4.102IleAsp: 4.102 ± 1.001
5.742IleGlu: 5.742 ± 1.657
2.461IlePhe: 2.461 ± 0.307
1.641IleGly: 1.641 ± 1.136
0.0IleHis: 0.0 ± 0.0
2.461IleIle: 2.461 ± 1.085
6.563IleLys: 6.563 ± 1.848
2.461IleLeu: 2.461 ± 0.785
0.82IleMet: 0.82 ± 0.568
1.641IleAsn: 1.641 ± 0.444
2.461IlePro: 2.461 ± 0.785
2.461IleGln: 2.461 ± 0.307
5.742IleArg: 5.742 ± 3.28
7.383IleSer: 7.383 ± 1.57
0.82IleThr: 0.82 ± 0.568
4.922IleVal: 4.922 ± 0.52
0.82IleTrp: 0.82 ± 0.568
2.461IleTyr: 2.461 ± 1.704
0.0IleXaa: 0.0 ± 0.0
Lys
2.461LysAla: 2.461 ± 0.307
0.0LysCys: 0.0 ± 0.0
4.922LysAsp: 4.922 ± 1.63
7.383LysGlu: 7.383 ± 4.069
2.461LysPhe: 2.461 ± 0.307
3.281LysGly: 3.281 ± 0.435
3.281LysHis: 3.281 ± 1.426
3.281LysIle: 3.281 ± 1.474
7.383LysLys: 7.383 ± 3.035
2.461LysLeu: 2.461 ± 0.998
4.102LysMet: 4.102 ± 0.933
2.461LysAsn: 2.461 ± 0.876
2.461LysPro: 2.461 ± 0.998
1.641LysGln: 1.641 ± 0.444
8.203LysArg: 8.203 ± 3.067
6.563LysSer: 6.563 ± 2.096
4.102LysThr: 4.102 ± 1.267
2.461LysVal: 2.461 ± 0.876
0.82LysTrp: 0.82 ± 0.522
0.82LysTyr: 0.82 ± 0.568
0.0LysXaa: 0.0 ± 0.0
Leu
7.383LeuAla: 7.383 ± 1.329
0.82LeuCys: 0.82 ± 0.522
4.922LeuAsp: 4.922 ± 0.52
8.203LeuGlu: 8.203 ± 1.22
3.281LeuPhe: 3.281 ± 0.575
9.844LeuGly: 9.844 ± 1.85
0.0LeuHis: 0.0 ± 0.0
8.203LeuIle: 8.203 ± 1.271
5.742LeuLys: 5.742 ± 2.336
8.203LeuLeu: 8.203 ± 1.659
3.281LeuMet: 3.281 ± 0.575
1.641LeuAsn: 1.641 ± 0.444
1.641LeuPro: 1.641 ± 1.044
2.461LeuGln: 2.461 ± 0.876
6.563LeuArg: 6.563 ± 1.858
4.922LeuSer: 4.922 ± 0.716
4.922LeuThr: 4.922 ± 1.668
7.383LeuVal: 7.383 ± 0.336
2.461LeuTrp: 2.461 ± 1.566
1.641LeuTyr: 1.641 ± 0.444
0.0LeuXaa: 0.0 ± 0.0
Met
3.281MetAla: 3.281 ± 0.888
0.82MetCys: 0.82 ± 0.744
0.82MetAsp: 0.82 ± 0.522
4.102MetGlu: 4.102 ± 2.802
2.461MetPhe: 2.461 ± 0.785
0.82MetGly: 0.82 ± 0.522
2.461MetHis: 2.461 ± 0.785
2.461MetIle: 2.461 ± 0.307
2.461MetLys: 2.461 ± 0.307
3.281MetLeu: 3.281 ± 0.435
0.82MetMet: 0.82 ± 0.522
2.461MetAsn: 2.461 ± 1.704
0.82MetPro: 0.82 ± 0.522
0.0MetGln: 0.0 ± 0.0
4.102MetArg: 4.102 ± 0.933
0.0MetSer: 0.0 ± 0.0
0.0MetThr: 0.0 ± 0.0
2.461MetVal: 2.461 ± 1.085
0.0MetTrp: 0.0 ± 0.0
0.82MetTyr: 0.82 ± 0.568
0.0MetXaa: 0.0 ± 0.0
Asn
2.461AsnAla: 2.461 ± 0.998
0.82AsnCys: 0.82 ± 0.568
4.102AsnAsp: 4.102 ± 1.96
0.0AsnGlu: 0.0 ± 0.0
0.82AsnPhe: 0.82 ± 0.568
4.102AsnGly: 4.102 ± 2.094
0.0AsnHis: 0.0 ± 0.0
3.281AsnIle: 3.281 ± 1.408
4.922AsnLys: 4.922 ± 0.613
0.82AsnLeu: 0.82 ± 0.522
1.641AsnMet: 1.641 ± 1.049
0.0AsnAsn: 0.0 ± 0.0
4.922AsnPro: 4.922 ± 0.716
3.281AsnGln: 3.281 ± 1.048
1.641AsnArg: 1.641 ± 0.737
2.461AsnSer: 2.461 ± 1.566
1.641AsnThr: 1.641 ± 0.709
2.461AsnVal: 2.461 ± 1.566
1.641AsnTrp: 1.641 ± 1.136
2.461AsnTyr: 2.461 ± 0.785
0.0AsnXaa: 0.0 ± 0.0
Pro
1.641ProAla: 1.641 ± 1.044
0.82ProCys: 0.82 ± 0.744
1.641ProAsp: 1.641 ± 0.737
4.922ProGlu: 4.922 ± 0.52
0.82ProPhe: 0.82 ± 0.568
1.641ProGly: 1.641 ± 1.044
2.461ProHis: 2.461 ± 0.785
4.102ProIle: 4.102 ± 0.168
1.641ProLys: 1.641 ± 0.737
3.281ProLeu: 3.281 ± 1.408
2.461ProMet: 2.461 ± 0.998
2.461ProAsn: 2.461 ± 0.998
2.461ProPro: 2.461 ± 1.356
0.0ProGln: 0.0 ± 0.0
1.641ProArg: 1.641 ± 1.044
4.102ProSer: 4.102 ± 0.933
2.461ProThr: 2.461 ± 0.785
1.641ProVal: 1.641 ± 1.136
0.82ProTrp: 0.82 ± 0.522
0.0ProTyr: 0.0 ± 0.0
0.0ProXaa: 0.0 ± 0.0
Gln
0.0GlnAla: 0.0 ± 0.0
0.0GlnCys: 0.0 ± 0.0
0.82GlnAsp: 0.82 ± 0.568
4.922GlnGlu: 4.922 ± 2.126
2.461GlnPhe: 2.461 ± 1.566
2.461GlnGly: 2.461 ± 0.876
0.0GlnHis: 0.0 ± 0.0
2.461GlnIle: 2.461 ± 1.085
0.82GlnLys: 0.82 ± 0.522
4.922GlnLeu: 4.922 ± 1.246
0.82GlnMet: 0.82 ± 0.744
0.82GlnAsn: 0.82 ± 0.522
0.0GlnPro: 0.0 ± 0.0
0.82GlnGln: 0.82 ± 0.568
0.0GlnArg: 0.0 ± 0.0
0.82GlnSer: 0.82 ± 0.744
0.82GlnThr: 0.82 ± 0.568
0.0GlnVal: 0.0 ± 0.0
0.0GlnTrp: 0.0 ± 0.0
1.641GlnTyr: 1.641 ± 0.444
0.0GlnXaa: 0.0 ± 0.0
Arg
4.922ArgAla: 4.922 ± 3.536
0.82ArgCys: 0.82 ± 0.744
1.641ArgAsp: 1.641 ± 1.044
4.102ArgGlu: 4.102 ± 1.792
4.102ArgPhe: 4.102 ± 1.96
0.82ArgGly: 0.82 ± 0.568
0.82ArgHis: 0.82 ± 0.568
3.281ArgIle: 3.281 ± 1.408
4.922ArgLys: 4.922 ± 1.63
13.126ArgLeu: 13.126 ± 0.785
0.82ArgMet: 0.82 ± 0.522
4.102ArgAsn: 4.102 ± 0.168
3.281ArgPro: 3.281 ± 2.07
2.461ArgGln: 2.461 ± 2.232
4.102ArgArg: 4.102 ± 1.164
4.102ArgSer: 4.102 ± 1.65
0.82ArgThr: 0.82 ± 0.568
5.742ArgVal: 5.742 ± 1.935
0.82ArgTrp: 0.82 ± 0.522
1.641ArgTyr: 1.641 ± 0.444
0.0ArgXaa: 0.0 ± 0.0
Ser
4.102SerAla: 4.102 ± 1.001
1.641SerCys: 1.641 ± 0.737
3.281SerAsp: 3.281 ± 0.575
9.844SerGlu: 9.844 ± 2.178
0.82SerPhe: 0.82 ± 0.522
5.742SerGly: 5.742 ± 0.597
0.0SerHis: 0.0 ± 0.0
2.461SerIle: 2.461 ± 1.368
4.102SerLys: 4.102 ± 1.267
5.742SerLeu: 5.742 ± 1.028
0.82SerMet: 0.82 ± 0.568
2.461SerAsn: 2.461 ± 1.368
1.641SerPro: 1.641 ± 0.444
0.82SerGln: 0.82 ± 0.568
5.742SerArg: 5.742 ± 0.542
2.461SerSer: 2.461 ± 1.085
1.641SerThr: 1.641 ± 0.737
6.563SerVal: 6.563 ± 0.864
0.0SerTrp: 0.0 ± 0.0
3.281SerTyr: 3.281 ± 0.575
0.0SerXaa: 0.0 ± 0.0
Thr
3.281ThrAla: 3.281 ± 2.272
1.641ThrCys: 1.641 ± 0.444
0.82ThrAsp: 0.82 ± 0.522
2.461ThrGlu: 2.461 ± 1.085
1.641ThrPhe: 1.641 ± 1.136
1.641ThrGly: 1.641 ± 1.044
2.461ThrHis: 2.461 ± 0.876
5.742ThrIle: 5.742 ± 2.216
3.281ThrLys: 3.281 ± 2.075
4.922ThrLeu: 4.922 ± 1.332
0.82ThrMet: 0.82 ± 0.568
1.641ThrAsn: 1.641 ± 1.044
1.641ThrPro: 1.641 ± 1.136
0.82ThrGln: 0.82 ± 0.744
2.461ThrArg: 2.461 ± 0.998
4.102ThrSer: 4.102 ± 1.267
0.82ThrThr: 0.82 ± 0.568
2.461ThrVal: 2.461 ± 0.998
0.0ThrTrp: 0.0 ± 0.0
0.0ThrTyr: 0.0 ± 0.0
0.0ThrXaa: 0.0 ± 0.0
Val
2.461ValAla: 2.461 ± 0.307
0.82ValCys: 0.82 ± 0.522
4.102ValAsp: 4.102 ± 2.61
6.563ValGlu: 6.563 ± 0.218
2.461ValPhe: 2.461 ± 0.785
2.461ValGly: 2.461 ± 0.785
1.641ValHis: 1.641 ± 0.709
2.461ValIle: 2.461 ± 0.307
4.102ValLys: 4.102 ± 1.65
8.203ValLeu: 8.203 ± 0.336
1.641ValMet: 1.641 ± 0.444
5.742ValAsn: 5.742 ± 0.597
4.922ValPro: 4.922 ± 1.57
3.281ValGln: 3.281 ± 1.426
4.102ValArg: 4.102 ± 1.101
1.641ValSer: 1.641 ± 0.709
2.461ValThr: 2.461 ± 1.704
5.742ValVal: 5.742 ± 2.216
0.82ValTrp: 0.82 ± 0.568
2.461ValTyr: 2.461 ± 0.876
0.0ValXaa: 0.0 ± 0.0
Trp
0.82TrpAla: 0.82 ± 0.522
0.82TrpCys: 0.82 ± 0.568
1.641TrpAsp: 1.641 ± 0.444
0.0TrpGlu: 0.0 ± 0.0
0.82TrpPhe: 0.82 ± 0.522
0.0TrpGly: 0.0 ± 0.0
1.641TrpHis: 1.641 ± 1.044
0.82TrpIle: 0.82 ± 0.522
0.82TrpLys: 0.82 ± 0.522
0.82TrpLeu: 0.82 ± 0.522
0.0TrpMet: 0.0 ± 0.0
0.82TrpAsn: 0.82 ± 0.568
0.82TrpPro: 0.82 ± 0.568
1.641TrpGln: 1.641 ± 1.044
0.82TrpArg: 0.82 ± 0.522
0.82TrpSer: 0.82 ± 0.522
2.461TrpThr: 2.461 ± 0.785
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.461TyrAla: 2.461 ± 1.704
0.0TyrCys: 0.0 ± 0.0
1.641TyrAsp: 1.641 ± 0.444
3.281TyrGlu: 3.281 ± 0.575
0.0TyrPhe: 0.0 ± 0.0
3.281TyrGly: 3.281 ± 1.257
1.641TyrHis: 1.641 ± 1.044
0.82TyrIle: 0.82 ± 0.522
0.82TyrLys: 0.82 ± 0.744
2.461TyrLeu: 2.461 ± 0.785
0.0TyrMet: 0.0 ± 0.0
2.461TyrAsn: 2.461 ± 1.085
2.461TyrPro: 2.461 ± 1.566
0.0TyrGln: 0.0 ± 0.0
1.641TyrArg: 1.641 ± 1.136
2.461TyrSer: 2.461 ± 1.704
1.641TyrThr: 1.641 ± 0.444
2.461TyrVal: 2.461 ± 1.704
0.0TyrTrp: 0.0 ± 0.0
0.0TyrTyr: 0.0 ± 0.0
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3 proteins (1220 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski